Anti-inflammatory and bronchodilator properties of KF19514, a phosphodiesterase 4 and 1 inhibitor

European Journal of Pharmacology

Volumn 332, Issue 1, 1997, Pages 97-107

  Manabe, Haruhiko ^a   Akuta, Kaori ^a   Sejimo, Hideko ^a   Kawasaki, Hirokazu ^a   Nukui, Etuko ^a   Ichimura, Michio ^a   Kase, Hiroshi ^a   Kawakita, Takashi ^a   Suzuki, Fumio ^a   Kitamura, Shigeto ^a   Sato, Soichiro ^a   Ohmori, Kenji ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Asthma; Bronchodilator; Eosinophil; Hyperreactivity; KF19514; Phosphodiesterase inhibitor

Indexed keywords

5 PHENYL 3 (3 PYRIDYL)METHYL 3H IMIDAZO[4,5 C][1,8]NAPHTHYRIDIN 4(5H) ONE; ACETYLCHOLINE; AMINOPHYLLINE; ANTIGEN; ANTIINFLAMMATORY AGENT; APAFANT; BRONCHODILATING AGENT; CARBACHOL; HISTAMINE; KF 19514; PHOSPHODIESTERASE I; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV; ROLIPRAM; THEOPHYLLINE; THROMBOCYTE ACTIVATING FACTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VINPOCETINE;

ANAPHYLAXIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; BRONCHODILATATION; BRONCHOSPASM; BRONCHUS HYPERREACTIVITY; CELL INFILTRATION; CONTROLLED STUDY; DOG; ENZYME INHIBITION; EOSINOPHIL; GUINEA PIG; INTRAVENOUS DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION; SMOOTH MUSCLE RELAXATION; TRACHEA MUSCLE;

ANAPHYLAXIS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIGENS; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHOCONSTRICTION; BRONCHODILATOR AGENTS; DOGS; EOSINOPHILS; GUINEA PIGS; HISTAMINE; HYPERSENSITIVITY; MALE; MICE; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; NAPHTHYRIDINES; PHOSPHODIESTERASE INHIBITORS; PLATELET ACTIVATING FACTOR; RABBITS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0030741162     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)01063-7     Document Type: Article

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