Expression of Pax-8, p53 and bcl-2 in human benign and malignant thyroid diseases

Anticancer Research

Volumn 20, Issue 1 A, 2000, Pages 311-316

  Puglisi, Fabio ^a,b   Cesselli, Daniela ^a   Damante, Giuseppe ^a   Pellizzari, Lucia ^a   Beltrami, Carlo Alberto ^a   Di Loreto, Carla ^a  

^a UNIVERSITY OF UDINE   (Italy)

^b UNIVERSITY HOSPITAL OF UDINE   (Italy)

Author keywords

Bcl 2; Neoplasms; p53; Pax 8; Thyroid

Indexed keywords

PROTEIN BCL 2; PROTEIN P53; TRANSCRIPTION FACTOR;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; FEMALE; GOITER; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPEROXIDASE STAINING; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; THYROID ADENOMA; THYROID DISEASE; THYROID FOLLICULAR CARCINOMA; THYROID GLAND; THYROID MEDULLARY CARCINOMA; THYROID PAPILLARY CARCINOMA;

ADENOCARCINOMA, FOLLICULAR; ADENOMA; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CARCINOMA; CARCINOMA, MEDULLARY; CARCINOMA, PAPILLARY; CELL DIFFERENTIATION; DNA-BINDING PROTEINS; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MIDDLE AGED; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PAIRED BOX TRANSCRIPTION FACTORS; PROTO-ONCOGENE PROTEINS C-BCL-2; THYROID DISEASES; THYROID NEOPLASMS; TRANS-ACTIVATORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0034077288     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Mitchell PJ, Tjian R: Transcriptional regulation in mammalian cells by sequence-specific DNA-binding proteins. Science 245: 371-378, 1989.
2. Stuart ET, Kiussi C, Gruss P: Mammalian Pax genes. Annu Rev Genet 27: 219-236, 1993.
3. Noll M: Evolution and role of Pax genes. Curr Opin Gen Devel 3: 595-605,1993.
4. Gruss P, Walther C: Pax in development. Cell: 69: 719-722, 1992.
5. Mansouri A, Hallonet M, Gruss P: Pax genes and their role in cell differentiation and development. Curr Opin Cell Biol 8: 851-857, 1996.
6. Treisman J, Harris E, Desplan C: The paired box encodes a second DNA-binding domain in the paired homeo domain proteins. Genes & Dev 5: 594-604, 1991.
7. Plachov D, Chowdhury K, Walther C, Simon D, Guenet JL, Gruss P: Pax-8, a murine paired box gene expressed in the developing excretory system and thyroid gland. Development 110: 643-651, 1990.
8. Zannini M, Francis-Lang H, Plachov D, Di Lauro R: Pax-8, a paired domain-containing protein, binds to a sequence overlapping the recognition site of a homeodomain and activates transcription from two thyroid-specific promoters. Mol Cel Biol 12: 4230-4241, 1992.
9. Ohno M, Zannini M, Levy O, Carrasco N, Di Lauro R: The paired-domain transcription factor Pax-8 binds to the upstream enhancer of the rat sodium/iodide symporter gene and partecipates in both thyroid-specific and cyclic-AMP-dependent transcription. Mol Cell Biol 19: 2051-2060, 1999.
10. Mansouri A, Chowdury K, Gruss P: Follicular cells of the thyroid gland require Pax-8 gene function. Nature Genetics 19: 87-90, 1998.
11. Fabbro D, Di Loreto C, Beltrami CA, Belfiore A, Di Lauro R, Damante G: Expression of thyroid-specific transcription factors TTF-1 and Pax-8 in human thyroid neoplasms. Cancer Res 54: 4744-4749, 1994.
12. Pavlovic-Hournac M, Delbauffe D: Discontinuity of thyroid gland response to hormonal stimulation: effect of TSH and cAMP on iodide organification. Mol Cell Endocrinol 8: 157-173, 1977.
13. Tagge EP, Hanson P, Re GG, Othersen HB Jr, Smith CD, Garvin AJ: Paired box gene expression in Wilms' tumor. J Pediatr Surg 29: 134-141, 1994.
14. Hazen-Martin DJ, Re GG, Garvin AJ, Sens DA: Distinctive properties of an anaplastic Wilms' tumor and its associated epithelial cell line. Am J Pathol 144: 1023-1034, 1994.
15. El Bahtimi R, Hazen-Martin DJ, Re GG, Willingham MC, Garvin AJ: Immunophenotype, mRNA expression, and gene structure of p53 in Wilms' tumor. Mod Pathol 9: 238-244, 1996.
16. Bardeesy N, Falkoff D, Petruzzi MJ, Nowak N, Zabel B, Adam M, Aguiar MC, Grundy P, Shows T, Pelletier J: Anaplastic Wilms' tumour, a subtype displaying poor prognosis, harbours p53 gene mutations. Nat Genet 7: 91-97, 1994.
17. Wen JG, van Steenbrugg GJ, Egeler RM, Nijman RM: Progress of fundamental research in Wilms' tumor. Urol Res 25: 223-230, 1997.
18. Lahoti C, Thorner P, Malkin D, Jeger H: Immunohistochemical detection of p53 in Wilms' tumors correlates with unfavorable outcome. Am J Pathol 148: 1577-1589, 1996.
19. Hall PA, Lane DP: p53 in tumour pathology: can we trust immunohistochemistry?-Revisited. J Pathol 172: 1-4, 1994.
20. Jossart GH, Epstein HD, Shaver JK, Weier HU, Greulich KM, Tezelman S, Grossman RF, Siperstein AE, Duh QY, Clark OH: Immunocytochemical detection of p53 in human thyroid carcinomas is associated with mutation and immortalization of cell lines. J Clin Endocrinol Metab 81: 3498-504, 1996.
21. Casamassimi A, Miano MG, Porcellini A, De Vita G, de Nigris F, Zannini M, Di Lauro R, Russo T, Avvedimento VE, Fusco A: p53 genes mutated in the DNA binding site or at a specific COOH-terminal site exert divergent effects on thyroid cell growth and differentiation. Cancer Res 58: 2888-2894, 1998.
22. Battista S, Martelli ML, Fedele M, Chiappetta G, Trapasso F, De Vita G, Battaglia C, Santoro M, Viglietto G, Fagin JA, Fusco A: A mutated p53 gene alters thyroid cell differentiation. Oncogene 16: 2029-2037, 1995.
23. Fagin JA, Tang SH, Zeki K, Di Lauro R, Fusco A, and Gonsky R: Re-expression of thyroid peroxidase in a derivative of an undifferentiated thyroid carcinoma cell line by introduction of wild-type p53. Cancer Res 56: 765-771, 1996.
24. Wyllie FS, Haughton MF, Rowson JM, Wynford-Thomas D: Human thyroid cancer cells as a source of iso-genic, iso-phenotypic cell lines with or without functional p53. Br J Cancer 79: 1111-1120, 1999.
25. Hewitt SM, Hamada S, Monarres A, Kottical RV, Saunders GF, McDonnell TJ: Transcriptional activation of the bcl-2 apoptosis suppressor gene by the paired box transcription factor Pax-8. Anticancer Res 17: 3211-3215, 1997.
26. Maulbecker CC, Gruss P: The oncogenic potential of Pax genes. The EMBO J 12: 2361-2367, 1993.