Proliferative involvement of ENX-1, a putative human Polycomb group gene, in haematopoietic cells

British Journal of Haematology

Volumn 108, Issue 4, 2000, Pages 842-847

  Fukuyama, Tomofusa ^a,b   Otsuka, Teruhisa ^a   Shigematsu, Hirokazu ^a   Uchida, Naoyuki ^a   Arima, Fumitou ^a   Ohno, Yuju ^a   Iwasaki, Hiromi ^a   Fukuda, Takahiro ^a   Niho, Yoshiyuki ^c  

^a KYUSHU UNIVERSITY   (Japan)

^b SAITAMA CANCER CENTER   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

Author keywords

ENX 1; EZH2; Haematopoiesis; Polycomb group genes (PcG); Proliferation

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; CD34 ANTIGEN; GENE PRODUCT; RETINOIC ACID;

ARTICLE; CELL PROLIFERATION; GENE EXPRESSION REGULATION; GRANULOCYTE; HEMATOPOIESIS; HEMATOPOIETIC CELL; HOMEOBOX; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTO ONCOGENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANTINEOPLASTIC AGENTS; B-LYMPHOCYTES; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; DNA; ERYTHROCYTES; GENE EXPRESSION REGULATION; GRANULOCYTES; HEMATOPOIETIC STEM CELLS; HUMANS; MEGAKARYOCYTES; OLIGONUCLEOTIDES, ANTISENSE; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; T-LYMPHOCYTES; TRETINOIN;

EID: 0034084913     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2000.01914.x     Document Type: Article

References (38)

1. Akasaka, T., Tsuji, K., Kawahira, H., Kanno, M., Harigaya, K., Hu, L., Ebihara, Y., Nakahata, T., Tetsu, O., Taniguchi, M. & Koseki, H. (1997) The role of mel-18, a mammalian Polycomb group gene, during IL-7-dependent proliferation of lymphocyte precursors. Immunity, 7, 135-146.
2. Bonnefoy-Berard, N., Munshi, A., Yron, I., Wu, S., Collins, T.L., Deckert, M., Shalom-Barak, T., Giampa, L., Herbert, E., Hernandez, J., Meller, N., Couture, C. & Altman, A. (1996) Vav: function and regulation in hematopoietic cell signaling. Stem Cells, 14, 250-268.
3. Breitman, T.R., Selonick, S.E. & Collins, S.J. (1980) Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid. Proceedings of the National Academy of Sciences of the United States of America, 77, 2936-2940.
4. Bustelo, X.R. & Barbacid, M. (1992) Tyrosine phosphorylation of the vav proto-oncogene product in activated B cells. Science, 256, 1196-1199.
5. Bustelo, X.R., Ledbetter, J.A. & Barbacid, M. (1992) Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates. Nature, 356, 68-71.
6. Bustelo, X.R., Suen, K., Michael, W.M., Dreyfuss, G. & Barbacid, M. (1995) Association of the vav proto-oncogene product with poly(rC)-specific RNA-binding proteins. Molecular and Cellular Biology, 15, 1324-1332.
7. Chen, H., Rossier, C. & Antonarakis, S.E. (1996) Cloning of a human homolog of the Drosophila enhancer of zeste gene (EZH2) that maps to chromosome 21q22.2. Genomics, 38, 30-37.
8. Denisenko, O.N. & Bomsztyk, K. (1997) The product of the murine homolog of the Drosophila extra sex combs gene displays transcriptional repressor activity. Molecular and Cellular Biology, 17, 4707-4717.
9. Denisenko, O., Shnyreva, M., Suzuki, H. & Bomsztyk, K. (1998) Point mutations in the WD40 domain of Eed block its interaction with Ezh2. Molecular and Cellular Biology, 18, 5634-5642.
10. Gateff, E. (1978) Malignant neoplasms of genetic origin in Drosophila melanogaster. Science, 200, 1448-1459.
11. Gulbins, E., Coggeshall, K.M., Baier, G., Katzav, S., Burn, P. & Altman, A. (1993) Tyrosine kinase-stimulated guanine nucleotide exchange activity of vav in T cell activation. Science, 260, 822-825.
12. Hobert, O., Jallal, B. & Ulrich, A. (1996) Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression. Molecular and Cellular Biology, 16, 3066-3073.
13. Inoue, K., Sugiyama, H., Ogawa, H., Nakagawa, M., Yamagami, T., Miwa, H., Kita, K., Hiraoka, A., Masaoka, T., Nasu, K., Kyo, T., Dohy, H., Nakauchi, H., Ishidate, T., Akiyama, T. & Kishimoto, T. (1994) WT1 as a new prognostic factor and a new marker for the detection of minimal residual disease in acute leukemia. Blood, 84, 3071-3079.
14. Joh, T., Kagami, Y., Yamamoto, K., Segawa, T., Takizawa, J., Takahashi, T., Ueda, R. & Selo, M. (1996) Identification of MLL and chimeric MLL gene products involved in 11q23 translocation and possible mechanisms of leukemogenesis by MLL truncation. Oncogene, 13, 1945-1953.
15. Kaneko, Y., Maseki, N., Takasaki, N., Sakurai, M., Hayashi, Y., Nakazawa, S., Mori, T., Sakurai, M., Takeda, T., Shikano, T. & Hiyoshi, Y. (1986) Clinical and hematologic characteristics in acute leukemia with 11q23 translocations. Blood, 67, 484-491.
16. Kanno, M., Hasegawa, M., Ishida, A., Isono, K. & Taniguchi, M. (1995) mel-18, a Polycomb group-related mammalian gene, encodes a transcriptional negative regulator with tumor suppressive activity. EMBO Journal, 14, 5672-5678.
17. Katzav, S., Martin-Zanca, D. & Barbacid, M. (1989) vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells. EMBO Journal, 8, 2283-2290.
18. LaJeunesse, D. & Shearn, A. (1996) E (z): a polycomb group gene or a trithorax group gene? Development, 122, 2189-2197.
19. Lawrence, H.J., Sauvageau, G., Humphries, R.K. & Largman, C. (1996) The role of HOX homeobox genes in normal and leukemic hematopoiesis. Stem Cells, 14, 281-291.
20. Lessard, J., Baban, S. & Sauvageau, G. (1998) Stage-specific expression of Polycomb group genes in human bone marrow cells. Blood, 91, 1216-1224.
21. Levy, L.S., Lobelle-Rich, P.A. & Overbaugh, J. (1993) flvi-2, a target of retroviral insertional mutagenesis in feline thymic lymphosarcomas, encodes bmi-1. Oncogene, 8, 1833-1838.
22. Lohuizen, M., Verbeek, S., Scheijen, B., Wientjens, E., Gulden, H. & Berns, A. (1991) Identification of cooperating oncogenes in Emmyc transgenic mice by provirus tagging. Cell, 65, 737-752.
23. Lohuizen, M., Tijms, M., Voncken, J.W., Schumacher, A., Magnuson, T. & Wientjens, E. (1998) Interaction of mouse Polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes. Molecular and Cellular Biology, 18, 3572-3579.
24. Lugt, N.M., Domen, J., Linders, K., Roon, M., Robanus-Maandag, E., Riele, H., Valk, M., Deschamps, J., Sofroniew, M., Lohuizen, M. & Berns, A. (1994) Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes and Development, 8, 757-769.
25. Matsuguchi, T., Inhorn, R.C., Carlesso, N., Xu, G., Drucker, B. & Griffin, J.D. (1995) Tyrosine phosphorylation of p95vav in myeloid cells is regulated by GM-CSF, IL-3 and steel factor and is constitutively increased by p210BCR/ABL. EMBO Journal, 14, 257-265.
26. Miyakawa, Y., Oda, A., Druker, B.J., Ozaki, K., Handa, M., Ohashi, H. & Ikeda, Y. (1997) Thrombopoietin and thrombin induce tyrosine phosphorylation of Vav in human blood platelets. Blood, 89, 2789-2798.
27. Nomura, M., Takihara, Y. & Shimada, K. (1994) Isolation and characterization of retinoic acid-inducible cDNA clones in F9 cells: one of the early inducible clones encodes a novel protein sharing several highly homologous regions with a Drosophila polyhomeotic protein. Differentiation, 57, 39-50.
28. Peytavi, R., Hong, S.S., Gay. B., d'Angeac, A.D., Selig, L., Benichou, S., Benarous, R. & Boulanger, P. (1999) HEED, the product of the human homolog of the murine eed gene, binds to the matrix protein of HIV-1. Journal of Biological Chemistry, 274, 1635-1645.
29. Pirrotta, V. (1997) Chromatin-silencing mechanisms in Drosophila maintain patterns of gene expression. Trends in Genetics, 13, 314-318.
30. Rastelli, L., Chan, O.S. & Pirrotta, V. (1993) Related chromosome binding sites for zeste, suppressors of zeste and Polycomb group proteins in Drosophila and their dependence on Enhancer of zeste function. EMBO Journal, 12, 1513-1522.
31. Schumacher, A. & Magnuson, T. (1997) Murine Polycomb-and trithorax-group genes regulate homeotic pathways and beyond. Trends in Genetics, 13, 167-170.
32. Sewalt, R.G.A.B., Vlag, J., Gunster, M., Hamer, K.M., Blaauwen, J.L., Satijn, D.P.E., Hendrix, T., Driel, R. & Otte, A.P. (1998) Characterization of interactions between the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes. Molecular and Cellular Biology, 18, 3586-3595.
33. Shigematsu, H., Iwasaki, H., Otsuka, T., Ohno, Y., Arima, F. & Niho, Y. (1997) Role of the vav proto-oncogene product (Vav) in erythropoietin-mediated cell proliferation and phosphatidylinositol 3-kinase activity. Journal of Biological Chemistry, 272, 14334-14340.
34. Shivdasani, R.A. & Orkin, S.H. (1996) The transcriptional control of hematopoiesis. Blood, 87, 4025-4039.
35. Simon, J. (1995) Locking in stable states of gene expression: transcriptional control during Drosophila development. Current Opinions in Cell Biology, 7, 376-385.
36. Takihara, Y., Tomotsune, D., Shirai, M., Katoh-Fukui, Y. Nishii, K., Motaleb, M.A., Nomura, M., Tsuchiya, R., Fujita, Y., Shibata, Y., Higashinakagawa, T. & Shimada, K. (1997) Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects. Development, 124, 3673-3682.
37. Tenen, D.G., Hromas, R., Licht, J.D. & Zhang, D.E. (1997) Transcription factors, normal myeloid development, and leukemia. Blood, 90, 489-519.
38. Yu, B.D., Hess, J.L., Horning, S.E., Brown, C.A.J. & Korsmeyer, S.J. (1995) Altered Hox expression and segmental identity in MII-mutant mice. Nature, 378, 505-508.