Inositol phosphoglycans and signal transduction systems in pregnancy in preeclampsia and diabetes: Evidence for a significant regulatory role in preeclampsia at placental and systemic levels

Molecular Genetics and Metabolism

Volumn 69, Issue 2, 2000, Pages 144-158

  Kunjara, Sirilaksana ^a   Greenbaum, A Leslie ^a   Wang, Dennis Y ^a   Caro, Hugo N ^a   McLean, Patricia ^a   Redman, Christopher W G ^b   Rademacher, Thomas W ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Apoptosis; Aspartat e transaminase; Diabetes; Inositol phosphoglycans; Platelets; Preeclampsia; Pregnancy; Proteinuria

Indexed keywords

AMINOTRANSFERASE; GLYCOGEN SYNTHASE; PHOSPHATIDYLINOSITIDE; PROTEIN KINASE; THYMIDINE;

ADULT; ARTICLE; CHROMATOGRAPHY; DIABETES MELLITUS; DISEASE ASSOCIATION; FEMALE; HUMAN; LIPOGENESIS; MAJOR CLINICAL STUDY; PREECLAMPSIA; PREGNANCY COMPLICATION; PRIORITY JOURNAL; PROTEINURIA; SIGNAL TRANSDUCTION; THROMBOCYTE COUNT; URINARY EXCRETION; URINE VOLUME;

EID: 0034068859     PISSN: 10967192     EISSN: None     Source Type: Journal    
DOI: 10.1006/mgme.2000.2964     Document Type: Article

References (63)

1. Redman C WG. Pre-eclampsia and the placenta. Placenta. 12:1991;301-308.
2. Robertson W B, Brosens I A, Dixon H G. The pathological response of the vessels of the placental bed to hypertensive pregnancy. J Pathol Bacteriol. 93:1967;581-592.
3. Roberts J M, Taylor R N, Musci T J, Rodgers G M, Hubel C A, McLaughlin M K. Pre-eclampsia: An endothelial cell disorder. Am J Obstet Gynecol. 161:1989;1200-1204.
4. Cockell A P, Learmont J G, Samarason A K, Redman C WG, Sargent I L, Poston L. Human placental syncytiotrophoblast microvillous membranes impair maternal vascular endothelial function. Br J Obstet Gynaecol. 104:1997;235-240.
5. Knight M, Redman C WG, Linton E A, Sargent I L. Shedding of syncytiotrophoblast microvilli into the maternal circulation in pre-eclamptic pregnancies. Br J Obstet Gynaecol. 105:1998;632-640.
6. Kertesz Z, Hurst G, Ward M, Willis A C, Caro H N, Linton E A, Sargent I L, Redman C WG. Purification and characterization of a complex from placental syncytiotrophoblast microvillous membranes which inhibits the proliferation of human umbilical vein endothelial cells. Placenta. 20:1999;71-79.
7. Arkwright P D, Rademacher T W, Dwek R A, Redman C WG. Pre-eclampsia is associated with an increase in trophoblast glycogen content and glycogen synthase activity similar to that found in hydatidiform mole. J Clin Invest. 91:1993;2744-2753.
8. Gabbe S G, Demers L M, Greep R O, Villee C A. Placental glycogen metabolism in diabetes mellitus. Diabetes. 21:1972;1185-1192.
9. Shafrir E, Barash V. Placental glycogen metabolism in diabetic pregnancy. Israel J Med Sci. 27:1991;449-461.
10. Nestler J E, Romero G, Huang L C, Zhang C, Larner J. Insulin mediators are the signal transduction system responsible for insulin's actions on human placental steroidogenesis. Endocrinology. 129:1991;2951-2956.
11. Jones D R, Varela-Nieto I. The rok of gylcosyl-phosphatidylinositol in signal transduction. Int J Biochem Cell Biol. 30:1998;313-326.
12. Larner J, Huang L C, Suzuki S, Tang E, Zhang C, Schwartz C FW, Romero G, Luttrell L, Kennington A S. Insulin mediators and the control of pyruvate dehydrogenase complex. Ann N Y Acad Sci. 573:1989;297-305.
13. Lilley K, Zhang C, Villar-Palasi C, Larner J, Huang L. Insulin mediator stimulation of pyruvate dehydrogenase phosphatase. Arch Biochem Biophys. 296:1992;170-174.
14. Saltiel A R. Insulin generates an enzyme modulator from hepatic plasma membrane: Regulation of cAMP phosphodiesterase, pyruvate dehydrogenase and adenylate cyclase. Endocrinology. 120:1987;967-972.
15. Villaba M, Kelly K L, Mato J M. Inhibition of cyclic AMP dependent protein kinase by the polar head group of an insulin-sensitive glycophospholipid. Biochim Biophys Acta. 968:1988;69-76.
16. Saltiel A R, Fox J A, Sherline P, Cuatrecasas P. Insulin-stimulated hydrolysis of a novel glycolipid generates modulators of cAMP phosphodiesterase. Science. 233:1986;967-972.
17. Varela-Nieto I, Leon Y, Caro H N. Cell signalling by inositol phosphoglycans from different species. Comp Biochem Physiol. 115B:1996;223-241.
18. Kunjara S, Caro H N, McLean P, Rademacher T W. Tissue specific release of inositol phosphoglycans. Svasti J. Biopolymers and bioproducts: Structure, function and applications. 1995;301-306 Samakkhisan (Dokya). Public Co. Ltd. Bangkok.
19. Brautigan D L. Protein phosphatases. Rec Prog Horm Res. 49:1994;197-214.
20. Diamant Y Z, Mayorek N, Neumann S, Shafrir E. Enzymes of glucose and fatty acid metabolism in early and term human placenta. Am J Obstet Gynecol. 121:1975;58-61.
21. Diamant Y Z, Beyth Y, Neumann S, Shafrir E. Activity of placental enzymes of carbohydrate and lipid metabolism in normal, toxemic and small-for-date pregnancies. Israel J Med Sci. 12:1976;243-247.
22. Shafrir E, Diamant Y Z. Regulation of placental enzymes of carbohydrate and lipid metabolic pathways. Ciba Found Symp. 63:1978;161-179.
23. Romero G. Inositol glycans and cellular signalling. Cell Biol Int Rev. 15:1991;827-851.
24. Romero G, Larner J. Insulin mediators and the mechanisms of insulin action. Adv Pharmacol. 28:1993;21-50.
25. Rademacher T W, Caro H N, Kunjara S, Wang D Y, Greenbaum A L, McLean P. Inositolphosphoglycan second messengers. Brazilian J Med Biol Res. 27:1994;327-341.
26. Caro H N, Kunjara S, Rademacher T W, Leon Y, Jones D R, Avila M A, Varela-Nieto I. Isolation and partial characterisation of insulin-mimetic inositol phosphoglycans from human liver. Biochem Molec Med. 61:1997;214-228.
27. Rodbell M. Metabolism of isolated fat cells. J Biol Chem. 239:1964;375-380.
28. Asplin I, Galasko G, Larner J. Chiro-Inositol deficiency and insulin resistance: A comparison of the chiro-inositol- and the myo-inositol-containing insulin mediators isolated from urine, hemodialysate, and muscle of control and type II diabetic subjects. Proc Natl Acad. Sci USA. 90:1993;5924-5928.
29. Lazar D F, Knez J J, Medof E, Cuatracasas P, Saltiel A R. Stimulation of glycogen synthesis by insulin in human erythroleukemia cells requires the synthesis of glycosyl-phosphatidyl inositol. Proc Natl Acad Sci USA. 91:1994;9665-9669.
30. Lawrence J C, Guinovart J J, Larner J. Activation of rat adipocyte glycogen synthase by insulin. J Biol Chem. 252:1977;444-450.
31. Lima F B, Bao S, Garvey W. Biological actions of insulin are differentially regulated by glucose and insulin in primary cultured adipocytes. Diabetes. 43:1994;53-62.
32. 14C-glucose. Anal Biochem. 25:1968;486-499.
33. Kunjara S, Wang D-Y, Greenbaum A L, McLean P, Kurtz A, Rademacher T W. Inositol phosphoglycans in diabetes and obesity: Urinary levels of IPG A-type and IPG P-type, and relationship to pathophysiological changes. Mol Genet Metab. 68:1999;488-502.
34. Suzuki S, Toyota T, Suzuki K, Goto Y. Partial purification from human mononuclear cells and placental membranes of an insulin mediator which stimulates pyruvate dehydrogenase and suppresses glucose 6-phosphatase. Arch Biochem Biophys. 235:1984;418-426.
35. Romero G, Garmey J C, Velduis J D. The involvement of inositol phosphoglycan mediators in the modulation of steroidogenesis by insulin and insulin-like growth factor-1. Endocrinology. 132:1993;1561-1568.
36. Barash V, Gutman A, Shafrir E. Mechanism of placental glycogen deposition in diabetes in the rat. Diabetologia. 24:1983;63-68.
37. Sochor M, Baquer N Z, McLean P. Glucose over- and under-utilization in diabetes. Molec Physiol. 2:1985;51-68.
38. Garner P R, D'Alton M E, Dudley D K, Huard P, Hardie M. Preeclampsia in diabetic pregnancies. Am J Obstet Gynecol. 163:1990;505-508.
39. Combs C A, Rosenn B, Kitzmiller J L, Khoury J C, Wheeler B C, Miodovnik M. Early pregnancy proteinuria in diabetes related to preeclampsia. Obstet Gynecol. 82:1993;802-807.
40. Hsu C D, Tan X Y, Hong S F, Nickless N A, Copel J A. Strategies for reducing the frequency of pre-eclampsia in pregnancies with insulin-dependent diabetes mellitus. Am J Perinatal. 13:1996;265-268.
41. Ekbom P. Lancet. 353:1999;377.
42. Fanjul L F, Marrero I, Estevez F, Gonzalez J, Quintana J, Santana P, Ruiz de Galarreta C M. Follicle-stimulating hormone and human chorionic gonadotrophin induced changes in granulosa cell glycosyl-phosphatidylinositol concentration. Cell Physiol. 155:1993;273-281.
43. Igarashi Y, Chambaz E M. A novel inositol phospholipid and the serum dependence of its metabolism in bovine adrenocortical cells. Biochem Biophys Res Commun. 145:1987;248-256.
44. Martiny L, Antonicelli F, Thuilliez B, Lambert B, Jaquemin C, Haye B. Control by thyrotropin of the production by thyroid cells of an inositol phosphate-glycan. Cell Signal. 2:1990;21-27.
45. Kojima I, Kitaoka M, Ogata E. Insulin-like growth factor-1 stimulates diacylglycerol production via multiple pathways in BALB/c 3T3 cells. J Biol Chem. 265:1990;16846-16850.
46. Vivien D, Petitfrere E, Martiny L, Sartelet H, Galera P, Hate B, Pujol J-P. IPG (inositolphosphate glycan) as a cellular signal for TGF-B1 modulation of chrondrocyte cell cycle. J Cell Physiol. 155:1993;437-444.
47. Bruni P, Vasta V, Berti L, Avila M A, Farnararo M, Varela-Nieto I. An inositol phosphoglycan stimulates glycolysis in human platelets. Biochem Biophys Res Commun. 180:1991;1041-1047.
48. Vuorinen K, Remes A, Sormunen R, Tapanainen J, Hassinen I E. Placental mitochondrial DNA and respiratory chain enzymes in the etiology of preclampsia. Obstet Gynecol. 91:1998;950-955.
49. Widschwendter M, Schrocksnadel H, Mortl M G. Pre-eclampsia: A disorder of placental mitochondria. Molec Med Today. July:1998;286-291.
50. Wang Y, Walsh S W. Placental mitochondria as a source of oxidative stress in pre-eclampsia. Placenta. 19:1998;581-586.
51. Poranen A K, Ekblad U, Uotila P, Ahotupa M. Lipid preoxidation and antioxidants in normal and pre-eclamptic pregnancies. Placenta. 17:1996;401-405.
52. Matsubara S, Minakami H, Sato I, Saito T. Decrease in cytochrome c oxidase activity detected cytochemically in the placental trophoblast of patients with pre-eclampsia. Placenta. 18:1997;255-259.
53. Knapen M FCM, Peters W HM, Mulder T PJ, Merkus H MWM, Jansen J BMJ, Steegers E AP. Glutathione and glutathione-related enzymes in decidua and placenta of controls and women with pre-eclampsia. Placenta. 20:1999;541-546.
54. Cai J, Jones D P. Superoxide and apoptosis. J Biol Chem. 273:1998;11401-11404.
55. DiFrederico E, Genbacev O, Fisher J. Pre-eclampsia is associated with widespread apoptosis of placental cytotrophoblasts within the uterine wall. Am J Pathol. 155:1999;293-301.
56. Gulmezoglu A M, Hofmeyr G L, Oosthuizen M M. Antioxidants in the treatment of severe pre-eclampsia; a randomised control trial. Br J Obstet Gynaecol. 104:1997;689-696.
57. Chappell L C, Seed P T, Briley A L, Kelly F K, Lee R, Hunt B J, Parmar K, Bewley S J, Shennan A H, Steer P J, Poston L. Effect of antioxiants on the occurrence of pre-eclampsia in women at increased risk: A randomised trial. Lancet. 354:1999;810-816.
58. Cai J, Yang J, Jones D P. Mitochondrial control of apoptosis: The role of cytochrome c. Biochim Biophys Acta. 1366:1998;139-149.
59. Slee E A, Harte M T, Kluck R M, Wolf B B, Casiano C A, Newmeyer D D, Wang H G, Reed J C, Nicholson D W, Alnemri E S, Green D R, Martin S J. Ordering the cytochrome c-initiated caspase cascade: Hierarchical activation of caspase-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J Cell Biol. 144:1999;281-292.
60. Baquer N Z, Hothersall J S, McLean P, Greenbaum A L. Function and regulation of the pentose phosphate pathway in brain. Curr Topics Cell Regul. 29:1988;265-289.
61. Walsh S W, Wang Y. Deficient glutathione peroxidase activity in pre-eclampsia is associated with increased placental production of thromboxane and lipid peroxides. Am J Obstet Gynecol. 169:1993;14456-14461.
62. Wang Y, Walsh S W. Antioxidant activities and mRNA expression of superoxide dismutase, catalase and glutathione peroxidase in normal and pre-eclamptic pregnancies. J Soc Gynecol Invest. 3:1996;179-184.
63. Myatt L, Eis A L, Brockman D E, Kossenjans W, Greer I A, Lyall F. Differential localization of superoxide dismutase isoforms in placental villous tissue of normotensive, pre-eclamptic, and intrauterine growth-restricted pregnancies. J Histochem Cytochem. 45:1997;1433-1438.