p53 genes mutated in the DNA binding site or at a specific COOH-terminal site exert divergent effects on thyroid cell growth and differentiation

Cancer Research

Volumn 58, Issue 13, 1998, Pages 2888-2894

  Casamassimi, Amelia ^a,f   Miano, Maria Giuseppina ^a   Porcellini, Antonio ^a   De Vita, Gabriella ^c   De Nigris, Filomena ^a   Zannini, Mariastella ^c   Di Lauro, Roberto ^c,d   Russo, Tommaso ^e   Avvedimento, Vittorio Enrico ^b   Fusco, Alfredo ^b,e  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b UNIVERSITY MEDITERRANEA OF REGGIO CALABRIA   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d STAZIONE ZOOLOGICA ANTON DOHRN   (Italy)

^e UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^f Assoc Italiana Ricerca sul Cancro

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; PROTEIN P53; THYROTROPIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL CULTURE; CELL DIFFERENTIATION; CELL GROWTH; CELL LEVEL; DNA BINDING; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSFECTION; IMMUNOBLOTTING; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; THYROID CELL;

ANIMALS; BINDING SITES; CELL DIFFERENTIATION; CELL DIVISION; CELLS, CULTURED; CYCLIC AMP; GENES, P53; MUTATION; PEROXIDASES; PHENOTYPE; RATS; RECEPTORS, THYROTROPIN; THYROGLOBULIN; THYROID GLAND; TRANSCRIPTION FACTOR AP-1; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 15444343748     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Nigro, J. M., Baker, S. J., Preisinger, A. C., Jessup, J. M., Hostetter, R., Cleary, K., Bigner, S. H., Davidson, N., Baylin, S., Devilee, P., Glover, T., Colling, F. S., Weston, A., Modali, R., Harris, C. C., and Vogelstein, B. Mutations in the p53 gene occur in diverse human tumor types. Nature (Lond.), 342: 705-707, 1989.
2. Hollstein, M., Sidransky, H., Vogelstein, B., and Harris, C. C. p53 mutations in human cancer. Science (Washington DC), 253: 49-53, 1991.
3. Harris, C. C., and Hollstein, M. N. Clinical implications of the p53 tumor suppressor gene. N. Engl. J. Med., 329: 1318-1327, 1993.
4. Wright, P. A., Lemoine, N. R., Goretski, P. E., Wyllie, F. S., Bond, J., Hughes, C., Roher, H. D., Williams, E. D., and Wynford-Thomas, D. Mutation of p53 gene in a differentiated human thyroid carcinoma cell line but not in primary thyroid tumors. Oncogene, 6: 1693-1697, 1991.
5. Ito, T., Seyama, T., Mizumo, T., Tsuyama, N., Hayashi, Y., Hayashi, Y., Dohi, K., Nakamura, N., Akiyama, M. Unique association of p53 mutations with undifferentiated carcinomas of the thyroid gland. Cancer Res., 52: 1369-1371, 1992.
6. Nakamura, T., Yana, I., Kobayashi, T., Shin, E., Karakawa, K., Fujita, S., Miya, A., Mori, T., Nishisho, I., and Takai, S-I. p53 gene mutations associated with anaplastic transformation of human thyroid carcinomas. Jpn. J. Cancer Res., 83: 1293-1298, 1992.
7. Donghi, R., Longoni, A., Pilotti, S., Michieli, P., Della Porta, G., and Pierotti, M. A. p53 mutations are restricted to poorly differentiated and undifferentiated carcinomas of the thyroid gland. J. Clin. Invest., 91: 1753-1760, 1993.
8. Fagin, J. A., Matsuo, K., Karmakar, A., Chen, D. L., Tang, S-H., and Koeffler, H. P. High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas. J. Clin. Invest., 91: 179-184, 1993.
9. Dobashi, Y., Sakamoto, A., Sugimura, H., Mernyei, M., Mori, M., Oyama, T., and Machinami, R. Overexpression of p53 as a possible prognostic factor in human thyroid carcinoma. Am. J. Surg. Pathol., 14: 375-381, 1993.
10. Salvatore, D., Celetti, A., Fabien, N., Paulin, C., Martelli, M. L., Battaglia, C., Califano, D., Monaco, C., Viglietto, G., Santoro, M., and Fusco, A. Low frequency of p53 mutations in human thyroid tumors; p53 and Ras mutation in two out of fifty-six thyroid tumors. Eur. J. Endocrinol., 134: 177-183, 1996.
11. Hartman, A., Blaszyk, H., McGovern, R. M., Schroeder, J. J., Cunningham, J., De Vries, E. M. G., Kovach, J. S., and Sommer, S. S. p53 gene mutations inside and outside of exons 5-8: the patterns differ in breast and other cancers. Oncogene, 10: 681-688, 1995.
12. Levine, A. J., and Momand, J. Tumor suppressor genes: the p53 and retinoblastoma sensitivity genes and gene products. Biochim. Biophys. Acta, 1032: 119-136, 1990.
13. Mercer, W. E., Shields, M. T., Amin, M., Sauve, G. J., Appella, E., Romano, J. W., and Ullrich, S. J. Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53. Proc. Natl. Acad. Sci. USA, 87: 6166-6170, 1990.
14. Baker, S. J., Markowitz, S., Fearon, E. R., Willson, J. K. V., and Vogelstein, B. Suppression of human colorectal carcinoma cell growth by wild-type p53. Science (Washington DC), 249: 912-915, 1990.
15. Donehower, L. A., and Bradley, A. The tumor suppressor p53. Biochim. Biophys. Acta, 1155: 181-205, 1993.
16. Diller, L., Kassel, J., Nelson, C. E., Gryka, M. A., Litwak, G., Gebhardt, M., Bressac, B., Oztork, M., Baker, S. J., Vogelstein, B., and Friend, S. H. p53 functions as a cell cycle control protein in osteosarcomas. Mol. Cell. Biol., 10: 5772-5781, 1990.
17. Lin, D., Shields, M. T., Ullrich, S. J., Appella, E., and Mercer, W. E. Casein kinase II is a negative regulator. Proc. Natl. Acad. Sci. USA, 89: 9210-9214, 1992.
18. Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., and Jacks, T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature (Lond.), 362: 847-849, 1993.
19. Clarke, A. R., Purdie, C. A., Harrison, D. J., Morris, R. G., Bird, C. C., Hooper, M. L., and Willie, A. H. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature (Lond.), 362: 849-852, 1993.
20. El Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., and Vogelstein, B. WAF1, a potential mediator of p53 tumor suppression. Cell, 75: 817-825, 1993.
21. Harper, J. W., Adami, G. R., Wei, N., Keyomarsi, K., and Elledge, S. J. The p21 cdk-interacting protein cipl is a potent inhibitor of G1 cyclin-dependent kinase. Cell, 75: 805-816, 1993.
22. Miyashita, T., and Reed, J. C. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell, 80: 293-299, 1995.
23. Pinna, L. A. Casein kinase 2: an 'eminence grise' in cellular regulation? Biochim. Biophys. Acta, 1054: 267-284, 1990.
24. Battista, S., Martelli, M. L., Fedele, M., Chiappetta, G., Trapasso, F., De Vita, G., Battaglia, C., Santoro, M., Viglietto, G., Fagin, J. A., and Fusco, A. A mutated p53 gene alters thyroid cell differentiation. Oncogene, 11: 2029-2037, 1995.
25. Fiscella, M., Zambrano, N., Ullrich, S. J., Unger, T., Lin, D., Cho, B., Mercer, W. E., Anderson, C. W., and Appella, E. The carboxy-terminal serine 392 phosphorylation site of human p53 is not required for wild-type activities. Oncogene, 9: 3249-3257, 1994.
26. Hall, S. R., Campbell, L. E., and Meek, D. W. Phosphorylation of p53 at the casein kinase II site selectively regulates p53-dependent transcriptional repression but not transactivation. Nucleic Acids Res., 24: 1119-1126, 1996.
27. Fusco, A., Berlingieri, M. T., Portella, G., Di Fiore, P. P., Grieco, M., and Vecchio, G. One- and two-step transformation of rat thyroid epithelial cells by retroviral oncogenes. Mol. Cell. Biol., 7: 3365-3370, 1987.
28. Graham, F. L., and Van der Eb, A. J. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology, 52: 456-467, 1973.
29. Chomczynski, P., and Sacchi, N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162: 156-159, 1987.
30. Sambrook, J., Fritsch, E. F., and Maniatis, T. Molecular Cloning: A Laboratory Manual, Ed 2. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 1989.
31. Di Lauro, R., Obici, S., Acquaviva, A., and Alvino, C. Construction of recombinant plasmids containing rat thyroglobulinse mRNA sequences. Gene (Amst.), 19: 117-125, 1982.
32. Akamizu, T., Ikuyama, S., Saji, M., Kosugi, S., Kozak, C., McBride, W. O., and Kohn, L. Cloning, chromosomal assignment, and regulation of the rat thyrotropin receptor: expression of the gene is regulated by thyrotropin, agents that increase cAMP levels, and thyroid autoantibodies. Proc. Natl. Acad. Sci. USA, 87: 5677-5681, 1990.
33. Zarrilli, R., Formisano, S., and Di Jeso, B. Hormonal regulation of thyroid peroxidase in normal and transformed rat thyroid cells. Mol. Endocrinol., 4: 39-45, 1990.
34. Di Palma, T., Tucci, M., Russo, G., Maglione, D., Lago, C. T., Romano, A., Saccone, S., Della Valle, G., De Gregorio, L., Dragani, T. A., Viglietto, G., and Persico, M. G. The placenta growth factor gene of the mouse. Mamm. Genome, 7: 6-12, 1996.
35. Guazzi, S., Price, M., De Felice, M., Damante, G., Mattei, M. G., and Di Lauro, R. Thyroid nuclear factor 1 (TTF1) contains a homodomain and displays a novel DNA binding specificity. EMBO J., 9: 3631-3639, 1990.
36. Zannini, M., Avantaggiato, V., Biffali, E., Amone, M. I., Sato, K., Pischetola, M., Taylor, B. A., Phillips, S. J., Simeone, A., and Di Lauro, R. TTF-2, a new forkhead protein, shows a temporal expression in the devolping thyroid which is consistent with a role in controlling the onset of differentiation. EMBO J., 16: 3185-3197, 1997.
37. Fagin, J. A., Tang, S-H., Zeki, K., Di Lauro, R., Fusco, A., and Gonsky, R. Reexpression of thyroid peroxidase in a derivative of an undifferentiated thyroid carcinoma cell line by introduction of wild-type p53. Cancer Res., 56: 765-771, 1996.
38. Viglietto, G., Maglione, D., Rambaldi, M., Cerutti, J., Romano, A., Trapasso, F., Fedele, M., Ippolito, P., Chiappetta, G., Botti, G., Fusco, A., and Persico, M. G. Upregulation of vascular endothelial growth factor (VEGF) and down-regulation of placenta growth factor (P1GF) associated with malignancy in human thyroid tumors and cell lines. Oncogene, 11: 1569-1579, 1995.
39. Viglietto, G., Romano, A., Manzo, G., Chiappetta, G., Paoletti, I., Califano, D., Galati, M. G., Mauriello, V., Bruni, P., Lago, C. T., Fusco, A., and Persico, M. G. Upregulation of the angiogenic factors PIGF, VEGF and their receptors (Fit-1, Flk-1/KDR) by TSH in cultured thyrocytes and thyroid gland of thiouracil-fed rats suggest a TSH-dependent paracrine mechanisms for goiter hypervascularization. Oncogene, 15: 2687-2698, 1997.
40. Ginsberg, D., Mechta, F., Yaniv, M., and Oren, M. Wild-type p53 can down-modulate the activity of various promoters. Proc. Natl. Acad. Sci. USA, 88: 9979-9983, 1991.
41. Vallone, D., Battista, S., Pierantoni, G. M., Fedele, M., Casalino, L., Santoro, M., Viglietto, G., Fusco, A., and Verde, P. Neoplastic transformation of rat thyroid cells requires the JunB and Fral gene induction which is dependent on the HMGI-C gene products. EMBO J., 17: 5310-5321, 1997.
42. Battista, S., de Nigris, F., Pierantoni, M. G., Fedele, M., Chiappetta, G., Scala, S., Santoro, M., Viglietto, G., Verde, P., and Fusco, A. Increase in AP-1 activity is a general event in thyroid cell transformation in vivo and in vitro. Oncogene, in press, 1998.
43. Milner, J., and Medcalf, E. A. Cotranslation of activated mutant p53 with wild type drives the wild-type protein into the mutant conformation. Cell, 65: 765-774, 1991.
44. Porcellini, A., Ruggiano, G., Pannain, S., Ciullo, I., Amabile, G., Fenzi, G., and Avvedimento, E. V. Mutations of thyrotropin receptor isolated from thyroid autonomous functioning adenomas confer TSH-independent growth to thyroid cells. Oncogene, 15: 781-789, 1997.
45. Rezzonico, R., Loubat, A., Lallemand, D., Pfarr, C. M., Far, D. F., Proudfoot, A., Rossi, B., and Ponzio, G. Cyclic AMP stimulates a JunD/Fra-2 AP-1 complex and inhibits the proliferation of interleukin-6-dependent cell lines. Oncogene, 11: 1069-1078, 1995.
46. Fontoura, B. M. A., Sorokina, E. A., David, E., and Carroll, R. B. p53 is covalently linked to 5.8S rRNA. Mol. Cell. Biol., 12: 5145-5151, 1992.
47. Hupp, T. R., Meek, D. W., Midgley, C. A., and Lane, D. P. Regulation of the specific DNA binding function of p53. Cell, 71: 875-886, 1992.
48. Milne, D. M., Palmer, R. H., and Meek, D. W. Mutation of the casein kinase II phosphorylation site abolishes the anti-proliferative activity of p53. Nucleic Acids Res., 20: 5565-5570, 1992.