The α(1a) and α(1b)-adrenergic receptor subtypes: Molecular mechanisms of receptor activation and of drug action

Pharmaceutica Acta Helvetiae

Volumn 74, Issue 2-3, 2000, Pages 173-179

  Cotecchia, Susanna ^a   Rossier, Olivier ^a   Fanelli, Francesca ^b   Leonardi, Amedeo ^c   De Benedetti, Pier G ^b  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c Pharmaceutical R and D Division   (Italy)

Author keywords

Adrenergic receptors; Constitutive activity; G protein coupled receptors; Inverse agonism; Molecular dynamics

Indexed keywords

2 [2 (4 HYDROXYPHENYL)ETHYLAMINOMETHYL]TETRALONE; 2 [[2 (2,6 DIMETHOXYPHENOXY)ETHYL]AMINOMETHYL] 1,4 BENZODIOXAN; 5 METHYLURAPIDIL; 8 [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] 8 AZASPIRO[4.5]DECANE 7,9 DIONE; 8 [2 [4 (5 CHLORO 2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] 8 AZASPIRO[4.5]DECANE 7,9 DIONE; 8 [3 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]PROPYLCARBAMOYL] 3 METHYLFLAVONE; 8 [3 [4 (5 CHLORO 2 METHOXYPHENYL) 1 PIPERAZINYL]PROPYLCARBAMOYL] 2 CYCLOHEXYL 3 METHYL 4H 1 BENZOPYRAN 4 ONE; AH 1111OA; ALFUZOSIN; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; CORYNANTHINE; CYCLAZOCINE; GUANINE NUCLEOTIDE BINDING PROTEIN; INDORAMIN; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; NIGULDIPINE; PHENTOLAMINE; PHOSPHOLIPASE A2; PHOSPHOLIPASE C; PRAZOSIN; REC 152615; REC 152869; RECEPTOR SUBTYPE; SPIPERONE; TAMSULOSIN; TERAZOSIN; UNCLASSIFIED DRUG;

COMPUTER SIMULATION; CONFERENCE PAPER; DRUG MECHANISM; DRUG RECEPTOR BINDING; ENZYME ACTIVITY; HUMAN; MOLECULAR MODEL; MUTATION; NONHUMAN; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION;

ANIMALS; HUMANS; RECEPTORS, ADRENERGIC, ALPHA-1;

EID: 0034073091     PISSN: 00316865     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-6865(99)00031-X     Document Type: Conference Paper

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