Further pharmacological analysis of the orphan 5-HT receptors mediating feline vasodepressor responses: Close resemblance to the 5-HT7 receptor

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 361, Issue 6, 2000, Pages 665-671

  Villalón, Carlos M ^a   Centurión, David ^a   Bravo, Guadalupe ^a   De Vries, Peter ^b   Saxena, Pramod R ^b   Ortiz, Mario I ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

^b ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

5 HT7 receptor; 5 Hydroxytryptamine; Blood pressure; Cat; GR127935; Hypotension; LY215840; Sumatriptan

Indexed keywords

5 CARBAMOYLTRYPTAMINE; 5 METHOXYTRYPTAMINE; LISURIDE; MESULERGINE; METITEPINE; N (2 HYDROXYCYCLOPENTYL) 1 ISOPROPYL 6 METHYLERGOLINE 8 CARBOXAMIDE; N [4 METHOXY 3 (4 METHYL 1 PIPERAZINYL)PHENYL] 2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL)[1,1' BIPHENYL] 4 CARBOXAMIDE; PINDOLOL; SEROTONIN; SEROTONIN 7 RECEPTOR; SUMATRIPTAN; TROPISETRON;

ANIMAL EXPERIMENT; ANTIHYPERTENSIVE ACTIVITY; ARTERY MUSCLE; ARTICLE; BLOOD PRESSURE REGULATION; CAT; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG RECEPTOR BINDING; DRUG SPECIFICITY; EXTERNAL CAROTID ARTERY; FEMALE; ILEUM; INTESTINE MUSCLE; MALE; MOLECULAR RECOGNITION; NONHUMAN; SMOOTH MUSCLE RELAXATION; VASODILATATION;

5-METHOXYTRYPTAMINE; ACETYLCHOLINE; ANIMALS; BLOOD PRESSURE; CATS; DRUG INTERACTIONS; FEMALE; HEART RATE; MALE; RECEPTORS, SEROTONIN; SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SUMATRIPTAN; SYMPATHECTOMY; VAGOTOMY;

EID: 0034079914     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002100000256     Document Type: Article

References (40)

1. 1 receptor subtype coupled to the inhibition of adenylate cyclase. Proc Natl Acad Sci USA 90:408-412
2. 7) positively linked to adenylate cyclase. J Biol Chem 268:23422-23426
3. Bom AH, Duncker DJ, Saxena PR, Verdouw PD (1988) 5-Hydroxytryptamine-induced tachycardia in the pig: possible involvement of a new type of 5-hydroxytryptamine receptor. Br J Pharmacol 93:663-671
4. 1B subtype. Eur J Pharmacol 171:87-96
5. Carter D, Champney M, Hwang B, Eglen RM (1995) Characterization of a postjunctional 5-HT receptor mediating relaxation of guinea-pig isolated ileum. Eur J Pharmacol 280:243-250
6. Connor HE, Feniuk W, Humphrey PP, Perren MJ (1986) 5-Carboxamidotryptamine is a selective agonist at 5-hydroxytryptamine receptors mediating vasodilatation and tachycardia in anaesthetized cats. Br J Pharmacol 87:417-426
7. 7 receptor ligand, blocks serotonin-induced relaxation in canine coronary artery. J Pharmacol Exp Ther 277:1560-1566
8. 1B/D receptor ligand, with functional 5-HT receptors. Naunyn-Schmiedeberg's Arch Pharmacol 355:423-430
9. 7 receptor. Naunyn-Schmiedeberg's Arch Pharmacol 356: 90-99
10. 7 receptor-mediated depressor responses in rats. Naunyn-Schmiedeberg's Arch Pharmacol 359:331-338
11. Feniuk W, Humphrey PP, Perren MJ (1989) The selective carotid arterial vasoconstrictor action of GR43175 in anaesthetized dogs. Br J Pharmacol 96:83-90
12. Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, Mylecharane EJ, Saxena PR, Humphrey PP (1994) International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). Pharmacol Rev 46:157-203
13. Kalkman HO, Engel G, Hoyer D (1984) The three distinct types of serotonergic receptors mediate the triphasic blood pressure response to serotonin in rats. J Hypertens 6:S421-S428
14. 7 receptors mediating direct relaxation in Cynomolgus monkey isolated jugular vein. Br J Pharmacol 117:926-930
15. 7) implicated in the regulation of mammalian circadian rhythms. Neuron 11:449-458
16. 7 receptor? Br J Pharmacol 114:383P
17. Martin GR, Leff P, Cambridge D, Barrett VJ (1987) Comparative analysis of two types of 5-hydroxytryptamine receptor mediating vasorelaxation: differential classification using tryptamines. Naunyn-Schmiedeberg's Arch Pharmacol 336:365-373
18. Paintal AS (1973) Vagal sensory receptors and their reflex effects. Physiol Rev 53:159-227
19. Perren MJ, Feniuk W, Humphrey PP (1989) The selective closure of feline carotid arteriovenous anastomoses (AVAs) by GR43175. Cephalalgia 9:41-46
20. Plassat JL, Amlaiky N, Hen R (1993) Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase. Mol Pharmacol 44:229-236
21. 7 receptors mediating relaxation of human colonie circular smooth muscle. Br J Pharmacol 128:849-852
22. 7) activating cAMP formation. Proc Natl Acad Sci USA 90: 8547-8551
23. 1 binding site. Drug Dev Res 13:245-258
24. 1 receptors. Arch Int Pharmacodyn Ther 277:235-252
25. 1 binding sites, dilates arterioles and constricts arteriovenous anastomoses. Br J Pharmacol 84:533-544
26. Saxena PR, Villalón CM (1990) Cardiovascular effects of serotonin agonists and antagonists. J Cardiovasc Pharmacol 15: S17-S34
27. Saxena PR, Villalón CM (1991) 5-Hydroxytryptamine: a chameleon in the heart. Trends Pharmacol Sci 12:223-227
28. 1-like receptors: a time to bid goodbye. Trends Pharmacol Sci 19:311-316
29. 7 serotonin receptor subtype. J Biol Chem 268: 18200-18204
30. 1D receptor antagonist. Behav Brain Res 73:157-161
31. Steel RGD, Torrie JH (1980) Principles and procedures of statistics. A biomedical approach, 2nd edn. McGraw-Hill Kogakusha, Tokyo
32. 1 receptor-induced smooth muscle contraction in dog saphenous vein. Br J Pharmacol 105: 603-608
33. 1A receptor. Eur J Pharmacol 133:47-56
34. Ullmer C, Schmuck K, Kalkman HO, Lübbert H (1995) Expression of serotonin receptor mRNAs in blood vessels. FEBS Lett 370:215-221
35. 4 receptor mediating tachycardia in the pig. Br J Pharmacol 102:107-112
36. 1-like receptors in the increase in external carotid blood flow induced by 5-hydroxytryptamine in the dog. Eur J Pharmacol 240:9-20
37. 1D receptor subtype. Naunyn-Schmiedeberg's Arch Pharmacol 354:550-556
38. 7 receptor. Br J Pharmacol 120: 1319-1327
39. 7 receptors mediating tachycardia in the cat. Br J Pharmacol 121:1187-1195
40. Villalón CM, Centurión D, Sánchez-López A, De Vries P, Saxena PR (1999) 5-HT receptors mediating external carotid vasoconstriction in vagosympathectomised dogs. Acta Pharmacol Sin 20:1057-1067