Nitric oxide mediates cyclosporine-induced apoptosis in cultured renal cells

Kidney International

Volumn 57, Issue 4, 2000, Pages 1549-1559

  Amore, Alessandro ^a,b   Emancipator, Steven N ^a,b   Cirina, Paola ^a,b   Conti, Giovanni ^a,b   Ricotti, Emanuela ^a,b   Bagheri, Nayer ^a,b   Coppo, Rosanna ^a,b  

^a REGINA MARGHERITA CHILDREN S HOSPITAL   (Italy)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cell death; Cyclosporine A; Fibrogenesis; Nephrotoxicity; NO

Indexed keywords

CYCLOSPORIN A; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL CELL; APOPTOSIS; CELL CULTURE; CONFERENCE PAPER; ENZYME ACTIVITY; ENZYME INDUCTION; HUMAN; HUMAN CELL; NEPHROTOXICITY; NONHUMAN; NORTHERN BLOTTING; PATHOGENESIS; PRIORITY JOURNAL;

EID: 0034070001     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2000.00999.x     Document Type: Conference Paper

References (60)

1. 1. KAHAN BD: Cyclosporin. N Engl J Med 321:1275-1738, 1989
2. 2. BERTANI T, FERRAZZI P, SCHIEPPATI A, RUGGENENTI P, GAMBA A, PARENZAN L, MECCA G, PERICO N, IMBERTI O, REMUZZI A, REMUZZI G: Nature and extent of glomerular injury induced by cyclosporin in heart transplanted patients. Kidney Int 40:243-250, 1991
3. 3. MYERS BD: Cyclosporin nephrotoxicity. Kidney Int 30:964-974, 1976
4. 4. MCNALLY PG, FEEHALLY J: Pathophysiology of cyclosporin A nephrotoxicity: Experimental and clinical observations. Nephrol Dial Transplant 7:791-804, 1992
5. 5. BENNETT WM: Insights into cyclosporine nephrotoxicity. Int J Pharmacol Ther 34:515-519, 1996
6. 6. SHIHAB FS: Cyclosporine nephropathy: Pathophysiology and clinical impact. Semin Nephrol 16:536-547, 1996
7. 7. CHRISTIANS U, SEWING KF: Alternative cyclosporine pathways and toxicity. Clin Biochem 28:547-559, 1995
8. 8. CUTOLO M, BARONE A, ACCARDO S, SETTI M, VILLAGGIO B: Effect of cyclosporin on apoptosis in human cultured monocytic THP-1 cells and synovial macrophages. Clin Exp Rheumatol 16:417-422, 1998
9. 2+-sensitive cyclical mitochondrial depolarizations in cell culture. Biochim Biophys Acta 1410:77-84, 1999
10. 10. ITO C, RIBEIRO RC, BEHM FG, RAIMONDI SC, PUI CH, CAMPANA D: Cyclosporin A induces apoptosis in childhood acute lymphoblastic leukemia cells. Blood 91:1001-1007, 1998
11. 11. HORIGOME A, HIRANO T, OKA K, TAKEUCHI H, SAKURAI E, KOZAKI K, MATSUNO N, NAGAO T, KOZAKI M: Glucocorticoids and cyclosporine induce apoptosis in mitogen-activated human peripheral mononuclear cells. Immunopharmacology 37:87-94, 1997
12. 12. WALTER DH, HAENDELER J, GALLE J, ZEIHER AM, DIMMELER S: Cyclosporin A inhibits apoptosis of human endothelial cells by preventing release of cytochrome C from mitochondria. Circulation 98:1153-1157, 1998
13. 13. ITO H, KASAGI N, SHOMORI K, OSAKI K, HADACHI H: Apoptosis in the human allografted kidney. Transplantation 60:794-798, 1995
14. 14. MEYER-LEHNERT H, BOKEMEYER D, FRIEDRICHS U, BACKER A, KRAMER HJ: Cellular mechanisms of cyclosporine A-associated side-effects: Role of endothelin. Kidney Int 61(Suppl):S27-S31, 1997
15. 15. LINDSEY JA, MORISAKI N, STITTS JM, ZAGER RA, CORNWELL DG: Fatty acid metabolism and cell proliferation. IV. Effect of prostanoid biosynthesis from endogenous fatty acid release with cyclosporine-A. Lipids 18:566-569, 1983
16. 16. ABASSI ZA, PIERUZZI F, NAKHOUL F, KEISER HR: Effects of cyclosporin A on the synthesis, excretion, and metabolism of endothelin in the rat. Hypertension 27:1140-1148, 1996
17. 17. PARRA T, DE ARRIBA G, ARRIBAS I, DE PERZ LEMA G, RODRIGUEZ-PUYOL D, RODRIGUEZ-PUYOL M: Cyclosporin A nephrotoxicity: Role of thromboxane and reactive oxygen species. J Lab Clin Med 131:63-70, 1998
18. 2 in glomerular mesangial cells. Adv Exp Med Biol 400A:279-286, 1997
19. 19. HERMAN WH, SIMONSON MS: Nuclear signaling by endothelin-1: A Ras pathway for activation of c-fos serum response element. J Biol Chem 270:11654-11661, 1995
20. 20. ARAKI S, HANEDA M, TOGAWA M, KIKKAWA R: Endothelin-1 activates c-Jun NH2-terminal kinases in mesangial cells. Kidney Int 51:631-639, 1997
21. 21. CLOHISY JC, CONNOLLY TJ, BERGMAN KD, QUINN CO, PARTRIDGE NC: Prostanoid-induced expression of metalloproteinsase-1 messenger ribonucleic acid in rat osteosarcoma cells. Endocrinology 135:1447-1454, 1994
22. 22. TAKAGISHI T, MURASASHI N, AZAGAMI S, MORIMATSU M, SASAGURI Y: Effect of angiotensin II and thromboxane A2 on the production of matrix metalloproteinase by human aortic smooth muscle cells. Biochem Mol Biol Int 35:265-273, 1995
23. 23. BARNES K, SHIMADA K, TAKAHASHI M, TANZAWA K, TURNER AJ: Metalloproteinase inhibitors induce an up-regulation of endothelin converting enzyme levels and its redistribution from the plasma membrane to an intracellular compartment. J Cell Sci 109:919-928, 1996
24. 24. WOLF G, ZAHNER G, ZYADEH FN, STAHL RA: Cyclosporin A induces transcription of transforming growth factor beta in a cultured murine proximal tubular cell line. Exp Nephrol 4:304-308, 1996
25. 25. WOLF G, THAISS F, STAHL RA: Cyclosporine stimulates expression of transforming growth factor-beta in renal cells: Possible mechanism of cyclosporine's antiproliferative effects. Transplantation 60:237-241, 1995
26. 26. BAKER AJ, MOONEY A, HUGHES J, LOMBARDI D, JOHNSON RJ, SAVILL J: Mesangial cell apoptosis: The major mechanism for resolution of glomerular hypercellularity in experimental mesangial proliferative nephritis. J Clin Invest 92:2105-2116, 1994
27. 27. SHIMIZU A, KITAMURA H, MASUDA Y, ISHIZAKI M, SUGISAKI Y, YAMANAKA N: Apoptosis in the repair process of experimental glomerulonephritis. Kidney Int 47:114-121, 1995
28. 28. HUGHES J, JOHNSON RJ, MOONEY A, HUGO C, GORDON K, SAVILL J: Neutrophil fate in experimental glomerular capillary injury in the rat: Emigration exceeds in situ clearance by apoptosis. Am J Pathol 150:223-234, 1997
29. 29. SAVILL J, SMITH J, SARRAF C, REN YI, ABBOTT F, REES A: Glomerular mesangial cells and inflammatory macrophages ingest neutrophils undergoing apoptosis. Kidney Int 42:924-936, 1992
30. 30. SAVILL J, MOONEY A, HUGHES J: Apoptosis and renal scarring. Kidney Int 54(Suppl):S14-S17, 1996
31. 31. SUGIYAMA H, KASHIHARA N, MAKINO H, YAMASAKI Y, OTA A: Apoptosis in glomerular sclerosis. Kidney Int 49:103-111, 1996
32. 32. HATTORI T, SHINDO S, KAWAMURA H: Apoptosis and expression of Bax protein and Fas antigen in glomeruli of a remnant-kidney model. Nephron 79:186-191, 1998
33. 33. AMORE A, GIANOGLIO B, GHIGO D, PERUZZI L, PORCELLINI MG, BUSSOLINO F, COSTAMAGNA C, CACACE G, PICCIOTTO G, MAZZUCCO G, SENA LM, COPPO R: A possible role for nitric oxide in modulating the functional cyclosporine toxicity by arginine. Kidney Int 47:1507-1514, 1995
34. 34. GROSS SS: Nitric oxide: Pathophysiological mechanisms. Annu Rev Physiol 57:737-769, 1995
35. 35. MONCADA S, PALMER RMJ, HIGGS EA: Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol Rev 43:109-142, 1991
36. 36. KRONCKE KD, FEHSEL K, KOLB-BACHOFEN V: Nitric oxide: Cytotoxicity versus cytoprotection: How, why, when, and where? Nitric Oxide 1:107-120, 1997
37. 37. SANDAU K, PFEILSCHIEFTER J, BRUNE B: Nitric oxide and Superoxide induced p53 and Bax accumulation during mesangial cell apoptosis. Kidney Int 52:378-386, 1997
38. 38. AMORE A, EMANCIPATOR SN, ROCCATELLO D, GIANOGLIO B, PERUZZI L, PORCELLINI MG, PICCOLI G, COPPO R: Functional consequences of the binding of gliadin to cultured rat mesangial cells: Bridging immunoglobulin A to cells and modulation of eicosanoid synthesis and altered cytokine production. Am J Kidney Dis 23:290-301, 1994
39. 39. PERUZZI L, TRUSOLINO L, AMORE A, GIANOGLIO B, CIRINA P, BASSO G, EMANCIPATOR SN, MARCHISIO PC, COPPO R: Tubulointerstitial responses in the progression of glomerular diseases: Albuminuria modulates alpha v beta 5 integrin. Kidney Int 50:1310-1320, 1996
40. 40. BUSSOLINO F, DE ROSSI M, SICA A, COLOTTA F, WANG JM, BOCCHIETTO E, PADURA IM, BOSIA A, DEJAND E, MANTOVANI A: Murine endothelioma cell lines transformed by polyoma middle T oncogene as target for and producers of cytokines. J Immunol 147:2122-2129, 1993
41. 41. GARLANDA C, PARRAVICINI C, SIRONO M, DE ROSSI M, WAINSTOK DE, CALAMANOVICI R, CAROZZI F, BUSSOLINO F, COLOTTA F, MANTOVANI A, VECCHI A: Progressive growth in immunodeficient mice and host cell recruitment by mouse endothelial cells transformed by polyoma middle-sized T: Implications for the pathogenesis of opportunistic vascular tumors. Proc Natl Acad Sci USA 91:7291-7295, 1994
42. 42. WILLIAMS RL, COURTNEIDGE SA, WAGNER EF: Embryonic lethalities and endothelial tumors in chimeric mice expressing polyoma virus middle T oncogene. Cell 52:121-131, 1988
43. 43. LABALETTE M. QUEYREL V, MASY E, NOEL C, PRUVOI FR, DESSAINT JP: Implication of cyclosporine in up-regulation of Bcl-2 expression and maintenance of CD8 lymphocytosis in cytomegalovirus-infected allograft recipients. Transplantation 59:1714-1723, 1995
44. 44. YAZDANBAKHSH K, CHOI JW, LI Y, LAU LF, CHOI Y: Cyclosporin A blocks apoptosis by inhibiting the DNA binding activity of the transcription factor Nur77. Proc Natl Acad Sci USA 92:437-441, 1995
45. 45. YOKOYAMA I, HAYAKAWA A, HAYASHI S, KOBAYASHI T, NEGITA M, KAIAYAMA T, NAGASAKA R, NAMII Y, KOJIMA T, KOIKE C, UCHIDA K, TAKAGI H: Fas antigen expression and apoptosis induction of in vitro cultured hepatocytes with high concentrations of cyclosporine A. Transplant Proc 28:1383-1384, 1996
46. 46. KITAGAKI K, NIWA S. HOSHIKO KI, NAGAI H, HAYASHI S, TOTSUKA T: Augmentation of apoptosis in bronchial exuded rat eosinophils by cyclosporin A. Biochem Biophys Res Commun 222:71-77, 1996
47. 47. NAGATA S: Apoptosis by death factor. Cell 88:355-365, 1997
48. 48. KROEMER G, PETIT P, ZANZAMI N, VAYSSIERE JL, MIGNOTTE B: The biochemistry of programmed cell death. FASEB J 9:1277-1287, 1995
49. 49. STELLER H: Mechanisms and genes of cellular suicide. Science 267:1445-1449, 1995
50. 50. SCHWARTZ LM, OSBORNE BA: Programmed cell death, apoptosis and killer genes. Immunol Today 14:582-590, 1993
51. 51. MENE P, AMORE A: Apoptosis: A potential role in renal diseases. Nephrol Dial Transplant 13:1936-1943, 1998
52. 52. BUTTKE TM, SANDSTROM PA: Oxidative stress as a mediator of apoptosis. Immunol Today 15:7-10, 1994
53. 53. KOHLI V, SELZNER M, MADDEN JF, BENTLEY RC, CLAVIEN PA: Endothelial cell and hepatocyte deaths occur by apoptosis after ischemia-reperfusion injury in the rat liver. Transplantation 67: 1099-1105, 1999
54. 54. KANETO H, FUJII J, SEO HG, SUZUKI K, MATSUOKA T, NAKAMURA M, TATSUMI H, YAMASAKI Y, KAMADA T, TANIGUCHI N: Apoptotic cell death triggered by nitric oxide in pancreatic beta-cells. Diabetes 44:733-738, 1995
55. 55. NISHIO E, WATANABE Y: Nitric oxide donor-induced apoptosis in smooth muscle cells is modulated by protein kinase A. Eur J Pharmacol 339:245-251, 1997
56. 56. TSUJI A, SAKURAI H: Generation of nitric oxide from streptozotocin (STZ) in the presence of copper (II) plus ascorbate: Implication for the development of STZ-induced diabetes. Biochem Biophys Res Commun 245:11-16, 1998
57. 57. STUEHR DJ, MARLETTA MA: Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines or interferon gamma. J. Immunology 139:518-525, 1987
58. 58. EL-DEIRY WS, HARPER JW, O'CONNOR PM, VELCULESCU VE, CANMAN CE, JACKMAN J, PIETENPOL JA, BURRELL M, HILL DE, WANG Y: WAF1/CIP1 is induced in p53-medialed G1 arrest and apoptosis. Cancer Res 54:1169-1174, 1994
59. 59. XIONG Y, HANNON GJ, ZHANG H: p21 is a universal inhibitor of cyclin kinases. Nature 366:701-704, 1993
60. 60. WAGA S, HANNON GJ, BEACH D:The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature 369:574-578, 1994