The cerebellum and cognition: Cerebellar lesions impair sequence learning but not conditional visuomotor learning in monkeys

Neuropsychologia

Volumn 38, Issue 7, 2000, Pages 1054-1072

  Nixon, P D ^a   Passingham, R E ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Cerebellar nuclei; Conditional motor learning; Primates; Procedural learning; Serial reaction time task

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CEREBELLUM; CEREBELLUM INJURY; CEREBELLUM NUCLEUS; COGNITION; CONDITIONING; CONTROLLED STUDY; LEARNING; MONKEY; NONHUMAN; TASK PERFORMANCE; VISUOMOTOR COORDINATION;

ANIMALS; CEREBELLUM; COGNITION; CONDITIONING, OPERANT; MACACA FASCICULARIS; MOTOR SKILLS; PHOTIC STIMULATION; PSYCHOMOTOR PERFORMANCE; REACTION TIME; SERIAL LEARNING; VISUAL PERCEPTION;

EID: 0034077796     PISSN: 00283932     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3932(99)00138-4     Document Type: Article

References (54)

1. Akshoomoff N.A., Courchesne E. A new role for the cerebellum in cognitive operations. Behavioral Neuroscience. 106:1992;731-738.
2. Akshoomoff N.A., Courchesne E. ERP evidence for a shifting attention deficit in patients with damage to the cerebellum. Journal of Cognitive Neuroscience. 6:1994;388-399.
3. Allen G., Buxton R.B., Wong E.C., Courchesne E. Attentional activation of the cerebellum independent of motor involvement. Science. 275:1940-1943.
4. Gasparini M., Di Piero V., Ciccarelli O., Cacioppo M.M., Pantano P., Lenzi G.L. Linguistic impairment after right cerebellar stroke: a case report. European Journal of Neurology. 6:1999;353-356.
5. Botez-Marquard T., Leveille J., Botez M.I. Neuropsychological functioning in unilateral cerebellar damage. Canadian Journal of Neurological Sciences. 21:1994;353-357.
6. Bracke-Tolkmitt R., Linden A., Canavan A.G.M., Rockstroh B., Scholz E., Wessel K., Diener H.C. The cerebellum contributes to mental skills. Behavioral Neuroscience. 103:1989;442-446.
7. Canavan A.G.M., Nixon P.D., Passingham R.E. Motor learning in monkeys (Macaca fascicularis) with lesions in motor thalamus. Experimental Brain Research. 77:1989;113-126.
8. Canavan A.G.M., Sprengelmeyer R., Diener H.-C., Homberg V. Conditional associative learning is impaired in cerebellar disease in humans. Behavioral Neuroscience. 108:1994;475-485.
9. Daum I., Ackermann H. Cerebellar contributions to cognition. Behavioural Brain Research. 67:1995;201-210.
10. Dimitrov M., Grafman J., Kosseff P., Wachs J., Alway D., Higgins J., Litvan I., Lou J.-S., Hallett M. Preserved cognitive processes in cerebellar degeneration. Behavioural Brain Research. 79:1996;131-135.
11. Di Piero V., Chollet F., Dolan R.J., Thomas D.J., Frackowiak R.S.J. The functional nature of cerebellar diaschisis. Stroke. 21:1990;1365-1369.
12. Doyon J., Gaudreau D., Laforce R., Castonguay M., Bedard P.J., Bedard F., Bouchard J.-P. Role of the striatum, cerebellum, and frontal lobes in the learning of a visuomotor sequence. Brain and Cognition. 34:1997;218-245.
13. Doyon J., Laforce R.J., Bouchard G., Gaudreau D., Roy J., Poirier M., Bedard P.J., Bedard F., Bouchard J.-P. Role of the striatum, cerebellum and frontal lobes in the automatization of a repeated visuomotor sequence of movements. Neuropsychologia. 36:1998;625-641.
14. Drepper J., Timmann D., Diener H.C. Non-motor associative learning in patients with isolated degenerative cerebellar disease. Brain. 122:1999;87-97.
15. Fiez J.A., Petersen S.E., Cheney M.K., Raichle M.E. Impaired non-motor learning and error detection associated with cerebellar damage. Brain. 115:1992;155-178.
16. Fiez J.A., Raichle M.E. Linguistic processing. Schmahmann J.D. The cerebellum and cognition. 1997;233-254 Academic Press, San Diego.
17. Grafman J., Litvan I., Massaquoi S., Stewart M., Sirigu A., Hallett M. Cognitive planning deficit in patients with cerebellar atrophy. Neurology. 42:1992;1493-1496.
18. Hikosaka O., Sakai K., Miyauchi S., Takino R., Sasaki Y., Putz B. Activation of human presupplementary motor area in learning of sequential procedures: a functional MRI study. Journal of Neurophysiology. 76:1996;617-621.
19. Ivry R. Cerebellar timing systems. Schmahmann J.D. The cerebellum and cognition. 1997;256-271 Academic Press, San Diego.
20. Jenkins I.H., Brooks D.J., Nixon P.D., Frakowiak R.S.J., Passingham R.E. Motor sequence learning: a study with positron emission tomography. The Journal of Neuroscience. 14:1994;3775-3790.
21. Kermadi I., Jurquet Y., Arzi M., Joseph J.P. Neural activity in the caudate nucleus of monkeys during spatial sequencing. Experimental Brain Research. 94:1993;352-356.
22. Kim S.-G., Ugurbil K., Strick P.L. Activation of a cerebellar output nucleus during cognitive processing. Science. 265:1994;949-9451.
23. Leiner H.C., Leiner A.L., Dow R.S. The underestimated cerebellum. Human Brain Mapping. 2:1995;244-254.
24. Lu X., Hikosaka O., Miyachi S. Role of monkey cerebellar nuclei in skill for sequential movement. Journal of Neurophysiology. 79:1998;2245-2254.
25. Mackel R. The role of the monkey sensory cortex in the recovery from cerebellar injury. Experimental Brain Research. 66:1987;638-652.
26. Martin R.F., Bowden D.M. A stereotaxic template atlas of the macaque brain for digital imaging and quantitative neuroanatomy. Neuroimage. 4:1996;119-150.
27. Matsumoto N., Hanakawa T., Maki S., Graybiel A.M., Kimura M. Nigrostriatal dopamine system in learning to perform sequential motor tasks in a predictive manner. Journal of Neurophysiology. 82:1999;978-998.
28. Miyachi S., Hikosaka O., Miyashita K., Karadi Z., Rand M.K. Differential roles of monkey striatum in learning of sequential hand movement. Experimental Brain Research. 115:1997;1-5.
29. Mushiake H., Strick P.L. Pallidal neuron activity during sequential arm movements. Journal of Neurophysiology. 74:1995;2754-2758.
30. Nakamura K., Sakai K., Hikosaka O. Neuronal activity in medial frontal cortex during learning of sequential procedures. Journal of Neurophysiology. 80:1998;2671-2687.
31. Nissen M.J., Bullemer P. Attentional requirements of learning: evidence from performance measures. Cognitive Psychology. 19:1987;1-32.
32. Nixon PD. The cerebellum and cognitive processes. Unpublished doctoral thesis, University of Oxford, UK, 1998.
33. Nixon PD, Passingham RE. The cerebellum and cognition: cerebellar lesions do not impair spatial working memory or visual associative learning in monkeys, European Journal of Neuroscience 1999;11:4070-80.
34. Pascual-Leone A., Grafman J., Clark K., Stewart M., Massaquoi S., Lou J.-S., Hallett M. Procedural learning in Parkinson's Disease and cerebellar degeneration. Annals of Neurology. 34:1993;594-602.
35. Paulesu E., Frith C.D., Frackowiak R.S.J. The neural correlates of the verbal component of working memory. Nature. 362:1993;342-345.
36. Perrett S.P., Ruiz B.P., Mauk M.D. Cerebellar cortex lesions disrupt learning-dependent timing of conditioned eyelid responses. Journal of Neuroscience. 13:1993;1708-1718.
37. Petersen S.E., Fox P.T., Posner M.I., Mintun M., Raichle M.E. Positron emission tomographic studies of the processing of single words. Journal of Cognitive Neuroscience. 1:1989;153-170.
38. Raichle M.E., Fiez J.A., Videen T.O., MacLeod A.K., Pardo J.V., Fox P.T., Petersen S.E. Practice related changes in human brain functional anatomy during non-motor learning. Cerebral Cortex. 4:1994;8-26.
39. Sakai K., Hikosaka O., Miyauchi S., Takino R., Sasaki Y., Putz B. Transition of brain activation from frontal to parietal areas in visuomotor sequence learning. Journal of Neuroscience. 18:1998;1827-1840.
40. Schmahmann J.D. An emerging concept: the cerebellar contribution to higher function. Archives of Neurology. 48:1991;1178-1187.
41. Schmahmann J.D. From movement to thought: anatomy of the cerebellar contribution to cognitive processing. Human Brain Mapping. 4:1996;174-198.
42. Schmahmann J.D. The cerebellum and cognition. 1997;Academic Press, San Diego.
43. Schmahmann J.D., Pandya D.N. The cerebrocerebellar system. Schmahmann J.D. The cerebellum and cognition. 1997;31-60 Academic Press, San Diego.
44. Seitz R.J., Roland P.E. Learning of sequential finger movements in man: a combined kinematic and positron emission tomography (PET) study. European Journal of Neuroscience. 4:1992;154-165.
45. Silveri M.C., Leggio M.G., Molinari M. The cerebellum contributes to linguistic production: a case of agrammatic speech following a right cerebellar lesion. Neurology. 44:1994;2047-2050.
46. Szabo J., Cowan W.M. A stereotaxic atlas of the brain of the cynomolgus monkey (Macaca fascicularis). The Journal of Comparative Neurology. 222:1984;265-300.
47. Tanji J., Shima K. Role for supplementary motor area cells in planning several movements ahead. Nature. 371:1994;413-416.
48. Thompson R.F., Bao S., Chen L., Cipriano B.D., Grethe J.S., Kim J.J., Thompson J.K., Tracy J.A., Weninger M.S., Krupa D.J. Associative learning. Schmahmann J.D. The cerebellum and cognition. 1997;151-189 Academic Press, San Diego.
49. Toni I., Krams M., Turner R., Passingham R.E. The time course of changes during motor sequence learning: a whole-brain fMRI study. Neuroimage. 8:1998;50-61.
50. Toni I., Passingham R.E. Prefrontal-basal ganglia pathways are involved in the learning of arbitrary visuomotor associations: a PET study. Experimental Brain Research. 127:19-32.
51. Tucker J., Harding A.E., Jahanshahi M., Nixon P.D., Rushworth M., Quinn N.P., Thompson P.D. Associative learning in patients with cerebellar ataxia. Behavioral Neuroscience. 110:1996;1-6.
52. Ungerleider L.G., Mishkin M. Two cortical visual systems. Ingle D.J., Goodale M.A., Mansfield R.J. Analysis of visual behavior. 1982;549-586 MIT Press, Cambrigde, MA.
53. Winn P. Excitotoxins as tools for producing brain lesions. Conn P.M. Methods in Neurosciences. vol. 7:1991;16-27 Academic Press.
54. Yeo C.H., Heslow G. Cerebellum and conditioned reflexes. Trends in Cognitive Sciences. 2:1998;322-330.