Glucocorticoids and cyclosporine induce apoptosis in mitogen-activated human peripheral mononuclear cells

Immunopharmacology

Volumn 37, Issue 1, 1997, Pages 87-94

  Horigome, Atsushi ^a   Hirano, Toshihiko ^a   Oka, Kitaro ^a   Takeuchi, Hironori ^b   Sakurai, Etsuo ^b   Kozaki, Koichi ^b   Matsuno, Naoto ^b   Nagao, Takeshi ^b   Kozaki, Masami ^b  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b TOKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Apoptosis; Cyclosporine; Glucocorticoids; Human peripheral blood lymphocytes

Indexed keywords

CONCANAVALIN A; CYCLOSPORIN A; DNA FRAGMENT; GLUCOCORTICOID; IMMUNOSUPPRESSIVE AGENT; METHYLPREDNISOLONE; PREDNISOLONE;

ADULT; AGAR GEL ELECTROPHORESIS; AGED; APOPTOSIS; ARTICLE; BLOOD; CELL CULTURE; CHRONIC KIDNEY FAILURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; LYMPHOCYTE ACTIVATION; LYMPHOCYTE TRANSFORMATION; MALE; MICROSCOPY; MONONUCLEAR CELL; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL;

APOPTOSIS; CONCANAVALIN A; CYCLOSPORINE; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS; GLUCOCORTICOIDS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY FAILURE, CHRONIC; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; MITOGENS; STIMULATION, CHEMICAL;

EID: 0030842392     PISSN: 01623109     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0162-3109(97)00036-2     Document Type: Article

References (31)

1. Alnemri, E.S., Fernandes, T.F., Haldar, S., Croce, C.M., Litwack, G., 1992. Involvement of BCL-2 in glucocorticoid-induced apoptosis of human pre-B-leukemias. Cancer Res. 52, 491-495.
2. Ashwell, J.D., 1994. Lymphocyte programmed cell death. In: Snow, E.C. (Ed.), Handbook of B- and T-lymphocytes. Academic Press, San Diego, CA, pp. 63-89.
3. Barry, J.M., 1992. Immunosuppressive drugs in renal transplantation. A review of the regimens. Drugs 44, 554-566.
4. Bowes, L.G., Dumble, L.J., Clunie, G.J., Francis, D.M., Macdonald, I.M., Kincaid, S.P., 1989. Increased risk of rejection in renal transplant recipients with in vitro cyclosporin-resistant lymphoid responses. Transplant Proc. 21, 1470-1471.
5. Brunetti, M., Martelli, N., Colasante, A., Piantelli, M., Musiani, P., Aiello, F.B., 1995. Spontaneous and glucocorticoid-induced apoptosis in human mature T-lymphocytes. Blood 86, 4199-4205.
6. Cohen, J.J., 1992. Glucocorticoid-induced apoptosis in the thymus. Semin. Immunol. 4, 363-369.
7. Collins, M.K., Marvel, J., Malde, P., Lopez, R.A., 1992. Interleukin 3 protects murine bone marrow cells from apoptosis induced by DNA damaging agents. J. Exp. Med. 176, 1043-1051.
8. Faulds, D., Goa, K.L., Benfield, P., 1993. Cyclosporin. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in immunoregulatory disorders. Drugs 45, 953-1040.
9. Francis, D.M., Dumble, L.J., Bowes, L., Clunie, G.J., Macdonald, I.M., 1988. Adverse influence of recipient lymphoid resistance to in vitro immunosuppression on the outcome of kidney transplants. Transplantation 46, 853-857.
10. Gillis, S., Crabtree, G.R., Smith, K.A., 1979a. Glucocorticoid-induced inhibition of T-cell growth factor production. I. The effect on mitogen-induced lymphocyte proliferation. J. Immunol. 123, 1624-1631.
11. Gillis, S., Crabtree, G.R., Smith, K.A., 1979b. Glucocorticoid-induced inhibition of T-cell growth factor production. II. The effect on the in vitro generation of cytolytic T-cells. J. Immunol. 123, 1632-1638.
12. Hirano, T., Oka, K., Kawashima, E., Akiba, M., 1989. Effects of synthetic and naturally occurring flavonoids on mitogen-induced proliferation of human peripheral-blood lymphocytes. Life Sci. 45, 1407-1411.
13. Hirano, T., Oka, K., Sakurai, E., Tamaki, T., Kozaki, M., 1991. Impaired prednisolone sensitivities of the endocrine system and peripheral-blood lymphocytes are closely related to clinical incidence in renal transplantation. J. Pharm. Pharmacol. 43, 569-573.
14. Hirano, T., Oka, K., Takeuchi, H., Sakurai, E., Matsuno, N., Tamaki, T., Kozaki, M., 1994. Clinical significance of glucocorticoid pharmacodynamics assessed by antilymphocyte action in kidney transplantation. Marked difference between prednisolone and methylprednisolone. Transplantation 57, 1341-1348.
15. + T-lymphocytes and computer-simulated analysis: Modeling a treatment scenario for HIV infection. Res. Immunol. 146, 101-108.
16. Hynes, R.C. Jr., 1991. Adrenocorticotropic hormone; adrenocortical steroids and their synthetic analogs; inhibitors of the synthesis and actions of adrenocortical hormones. In: Gilman, A.G., Rail, T.W., Nies, A.S., Taylor, P. (Eds.), Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed. Pergamon Press, New York, pp. 1431-1462.
17. Kang, X.X., Hirano, T., Oka, K., Sakurai, E., Tamaki, T., Kozaki, M., 1991. Role of altered prednisolone-specific lymphocyte sensitivity in chronic renal failure as a pharmacodynamic marker of acute allograft rejection after kidney transplantation. Eur. J. Clin. Pharmacol. 41, 417-423.
18. Langhoff, E., Ladefoged, J., Jakobsen, B.K., Platz, P., Ryder, L.P., Svejgaard, A., Thaysen, J.H., 1986. Recipient lymphocyte sensitivity to methylprednisolone affects cadaver kidney graft survival. Lancet 1, 1296-1297.
19. Lanza, L., Scudeletti, M., Puppo, F., Bosco, O., Peirano, L., Filaci, G., Fecarotta, E., Vidali, G., Indiveri, F., 1996. Prednisone increases apoptosis in in vitro activated human peripheral blood T-lymphocytes. Clin. Exp. Immunol. 103, 482-490.
20. Los, M., Schenk, H., Hexel, K., Baeuerle, P.A., Droge, W., Schulze, O.K., 1995. IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase. Embo. J. 14, 3731-3740.
21. Masy, E., Labalette, H.M., Dessaint J, P., 1994. Individual susceptibility to cyclosporine: Possible involvement of the CD28/CD80 (B7/BB1) pathway. Transplant. Proc. 26, 2846-2848.
22. Memon, S.A., Moreno, M.B., Petrak, D., Zacharchuk, C.M., 1995. Bcl-2 blocks glucocorticoid- but not Fas- or activation-induced apoptosis in a T-cell hybridoma. J. Immunol. 155, 4644-4652.
23. Migliorati, G., Nicoletti, I., Nocentini, G., Pagliacci, M.C., Riccardi, C., 1994. Dexamethasone and interleukins modulate apoptosis of murine thymocytes and peripheral T-lymphocytes. Pharmacol. Res. 30, 43-52.
24. Nagata, S., Golstein, P., 1995a. The Fas death factor. Science 267, 1449-1456.
25. Nagata, S., Suda, T., 1995b. Fas and Fas ligand: lpr and gld mutations. Immunol. Today 16, 39-43.
26. Saiagh, S., Auger, C., Fabien, N., Monier, J.C., 1994. Induction of apoptosis in mouse thymocytes by cyclosporin A: an in vitro study. Immunopharmacol. Immunotoxicol. 16, 359-388.
27. Shi, Y., Radvanyi, L.G., Sharma, A., Shaw, P., Green, D.R., Miller, R.G., Mills, G.B., 1995. CD28-mediated signaling in vivo prevents activation-induced apoptosis in the thymus and alters peripheral lymphocyte homeostasis. J. Immunol. 155, 1829-1837.
28. Tamura, A., Yui, K., 1995. Age-dependent reduction of Bcl-2 expression in peripheral T cells of lpr and gld mutant mice. J. Immunol. 155, 499-507.
29. Tuosto, L., Cundari, E., Montani, M.S., Piccolella, E., 1994. Analysis of susceptibility of mature human T-lymphocytes to dexamethasone-induced apoptosis. Eur. J. Immunol. 24, 1061-1065.
30. Van, G.S., Ceuppens, J.L., Walter, H., de, B.M., 1994. Synergy between cyclosporin A and a monoclonal antibody to B7 in blocking alloantigen-induced T-cell activation. Blood 83, 176-183.
31. Zubiaga, A.M., Munoz, E., Huber, B.T., 1992. IL-4 and IL-2 selectively rescue Th cell subsets from glucocorticoid-induced apoptosis. J. Immunol. 149, 107-112.