Disruption of the substance P receptor (neurokinin-1) gene does not prevent upregulation of preprotachykinin-A mRNA in the spinal cord of mice following peripheral inflammation

European Journal of Neuroscience

Volumn 11, Issue 10, 1999, Pages 3531-3538

  Palmer, James A ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

Hyperalgesia; Inflammation; Neurokinin 1 receptor; Spinal cord; Substance P

Indexed keywords

DYNORPHIN; FREUND ADJUVANT; MESSENGER RNA; NEUROTRANSMITTER; PREPROTACHYKININ; SUBSTANCE P; SUBSTANCE P RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENE DISRUPTION; GENETIC RECOMBINATION; GENOTYPE; HYPERALGESIA; INFLAMMATION; MESSENGER RNA SYNTHESIS; MOUSE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSORY NERVE CELL; SPINAL CORD;

ANIMALS; DYNORPHINS; FREUND'S ADJUVANT; GENE EXPRESSION; HYPERALGESIA; MICE; MICE, KNOCKOUT; NEURITIS; PERIPHERAL NERVES; POSTERIOR HORN CELLS; PROTEIN PRECURSORS; RECEPTORS, NEUROKININ-1; RNA, MESSENGER; SUBSTANCE P; TACHYKININS;

EID: 0032846762     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.1999.00771.x     Document Type: Article

References (3)

1. Abbadie, C., Brown, J.L., Mantyh, P.W. & Basbaum, A.I. (1996) Spinal cord substance P receptor immunoreactivity increases in both inflammatory and nerve injury models of persistent pain. Neuroscience, 70, 201-209.
2. Abbadie, C, Trafton, J., Liu, H., Mantyh, P.W. & Basbaum, A.I. (1997) Inflammation increases the distribution of dorsal horn neurons that internalize the neurokinin-1 receptor in response to noxious and nonnoxious stimulation. J. Neurosci., 17, 8049-8060.
3. Alien, B.J., Rogers, S.D., Ghilardi, J.R., Menning, P.M., Kuskowski, M.A., Basbaum, A.I., Simone, D.A. & Mantyh, P.W. (1997) Noxious cutaneous thermal stimuli induce a graded release of endogenous substance P in the spinal cord: imaging peptide action in vivo. J. Neurosci., 17, 5921-5927.