Nature of 5-HT1-like receptors mediating depressor responses in vagosympathectomized rats; close resemblance to the cloned 5-ht7 receptor

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 356, Issue 1, 1997, Pages 90-99

  De Vries, Peter ^a   Villalón, Carlos M ^a,b   Heiligers, Jan P C ^a   Saxena, Pramod R ^a  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^b DEPARTAMENTO DE FÍSICA   (Mexico)

Author keywords

5 ht7 Receptor; 5 Hydroxytryptamine; Blood pressure; GR127935; Hypotension; Rat; Sumatriptan

Indexed keywords

5 CARBAMOYLTRYPTAMINE; 5 METHOXYTRYPTAMINE; CLOZAPINE; ISOPRENALINE; KETANSERIN; LISURIDE; MESULERGINE; METERGOLINE; METITEPINE; N [4 METHOXY 3 (4 METHYL 1 PIPERAZINYL)PHENYL] 2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL)[1,1' BIPHENYL] 4 CARBOXAMIDE; RITANSERIN; SEROTONIN; SEROTONIN 1 RECEPTOR; SEROTONIN RECEPTOR; SUMATRIPTAN; 5-CARBOXAMIDOTRYPTAMINE; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; DRUG DERIVATIVE; ERGOLINE DERIVATIVE; OXADIAZOLE DERIVATIVE; PIPERAZINE DERIVATIVE; SEROTONIN 7 RECEPTOR; SEROTONIN AGONIST; SEROTONIN ANTAGONIST;

ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DEPRESSOR RESPONSE; HYPOTENSION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; RAT; SYMPATHECTOMY; ANIMAL; CLASSIFICATION; DRUG EFFECT; HEART RATE; PHYSIOLOGY; WISTAR RAT;

5-METHOXYTRYPTAMINE; ADRENERGIC BETA-AGONISTS; ANIMALS; BLOOD PRESSURE; CLOZAPINE; ERGOLINES; HEART RATE; ISOPROTERENOL; LISURIDE; MALE; METERGOLINE; METHIOTHEPIN; OXADIAZOLES; PIPERAZINES; RATS; RATS, WISTAR; RECEPTORS, SEROTONIN; SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SUMATRIPTAN; SYMPATHECTOMY;

EID: 0030611205     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00005034     Document Type: Article

References (45)

1. 7) positively linked to adenylate cyclase. J Biol Chem 268:23422-23426
2. Bom AH, Duncker DJ, Saxena PR, Verdouw PD (1988) 5-Hydroxytryptamine-induced tachycardia in the pig: possible involvement of a new type of 5-hydroxytryptamine receptor. Br J Pharmacol 93:663-671
3. Bouchelet I, Cohen Z, Case B, Seguela P, Hamel E (1996) Differential expression of sumatriptan-sensitive 5-hydroxytryptamine receptors in human trigeminal ganglia and cerebral blood vessels. Mol Pharmacol 50:219-223
4. Carter D, Champney M, Hwang B, Eglen RM (1995) Characterisation of a postjunctional 5-HT receptor mediating relaxation of guinea-pig isolated ileum. Eur J Pharmacol 280:243-250
5. Connor HE, Feniuk W, Humphrey PPA, Perren MJ (1986) 5-Carboxamidotryptamine is a selective agonist at 5-hydroxytryptamine receptors mediating vasodilatation and tachycardia in anaesthetized cats. Br J Pharmacol 87:417-426
6. Dalton DW, Feniuk W, Humphrey PPA (1986) An investigation into the mechanisms of the cardiovascular effects of 5-hydroxytryptamine in conscious normotensive and DOCA-salt hypertensive rats. J Auton Pharmacol 6:219-228
7. 1-like receptors in the reduction of porcine cranial arteriovenous anastomotic shunting by sumatriptan. Br J Pharmacol 102:323-330
8. 1D receptor antagonist. Br J Pharmacol 118:85-92
9. 1B/D receptor ligand, with functional 5-HT receptors. Naunyn-Schmiedeberg's Arch Pharmacol 355:423-430
10. 1C-like receptors. Naunyn-Schmiedeberg's Arch Pharmacol 347:471-477
11. Feniuk W, Humphrey PPA, Perren MJ (1989) The selective carotid arterial vasoconstrictor action of GR43175 in anaesthetized dogs. Br J Pharmacol 96:83-90
12. 1Dß receptor subtype in human and bovine cerebral arteries. Mol Pharmacol 44:242-246
13. 1D receptor subtypes. Trends Pharmacol Sci 17:103-105
14. Hirst WD, Price GW, Rattray M, Wilkin GP (1997) Identification of 5-hydroxytryptamine receptors positively coupled to adenylyl cyclase in rat cultured astrocytes. Br J Pharmacol 120:509-515
15. Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, Mylecharane EJ, Saxena PR, Humphrey PPA (1994) International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). Pharmacol Rev 46:157-203
16. Kalkman HO, Engel G, Hoyer D (1984) Three distinct phases of serotonergic receptors mediate the triphasic blood pressure response to serotonin in rats. J Hypert 2 [suppl 3]:143-145
17. 1Dß receptors. Circulation 90:1141-1153
18. 7 receptors mediating direct relaxation in Cynomolgus monkey isolated jugular vein. Br J Pharmacol 117:926-930
19. 7) implicated in the regulation of mammalian circadian rhythms. Neuron 11:449-458
20. Martin GR, Leff P, Cambridge D, Barrett VJ (1987) Comparative analysis of two types of 5-hydroxytryptamine receptor mediating vasorelaxation: differential classification using tryptamines. Naunyn-Schmiedeberg's Arch Pharmacol 336:365-373
21. 7 receptor? Br J Pharmacol 114:383P
22. Monsma FJ, Shen Y, Ward RP, Hamblin MW, Sibley DR (1993) Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol Pharmacol 43:320-327
23. Page JH, McCubbin JW (1953) Modification of vascular responses to serotonin. Am J Physiol 174:436-440
24. Paintal AS (1973) Vagal sensory receptors and their reflex effects. Physiol Rev 53:159-227
25. Perren MJ, Feniuk W, Humphrey PPA (1989) The selective closure of feline carotid arteriovenous anastomoses (AVAs) by GR43175. Cephalalgia 9:41-46
26. Rand MJ, Majewski H, Wong-Dusting H, Story DF, Loiacono RE, Ziogas J (1987) Modulation of neuroeffector transmission. J Cardiovasc Pharmacol 10:S33-44
27. 7) activating cAMP formation. Proc Natl Acad Sci USA 90:8547-8551
28. 1 receptors. Arch Int Pharmacodyn Ther 277:235-252
29. 1-like receptors. Naunyn-Schmiedeberg's Arch Pharmacol 330:121-129
30. Saxena PR, Villalón CM (1990) Cardiovascular effects of serotonin agonists and antagonists. J Cardiovasc Pharmacol 15:S17-34
31. Saxena PR, Villalón CM (1991) 5-Hydroxytryptamine, a chameleon in the heart. Trends Pharmacol Sci 12:223-227
32. 1D receptor subtype. J Pharmacol Exp Ther 252:387-395
33. 7 receptors in human vascular smooth muscle cells. Br - J Pharmacol 117:993-994
34. 7 serotonin receptor subtype. J Biol Chem 268:18200-18204
35. 1D receptor antagonist. Behav Brain Res 73:157-161
36. nd edn. McGraw-Hill Kogakusha Ltd. Tokyo
37. Ullmer C, Schmuck K, Kalkman HO, Lübbert H (1995) Expression of serotonin receptor mRNAs in blood vessels. FEBS Lett 370:215-221
38. Van Gelderen EM, Saxena PR (1992) Effect of N(G)-nitro-L-arginine methyl ester on the hypotensive and hypertensive responses to 5-hydroxytryptamine in pithed rats. Eur J Pharmacol 222:185-191
39. 1-like receptors in the increase in external carotid blood flow induced by 5-hydroxytryptamine in the dog. Eur J Pharmacol 240:9-20
40. 1D subtype. Br J Pharmacol 113:13-20
41. Villalón CM, Contreras J, Ramírez-San Juan E, Castillo C, Perusquía M, Terrón JA (1995a) Characterization of prejunctional 5-HT receptors mediating inhibition of sympathetic vasopressor responses in the pithed rat. Br J Pharmacol 116:3330-3336
42. Villalón CM, Ramírez-San Juan E, Castillo C, Castillo E, López-Muñoz FJ, Terrón JA (1995b) Pharmacological profile of the receptors that mediate external carotid vasoconstriction by 5-HT in vagosympathectomized dogs. Br J Pharmacol 116:2778-2784
43. 1D receptor subtype. Naunyn-Schmiedeberg's Arch Pharmacol 354:550-556
44. 7 receptor. Br J Pharmacol 120:1319-1327
45. 7 receptors mediating tachycardia in the cat. Br J Pharmacol (in press)