Molecular characterization of HHV-8 positive primary effusion lymphoma reveals pathogenetic and histogenetic features of the disease

Journal of Clinical Virology

Volumn 16, Issue 3, 2000, Pages 215-224

  Gaidano, Gianluca ^a   Capello, Daniela ^a   Fassone, Lucia ^a   Gloghini, Annunziata ^b   Cilia, Anna Maria ^b   Ariatti, Cristiano ^a   Buonaiuto, Daniela ^a   Vivenza, Daniela ^a   Gallicchio, Margherita ^a   Avanzi, Gian Carlo ^a   Prat, Maria ^a   Carbone, Antonino ^b  

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^b Division of Pathology   (Italy)

Author keywords

EBV; HGF; HHV 8; MET; Pathogenesis; Primary effusion lymphoma

Indexed keywords

SCATTER FACTOR; TYROSINE KINASE RECEPTOR;

ARTICLE; CASE REPORT; CELL LINE; CHROMOSOME ABERRATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOGENETICS; DNA SEQUENCE; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPSTEIN BARR VIRUS; FLUORESCENCE IN SITU HYBRIDIZATION; GENE EXPRESSION; GENE MUTATION; GENOTYPE; HISTOGENESIS; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 8; IMMUNOCYTOCHEMISTRY; KARYOTYPE; LYMPHOMA; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EPSTEIN-BARR VIRUS NUCLEAR ANTIGENS; FEMALE; HEPATOCYTE GROWTH FACTOR; HERPESVIRUS 4, HUMAN; HERPESVIRUS 8, HUMAN; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KARYOTYPING; LYMPHOMA, B-CELL; MALE; PROTO-ONCOGENE PROTEINS C-MET; TUMOR CELLS, CULTURED; VARIATION (GENETICS);

EID: 0034063240     PISSN: 13866532     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1386-6532(99)00082-7     Document Type: Article

References (41)

1. Ansari M.Q., Dawson D.B., Nador R., Rutherford C., Schneider N.R., Latimer M.J., Picker L., Knowles D.M., Mckenna R.W. Primary body cavity-based AIDS-related lymphomas. Am. J. Clin. Pathol. 105:1996;221-229.
2. Arvanitakis L., Mesri E.A., Nador R.G., Said J.W., Asch A.S., Knowles D.M., Cesarman E. Establishment and characterization of primary effusion (body cavity-based) lymphoma cell line (BC-3) harboring Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in the absence of Epstein-Barr virus. Blood. 88:1996;2648-2654.
3. Baer R., Bankier A.T., Biggin M.D., Deininger P.L., Farrell P.J., Gibson T.J., Hatfull G., Hudson G.S., Satchwell S.C., Seguin C., Tuffnell P.S., Barrell B.G. DNA sequence and expression of the B95-8 Epstein-Barr virus genome. Nature. 310:1984;207-211.
4. Bhatia K., Raj A., Gutierrez M.I., Judde J.-G., Spangler G., Venkatesh H., Magrath I.T. Variation in the sequence of Epstein Barr virus nuclear antigen 1 in normal peripheral blood lymphocytes and in Burkitt's lymphomas. Oncogene. 13:1996;177-181.
5. Borset M., Hjorth-Hansen H., Seidel C., Sundan A., Waage A. Hepatocyte growth factor and its receptor c-Met in multiple myeloma. Blood. 88:1996;3998-4004.
6. Borset M., Lien E., Espevik T., Helseth E., Waage A., Sundan A. Concomitant expression of hepatocyte growth factor/scatter factor and the receptor c-MET in human myeloma cell lines. J. Biol. Chem. 271:1996;24655-24661.
7. + cell line (BCP-1) from peripheral blood and characterizing its growth in Nod/SCID mice. Blood. 91:1998;1671-1679.
8. Carbone A., Gaidano G. HHV-8-positive body cavity-based lymphoma: a novel lymphoma entity. Br. J. Haematol. 97:1997;515-522.
9. Carbone A., Gloghini A., Vaccher E., Zagonel V., Pastore C., Dalla Palma C., Branz F., Saglio G., Volpe R., Tirelli U., Gaidano G. Kaposi's sarcoma-associated herpesvirus DNA sequences in AIDS-related and AIDS-unrelated lymphomatous effusions. Br. J. Haematol. 94:1996;533-543.
10. Carbone A., Cilia A.M., Gloghini A., Canzonieri V., Pastore C., Todesco M., Cozzi M., Perin T., Volpe R., Pinto A., Gaidano G. Establishment of HHV-8 positive and HHV-8 negative lymphoma cell lines from primary lymphomatous effusions. Int. J. Cancer. 73:1997;562-569.
11. Carbone A., Cilia A.M., Gloghini A., Capello D., Todesco M., Quattrone S., Volpe R., Gaidano G. Establishment and characterization of EBV-positive and EBV-negative primary effusion lymphoma cell lines harbouring human herpesvirus type-8. Br. J. Haematol. 102:1998;1081-1089.
12. Cesarman E., Chang Y., Moore P.S., Said J.W., Knowles D.M. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N. Engl. J. Med. 332:1995;1186-1191.
13. Cesarman E., Moore P.S., Rao P.H., Inghirami G., Knowles D.M., Chang Y. In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA sequences. Blood. 86:1995;2708-2714.
14. Dotti G., Fiocchi R., Motta T., Facchinetti B., Chiodini B., Borleri G.M., Gavazzeni G., Barbui T., Rambaldi A. Primary effusion lymphoma after heart transplantation: a new entity associated with human herpesvirus-8. Leukemia. 13:1999;664-670.
15. Drexler H.G., Minowada J. History and classification of human leukemia-lymphoma cell lines. Leuk. Lymphoma. 31:1998;305-316.
16. Drexler H.G., Uphoff C.C., Gaidano G., Carbone A. Lymphoma cell lines: in vitro models for the study of HHV-8+ primary effusion lymphomas (body cavity-based lymphomas). Leukemia. 12:1998;1507-1517.
17. Fais F., Gaidano G., Capello D., Gloghini A., Ghiotto F., Roncella S., Carbone A., Chiorazzi N., Ferrarini M. Immunoglobulin V region gene use and structure suggest antigen selection in AIDS-related primary effusion lymphomas. Leukemia. 13:1999;1093-1099.
18. Gaidano G., Dalla-Favera R. Molecular biology of lymphomas. De Vita V.T., Hellman S., Rosenberg S.A. Cancer. Principles and Practice of Oncology. 5th edn:1997;2131-2145 Lippincott, Philadelphia, PA.
19. Gaidano G., Cechova K., Chang Y., Moore P.S., Knowles D.M., Dalla-Favera R. Establishment of AIDS-related lymphoma cell lines from lymphomatous effusions. Leukemia. 10:1996;1237-1240.
20. Gaidano G., Gloghini A., Gattei V., Rossi M.F., Cilia A.M., Godeas C., Degan M., Perin T., Canzonieri V., Aldinucci D., Saglio G., Carbone A., Pinto A. Association of Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma with expression of the CD138/syndecan-1 antigen. Blood. 90:1997;4894-4900.
21. Gaidano G., Capello D., Cilia A.M., Gloghini A., Perin T., Quattrone S., Migliazza A., Lo Coco F., Saglio G., Ascoli V., Carbone A. Genetic characterization of HHV-8/KSHV-positive primary effusion lymphoma reveals frequent mutations of BCL6: Implications for disease pathogenesis and histogenesis. Genes Chromosomes Cancer. 24:1999;16-23.
22. Giordano S., di Renzo M.F., Olivero M., Mondino A., Zhen Z., Medico E., Comoglio P.M. The c-met/HGF receptor in human tumours. Eur. J. Cancer Prev. 1(Suppl. 3):1992;45-49.
23. Gutierrez M.I., Raj A., Spangler G., Sharma A., Hussain A., Judde J.-G., Tsao S.W., Yuen P.W., Joab I., Magrath I.T., Bhatia K. Sequence variations in EBNA-1 may dictate restriction of tissue distribution of Epstein-Barr virus in normal and tumour cells. J. Gen. Virol. 78:1997;1663-1670.
24. Horenstein M.G., Nador R.G., Chadburn A., Hyjek E.M., Inghirami G., Knowles D.M., Cesarman E. Epstein-Barr virus latent gene expression in primary effusion lymphomas containing Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8. Blood. 90:1997;1186-1191.
25. ISCN. In: Mitelman F, editor. An International System for Human Cytogenetic Nomenclature. Basle: Karger, 1995.
26. Jaffe E.S., Harris N.L., Diebold J., Muller-Hermelink H.K. World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues. A progress report. Am. J. Clin. Pathol. 111(Suppl. 1):1999;S8-S12.
27. Kiwanuka J., Shiramizu B., Sandlund T., Barriga F., McManaway M., Novikovs L., Huber B., Magrath I.T. The contribution of Burkitt's lymphoma cell lines to the understanding of the pathogenesis of Burkitt's lymphoma. Cancer Rev. 10:1988;63-91.
28. Klein G. Viral latency and transformation: The strategy of Epstein-Barr virus. Cell. 58:1989;5-8.
29. Maggiora P., Gambarotta G., Olivero M., Giordano S., Di Renzo M.F., Comoglio P.M. Control of invasive growth by the HGF receptor family. J. Cell. Physiol. 173:1997;183-186.
30. Maier J.A.M., Mariotti M., Albini A., Comi P., Prat M., Comoglio P., Soria M.R. Over-expression of hepatocyte growth factor in human Kaposi's sarcoma. Int. J. Cancer. 65:1996;168-172.
31. Naidu Y.M., Rosen E.M., Zitnick R., Goldberg I., Park M., Naujokas M., Polverini P.J., Nickoloff B.J. Role of scatter factor in the pathogenesis of AIDS-related Kaposi sarcoma. Proc. Natl. Acad. Sci. USA. 91:1994;5281-5285.
32. Pasqualucci L., Migliazza A., Fracchiolla N., William C., Neri A., Baldini L., Chaganti R.S., Klein U., Kuppers R., Rajewsky K., Dalla-Favera R. BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci. Proc. Natl. Acad. Sci. USA. 95:1998;11816-11821.
33. Pastore C., Gaidano G., Ghia P., Fassone L., Cilia A.M., Gloghini A., Capello D., Buonaiuto D., Gonella S., Roncella S., Carbone A., Saglio G. Patterns of cytokine expression in AIDS-related non-Hodgkin's lymphoma. Br. J. Haematol. 103:1998;143-149.
34. Peng H.-Z., Du M.-Q., Koulis A., Aiello A., Dogan A., Pan L.-X., Isaacson P.G. Nonimmunoglobulin gene hypermutation in germinal center B cells. Blood. 93:1999;2167-2172.
35. Pinkel D., Straume T., Gray J.W. Cytogenetic analysis using quantitative, high-sensitivity, fluorescence hybridization. Proc. Natl. Acad. Sci. USA. 83:1986;2934-2938.
36. Prat M., Crepaldi T., Gandino L., Giordano S., Longati P., Comoglio P. C-terminal truncated forms of Met, the hepatocyte growth factor receptor. Mol. Cell. Biol. 11:1991;5954-5962.
37. Ruf I.K., Rhyne P.W., Yang H., Borza C.M., Hutt-Fletcher L.M., Cleveland J.L., Sample J.T. Epstein-Barr virus regulates c-MYC, apoptosis, and tumorigenicity in Burkitt lymphoma. Mol. Cell. Biol. 19:1999;1651-1660.
38. Shen H.M., Peters A., Baron B., Zhu X., Storb U. Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes. Science. 280:1998;1750-1752.
39. Uphoff C.C., Habig S., Carbone A., Gaidano G., Drexler H.G. HHV-8 infection is specific for cell lines derived from primary effusion (body cavity-based) lymphomas. Leukemia. 12:1998;1806-1809.
40. van der Woort R., Taher T.E.I., Keehnen R.M.J., Smit L., Groenink M., Pals S.T. Paracrine regulation of germinal center B cell adhesion through the c-Met-hepatocyte growth factor/scatter factor pathway. J. Exp. Med. 185:1997;2121-2131.
41. 1 integrins. Blood. 89:1997;990-1000.