Mediation of 5-HT-induced external carotid vasodilatation in GR 127935-pretreated vagosympathectomized dogs by the putative 5-HT7 receptor

British Journal of Pharmacology

Volumn 120, Issue 7, 1997, Pages 1319-1327

  Villalón, Carlos M ^a   Centurión, David ^a   Luján Estrada, Miguel ^b   Terrón, José A ^a   Sánchez López, Araceli ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

^b UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

5 HT7 receptor; 5 hydroxytryptamine; Carotid blood flow; GR 127935; Vagosympathectomized dog; Vasodilatation

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 5 CARBAMOYLTRYPTAMINE; 5 METHOXYTRYPTAMINE; CISAPRIDE; CLOZAPINE; GRANISETRON; LISURIDE; MESULERGINE; METERGOLINE; METHYSERGIDE; METITEPINE; N [4 METHOXY 3 (4 METHYL 1 PIPERAZINYL)PHENYL] 2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL)[1,1' BIPHENYL] 4 CARBOXAMIDE; PINDOLOL; RITANSERIN; SEROTONIN; SEROTONIN 1B RECEPTOR; SEROTONIN 1D RECEPTOR; SEROTONIN 7 RECEPTOR; SEROTONIN RECEPTOR; SODIUM CHLORIDE; SUMATRIPTAN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTERY DILATATION; ARTICLE; CAROTID ARTERY; CAROTID ARTERY FLOW; CAT; CONTROLLED STUDY; CORONARY ARTERY; DOG; DOSE RESPONSE; FEMORAL VEIN; GUINEA PIG; ILEUM; INTRACEREBRAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; RABBIT; SMOOTH MUSCLE RELAXATION; SYMPATHECTOMY; SYMPATHETIC TONE; TACHYCARDIA;

5-METHOXYTRYPTAMINE; ACETYLCHOLINE; ANIMALS; CAROTID ARTERIES; DOGS; HEMODYNAMIC PROCESSES; OXADIAZOLES; PIPERAZINES; RECEPTORS, SEROTONIN; SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; VASODILATION;

EID: 0030944861     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701020     Document Type: Article

References (43)

1. 7) positively linked to adenylate cyclase. J. Biol. Chem., 268, 23422 - 23426.
2. 1B subtype. Eur. J. Pharmacol., 171, 87 - 96.
3. CARTER, D., CHAMPNEY, M., HWANG, B. & EGLEN, R.M. (1995). Characterization of a postjunctional 5-HT receptor mediating relaxation of guinea-pig ileum. Eur. J. Pharmacol., 280, 243 - 250.
4. CASTILLO, C., IBARRA, M., TERRÓN, J.A., VILLALÓN, C.M. & HONG, E. (1994). Direct effects of indorenate and 8-OH-DPAT on the blood pressure of pithed rats. Drug Develop. Res., 33, 20 - 25.
5. 1D antagonists. J. Med. Chem., 37, 2253 - 2257.
6. CONNOR, H.E., FENIUK, W., HUMPHREY, P.P.A. & PERREN, M.J. (1986). 5-Carboxamidotryptamine is a selective agonist at 5-hydroxytryptamine receptors mediating vasodilatation and tachycardia in anaesthetized cats. Br. J. Pharmacol., 87, 417 - 426.
7. 1D-receptors involved? Naunyn-Schmiedeberg's Arch. Pharmacol., 345, 509 - 515.
8. FENIUK, W., HUMPHREY, P.P.A. & WATTS, A.D. (1983). 5-Hydroxytryptamine-induced relaxation of isolated mammalian smooth muscle. Eur. J. Pharmacol., 96, 71 - 78.
9. FENIUK, K., HUMPHREY, P.P.A. & PERREN, M.J. (1989). The selective carotid arterial vasoconstrictor action of GR43175 in anaesthetized dogs. Br. J. Pharmacol., 96, 83 - 90.
10. 1D receptor subtypes. Trends Pharmacol. Sci., 17, 103 - 105.
11. HOYER, D., CLARKE, D.E., FOZARD, J.R., HARTIG, P.R., MARTIN, G.R., MYLECHARANE, E.J., SAXENA, P.R. & HUMPHREY, P.P.A. (1994). International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol. Rev., 46, 157 - 203.
12. 7 receptors mediating direct relaxation in Cynomulgus monkey isolated jugular vein. Br. J. Pharmacol., 117, 926 - 930.
13. 7) implicated in the regulation of mammalian circadian rhythms. Neuron, 11, 449 - 458.
14. MARTIN, G.R. (1994). Vascular receptors for 5-hydroxytryptamine: distribution, function and classification. Pharmacol. Ther., 62, 283 - 324.
15. 7 receptor? Br. J. Pharmacol., 114, 383P.
16. MARTIN, G.R., LEFF, P., CAMBRIDGE, D. & BARRETT, V.J. (1987). Comparative analysis of two types of 5-hydroxytryptamine receptor mediating vasorelaxation: differential classification using tryptamines. Naunyn-Schmiedeherg's Arch. Pharmacol., 336, 365 - 373.
17. MONSMA, F.J., SHEN, Y., WARD, R.P., HAMBLIN, M.W. & SIBLEY, D.R. (1993). Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol. Pharmacol., 43, 320 - 327.
18. PAGE, I.H. & McCUBBIN, J.W. (1953). Modification of vascular responses to serotonin. Am. J. Physiol., 174, 436 - 440.
19. PERREN, M.J., FENIUK, W. & HUMPHREY, P.P.A. (1989). The selective closure of feline carotid arteriovenous anastomoses by GR43175. Cephalalgia, 9 (Suppl. 9), 41 - 46.
20. PLASSAT, J.L., AMLAIKY, N. & HEN, R. (1993). Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase. Mol. Pharmacol., 44, 229 - 236.
21. 7) activating cAMP formation. Proc. Natl. Acad. Sci. U.S.A., 90, 8547 - 8551.
22. SAXENA, P.R. (1972). The effects of antimigraine drugs on the vascular responses by 5-hydroxytryptamine and related biogenic substances on the external carotid bed of dogs: Possible pharmacological implications to their antimigraine action. Headache, 12, 44 - 54.
23. SAXENA, P.R. (1974). Selective vasoconstriction in carotid vascular bed by methysergide: possible relevance to its antimigraine effect. Eur. J. Pharmacol., 27, 99 - 105.
24. 1 binding site. Drug Develop. Res., 13, 245 - 258.
25. 1 receptors. Arch. Int. Pharmacodyn., 277, 235 - 252.
26. 1-like receptors. Naunyn-Schmiedeberg's Arch. Pharmacol., 330, 121 - 129.
27. SAXENA, P.R. & VILLALÓN, C.M. (1990). Cardiovascular effects of serotonin agonists and antagonists. J. Cardiovasc. Pharmacol., 15 (Suppl. 7), S17 - S34.
28. 7 serotonin receptor subtype. J. Biol. Chem., 268, 18200 - 18204.
29. 1D receptor antagonist. Behav. Brain Res., 73, 157 - 161.
30. STEEL, R.G.D. & TORRIE, J.H. (1980). Principles and Procedures of Statistics, A Biomedical Approach, 2nd edn, Tokyo: McGraw-Hill Kogakusha, Ltd.
31. SUMNER, M.J., FENIUK, W. & HUMPHREY, P.P.A. (1989). Further characterization of the 5-HT receptor mediating vascular relaxation and elevation of cyclic AMP in porcine isolated vena cava. Br. J. Pharmacol., 97, 292 - 300.
32. 7 receptor subtype. Br. J. Pharmacol., 118, 1421 - 1428.
33. TERRÓN, J.A., HONG, E., LÓPEZ-MUÑOZ, F.J. & VILLALÕN. C.M. (1994). Inhibition of serotonin-induced increase in canine external carotid blood flow by drugs that decrease the sympathetic outflow. J. Auton. Pharmacol., 14, 165 - 175.
34. 1-adrenoceptors in the reduction of external carotid blood flow induced by buspirone and ipsapirone in the dog. Life Sci., 58, 63 - 73.
35. TREVETHICK, M.A., FENIUK, W. & HUMPHREY, P.P.A. (1984). 5-Hydroxytryptamine-induced relaxation of neonatal porcine vena cava in vitro. Life Sci., 35, 477 - 486.
36. TREVETHICK, M.A., FENIUK, W. & HUMPHREY, P.P.A. (1986). 5-Carboxamidotryptamine: a potent agonist mediating relaxation and elevation of cyclic AMP in isolated neonatal porcine vena cava. Life Sci., 38, 1521 - 1528.
37. 4 receptor mediating tachycardia in the pig. Br. J. Pharmacol., 102, 107 - 112.
38. VILLALÓN, C.M., RAMÍREZ-SAN JUAN, E., CASTILLO, C., CASTILLO, E., LÓPEZ-MUÑOZ, F.J. & TERRÕN, J.A. (1995). Pharmacological profile of the receptors that mediate external carotid vasoconstriction by 5-HT in vagosympathectomized dogs. Br. J. Pharmacol., 116, 2778 - 2784.
39. 1D receptor subtype. Naunyn-Schmiedeberg's Arch. Pharmacol., 354, 550 - 556.
40. VILLALÓN, C.M., SÁNCHEZ-LÓPEZ, A. & CENTURION, D (1996b). 5-HT receptors mediating the increases in external carotid blood flow in vagosympathectomized dogs pretreated with GR 127935. Br. J. Pharmacol., 117, 45P.
41. 1D subtype. Br J. Pharmacol., 113, 13 - 20.
42. 1-like receptors in the increase in external carotid blood flow induced by 5-hydroxytryptamine in the dog. Eur. J. Pharmacol., 240, 9 - 20.
43. 1-like receptors mediating the increase in external carotid blood flow in the dog. Drug Develop. Res., 29, 271 - 281.