KF19514, a Phosphodiesterase 4 and 1 Inhibitor, Inhibits PAF-lnduced Lung Inflammatory Responses by Inhaled Administration in Guinea Pigs

International Archives of Allergy and Immunology

Volumn 114, Issue 4, 1997, Pages 389-399

  Manabe, Haruhiko ^a   Akuta, Kaori ^a   Okamura, Kyoko ^a   Ohmori, Kenji ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Hyperresponsiveness; Inflammation; Inhalation; KF19514; Phosphodiesterase; Platelet activating factor; Tachykinin

Indexed keywords

KF 19514; PHOSPHODIESTERASE INHIBITOR; TACHYKININ; THROMBOCYTE ACTIVATING FACTOR; UNCLASSIFIED DRUG; 2 PYRROLIDONE DERIVATIVE; 3',5' CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; ACETYLCHOLINE; BRONCHODILATING AGENT; CALCIUM-CALMODULIN-DEPENDENT PHOSPHODIESTERASE; CYCLIC GMP PHOSPHODIESTERASE; NAPHTHYRIDINE DERIVATIVE; NEUROKININ A; PHOSPHODIESTERASE; PHOSPHODIESTERASE (CALCIUM,CALMODULIN); PHOSPHODIESTERASE IV; ROLIPRAM; SUBSTANCE P;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRONCHOSPASM; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; DRUG MECHANISM; ELECTRIC FIELD; EOSINOPHIL; GUINEA PIG; INFLAMMATION; INHALATIONAL DRUG ADMINISTRATION; MALE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; ANIMAL; ARTIFICIAL VENTILATION; ASTHMA; BRONCHUS; CHEMICALLY INDUCED DISORDER; CYTOLOGY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ELECTROSTIMULATION; LUNG LAVAGE; MUSCLE CONTRACTION; SMOOTH MUSCLE;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ACETYLCHOLINE; ANIMALS; ASTHMA; BRONCHI; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHOCONSTRICTION; BRONCHODILATOR AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; EOSINOPHILS; GUINEA PIGS; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NAPHTHYRIDINES; NEUROKININ A; NEUTROPHILS; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PLATELET ACTIVATING FACTOR; PYRROLIDINONES; RESPIRATORY THERAPY; ROLIPRAM; SUBSTANCE P;

EID: 0030608887     PISSN: 10182438     EISSN: 14230097     Source Type: Journal    
DOI: 10.1159/000237700     Document Type: Article

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