The epidemiology of selenium and human cancer

Tumori

Volumn 86, Issue 2, 2000, Pages 105-118

  Vinceti, Marco ^a   Rovesti, Sergio ^a   Bergomi, Margherita ^a   Vivoli, Gianfranco ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Cancer incidence; Diet; Environment; Selenium

Indexed keywords

SELENIUM;

CANCER; CANCER EPIDEMIOLOGY; CANCER INCIDENCE; CANCER RISK; CHEMICAL CARCINOGENESIS; DISEASE ASSOCIATION; ENVIRONMENTAL EXPOSURE; HUMAN; MEDICAL LITERATURE; PROSTATE CARCINOMA; REVIEW; RISK ASSESSMENT;

EID: 0034075969     PISSN: 03008916     EISSN: None     Source Type: Journal    
DOI: 10.1177/030089160008600201     Document Type: Review

References (133)

1. Amodio-Cocchieri R., Arnese A., Roncioni A., Silvestri G.: Evaluation of the selenium content of the traditional Italian diet. Int. J. Food Sci. Nutr., 46: 149-154, 1995.
2. Ankerst J., Sjogren H.O.: Effect of selenium on the induction of breast fibroadenomas by adenovirus type 9 and 1,2-dimethylhydrazine-induced bowel carcinogenesis in rats. Int. J. Cancer, 29: 707-710, 1982.
3. Avanzini P., Vinceti M., Ilariucci F., Masini L., D'Inca M., Vivoli G.: Serum selenium concentrations in patients with newly diagnosed lymphoid malignancies. Haematologica, 80: 505-511, 1995.
4. Barceloux D.G.: Selenium. J. Toxicol. Clin. Toxicol., 37: 145-172, 1999.
5. Batieha A.M., Armenian H.K., Norkus E.P., Morris J.S., Spate V.E., Comstock G.W.: Serum micronutrients and the subsequent risk of cervical cancer in a population-based nested case-control study. Cancer Epidemiol. Biomarkers Prev., 2: 335-339, 1993.
6. Behne D., Gessner H., Kyriakopoulos A.: Information on the selenium status of several body compartments of rats from the selenium concentrations in blood fractions, hair and nails. J. Trace Elem. Med. Biol., 10: 174-179, 1996.
7. Birt D.F., Pour, P.M., Pelling, J.C.: The influence of dietary selenium on colon, pancreas, and skin tumorigenesis. In: Selenium in Biology and Medicine. Wendel A. (Ed.), pp. 297-304, Springer-Verlag, Berlin, 1989.
8. Blot W.J.: Vitamin/mineral supplementation and cancer risk: international chemoprevention trials. Proc. Soc. Exp. Biol. Med., 216: 291-296, 1997.
9. Bogden J.D., Kemp F.W., Buse M., Thind I.S., Louria D.B., Forgacs J., Llanos G., Moncoya Terrones I.: Composition of tobaccos from countries with high or low incidence of lung cancer. I. Selenium, polonium-210, Alternaria, tar, and nicotine. J. Natl. Cancer Inst., 66: 27-31, 1981.
10. Borella P., Bargellini A., Caselgrandi E., Menditto A., Patriarca M., Taylor A., Vivoli G.: Selenium determination in biological matrices. Microchem. J., 58: 325-336, 1998.
11. Bostick R.M., Potter J.D., McKenzie D.R., Sellers T.A., Kushi L.H., Steinmetz K.A., Folsom A.R.: Reduced risk of colon cancer with high intake of vitamin E: the Iowa Women's Health Study. Cancer Res., 53: 4230-4237, 1993.
12. Breslow R.A., Alberg A.J., Helzlsouer K.J., Bush T.L., Norkus E.P., Morris J.S., Spate V.E., Comstock G.W.: Serological precursors of cancer: malignant melanoma, basal and squamous cell skin cancer, and prediagnostic levels of retinol, beta-carotene, lycopene, alpha-tocopherol, and selenium. Cancer Epidemiol. Biomarkers Prev., 4: 837-842, 1995.
13. Brown J.S. Jr.: Role of selenium and other trace elements in the geography of schizophrenia. Schizophrenia Bull., 20: 387-398, 1994.
14. Burney P.G., Comstock G.W., Morris J.S.: Serologic precursors of cancer: serum micronutrients and the subsequent risk of pancreatic cancer. Am. J. Clin. Nutr., 49: 895-900, 1989.
15. Casey C.E.: Selenophilia. Proc. Nutr. Soc., 47: 55-62, 1988.
16. Chen F., Cole P., Wen L., Mi Z., Trapido E.: Estimates of trace element intakes in Chinese farmers. J. Nutr., 124: 126-201, 1994.
17. Chen J., Geissler C., Parpia B., Li J., Campbell T.C.: Antioxidant status and cancer mortality in China. Int. J. Epidemiol., 21: 625-635, 1992.
18. Chow C.K., Dillard C.J., Tappel A.L.: Glutathione peroxidase and lysozyme in rats exposed to ozone or nitrogen dioxide. Environ. Res., 7: 311-319, 1974.
19. Clark L., Graham G., Bray J.: Nonmelanoma skin cancer and plasma selenium. Am. J. Epidemiol., 122: 528, 1985.
20. Clark L.C., Cantor K.P., Allaway W.H.: Selenium in forage crops and cancer mortality in U.S. counties. Arch. Environ. Health, 46: 37-42, 1991.
21. Clark L.C., Combs G.F. Jr., Turnbull B.W., Slate E.H., Chalker D.K., Chow J., Davis L.S., Glover R.A., Graham G.F., Gross E.G., Krongrad A., Lesher J.L. Jr, Park H.K., Sanders B.B. Jr., Smith C.L., Taylor J.R.: Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group. JAMA, 276: 1957-1963, 1996.
22. Clark L.C., Hixson L.J., Combs G.F. Jr., Reid M.E., Turnbull B.W., Sampliner R.E.: Plasma selenium concentration predicts the prevalence of colorectal adenomatous polyps. Cancer Epidemiol. Biomarkers Prev., 2: 41-46, 1993.
23. Coates R.J., Weiss N.S., Daling J.R., Morris J.S., Labbe R.F.: Serum levels of selenium and retinol and the subsequent risk of cancer. Am. J. Epidemiol., 128: 515-523, 1988.
24. Combs G.F. Jr., Gray W.P.: Chemopreventive agents: selenium. Pharmacol. Ther., 79: 179-192, 1998.
25. Comstock G.W., Alberg A.J., Huang H.Y., Wu K., Burke A.E., Hoffman S.C., Norkus E.P., Gross M., Cutler R.G., Morris J.S., Spate V.L., Helzlsouer K.J.: The risk of developing lung cancer associated with antioxidants in the blood: ascorbic acid, carotenoids, alpha-tocopherol, selenium, and total peroxyl radical absorbing capacity. Cancer Epidemiol. Biomarkers Prev., 6: 907-916, 1997.
26. Criqui M.H., Bangdiwala S., Goodman D.S., Blaner W.S., Morris J.S., Kritchevsky S., Lippel K., Mebane I., Tyroler H.A.: Selenium, retinol, retinol-binding protein, and uric acid. Associations with cancer mortality in a population-based prospective case-control study. Ann. Epidemiol., 1: 385-393, 1991.
27. Csallany A.S., Su L.C., Menken B.Z.: Effect of selenite, vitamin E and N,N'-diphenyl-p-phenylenediamine on liver organic solvent-soluble lipofuscin pigments in mice. J. Nutr., 114: 1582-1587, 1984.
28. Davis R.L., Spallholz J.E.: Inhibition of selenite-catalyzed superoxide generation and formation of elemental selenium (Se(o)) by copper, zinc, and aurintricarboxylic acid (ATA). Biochem. Pharmacol., 51: 1015-1020, 1996.
29. Deffuant C., Celerier P., Boiteau H.L., Litoux P., Dreno B.: Serum selenium in melanoma and epidermotropic cutaneous T-cell lymphoma. Acta Derm. Venereol., 74: 90-92, 1994.
30. Dorgan J.F., Sowell A., Swanson C.A., Potischman N., Miller R., Schussler N., Stephenson H.E. Jr.: Relationships of serum carotenoids, retinol, alpha-tocopherol, and selenium with breast cancer risk: results from a prospective study in Columbia, Missouri (United States). Cancer Causes Control, 9: 89-97, 1998.
31. Dworkin B.M., Rosenthal W.S., Mittelman A., Weiss L., Applebee-Brady L., Arlin Z.: Selenium status and the polyp-cancer sequence: a colonoscopically controlled study. Am. J. Gastroenterol., 83: 748-751, 1988.
32. Engeland A., Haldorsen T., Tretli S., Hakulinen T., Horte L.G., Luostarinen T., Magnus K., Schou G., Sigvaldason H., Storm H.H.: Prediction of cancer incidence in the Nordic countries up to the years 2000 and 2010. A collaborative study of the five Nordic Cancer Registries. A.P.M.I.S. Suppl., 38: 1-124, 1993.
33. Environmental Health Criteria: Selenium. World Health Organization, Geneva, 1987.
34. Ewertz M., Gill C.: Dietary factors and breast-cancer risk in Denmark. Int. J. Cancer, 46: 779-784, 1990.
35. Fex G., Pettersson B., Akesson B.: Low plasma selenium as a risk factor for cancer death in middle-aged men. Nutr. Cancer, 10: 221-229, 1987.
36. Finley J.W., Matthys L., Schuler T., Korynta E.: Selenium content of foods purchased in North Dakota. Nutr. Res., 16: 723-728, 1996.
37. Fredrikson M., Hardell L., Bengtsson N., Axelson O.: Colon cancer and dietary habits - a case-control study. Int. J. Oncol., 7: 133-141, 1995.
38. Garland M., Morris J.S., Rosner B.A., Stampfer M.J., Spate V.L., Baskett C.J., Willett W.C., Hunter D.J.: Toenail trace element levels as biomarkers: reproducibility over a 6-year period. Cancer Epidemiol. Biomarkers Prev., 2: 493-497, 1993.
39. Garland M., Morris J.S., Stampfer M.J., Colditz G.A., Spate V.L., Baskett C.K., Rosner B., Speizer F.E., Willett W.C., Hunter D.J.: Prospective study of toenail selenium levels and cancer among women. J. Natl. Cancer Inst., 87: 497-505, 1995.
40. Garland, M., Stampfer, M.J., Willett, W.C., Hunter, D.: The epidemiology of selenium and human cancer. In: Natural Antioxidants in Human Health and Disease. Academic Press, San Diego, 1994.
41. Girodon F., Galan P., Monget A.L., Boutron-Ruault M.C., Brunet-Lecomte P., Preziosi P., Arnaud J., Manuguerra J.C., Herchberg S.: Impact of trace elements and vitamin supplementation on immunity and infections in institutionalized elderly patients: a randomized controlled trial. MIN. VIT. AOX. geriatric network. Arch. Intern. Med., 159: 748-754, 1999.
42. Glattre E., Thomassen Y., Thoresen S.O., Haldorsen T., Lund-Larsen P.G., Theodorsen L., Aaseth J.: Prediagnostic serum selenium in a case-control study of thyroid cancer. Int. J. Epidemiol., 18: 45-49, 1989.
43. Glover J.R.: Selenium in human urine: a tentative maximum allowable concentration for industrial and rural population. Ann. Occup. Hygiene, 10: 3-14, 1967.
44. Guo W., Chow W., Zheng W., Li J., Blot W.J.: Diet, serum markers and breast cancer mortality in China. Jpn. J. Cancer Res., 85: 572-577, 1994.
45. Guo W., Hsing A.W., Li J., Chen J., Chow W., Blot W.J.: Correlation of cervical cancer mortality with reproductive and dietary factors, and serum markers in China. Int. J. Epidemiol., 23: 1127-1132, 1994.
46. Hafeman D.G., Sunde R.A., Hoekstra W.G.: Effect of dietary selenium on erythrocyte and liver glutathione peroxidase in the rat. J. Nutr., 104: 580-587, 1974.
47. Hartman T.J., Albanes D., Pietinen P., Hartman A.M., Rautalahti M., Tangrea J.A., Taylor P.R.: The association between baseline vitamin E, selenium, and prostate cancer in the alpha-tocopherol, beta-carotene cancer prevention study. Cancer Epidemiol. Biomarkers Prev., 7: 335-340, 1998.
48. Helzlsouer K.J., Alberg A.J., Norkus E.P., Morris J.S., Hoffman S.C., Comstock G.W.: Prospective study of serum micronutrients and ovarian cancer. J. Natl. Cancer Inst., 88: 32-37, 1996.
49. Helzlsouer K.J., Comstock G.W., Morris J.S.: Selenium, lycopene, alpha-tocopherol, beta-carotene, retinol, and subsequent bladder cancer. Cancer Res., 49: 6144-6148, 1989.
50. Hunter D.J., Morris J.S., Chute C.G., Kushner E., Colditz G.A., Stampfer M.J., Speizer F.E., Willett W.C.: Predictors of selenium concentration in human toenails. Am. J. Epidemiol., 132: 114-122, 1990.
51. Hunter D.J., Morris J.S., Stampfer M.J., Colditz G.A., Speizer F.E., Willett W.C.: A prospective study of selenium status and breast cancer risk. JAMA. 264: 1128-1131, 1990.
52. Ip C.: Lessons from basic research in selenium and cancer prevention. J. Nutr., 128: 1845-1854, 1998.
53. Jossa F., Trevisan M., Krogh V., Farinaro E., Giumetti D., Fusco G., Galasso R., Panico S., Frascatore S., Mellone C., Mancini M.: Serum selenium and coronary heart disease risk factors in southern Italian men. Atherosclerosis, 87: 129-134, 1991.
54. Kabuto M., Imai H., Yonezawa C., Neriishi K., Akiba S., Kato H., Suzuki T., Land C.E., Blot W.J.: Prediagnostic serum selenium and zinc levels and subsequent risk of lung and stomach cancer in Japan. Cancer Epidemiol. Biomarkers Prev., 3: 465-469, 1994.
55. Karagas M.R., Greenberg E.R., Nierenberg D., Stukel T.A., Morris J.S., Stevens M.M., Baron J.A.: Risk of squamous cell carcinoma of the skin in relation to plasma selenium, alpha-tocopherol, beta-carotene, and retinol: a nested case-control study. Cancer Epidemiol. Biomarkers Prev., 6: 25-29, 1997.
56. Knekt P., Aromaa A., Alfthan G., Maatela J., Hakama M., Hakulinen T., Teppo L.: Prospective study of serum micronutrients and ovarian cancer. J. Natl. Cancer Inst., 88: 1408, 1996.
57. Knekt P., Aromaa A., Maatela J., Aaran R.K., Nikkari T., Hakama M., Hakulinen T., Peto R., Saxen E., Teppo L.: Serum vitamin E and risk of cancer among Finnish men during a 10-year follow-up. Am. J. Epidemiol., 127: 28-41, 1988.
58. Knekt P., Aromaa A., Maatela J., Alfthan G., Aaran R.K., Hakama M., Hakulinen T., Peto R., Teppo L.: Serum selenium and subsequent risk of cancer among Finnish men and women. J. Natl. Cancer Inst., 82: 864-868, 1990.
59. Knekt P., Aromaa A., Maatela J., Alfthan G., Aaran R.K., Nikkari T., Hakama M., Hakulinen T., Teppo L.: Serum micronutrients and risk of cancers of low incidence in Finland. Am. J. Epidemiol., 134: 356-361, 1991.
60. Knekt P., Jarvinen R., Seppanen R., Rissanen A., Aromaa A., Heinonen O.P., Albanes D., Heinonen M., Pukkala E., Teppo L.: Dietary antioxidants and the risk of lung cancer. Am. J. Epidemiol., 134: 471-479, 1991.
61. Knekt P., Marniemi J., Teppo L., Heliovaara M., Aromaa A.: Is low selenium status a risk factor for lung cancer? Am. J. Epidemiol., 148: 975-982, 1998.
62. Kneller R.W., Guo W., Hsing A.W., Chen J., Blot W.J., Li J., Forman D., Fraumeni J.F. Jr.: Risk factors for stomach cancer in sixty-five Chinese counties. Cancer Epidemiol. Biomarkers Prev., 1: 113-118, 1992.
63. Kok F.J., de Bruijn A.M., Hofman A., Vermeeren R., Valkenburg H.A.: Is serum selenium a risk factor for cancer in men only? Am. J. Epidemiol., 125: 12-6, 1987.
64. LeBoeuf R.A., Laishes B.A., Hoekstra W.G.: Effects of dietary selenium concentration on the development of enzyme-altered liver foci and hepatocellular carcinoma induced by diethylnitrosamine or N-acetylaminofluorene in rats. Cancer Res., 45: 5489-5495, 1985.
65. Lemaitre D., Vericel E., Polette A., Lagarde M.: Effects of fatty acids on human platelet glutathione peroxidase: possible role of oxidative stress. Biochem. Pharmacol., 53: 479-486, 1997.
66. Lo M., Sandi E.: Selenium: occurrence in foods and its toxicologic significance. A review. J. Environ. Pathol. Toxicol., 4: 193-218, 1980.
67. Lockitch G.: Selenium: clinical significance and analytical concepts. Crit. Rev. Clin. Lab. Sci., 27: 483-541, 1989.
68. Longnecker M.P., Stram D.O., Taylor P.R., Levander O.A., Howe M., Veillon C., McAdam P.A., Patterson K.Y., Holden J.M., Morris J.S., Swanson C.A., Willett W.C.: Use of selenium concentration in whole blood, serum, toenails, or urine as a surrogate measure of selenium intake. Epidemiology, 7: 384-390, 1996.
69. Lu J., Jiang C., Kaeck M., Ganther H., Vadhanavikit S., Ip C., Thompson H.: Dissociation of the genotoxic and growth inhibitory effects of selenium. Biochem. Pharmacol., 50: 213-219, 1995.
70. Mannisto S., Virtanen M., Mikkonen T., Pietinen P.: Reproducibility and validity of a food frequency questionnaire in a case-control study on breast cancer. J. Clin. Epidemiol., 49: 401-409, 1996.
71. Menkes M.S., Comstock G.W., Vuilleumier J.P., Helsing K.J., Rider A.A., Brookmeyer R.: Serum beta-carotene, vitamins A and E, selenium, and the risk of lung cancer. N. Engl. J. Med., 315: 1250-1254, 1986.
72. Moxon A.L., Rhan M.: Selenium poisoning. Physiol. Rev., 23: 305-337, 1943.
73. Nehru B., Iyer A.: Effect of selenium on lead-induced neurotoxicity in different brain regions of adult rats. J. Environ. Pathol. Toxicol. Oncol., 13: 265-268, 1994.
74. Nelson R.L., Davis F.G., Sutter E., Kikendall J.W., Sobin L.H., Milner J.A., Bowen P.E.: Serum selenium and colonic neoplastic risk. Dis. Colon Rectum, 38: 1306-1310, 1995.
75. Nève J.: Methods in determination of selenium states. J. Trace Elem. Electrolytes Health Dis., 5: 1-17, 1991.
76. Nève J.: Human selenium supplementation as assessed by changes in blood selenium concentration and glutathione peroxidase activity. J. Trace Elem. Med. Biol., 9: 65-73, 1995.
77. Nomura A., Heilbrun L.K., Morris J.S., Stemmermann G.N.: Serum selenium and the risk of cancer, by specific sites: case-control analysis of prospective data. J. Natl. Cancer Inst., 79: 103-108, 1987.
78. Nyberg-Swenson B.E.: The selenium link: the missing link in our understanding of biochemical trigger reactions? Med. Hypotheses. 52: 125-131, 1999.
79. Osterlind A., Tucker M.A., Stone B.J., Jensen O.M.: The Danish case-control study of cutaneous malignant melanoma. IV. No association with nutritional factors, alcohol, smoking or hair dyes. Int. J. Cancer, 42: 825-828, 1988.
80. Ovaskainen M.L., Virtamo J., Alfthan G., Haukka J., Pietinen P., Taylor P.R., Huttunen J.K.: Toenail selenium as an indicator of selenium intake among middle-aged men in an area with low soil selenium. Am. J. Clin. Nutr., 57: 662-665, 1993.
81. Overvad K.: Selenium and cancer. Bibl. Nutr. Dieta, 54: 141-149, 1998.
82. Overvad K., Gron P., Langhoff O., Tarp U., Foldspang A., Thorling E.B.: Selenium in human mammary carcinogenesis: a case-referent study. Eur. J. Cancer Prev., 1: 27-30, 1991.
83. Panter K.E., Hartley W.J., James L.F., Mayland H.F., Stegelmeier B.L., Kechele P.O.: Comparative toxicity of selenium from seleno-DL-methionine, sodium selenate, and Astragalus bisulcatus in pigs. Fund. Appl. Toxicol., 32: 217-223, 1996.
84. Patterson B.H., Levander O.A.: Naturally occurring selenium compounds in cancer chemoprevention trials: a workshop summary. Cancer Epidemiol. Biomarkers Prev., 6: 63-69, 1997.
85. Patterson R.E., Neuhouser M.L., White E., Hunt J.R., Kristal A.R.: Cancer-related behavior of vitamin supplement users. Cancer Epidemiol. Biomarkers Prev., 7: 79-81, 1998.
86. Peleg I., Morris S., Hames C.G.: Is serum selenium a risk factor for cancer? Med. Oncol. Tumor. Pharmacother., 2: 157-163, 1985.
87. Perchellet J.P., Abney N.L., Thomas R.M., Guislain Y.L., Perchellet E.M.: Effects of combined treatments with selenium, glutathione, and vitamin E on glutathione peroxidase activity, ornithine decarboxylase induction, and complete and multistage carcinogenesis in mouse skin. Cancer Res., 47: 477-485, 1987.
88. Rajotte B.J., P'an A.Y., Malick A., Robin J.P.: Evaluation of selenium exposure in copper refinery workers. J. Toxicol. Environ. Health, 48: 239-251, 1996.
89. Ringstad J., Jacobsen B.K., Tretli S., Thomassen Y.: Serum selenium concentration associated with risk of cancer. J. Clin. Pathol., 41: 454-457, 1988.
90. Rizk S.L., Sky-Peck H.S.: Comparison between concentrations of trace elements in normal and neoplastic human breast tissue. Cancer Res., 44: 5390-5394, 1984.
91. Robinson M.F., Godfrey P.J., Thomson C.D., Rea H.M., van Rij A.M.: Blood selenium and glutathione peroxidase activity in normal subjects and in surgical patients with and without cancer in New Zealand. Am. J. Clin. Nutr., 32: 1477-1485, 1979.
92. Rogers M.A., Thomas D.B., Davis S., Weiss N.S., Vaughan T.L., Nevissi A.E.: A case-control study of oral cancer and pre-diagnostic concentrations of selenium and zinc in nail tissue. Int. J. Cancer, 48: 182-188, 1991.
93. Rothman, K.J., Greenland, S.: Modern Epidemiology. Second Edition. Lippincott-Raven, Philadelphia, 1998.
94. Russo M.W., Murray S.C., Wurzelmann J.I., Woosley J.T., Sandier R.S.: Plasma selenium levels and the risk of colorectal adenomas. Nutr. Cancer, 28: 125-129, 1997.
95. Salbe A.D., Levander O.A.: Effect of various dietary factors on the deposition of selenium in the hair and nails of rats. J. Nutr., 120: 200-206, 1990.
96. Salonen J.T., Alfthan G., Huttunen J.K., Puska P.: Association between serum selenium and the risk of cancer. Am. J. Epidemiol., 120: 342-349, 1984.
97. Salonen J.T., Salonen R., Lappetelainen R., Maenpaa P.H., Alfthan G., Puska P.: Risk of cancer in relation to serum concentrations of selenium and vitamins A and E: matched case-control analysis of prospective data. BMJ, 290: 417-420, 1985.
98. Sandstrom B.: Toxicity considerations when revising the Nordic nutrition recommendations. J. Nutr., 128: 372S-374S, 1998.
99. Schober S.E., Comstock G.W., Helsing K.J., Salkeld R.M., Morris J.S., Rider A.A., Brookmeyer R.: Serologic precursors of cancer. I. Prediagnostic serum nutrients and colon cancer risk. Am. J. Epidemiol., 126: 1033-1041, 1987.
100. Shallom J., Juvekar A., Chitnis M.: Selenium (Se) cytotoxicity in drug sensitive and drug resistant murine tumour. Cancer Biother., 10: 243-248, 1995.
101. Shamberger R.J., Frost D.V.: Possible protective effect of selenium against human cancer. Can. Med. Assoc. J., 100: 682, 1969.
102. Shen H.M., Yang C.F., Ong C.N.: Sodium selenite-induced oxidative stress and apoptosis in human hepatoma HepG2 cells. Int. J. Cancer, 81: 820-828, 1999.
103. Shiobara Y., Yoshida T., Suzuki K.T.: Effects of dietary selenium species on Se concentrations in hair, blood, and urine. Toxicol. Appl. Pharmacol., 152: 309-314, 1998.
104. Slattery M.L., Abbott T.M., Overall J.C. Jr., Robison L.M., French T.K., Jolles C., Gardner J.W., West D.W.: Dietary vitamins A, C, and E and selenium as risk factors for cervical cancer. Epidemiology, 1: 8-15, 1990.
105. Spallholz J.E.: On the nature of selenium toxicity and carcinostatic activity. Free Radic. Biol. Med., 17: 45-64, 1994.
106. Srikumar T.S., Johansson G.K., Ockerman P.A., Gustafsson J.A., Akesson B.: Trace element status in healthy subjects switching from a mixed to a lactovegetarian diet for 12 mo. Am. J. Clin. Nutr., 55: 885-890, 1992.
107. Swanson C.A., Longnecker M.P., Veillon C., Howe M., Levander O.A., Taylor P.R., McAdam P.A., Brown C.C., Stampfer M.J., Willett W.C.: Selenium intake, age, gender, and smoking in relation to indices of selenium status of adults residing in a seleniferous area. Am. J. Clin. Nutr., 52: 858-862, 1990.
108. van den Brandt P.A., Goldbohm R.A., van't Veer P., Bode P., Dorant E., Hermus R.J., Sturmans F.: A prospective cohort study on toenail selenium levels and risk of gastrointestinal cancer. J. Natl. Cancer Inst., 85: 224-229, 1993.
109. van den Brandt P.A., Goldbohm R.A., van't Veer P., Bode P., Dorant E., Hermus R.J., Sturmans F.: A prospective cohort study on selenium status and the risk of lung cancer. Cancer Res., 53: 4860-4865, 1993.
110. van den Brandt P.A., Goldbohm R.A., van't Veer P., Bode P., Dorant E., Hermus R.J., Sturmans F.: Toenail selenium levels and the risk of breast cancer. Am. J. Epidemiol., 140: 20-26, 1994.
111. van den Brandt P.A., Goldbohm R.A., van't Veer P., Bode P., Hermus R.J., Sturmans F.: Predictors of toenail selenium levels in men and women. Cancer Epidemiol. Biomarkers Prev., 2: 107-112, 1993.
112. van Noord P.A., Collette H.J., Maas M.J., de Waard F.: Selenium levels in nails of premenopausal breast cancer patients assessed prediagnostically in a cohort-nested case-referent study among women screened in the DOM project. Int. J. Epidemiol., 16: 318-322, 1987.
113. van Noord P.A., Maas M.J., van der Tweel I., Collette C.: Selenium and the risk of postmenopausal breast cancer in the DOM cohort. Breast Cancer Res. Treat., 25: 11-19, 1993.
114. van't Veer P., van der Wielen R.P., Kok F.J., Hermus R.J., Sturmans F.: Selenium in diet, blood, and toenails in relation to breast cancer: a case-control study. Am. J. Epidemiol., 131: 987-994, 1990.
115. Varo, P., Alfthan, G., Ekholm, P., Aro, A.: Effects of selenium supplementation of fertilizers on human nutrition and selenium status. In: Environmental Chemistry of Selenium. Frankenberger, W.T. Jr, Engberg, R.A. (Eds.), Marcel Dekker, New York, 1998.
116. Varo P., Alfthan, G., Huttunen, J.K., Aro A.: Nationwide selenium supplementation in Finland. Effects on diet, blood and tissue levels, and health. In: Selenium in biology and human health. Burk R.F., Ed. Springer-Verlag, New York, 1994.
117. Venalainen E.R., Hirvi T., Hirn J.: Effect of selenium supplementation on the selenium content in muscle and liver of Finnish pigs and cattle. J. Agric. Food Chem., 45: 810-813, 1997.
118. Vinceti M., Bergomi M., Vivoli G.: Effect of naturally-occurring exposure to selenium through drinking water on mortality from cancer and cardiovascular disease. Epidemiology, 8: S35, 1997.
119. Vinceti M., Rothman K.J., Bergomi M., Borciani N., Serra L., Vivoli G.: Excess melanoma incidence in a cohort exposed to high levels of environmental selenium. Cancer Epidemiol. Biomarkers Prev., 7: 853-856, 1998.
120. Vinceti M., Rovesti S., Gabrielli C., Marchesi C., Bergomi M., Martini M., Vivoli G.: Cancer mortality in a residential cohort exposed to environmental selenium through drinking water. J. Clin. Epidemiol., 48: 1091-1097, 1995.
121. Virtamo J., Valkeila E., Alfthan G., Punsar S., Huttunen J.K., Karvonen M.J.: Serum selenium and risk of cancer. A prospective follow-up of nine years. Cancer, 60: 145-148, 1987.
122. Watson R.R., Moriguchi S., McRae B., Tobin L., Mayberry J.C., Lucas D.: Effects of selenium in vitro on human Tlymphocyte functions and K-562 tumor cell growth. J. Leukoc. Biol., 39: 447-456, 1986.
123. West D.W., Slattery M.L., Robison L.M., French T.K., Mahoney A.W.: Adult dietary intake and prostate cancer risk in Utah: a case-control study with special emphasis on aggressive tumors. Cancer Causes Control, 2: 85-94, 1991.
124. Whanger P.D.: Selenium in the treatment of heavy metal poisoning and chemical carcinogenesis. J. Trace Elem. Electrolytes Health Dis., 6: 209-221, 1992.
125. Willett W.C., Polk B.F., Morris J.S., Stampfer M.J., Pressel S., Rosner B., Taylor J.O., Schneider K., Hames C.G.: Prediagnostic serum selenium and risk of cancer. Lancet, 2: 130-134, 1983.
126. World Health Organization: Trace elements in human nutrition and health. WHO, Geneva, 1996.
127. Woutersen R.A., Appel M.J., Van Garderen-Hoetmer A.: Modulation of pancreatic carcinogenesis by antioxidants. Food Chem. Toxicol., 37: 981-984, 1999.
128. Yan L., Yee J.A., Li D., McGuire M.H., Graef G.L.: Dietary supplementation of selenomethionine reduces metastasis of melanoma cells in mice. Anticancer Res., 19: 1337-1342, 1999.
129. Yang G.Q., Wang S.Z., Zhou R.H., Sun S.Z.: Endemic selenium intoxication of humans in China. Am. J. Clin. Nutr., 37: 872-881, 1983.
130. Yoshizawa K., Willett W.C., Morris S.J., Stampfer M.J., Spiegelman D., Rimm E.B., Giovannucci E.: Study of prediagnostic selenium level in toenails and the risk of advanced prostate cancer. J. Natl. Cancer Inst., 90: 1219-1224, 1998.
131. Yu M.W., Horng I.S., Hsu K.H., Chiang Y.C., Liaw Y.F., Chen C.J.: Plasma selenium levels and risk of hepatocellular carcinoma among men with chronic hepatitis virus infection. Am. J. Epidemiol., 150: 367-374, 1999.
132. Yu S.Y., Zhu Y.J., Li W.G.: Protective role of selenium against hepatitis B virus and primary liver cancer in Qidong. Biol. Trace Elem. Res., 56: 117-124, 1997.
133. Zheng W., Blot W.J., Diamond E.L., Norkus E.P., Spate V., Morris J.S., Comstock G.W.: Serum micronutrients and the subsequent risk of oral and pharyngeal cancer. Cancer Res., 53: 795-798, 1993.