Effects of dibutyl phthalate on reproductive function in pregnant and pseudopregnant rats

Reproductive Toxicology

Volumn 14, Issue 1, 2000, Pages 13-19

  Ema, Makoto ^a   Miyawaki, Emiko ^a   Kawashima, Kunio ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Decidual cell response; Dibutyl phthalate; Early embryonic loss; Early pregnancy; Phthalic acid ester; Pseudopregnancy; Uterine function

Indexed keywords

PHTHALIC ACID DIBUTYL ESTER; PHTHALIC ACID ESTER; PROGESTERONE; TERATOGENIC AGENT;

ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD; BREEDING; CONTROLLED STUDY; DECIDUALIZATION; DOSE RESPONSE; DRUG EFFECT; EMBRYO DEATH; EMBRYOTOXICITY; FEMALE; FETUS; HISTOLOGY; HISTOPATHOLOGY; IATROGENIC DISEASE; MALE; NIDATION; NONHUMAN; ORGAN WEIGHT; OVARY; PATHOPHYSIOLOGY; PHYSIOLOGY; PREGNANCY; PREGNANCY COMPLICATION; PSEUDOPREGNANCY; RAT; RAT STRAIN; REPRODUCTIVE TOXICITY; TERATOGENICITY; UTERUS; UTERUS WEIGHT;

ANIMALIA;

EID: 0034057370     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0890-6238(99)00066-0     Document Type: Article

References (38)

1. Autian J. Toxicity and health threats of phthalate esters review of the literature . Environ Health Perspect. 4:1973;3-26.
2. Final report on the safety assessment of butyl benzyl phthalate. J Am Coll Toxicol. 11:1992;1-23.
3. Final report on the safety assessment of dibutyl phthalate, dimethyl phthalate, and diethyl phthalate. J Am Coll Toxicol. 4:1985;267-303.
4. Shiota K., Chou M.J., Nishimura H. Embryotoxic effects of di-2-ethylhexyl phthalate (DEHP) and di-n-butyl phthalate (DBP) in mice. Environ Res. 22:1980;245-253.
5. Lamb J.C. IV, Chapin R.E., Teague J., Lawton A.D., Reel J.R. Reproductive effects of four phthalic acid esters in the mouse. Toxicol Appl Pharmacol. 88:1987;255-269.
6. Singh A.R., Lawrence W.H., Autian J. Teratogenicity of phthalate esters in rats. J Pharm Sci. 61:1972;51-55.
7. Nikonorow M., Mazur H., Piekacz H. Effect of orally administered plasticizers and polyvinyl chloride stabilizers in the rat. Toxicol Appl Pharmacol. 26:1973;253-259.
8. Peters J.W., Cook R.M. Effect of phthalate esters on reproduction in rats. Environ Health Perspect. 3:1973;91-94.
9. Ema M., Amano H., Itami T., Kawasaki H. Teratogenic evaluation of di-n- butyl phthalate in rats. Toxicol Lett. 69:1993;197-203.
10. Ema M., Amano H., Ogawa Y. Characterization of the developmental toxicity of di-n-butyl phthalate in rats. Toxicology. 86:1994;163-174.
11. Ema M., Kurosaka R., Amano H., Ogawa Y. Comparative developmental toxicity of n-butyl benzyl phthalate and di-n-butyl phthalate in rats. Arch Environ Contam Toxicol. 28:1995;223-228.
12. Ema M., Harazono A., Miyawaki E., Ogawa Y. Developmental effects of di-n-butyl phthalate after a single administration in rats. J Appl Toxicol. 17:1997;223-229.
13. Mylchreest E., Cattley R.C., Foster P.M.D. Male reproductive tract malformations in rats following gestational and lactational exposure to di(n-butyl) phthalate an antiandrogenic mechanism? Toxicol Sci. 43:1998;47-60.
14. Ema M., Miyawaki E., Kawashima K. Further evaluation of developmental toxicity of di-n-butyl benzyl phthalate following administration during late pregnancy in rats. Toxicol Lett. 98:1998;87-93.
15. Wine R.N., Li L.H., Barnes L.H., Gulati D.K., Chapin R.E. Reproductive toxicity of di-n-butylphthalate in a continuous breeding protocol in Sprague-Dawley rats. Environ Health Perspect. 105:1997;102-107.
16. Ema M., Harazono A., Miyawaki E., Ogawa Y. Embryolethality following maternal exposure to dibutyl phthalate during early pregnancy in rats. Bull Environ Contam Toxicol. 58:1997;636-643.
17. Jobling S., Reynolds T., White R., Parker M.G., Sumpter J.P. A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic. Environ Health Perspect. 103:1995;582-587.
18. Harris C.A., Henttu P., Parker M.G., Sumpter J.P. The estrogenic activity of phthalate esters in vitro. Environ Health Perspect. 105:1997;802-811.
19. Sing L.T., Spencer F. A post-implantational study on the effects of zineb on reproduction using the decidualized pseudopregnant rat as a model. Bull Environ Contam Toxicol. 27:1981;418-425.
20. Bui Q.Q., Tran M.B., West W.L. Evidence for hormonal imbalance after methadone treatment in pregnant and pseudopregnant rats. Proc Soc Exp Biol Med. 173:1983;398-407.
21. Cummings A.M. Toxicological mechanisms of implantation failure. Fundam Appl Toxicol. 15:1990;571-579.
22. Yamada T., Hara M., Ohba Y., Inoue T., Ohno H. Studies on implantation traces in rats. II. Staining of cleared uteri, formation and distribution of implantation traces. Exp Anim. 34:1985;249-260.
23. De Feo V.J. Temporal aspect of uterine sensitivity in the pseudopregnant or pregnant rat. Endocrinology. 72:1963;305-316.
24. Enders A.C., Schlafke S. A morphological analysis of the early implantation stages in the rat. Am J Anat. 120:1967;185-226.
25. Beaudoin A.R. Embryology and teratology. Baker H.J., Lindsey J.R., Weisbroth S.H. The laboratory rat. vol. 2:1980;75-101 Academic Press, New York.
26. Niswender G.D., Nett T.M. The corpus luteum and its control. Knobil E., Neill J., et al. The physiology of reproduction. 1988;489-525 Raven Press, New York.
27. Yochim J.M., De Feo V.J. Control of decidual growth in the rat by steroid hormones of the ovary. Endocrinology. 71:1962;134-142.
28. Hashimoto I., Wiest W.G. Correlation of the secretion of ovarian steroids with function of a single generation of corpora lutea in the immature rat. Endocrinology. 84:1969;873-885.
29. Gray L.E. Jr, Laskey J., Ostby J., Sigmon E.R. Correlation of phthalate-induced embryotoxicity with maternal in vivo and in vitro ovarian function. Teratology. 41:1990;561-562.
30. Cummings A.M., Gray L.E. Jr. Dibutyl phthalate maternal effects versus fetotoxicity . Toxicol Lett. 39:1987;43-50.
31. Albro P.W., Moore B. Identification of the metabolites of simple phthalate diesters in rat urine. J Chlomatogr. 94:1974;209-218.
32. 14C in the rat. J Agric Food Chem. 23:1975;854-858.
33. Tanaka A., Matsumoto A., Yamaha T. Biochemical studies on phthalic esters. III. Metabolism of dibutyl phthalate (DBP) in animals. Toxicology. 9:1978;109-123.
34. Eigenberg D.A., Bozigian H.P., Carter D.E., Sipes I.G. Distribution, excretion, and metabolism of butylbenzyl phthalate in the rat. J Toxicol Environ Health. 17:1986;445-456.
35. Mikuriya H., Ikemoto I., Tanaka A. Urinary metabolites contributing to testicular damage induced by butylbenzyl phthalate. Jikeikai Med J. 35:1988;403-409.
36. Ema M., Kurosaka R., Harazono A., Amano H., Ogawa Y. Phase specificity of developmental toxicity after oral administration of mono-n-butyl phthalate in rats. Arch Environ Contam Toxicol. 31:1996;170-176.
37. Saillenfait A.M., Payan J.P., Fabry J.P., Beydon D., Langonne I., Gallissot F., Sabate J.P. Assessment of the developmental toxicity, metabolism, and placental transfer of di-n-butyl phthalate administered to pregnant rats. Toxicol Sci. 45:1998;212-224.
38. Ema M., Miyawaki E., Kawashima K. Reproductive effects of butyl benzyl phthalate in pregnant and pseudopregnant rats. Reprod Toxicol. 12:1998;127-132.