Physicochemical and biological characterisation of an antisense oligonucleotide targeted against the bcl-2 mRNA complexed with cationic-hydrophilic copolymers

European Journal of Pharmaceutical Sciences

Volumn 10, Issue 3, 2000, Pages 169-177

  Read, Martin L ^a   Dash, Philip R ^a   Clark, Anya ^a   Howard, Kenneth A ^a   Oupicky, David ^a   Toncheva, Veska ^b   Alpar, H Oya ^d   Schacht, Etienne H ^b   Ulbrich, Karel ^c   Seymour, Leonard W ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b GHENT UNIVERSITY   (Belgium)

^c INSTITUTE OF MACROMOLECULAR CHEMISTRY   (Czech Republic)

^d ASTON UNIVERSITY   (United Kingdom)

Author keywords

Antisense; Cationic polymers; Gene therapy; Oligonucleotide

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CATION; COPOLYMER; DNA; MACROGOL; MESSENGER RNA; PHOSPHORUS 32; POLY(TRIMETHYLAMMONIOETHYL METHACRYLATE CHLORIDE); POLY[N (2 HYDROXYPROPYL)METHACRYLAMIDE]; POLYELECTROLYTE; POLYLYSINE; POLYMER; PROTEIN BCL 2; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

AGAR GEL ELECTROPHORESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG STABILITY; DRUG TARGETING; DRUG TISSUE LEVEL; FEMALE; FLUORESCENCE; GENE THERAPY; MOUSE; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SURFACE CHARGE; TECHNIQUE; URINARY EXCRETION; ZETA POTENTIAL;

ANIMALS; CHEMISTRY, PHYSICAL; DNA; ELECTROPHORESIS, AGAR GEL; FEMALE; INTERCALATING AGENTS; METHACRYLATES; MICE; MICE, INBRED BALB C; OLIGONUCLEOTIDES, ANTISENSE; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POLYMERS; PROPIDIUM; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, MESSENGER; SPECTROMETRY, FLUORESCENCE; SURFACE PROPERTIES; TISSUE DISTRIBUTION; VEHICLES;

EID: 0034067396     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(00)00069-5     Document Type: Article

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