Cerebellum and conditioned reflexes

Trends in Cognitive Sciences

Volumn 2, Issue 9, 1998, Pages 322-330

  Yeo, Christopher H ^a   Hesslow, Germund ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTATION; CEREBELLUM; CLIMBING FIBER; CONDITIONED REFLEX; EVOLUTION; EYELID REFLEX; HUMAN; LEARNING; MOSSY FIBER; MOTOR CONTROL; NICTITATING MEMBRANE; NONHUMAN; PURKINJE CELL; REVIEW; VESTIBULOOCULAR REFLEX;

EID: 0031857901     PISSN: 13646613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1364-6613(98)01219-4     Document Type: Review

References (86)

1. Flourens, P. (1824) Recherches expérimentales sur les propriétés et les fonctions de système nerveux, dans les animaux vertébrés, Crevot, Paris.
2. Luciani, L. (1915). The hind-brain, in Human Physiology (Holmes, G.M., ed.), pp. 419-485, MacMillan.
3. Bloedel J.R., Bracha V. On the cerebellum, cutaneomuscular reflexes, movement control and the elusive engrams of memory. Behav. Brain Res. 68:1995;1-44.
4. Welsh, J.P. and Harvey, J.A. (1992). The role of the cerebellum in voluntary and reflexive movements: history and current status, in The Cerebellum Revisited (Llinas, R. and Sotelo, C., eds.), pp. 301-334, Springer-Verlag.
5. Marr D. A theory of cerebellar cortex. J. Physiol. 202:1969;437-470.
6. Albus J.S. A theory of cerebellar function. Math. Biosci. 10:1971;25-61.
7. Ito M. Cerebellar control of the vestibulo-ocular reflex: around the flocculus hypothesis. Annu. Rev. Neurosci. 5:1982;275-296.
8. Gilbert P.F.C. How the cerebellum could memorize movements. Nature. 254:1975;688-689.
9. Gilbert P.F.C. A theory of memory that explains the function and structure of the cerebellum. Brain Res. 70:1974;1-18.
10. Houk J.C., Buckingham J.T., Barto A.G. Models of the cerebellum and motor learning. Behav. Brain Sci. 19:1996;368-383.
11. Smith A.M. Does the cerebellum learn strategies for the optimal time-varying control of joint stiffness? Behav. Brain Sci. 19:1996;399-410.
12. Thach W.T. On the specific role of the cerebellum in motor learning and cognition: clues from PET activation and lesion studies in man. Behav. Brain Sci. 19:1996;411-431.
13. Ito M. The cellular basis of cerebellar plasticity. Curr. Opin. Neurobiol. 1:1991;616-620.
14. Gilbert P.F.C., Thach W.T. Purkinje cell activity during motor learning. Brain Res. 128:1977;309-328.
15. Dean P. Saccades and the adjustable pattern generator. Behav. Brain Sci. 19:1996;441-442.
16. McCormick D.A.et al. Initial localization of the memory trace for a basic form of learning. Proc. Natl. Acad. Sci. U. S. A. 79:1982;2731-2735.
17. Yeo C.H., Hardiman M.J., Glickstein M. Classical conditioning of the nictitating membrane response of the rabbit. I. Lesions of the cerebellar nuclei. Exp. Brain Res. 60:1985;87-98.
18. Thompson R.F. The neurobiology of learning and memory. Science. 233:1986;941-947.
19. Thompson R.F., Krupa D.J. Organization of memory traces in the mammalian brain. Annu. Rev. Neurosci. 17:1994;519-549.
20. Yeo C.H. Cerebellum and classical conditioning of motor responses. Ann. New York Acad. Sci. 627:1991;292-304.
21. Yeo C.H., Hardiman M.J., Glickstein M. Classical conditioning of the nictitating membrane response of the rabbit. III. Connections of cerebellar lobule HVI. Exp. Brain Res. 60:1985;114-126.
22. Larsell, O. (1970) The Comparative Anatomy and Histology of the Cerebellum from Monotremes Through Apes, University of Minnesota Press.
23. Yeo C.H., Hardiman M.J., Glickstein M. Discrete lesions of the cerebellar cortex abolish the classically conditioned nictitating membrane response of the rabbit. Behav. Brain Res. 13:1984;261-266.
24. Yeo C.H., Hardiman M.J., Glickstein M. Classical conditioning of the nictitating membrane response of the rabbit. II. Lesions of the cerebellar cortex. Exp. Brain Res. 60:1985;99-113.
25. Yeo C.H., Hardiman M.J. Cerebellar cortex and eyeblink conditioning: a reexamination. Exp. Brain Res. 88:1992;623-638.
26. Hardiman M.J., Yeo C.H. The effect of kainic acid lesions of the cerebellar cortex on the conditioned nictitating membrane response in the rabbit. Eur. J. Neurosci. 4:1992;966-980.
27. van Ham J.J., Yeo C.H. The central distribution of primary afferents from the external eyelids, conjunctiva, and cornea in the rabbit, studied using WGA-HRP and B-HRP as transganglionic tracers. Exp. Neurol. 142:1996;217-225.
28. van Ham J.J., Yeo C.H. Trigeminal inputs to eyeblink motoneurons in the rabbit. Exp. Neurol. 142:1996;244-257.
29. Eccles, J.C., Ito, M. and Szentágothai, J. (1967) The Cerebellum as a Neuronal Machine, Springer-Verlag.
30. McCormick D.A., Thompson R.F. Cerebellum: essential involvement in the classically conditioned eyelid response. Science. 223:1984;296-299.
31. Lavond D.G.et al. Reacquisition of classical conditioning after removal of cerebellar cortex. Exp. Brain Res. 67:1987;569-593.
32. Harvey J.A.et al. Recoverable and nonrecoverable deficits in conditioned responses after cerebellar cortical lesions. J. Neurosci. 13:1993;1624-1635.
33. Lavond D.G., Steinmetz J.E. Acquisition of classical conditioning without cerebellar cortex. Behav. Brain Res. 33:1989;113-164.
34. Welsh J.P., Harvey J.A. Cerebellar lesions and the nictitating membrane reflex: performance deficits of the conditioned and unconditioned response. J. Neurosci. 9:1989;299-311.
35. Steinmetz J.E.et al. Disruption of classical eyelid conditioning after cerebellar lesions: damage to a memory trace system or a simple performance deficit? J. Neurosci. 12:1992;4403-4426.
36. Bracha V.et al. Effects of muscimol inactivation of the cerebellar interposed-dentate nuclear complex on the performance of the nictitating membrane response in the rabbit. Exp. Brain Res. 100:1994;453-468.
37. Davis K.D., Dostrovsky J.O. Modulatory influences of red nucleus stimulation on the somatosensory responses of cat trigeminal subnucleus oralis neurons. Exp. Neurol. 91:1986;80-101.
38. Gruart A., Yeo C.H. Cerebellar cortex and eyeblink conditioning: bilateral regulation of conditioned responses. Exp. Brain Res. 104:1995;431-448.
39. Perrett S.P., Ruiz B.P., Mauk M.D. Cerebellar cortex lesions disrupt learning-dependent timing of conditioned eyelid responses. J. Neurosci. 13:1993;1708-1718.
40. Perrett S.P., Mauk M.D. Extinction of conditioned eyelid responses requires the anterior lobe of cerebellar cortex. J. Neurosci. 15:1995;2074-2080.
41. Ivarsson M., Svensson P., Hesslow G. Bilateral disruption of conditioned responses after unilateral blockade of cerebellar output in the decerebrate ferret. J. Physiol. 502:1997;189-201.
42. Ivarsson M., Hesslow G. Bilateral control of the orbicularis oculi muscle by one cerebellar hemisphere in the ferret. NeuroReport. 4:1993;1127-1130.
43. Clark R.E., Gohl E.B., Lavond D.G. The learning-related activity that develops in the pontine nuclei during classical eye-blink conditioning is dependent on the interpositus nucleus. Learn. Mem. 3:1997;532-544.
44. Clark R.E., Lavond D.G. Neural unit activity in the trigeminal complex with interpositus or red nucleus inactivation during classical eyeblink conditioning. Behav. Neurosci. 110:1996;13-21.
45. Berthier N.E., Moore J.W. Cerebellar Purkinje cell activity related to the classically conditioned nictitating membrane response. Exp. Brain Res. 63:1986;341-350.
46. Hesslow G., Ivarsson M. Suppression of cerebellar Purkinje cells during conditioned responses in ferrets. NeuroReport. 5:1994;649-652.
47. Steinmetz J.E.et al. Classical conditioning of the rabbit eyelid response with a mossy-fiber stimulation CS: I. Pontine nuclei and middle cerebellar peduncle stimulation. Behav. Neurosci. 100:1986;878-887.
48. Steinmetz J.E., Lavond D.G., Thompson R.F. Classical conditioning in rabbits using pontine nucleus stimulation as a conditioned stimulus and inferior olive stimulation as an unconditioned stimulus. Synapse. 3:1989;225-233.
49. Svensson P., Ivarsson M., Hesslow G. Effect of varying the intensity and train frequency of forelimb and cerebellar mossy fibre conditioned stimuli on the latency of conditioned eye-blink responses in decerebrate ferrets. Learn. Mem. 3:1997;105-115.
50. Mauk M.D., Steinmetz J.E., Thompson R.F. Classical conditioning using stimulation of the inferior olive as the unconditioned stimulus. Proc. Natl. Acad. Sci. U. S. A. 83:1986;5349-5353.
51. Colin F., Desclin J., Manil J. The olivocerebellar system. Delayed and slow inhibitory effects: an overlooked salient feature of the cerebellar climbing fibers. Brain Res. 187:1980;3-27.
52. Montarolo P.G., Palestini M., Strata P. The inhibitory effect of the olivocerebellar input on the cerebellar Purkinje cells in the rat. J. Physiol. 332:1982;187-202.
53. McCormick D.A., Steinmetz J.E., Thompson R.F. Lesions of the inferior olivary complex cause extinction of the classically conditioned eyeblink response. Brain Res. 359:1985;120-130.
54. Yeo C.H., Hardiman M.J., Glickstein M. Classical conditioning of the nictitating membrane response of the rabbit: IV. Lesions of the inferior olive. Exp. Brain Res. 63:1986;81-92.
55. Yeo, C.H. (1989) The inferior olive and classical conditioning, in The Olivocerebellar System in Motor Control (Strata, P., ed.), pp. 363-373, Springer-Verlag.
56. Hesslow G. Inhibition of inferior olivary transmission by mesencephalic stimulation in the cat. Neurosci. Lett. 63:1986;76-80.
57. Nelson, B. and Mugnaini, E. (1989) Origins of GABA-ergic inputs to the inferior olive, in The Olivocerebellar System in Motor Control (Strata, P., ed.), pp. 86-107, Springer-Verlag.
58. Andersson G., Garwicz M., Hesslow G. Evidence for a GABA-mediated cerebellar inhibition of the inferior olive in the cat. Exp. Brain Res. 72:1988;450-456.
59. Hesslow G., Ivarsson M. Inhibition of the inferior olive during conditioned responses in the decerebrate ferret. Exp. Brain Res. 110:1996;36-46.
60. Kamin, L.J. (1969) Predictability, surprise, attention and conditioning, in Punishment and Aversive Behaviour (Campbell, B.A. and Church, R.M., eds), pp. 279-296, Appleton-Century-Crofts.
61. Kim J., Krupa D.J., Thompson R.F. Inhibitory cerebello-olivary projections and blocking effect in classical conditioning. Science. 279:1998;570-573.
62. Welsh J.P., Harvey J.A. Pavlovian conditioning in the rabbit during inactivation of the interpositus nucleus. J. Physiol. 444:1991;459-480.
63. Clark R.E., Zhang A.A., Lavond D.G. Reversible lesions of the cerebellar interpositus nucleus during acquisition and retention of a classically conditioned behavior. Behav. Neurosci. 106:1992;879-888.
64. Krupa D.J., Thompson J.K., Thompson R.F. Localization of a memory trace in the mammalian brain. Science. 260:1993;989-991.
65. Ramnani N., Yeo C.H. Reversible inactivations of the cerebellum prevent the extinction of conditioned nictitating membrane responses in rabbits. J. Physiol. 495:1996;159-168.
66. Hardiman M.J., Ramnani N., Yeo C.H. Reversible inactivations of the cerebellum with muscimol prevent the acquisition and extinction of conditioned nictitating membrane responses in the rabbit. Exp. Brain Res. 110:1996;235-247.
67. Yeo C.H., Lobo D.H., Baum A. Acquisition of a new-latency conditioned nictitating membrane response: major, but not complete, dependence on the ipsilateral cerebellum. Learn. Mem. 3:1997;557-577.
68. Krupa D.J., Thompson R.F. Inactivation of the superior cerebellar peduncle blocks expression but not acquisition of the rabbit's classically conditioned eye-blink response. Proc. Natl. Acad. Sci. U. S. A. 92:1995;5097-5101.
69. Salin P.A., Malenka R.C., Nicoll R.A. Cyclic AMP mediates a presynaptic form of LTP at cerebellar parallel fiber synapses. Neuron. 16:1996;797-803.
70. Hartell N.A. Strong activation of parallel fibres produces localised calcium transients and a form of LTD that spreads to distant synapses. Neuron. 16:1996;601-610.
71. Mauk M.D., Donegan N.H. A model of Pavlovian eyelid conditioning based on the synaptic organization of the cerebellum. Learn. Mem. 3:1997;130-158.
72. Moore J.W., Choi J-S. Conditioned response timing and integration in the cerebellum. Learn. Mem. 3:1997;116-129.
73. Supple W.F., Leaton R.H. Lesions of the cerebellar vermis and cerebellar hemispheres: effects on heart rate conditioning in rats. Behav. Neurosci. 104:1990;934-947.
74. Ghelarducci B., Sebastiani L. Classical heart rate conditioning and affective behavior: the role of the cerebellar vermis. Arch. Ital. Biol. 135:1997;369-384.
75. Donahoe, J.W. and Palmer, D.C. (1994) Learning and Complex Behavior, Allyn & Bacon.
76. Pavlov, I.P. (1927) Conditioned Reflexes: An Investigation of the Physiological Activity of the Cerebral Cortex (G.V. Anrep, trans.), Oxford University Press.
77. Gormezano, I., Kehoe, E.J. and Marshall-Goodell, B. (1983) Twenty years of classical conditioning research with the rabbit, in Progress in Psychobiology and Physiological Psychology (Sprague J.M. and Epstein, A.N., eds.), pp. 197-275, Academic Press.
78. Thompson R.F. The search for the engram. Am. Psychol. 31:1976;209-227.
79. Gormezano, I. (1966) Classical conditioning, in Experimental Methods and Instrumentation in Psychology (Sidowski, J.B., ed.), pp. 385-420, McGraw-Hill.
80. Mauk M.D., Thompson R.F. Retention of classically conditioned eyelid responses following acute decerebration. Brain Res. 403:1987;89-95.
81. Ivarsson M., Svensson P., Hesslow G. Bilateral disruption of conditioned responses after unilateral blockade of cerebellar output in the decerebrate ferret. J. Physiol. 502:1997;189-201.
82. Voogd J. The morphology of the cerebellum: the last 25 years. Eur. J. Morphol. 30:1992;81-96.
83. Oscarsson, O. (1980) Functional organization of olivary projection to the cerebellar anterior lobe, in The Inferior Olivary Nucleus (Courville, J., de Montigny, C. and Lamarre, Y., eds.), pp. 279-289, Raven Press.
84. Hesslow G. Correspondence between climbing fibre input and motor output in eyeblink-related areas in cat cerebellar cortex. J. Physiol. 476:1994;229-244.
85. Hesslow G. Inhibition of classically conditioned eyeblink responses by stimulation of the cerebellar cortex in the decerebrate cat. J. Physiol. 476:1994;245-256.
86. Larsell, O. (1970) The Comparative Anatomy and Histology of the Cerebellum from Monotremes Through Apes, University of Minnesota Press.