Immunohistochemical detection of p53 in Wilms' tumors correlates with unfavorable outcome

American Journal of Pathology

Volumn 148, Issue 5, 1996, Pages 1577-1589

  Lahoti, Chitra ^a   Thorner, Paul ^a   Malkin, David ^a   Yeger, Herman ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; PROTEIN P53;

ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFANT; MALE; NEPHROBLASTOMA; PATHOGENESIS; PRIORITY JOURNAL; PROGNOSIS; SINGLE STRAND CONFORMATION POLYMORPHISM; TREATMENT OUTCOME; TUMOR GROWTH;

BLOTTING, WESTERN; CHILD; CHILD, PRESCHOOL; DNA, NEOPLASM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, WILMS TUMOR; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT; KIDNEY; KIDNEY NEOPLASMS; MALE; MUTATION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROGNOSIS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; WILMS TUMOR;

EID: 0029864908     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Coppes MJ: The management and biological behavior of Wilms' tumor Int Rev Exp Pathol 1994, 35:149-176
2. Grundy PE, Telzerow PE, Breslow N, Moksness J, Huff V, Paterson MC. Loss of heterozygosity for chromosome 16q and 1p in Wilms' tumors predicts an adverse outcome. Cancer Res 1994, 54 2331-2333
3. Greenblatt MS, Bennett WP, Hollstein M, Harris CC. Mutations of p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis Cancer Res 1994, 54:4855-4878
4. Bosani S, Viale G, Bossi P, Maggioni M, Coggi G, Murray JJ, Lee AKC: Cytoplasmic accumulation of p53 protein: an independent prognostic indicator in colorectal adenocarcinoma J Natl Cancer Inst 1994, 86: 681-687
5. Thor AD, Moore DH II, Edgerton SM, Kawaski ES, Reihsaus E, Lynch HT, Marcus JN, Schwartz L, Chen L-C, Mayall BH, Smith HS Accumulation of p53 tumor suppressor gene protein: an independent marker of prognosis in breast cancers. J Natl Cancer Inst 1992, 84: 845-855
6. Quinlan DC, Davidson AG, Summers CL, Warden HE, Doshi HM: Accumulation of p53 protein correlates with poor prognosis in human lung cancer. Cancer Res 1992, 52.4828-4831
7. Kastan MB, Zhan Q, El-Deiry WS, Carrier F, Jacks T, Walsh WV, Plunkett BS, Vogelstein B, Fornace AJ: A mammalian cell cycle check point pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia Cell 1992, 71.587-591
8. Harper JW, Adami GR, Wei N, Keyomarsi SJ, Elledge SJ. The p21 cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 1993, 75 805-816
9. Miyashita T, Reed JC: Tumor suppressor p53 is a direct transcriptional activator of the human bax gene Cell 1995, 80:293-299
10. Ryan JJ, Prochownik E, Gottleib CA, Apel IJ, Merino R, Nunez G, Clarke MF: c-myc and bcl-2 modulate p53 function by altering p53 subcellular trafficking during the cell cycle. Proc Natl Acad Sci USA 1994, 91:5878-5882
11. Oliner JD, Pietenpol JA, Thiagalingam S, Gyuris J, Kinzler KW, Vogelstein B: Oncoprotein mdm2 conceals the activation domain of tumor suppressor p53. Nature 1993, 362 857-860
12. Spandau DA: Distinct conformations of p53 are observed at different stages of keratinocyte differentiation Oncogene, 1994, 9.1861-1868
13. Jeffers MD, Richmond J, Farquharson M, McNicol AM: p53 immunoreactivity in cervical intraepithelial neoplasia and non-neoplastic cervical squamous epithelium. J Clin Pathol 1994, 47:1073-1076
14. Lemoine NR, Hughes CM, Cowell JK: Aberrant expression of the tumor suppressor gene p53 is very frequent in Wilms' tumor. J Pathol 1992, 168.237-242
15. Malkin D, Sexsmith E, Yeger H, Williams BRG, Coppes MJ: Mutations of p53 tumor suppressor gene occur infrequently in Wilms' tumor. Cancer Res 1993, 54: 2077-2079
16. Waber PG, Chen J, Nisen PD: Infrequency of ras, WT1 or Rb gene alterations in Wilms' tumors. Cancer 1993, 72:3733-3738
17. Takeuchi S, Bartram CR, Ludwig R, Royer-Pokora B, Schneider S, Imamura J, Koeffler HP mutations in p53 in Wilms' tumors. Modern Pathol 1995, 8:483-487
18. Call KM, Glaser T, Ito CY, Buckler AJ, Pelletier J, Haber DA, Rose EA, Kral A, Yeger H, Lewis WH, Jones C, Housman DE. Isolation and characterization of a Zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus. Cell 1990, 60 509-520
19. Yeger H, Cullinane C, Flenniken A, Chilton-MacNeill S, Campbell C, Huang A, Bonetta L, Thorner P, Williams BRG Coordinate expression of Wilms' tumor genes correlates with Wilms' tumor phenotypes. Cell Growth Differ 1992, 3:855-864
20. Maheshwaren S, Park S, Benard A, Morris JF, Rauscher F III, Hill DE, Haber DA: Physical and functional interactions between WT1 and p53 Proc Natl Acad Sci USA 1993, 90.5100-5104
21. Delarue F, Virone A, Hagege J, Lacave R, Peraldi M-N, Adida C, Rondeau, Feunteun J, Sraer J-D: Stable cell line of T-SV40 immortalized human glomerular visceral epithelial cells Kidney Int 1991, 40.906-912
22. Bardeesy N, Falkoff D, Petruzzi MJ, Nowak N, Zabel B, Adam M, Aguiar MC, Grundy P, Shows T, Pelletier J. Anaplastic Wilms' tumor, a sub-type displaying poor prognosis, harbours p53 gene mutations. Nat Genet 1994, 7:91-97
23. Ueda H, Ullrich SJ, Gangeni D, Kappel CA, Ngo L, Feitelson MA, Jay G: Functional inactivation but not structural mutations of p53 causes liver cancer. Nat Genet 1995, 9 41-47
24. Cripps KJ, Purdie CA, Carder PJ, White S, Komine K, Bird CC, Wyllie AH: A study of stabilization of p53 protein versus point mutations in colorectal cancers. Oncogene 1994, 9.2739-2743
25. Moll UM, Riou G, Levine AJ Two distinct mechanisms alter p53 in breast cancer, mutation and nuclear exclusion Proc Natl Acad Sci USA 1992, 89: 7262-7266
26. Wyllie FS, Haughton MF, Blaydes JP, Schlumberger M, Wynford-Thomas D: Evasion of p53 mediated growth control occurs by three alternative mechanisms in transformed thyroid epithelial cells. Oncogene 1995, 10 49-59
27. Pezella F, Micklem K, Turley H, Pulford K, Jones M, Kocialkowski S, Delia D, Aiello A, Bicknell R, Smith K, Harris L, Gattner KC, Mason DY Antibody for detecting p53 protein by immunohistochemistry in normal tissues. J Clin Pathol 1994, 47.592-96
28. Bardeesy N, Beckwith JB, Pelletier J: Clonal expansion and attenuated apoptosis in Wilms' tumors are associated with p53 gene mutations. Cancer Res 1995, 55: 251-219
29. Pelletier J: Molecular genetics of Wilms' tumor: insights into normal and abnormal renal development. Can J Oncol 1994, 4.262-272
30. Anderson LM, Castleberg RL, Harsh GR IV, Louis DN, Hanson JW: Human ghomas with wild type p53 express bcl-2 Cancer Res 1995, 55:999-1001
31. Moll UM, LaQuaglia M, Benard J, Riou G: Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors. Proc Natl Acad Sci USA 1995, 92:4407-4411