New findings concerning vertebrate porin

Naturwissenschaften

Volumn 84, Issue 11, 1997, Pages 480-498

  Thinnes, Friedrich P ^a   Reymann, Susanne ^a  

^a MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; ADENOSINE TRIPHOSPHATE; ANION CHANNEL; CHLORIDE CHANNEL; EPITOPE; MONOCLONAL ANTIBODY; POLYAMINE; PORIN; SPERMIDINE; SPERMINE; TAURINE; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ANIMAL CELL; B LYMPHOCYTE; CASE REPORT; CELL MEMBRANE DEPOLARIZATION; ENCEPHALOMYOPATHY; HUMAN; HUMAN CELL; LIPID MEMBRANE; MAMMAL CELL; NONHUMAN; OOCYTE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVIEW; SKELETAL MUSCLE; VERTEBRATE; XENOPUS LAEVIS;

AMINO ACID SEQUENCE; ANIMALS; CELL MEMBRANE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; HUMANS; ION CHANNELS; MAMMALS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PORINS; PROTEIN CONFORMATION; PROTEIN FOLDING; VERTEBRATES;

EID: 0031435669     PISSN: 00281042     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001140050432     Document Type: Review

References (117)

1. Babel, D., Walter, G., Götz, H., Thinnes, F.P., Jürgens, L., König, U., Hilschmann, N. (1991) Studies on Human Porin. VI. Production and Characterization of Eight Monoclonal Mouse Antibodies Against the Human VDAC "Porin 31HL" and Their Application for Histotopological Studies in Human Skeletal Muscle. Biol. Chem. Hoppe-Seyler 372, 1027-1034
2. Benz, R. (1994) Permeation of Hydrophilic Solutes Through Mitochondrial Outer Membranes: Review on Mitochondrial Porins. Biochim. Biophys. Acta 1197, 167-196
3. Benz, R., Maier, E., Thinnes, F.P., Götz, H., Hilschmann, N. (1992) Studies on Human Porin. VII. The Channel Properties of the Human B-Lymphocyte Membrane-Derived "Porin 31HL" are Similar to Those of Mitochondrial Porins. Biol. Chem. Hoppe-Seyler 373, 295-303
4. Blachly-Dyson, E., Peng, S., Colombini, M., Forte, M. (1990) Selectivity Changes in Site-Directed Mutants of the VDAC Ion Channel: Structural Implications. Science 247, 1233-1236
5. Blachly-Dyson, E., Zambronicz, E.B., Yu, W.H., Adams, V. McCabe, E.R.B., Adelman, J., Colombini, M., Forte, M. (1993) Cloning and Functional Expression in Yeast of Two Human Isoforms of the Outer Mitochondrial Membrane Channel, the Voltage-Dependent Anion Channel. J. Biol. Chem. 268, 1835-1841
6. Blachly-Dyson, E., Baldini, A., Litt, M., McCabe, E.R.B., Forte, M. (1994) Human Genes Encoding the Voltage-Dependent Anion Channel (VDAC) of the Outer Mitochondrial Membrane: Mapping and Identification of Two New Isoforms. Genomics 20, 62-67
7. Blair, H.C., Schlesinger, P.H. (1990) Purification of a Stilbene Sensitive Chloride Channel and Reconstitution of Chloride Conductivity into Phospholipid vesicles. Biochem. Biophys. Res. Commun. 171, 920-925
8. Blatz, A.L. (1994) Chloride Channels in Skeletal Muscle and Cerebral Cortical Neurons. Curr. Top. Membr. 42, 131-151
9. Blatz, A.L., Magleby, K.L. (1983) Single Voltage-Dependent Chloride-Selective Channels of Large Conductance in Cultured Rat Muscle. Biophys. J. 43, 237-241
10. Bosma, M.M. (1989) Anion Channels with Multiple Conductance Levels in a Mouse B Lymphocyte Cell Line. J. Physiol. (Lond.) 410, 67-90
11. Boucher, R.C. (1994a) Human Airway Ion Transport I. Am. J. Respir. Crit. Care Med. 150, 271-281
12. Boucher, R.C. (1994b) Human Airway Ion Transport II. Am. J. Respir. Crit. Care Med. 150, 581-593
13. Breuer, W. (1990) Reconstitution of a Kidney Chloride Channel and Its Identification by Covalent Labeling. Biochim. Biophys. Acta 1022, 229-236
14. Bureau, M.H., Khrestchatisky, M., Heeren, M.A., Zambrowicz, E.B., Kim, H., Grisar, T.M., Colombini, M., Tobin, A.J., Olsen, R.W. (1992) Isolation and Cloning of a Voltage-Dependent Anion Channel-like Mr 36.000 Polypeptide from Mammalian Brain. J. Biol. Chem. 267, 12:8679-8684
15. Cantiello, H.F. (1997) Nucleotide Transport Through the Cystic Fibrosis Transmembrane Conductance Regulator. Biosci. Rep. 17, 147-171
16. Cole, T., Awni, L. A., Nyakatura, E., Götz, H., Walter, G., Thinnes, F.P., Hilschmann, N. (1992) Studies on Human Porin. VIII. Expression of "Porin 31HL" Channels in the Plasmalemma of the Acute-Lymphoblastic-Leukemia Cell Line KM3 as Revealed by Light- and Electron-Microscopy. Biol. Chem. Hoppe-Seyler 373, 891-896
17. Colombini, M. (1979) A Candidate for the Permeability Pathway of The Outer Mitochondrial Membrane. Nature 279, 643-645
18. Colombini, M. (1994) Anion Channels in the Mitochondrial Outer Membrane. Curr. Top. Membr. 42, 73-101
19. Colombini, M., Blachly-Dyson, E., Forte, M. (1996) VDAC, a Channel in the Outer Mitochondrial Membrane. In: T. Narahashi (ed) Ion Channels, vol. 4. Plenum Press, New York, pp. 169-202
20. Court, D.A., Kleene, R., Neupert, W., Lill, R. (1996) Role of the N- and C-Termini of Porin in Import into the Outer Membrane of Neurospora Mitochondria. FEBS Lett. 390, 73-77
21. DePinto, V., Ludwig, O., Krause, J., Benz, R., Palmieri, F. (1987) Porin Pores of Mitochondrial Outer Membranes from High and Low Eukaryotic Cells: Biochemical and Biophysical Characterization. Biochim. Biophys. Acta 894, 109-119
22. DePinto, V., Benz, R., Palmieri, F. (1989) Interaction of Non-Classical Detergents with the Mitochondrial Porin. Eur. J. Biochem. 183, 179-187
23. DePinto, V., Prezioso, G., Thinnes, F., Link, T.A., Palmieri, F. (1991) Peptide-Specific Antibodies and Proteases as Probes of the Transmembrane Topology of the Bovine Heart Mitochondrial Porin. Biochemisty 30, 10191-10200
24. Dermietzel, R., Hwang, Th.-K., Buettner, R., Hofer, A., Dotzler, E., Kremer, M., Deutzmann, R., Thinnes, F.P., Fishman, G.I., Spray, D.C., Siemen, D. (1994) Cloning and in situ Localization of a Brain-Derived Porin That Constitutes a Large-Conductance Anion Channel in Astrocytic Plasma Membranes. Proc. Natl. Acad. Sci. USA 91, 499-503
25. Devidas, S., Guggino, W.B. (1997) The Cystic Fibrosis Transmembrane Conductance Regulator and ATP. Curr. Opin. Cell Biol. 9, 547-552
26. Dihanich, M. (coordinator) (1990) Multi-Author Review. Pore-Forming Proteins of Biological Membranes. Experientia 46, 131-201
27. - Channels Underlie Volume-Regulated Cl Currents in Heart. Circ. Res. 80, 103-113
28. Dulhunty, A.F., Junankar, P.R., Eager, K.R., Ahern, G.P., Laver, D.R. (1996) Ion Channels in the Sarcoplasmic Reticulum of Striated Muscle. Acta Physiol. Scand. 156, 375-385
29. - Channels by Protein Kinase A Corrected by Insertion of CFTR. Nature 358, 581-584
30. Egert, G., Thinnes, F.P., Götz, H., Pauly, E., Kratzin, H., Yang, Ch.-Y., Kölbel, S., Altevogt, P., Wernet, P., Hilschmann, N. (1984) Primärstruktur der Menschlichen Histokompatibilitätsantigene der Klasse II (HLA-D). II. Trennung der α-von den β-Ketten des HLA-D einer Homozygoten, Lymphoblastoiden B-Zell-Linie, H2LCL (HLA-A3,3; B7,7; Dw2,2; DR2,2; MT1,1; DC1,1; MB1,1), und Charakterisierung der isolierten Ketten. Hoppe-Seyler's Z. Physiol. Chem. 365, 1291-1308
31. Flörke, H., Thinnes, F.P., Winkelbach, H., Stadtmüller, U., Paetzold, G., Morys-Wortmann, C., Hesse, D., Sternbach, H., Zimmermann, B., Kaufmann-Kolle, P., Heiden, M., Karabinos, A., Reymann, S., Lalk, V.E., Hilschmann, N. (1994) Channel Active Mammalian Porin, Purified from Crude Membrane Fractions of Human B Lymphocytes and Bovine Skeletal Muscle, Reversibly Binds Adenosine Triphosphate (ATP). Studies on Human Porin, part XI. Biol. Chem. Hoppe-Seyler 375, 513-520
32. Forte, M., Guy, H.R., Mannella, C.A. (1987) Molecular Genetics of the VDAC Ion Channel: Structural Model and Sequence Analysis. J. Bioenerg. Biomembr. 19, 341-350
33. Gabriel, S.E., Clarke, L.L., Boucher, R.C., Stutts, M.J. (1993) CFTR and Outward Rectifying Chloride Channels are Distinct Proteins with a Regulatory Relationship. Nature 363, 263-266
34. Götz, H., Kratzin, H., Thinnes, F.P., Yang, Ch.-Y., Kruse, T., Pauly, E., Kölbel, S., Egert, G., Wernet, P., Hilschmann, N. (1983) Primary Structure of Human Class II Histocompatibility Antigens. 3rd Communication. Amino Acid Sequence Comparison between DR and DC Subclass Antigens Derived from a Lymphoblastoid B Cell Line Homozygous at the HLA Loci (HLA-A3,3; B7,7; Dw2,2; DR2,2; MT1,1; DC1,1; MB1,1). Hoppe-Seyler's Z. Physiol. Chem. 364, 749-755
35. Groschner, K., Kukovetz, W.R. (1992) Voltage-Sensitive Chloride Channels of Large Conductance in the Membrane of Pig Aortic Endothelial Cells. Pflügers Arch. 421, 209-217
36. Guggino, W.B. (1993) Outwardly Rectifying Chloride Channels and CF: a Divorce and Remarriage. J. Bioenerg. Biomembr. 25, 27-35
37. Guggino, W.B. (ed) (1994) Chloride Channels. Curr. Top. Membr. 42, 1-354, Academic Press, San Diego
38. Ha, H., Hajek, P., Bedwell, D.M., Burrows, P.D. (1993) A Mitochondrial Porin cDNA Predicts the Existence of Multiple Human Porins. J. Biol. Chem. 268, 12143-12149
39. Heiden, M., Kroll, K., Thinnes, F.P., Hilschmann, N. (1996) Proteins of Cytosol and Amniotic Fluid Increase the Voltage Dependence of Human Type-1 Porin. J. Bioenerg. Biomembr. 28, 171-180
40. Hein, A. (1992) Primärstrukturanalyse des Plasmalemmständigen Porins aus EBV-transformierten B-Zellen eines Patienten mit Cystischer Fibrose. PhD thesis, University of Göttingen
41. Herbert, S.C., Reeves, W.B. (Guest Editors) (1995) Symposium on Ion Channels. Kidney Int. 48, 917-1361
42. Higgins, C.F. (1995) The ABC of Channel Regulation. Cell 82, 693-696
43. Holden, M.J., Colombini, M. (1993) The Outer Mitochondrial Membrane Channel, VDAC, is Modulated by a Protein Localized in the Intermembrane Space. Biochim. Biophys. Acta 1144, 396-402
44. Horn, A., Reymann, S., Thinnes, F.P. Biogenic Polyamines as well as the Synthetic Histamine-Releaser "Compound 48/80" Reduce the Voltage-Dependence of Native Human Type-1 Porin in Artificial Planar Lipid Bilayers - Spermine and Spermidine Inducing Asymmetric Voltage Gating on the Channel (submitted)
45. Huizing, M., Ruitenbeek, W., Thinnes, F.P., DePinto, V. (1994) Lack of Voltage-Dependent Anion Channel in Human Mitochondrial Myopathies. Lancet 344, 762
46. Huizing, M., Ruitenbeek, W., Thinnes, F.P., De Pinto, V., Wendel, U., Trijbels, F.J.M., Smit, L.M.E., Ter Laak, H.J., Van den Heuvel, L.P. (1996) Deficiency of the Voltage-Dependent Anion Channel: a Novel Cause of Mitochondriopathy. Pediatr. Res. 39, 760-765
47. Jakob, Ch., Götz, H., Hellmann, T., Hellmann, K.P., Reymann, S., Flörke, H., Thinnes, F.P., Hilschmann, N. (1995) Studies on Human Porin: XIII. The Type-1 VDAC 'Porin 31HL' Biotinylated at the Plasmalemma of Trypan Blue Excluding Human B Lymphocytes. FEBS Lett. 368, 5-9
48. Janisch, U., Skofitsch, G., Thinnes, F.P., Graier, W.F., Groschner, K. (1993) Evidence for the Involvement of a Plasma Membrane Porin in Agonist-Induced Activation of Vascular Endothelial Cells. Naunyn-Schmiedeberg's Arch. Pharmacol. 347 [Suppl], 289, R 73
49. Jovov, B., Ismailov, I.I., Benos, D.J. (1995) Cystic Fibrosis Transmembrane Conductance Regulator is Required for Protein Kinase A Activation of an Outwardly Rectified Anion Channel Purified from Bovine Tracheal Epithelia. J. Biol. Chcm. 270, 1521-1528
50. Junankar, P.R., Curtis, S.M., Pace, S.M., Dulhunty, A.F. (1993) Immunogold Localisation of the VDAC Channel in Mammalian Skeletal and Cardiac Muscle. Proc. Austral. Physiol. Pharmacol. Soc. 24, 179P
51. Junankar, P.R., Dulhunty, A.F., Curtis, S.M., Pace, S.M., Thinnes, F.P. (1995) Porin-Type 1 Proteins in Sarcoplasmic Reticulum and Plasmalemma of Striated Muscle Fibres. J. Muscle Res. Cell Motil. 16, 595-610
52. Jürgens, L., Ilsemann, P., Kratzin, H.D., Hesse, D., Eckart, K., Thinnes, F.P., Hilschmann, N. (1991) Studies on Human Porin. IV. The Primary Structures of "Porin 31HM" Purified from Human Skeletal Muscle Membranes and of "Porin 31HL" Derived from Human B Lymphocyte Membranes are Identical. Biol. Chem. Hoppe-Seyler 372, 455-463
53. Kayser, H., Kratzin, H.D., Thinnes, F.P., Götz, H., Schmidt, W.E., Eckart, K., Hilschmann, N. (1989) Zur Kenntnis der Porine des Menschen. II. Charakterisierung und Primärstruktur eines 31-kDa-Porins aus Menschlichen B-Lymphozyten (Porin 31HL). Biol. Chem. Hoppe-Seyler 370, 1265-1278
54. Kirk, K. (1997) Swelling-Activated Organic Osmolyte Channels. J. Memhr. Biol. 158, 1-16
55. Kleene, R., Pfanner, N., Pfaller, R., Link, T.A., Sebald, W., Neupert, W., Tropschug, M. (1987) Mitochondrial Porin of Neurospora crassa: cDNA cloning, In Vitro Expression and Import into Mitochondria. EMBO J. 6, 2627-2633
56. König, U., Götz, H., Walter, G., Babel, D., Hohmeier, H.-E., Thinnes, F.P., Hilschmann, N. (1991) Zur Kenntnis der Porine des Menschen. V. Die Plasmalemmständigkeit von "Porin 31HL" ist keine Folge einer Zell-Transformation. Biol. Chem. Hoppe-Seyler 372, 565-572
57. Kratzin, H., Yang, Ch.-Y., Götz, H., Pauly, E., Kölbel, S., Egert, G., Thinnes, F.P., Wernet, P., Altevogt, P., Hilschmann, N. (1981) Primärstruktur Menschlicher Histokompatibilitätsantigene der Klasse II. 1. Mitteilung: Aminosäuresequenz der N-terminalen 198 Reste der β-Kette des HLA-Dw2,2, DR2,2-Alloantigens. Z. Physiol. Chem. 362, 1665-1669
58. Krick, W., Disser, J., Hazama, A., Burckhardt, G., Frömter, E. (1991) Evidence for a Cytosolic Inhibitor of Epithelial Chloride Channels. Pflügers Arch. 418, 491-499
59. Kunzelmann, K., Pavenstädt, H., Greger, R. (1989) Properties and Regulation of Chloride Channels in Cystic Fibrosis and Normal Airway Cells. Pflügers Arch. 415, 172-182
60. Lindén, M., Andersson, G., Gellerfors, P., Nelson, B.D. (1984) Subcellular Distribution of Rat Liver Porin. Biochim. Biophys. Acta 770, 93-96
61. Lisanti, M.P., Scherer, P.-E., Vidugiriene, J., Tang, Z.L., Hermanowski-Vosatka, A., Tu, Y.-H., Cook, R.F., Sargiacomo, M. (1994) Characterization of Caveolin-rich Membrane Domains Isolated from an Endothelial-rich Source: Implications for Human Disease. J. Cell Biol. 126, 111-126
62. Liu, M.Y., Torgrimson, A., Colombini, M. (1994) Characterization and Partial Purification of the VDAC-Channel-Modulating Protein from Calf Liver Mitochondria. Biochim. Biophys. Acta 1185, 203-212
63. Mannella, C.A. (1992) The 'Ins' and 'Outs' of Mitochondrial Membrane Channels. Trends Biol. Sci. 17, 315-320
64. Mannella, C.A., Tedeschi, H. (eds.) (1992) Minireview Series: Mitochondrial Channels. J. Bioenerg. Biomembr. 24, 1-117
65. Mihara, K., Sato, R. (1985) Molecular Cloning and Sequencing of cDNA for Yeast Porin, an Outer Mitochondrial Membrane Protein: a Search for Targeting Signal in the Primary Structure. EMBO J. 4 No. 3, 769-774
66. - Channels in Undifferentiated Human Colonic Cells (HT-29). II. Regulation and rundown. Am. J. Physiol. 264, C977-C985
67. Neher, E., Sakman, B. (1976) Single-Channel Currents Recorded from Membrane of Denervated Frog Muscle Fibres. Nature 260, 799-802
68. - Channels in Intact Human T Lymphocytes. J. Membr. Biol. 125, 171-183
69. Popp, B., Court, D.A., Benz, R., Neupert, W., Lill, R. (1996) The Role of the N and C Termini of Recombinant Neurospora Mitochondrial Porin in Channel Formation and Voltage-Dependent Gating. J. Biol. Chem. 271, 13593-13599
70. Puchelle, E., Jacqout, J., Fuchey, C., Burlet, H., Klossek, J.-M., Gilain, L., Triglia, J.M., Thinnes, F.P., Hilschmann, N. (1993) Studies on Human Porin. IX. Immunolocalization of Porin and CFTR Channels in Human Surface Respiratory Epithelium. Biol. Chem. Hoppe-Seyler 374, 297-304
71. Quinton, P.M. (1990) Cystic Fibrosis: a Disease in Electrolyte Transport. FASEB J. 4, 2709-2717
72. Quinton, P.M. (1995) Why Does Altered CFTR Cause Cystic Fibrosis? Highlights. Selected Proceedings from the Ninth Annual American Cystic Fibrosis Conference, Dallas, Texas, October 11-15, pp 6, Cystic Fibrosis Foundation, USA
73. Rauch, G., Moran, O. (1994) On the Structure of Mitochondrial Porins and its Homologies with Bacterial Porins. Biochem. Biophys. Res. Commun. 200, 908-915
74. Reisin, I.L., Prat, A.G., Abraham, E.H., Amara, J.F., Gregory, R.J., Ausiello, D.A., Cantiello, H.F. (1994) The Cystic Fibrosis Transmembrane Conductance Regulator Is a Dual ATP and Chloride Channel. J. Biol. Chem. 269, 20584-20591
75. Reymann, S. (1997) Studien zur Expression von Porin-Isotypen in der Wirbeltierreihe unter Besonderer Berücksichtigung des Frosches Xenopus laevis. Dissertation, University of Göttingen
76. Reymann, S., Flörke, H., Heiden, M., Jakob, Ch., Stadtmüller, U., Steinacker, P., Lalk, V.E., Pardowitz, I., Thinnes, F.P. (1995) Further Evidence for Multitopological Localization of Mammalian Porin (VDAC) in the Plasmalemma Forming Part of a Chloride Channel Complex Affected in Cystic Fibrosis and Encephalomyopathy. Biochem. Mol. Med. 54, 75-87
77. Reymann, S., Steinacker, P., Kratzin, H.D., Thinnes, F.P. (1996) Anti-Human Type-1 Porin Antibodies Recognize Corresponding Proteins in all Vertebrate Classes. In Xenopus laevis the Channel is Expressed in the Plasmalemma of Oocytes. Biophys. J. 70, A2
78. Reymann, S., Kratzin, H.D., Hesse, D., Hesse, J.-O., Klebert, S., Kiafard, Z., Zimmermann, B., Spengler, B., Metzger, S., Thinnes, F.P., Hilschmann, N. (1997) SWISS-PROT, Accession Number: P81004
79. Riordan, J.R. (1993) The Cystic Fibrosis Transmembrane Conductance Regulator. Annu. Rev. Physiol. 55, 609-630
80. Rohm, B. (1997) Isolierung und Primärstrukturanalyse des Haimuskel-Porins. PhD thesis, University of Göttingen
81. Rohm, B., Schmid, A., Maier, E., Thinnes, F.P., Hilschmann, N. (1996) Taurine Passing Human Porin Makes the Channel a Candidate for the Volume-Sensitive Organic Osmolyte-Anion Channel (VSOAC). Frontiers of Mitochondrial Research; The 1996 Albany Conference, September 19-22, 1996; Rensselaerville Conference Center, USA; A 39
82. Sampson, M.J., Lovell, R.S., Craigen, W.J. (1996a) Isolation, Characterization, and Mapping of Two Mouse Mitochondrial Voltage-Dependent Anion Channel Isoforms. Genomics 33, 283-288
83. Sampson, M.J., Lovell, R.S., Davidson, D.B., Craigen, W.J. (1996b) A Novel Mouse Mitochondrial Voltage-Dependent Anion Channel Gene Localizes to Chromosome 8. Genomics 36, 192-196
84. Sampson, M.J., Lovell, R.S., Craigen, W.J. (1997) The Murine Voltage-Dependent Anion Channel Gene Family. J. Biol. Chem. 272, 18966-18973
85. Schein, St.J., Colombini, M., Finkelstein, A. (1976) Reconstitution in Planar Lipid Bilayers of a Voltage-Dependent Anion-Selective Channel Obtained from Paramecium Mitochondria. J. Membr. Biol. 30, 99-120
86. Schwarzer, Ch. (1996) Versuche zur in vitro-Transkription von Humanem Typ-1 Porin und seiner Expression in Xenopus Oozyten. PhD thesis, University of Göttingen
87. Schwiebert, E.M., Egan, M.E., Hwang, T.-H., Fulmer, S.B., Allen, S.S., Cutting, G.R., Guggino, W.B. (1995) CFTR Regulates Outwardly Rectifying Chloride Channels through an Autocrine Mechanism Involving ATP. Cell 81, 1063-1073
88. Shoshan-Barmatz, V., Hadad, N., Feng, W., Shafir, I., Orr, I., Varsanyi, M., Heilmeyer, L.M.G. (1996) VDAC/Porin is Present in Sarcoplasmic Reticulum from Skeletal Muscle. FEBS Lett. 386, 205-210
89. - Channels in Normal and Cystic Fibrosis Epithelial Cells. Am. J. Physiol. 261, C658-674
90. Sorgato, M.C., Moran, O. (1993) Channels in Mitochondrial Membranes: Knowns, Unknowns, and Prospects for the Future. Crit. Rev. Biochem. Mol. Biol. 18, 127-171
91. Stadtmüller, U. (1995) Studien zum Vergleich von Mitochondrialem und Extramitochondrialem Porin in Humanen B-Lymphozyten. Dissertation, Georg-August-University of Göttingen
92. Stanley, S., Dias, J.A., D'Arcangelis, D., Mannella, C.A. (1995) Peptide-Specific Antibodies as Probes of the Topography of the Voltage-Gated Channel in the Mitochondrial Outer Membrane of Neurospora crassa. J. Biol. Chem. 270, 16694-16700
93. Steinacker, P., Reymann, S., Schwarzer, C., Walter, G., Kratzin, H., Thinnes, F.P., Hilschmann, N. (1997a) Endogenous Expression of VDAC in the Plasma Membrane of Xenopus laevis Oocytes. Pflügers Arch. 433 [Suppl], R-141
94. Steinacker, P., Sternbach, H., Rohm, B., Walter, G., Thinnes, F.P., Hilschmann, N. (1997b) VDAC is involved in osmotically activated Taurine-Efflux in HeLa Cells. Pflügers Arch. 433 [Suppl], R-162
95. Strange, K., Emma, F., Jackson, P.S. (1996) Cellular and Molecular Physiology of Volume-Sensitive Anion Channels. Am. J. Physiol. 270, C711-C730
96. Strutz, N., Studien zur Primärstruktur des Vogelporins und zu Seiner Reaktivität Gegenüber Cibacron Blau. PhD thesis, University of Göttingen (in preparation)
97. - Channels in Normal and Cystic Fibrosis Airway Epithelial Cells by Extracellular ATP. Proc. Natl. Acad. Sci. USA 89, 1621-1625
98. Stutts, M.J., Fitz, J.G., Paradiso, A.M., Boucher, R.C. (1994) Multiple Modes of Regulation of Airway Epithelial Chloride Secretion by Extracellular ATP. Am. J. Physiol. 267, C1442-C1451
99. Thinnes, F.P. (1992) Evidence for Extra-Mitochondrial Localization of the VDAC/Porin Channel in Eucaryotic Cells. Minireview. J. Bioenerg. Biomembr. 24, 71-75
100. Thinnes, F.P., Hilschmann, N., Kayser H., Götz, H. (1983) 1st das HLA-DR-Assoziierte Glycoprotein p31 ein Ubiquitäres Molekül? Hoppe-Seyler's Z. Physiol. Chem. 364, 1805-1811
101. Thinnes, F.P., Egert, G., Götz, H., Pauly, E., Altevogt, P., Kölbel, S., Wernet, P., Kratzin, H., Yang, Ch.-Y., Hilschmann, N. (1984a) Primärstruktur der Menschlichen Histokompatibilitätsantigene der Klasse II (HLA-D). I. Isolierung, Reinigung und Charakterisierung des α/β-Ketten-Komplexes des HLA-D einer Homozygoten, Lymphoblastoiden B-Zell-Linie, H2LCL (HLA-A3,3; B7,7; Dw2,2; DR2,2; MT1,1; DC1,1; MB1,1). Hoppe-Seyler's Z. Physiol. Chem. 365, 1277-1289
102. Thinnes, F.P., Meyer, A., Schwartzenberg, von K. (1984b) On a Basic 31 kDa Muscle Membrane Protein in Cattle and Pig, Presumably Equivalent to the Class II Antigen Associated p31 Molecule. Anim. Blood Groups Biochem. Genet. 15, 181-189
103. Thinnes, F.P., Götz, H., Kayser, H., Benz, R., Schmidt, W.E., Kratzin, H.D., Hilschmann, N. (1989) Zur Kenntnis der Porine des Menschen. I. Reinigung eines Porins aus Menschlichen B-Lymphozyten (Porin 31HL) und Sein Topochemischer Nachweis auf dem Plasmalemm der Herkunftszelle. Biol. Chem. Hoppe-Seyler 370, 1253-1264
104. Thinnes, F.P., Schmid, A., Benz, R., Hilschmann, N. (1990) Studies on Human Porin. III. Does the Voltage-Dependent Anion Channel "Porin 31HL" Form Part of the Chloride Channel Complex, Which is Observed in Different Cells and Thought to be Affected in Cystic Fibrosis? Biol. Chem. Hoppe-Seyler 371, 1047-1050
105. Thinnes, F.P., Babel, D., Hein, A., Jürgens, L., König, U., Schmid, A., Hilschmann, N. (1991) Ein Flip-Flop-Modell des Chlorid-Kanal-Komplexes erklärt die Fehlregulation des Chloridflusses am Plasmalemm von Zellen bei der Cystischen Fibrose. Klin. Wochenschr. 69, 283-288
106. Thinnes, F.P., Flörke, H., Heiden, M., Stadtmüller, U., Hilschmann, N. (1993) Plasmalemma-Integrated Human Porin Discussed as Part of the ORDIC Channel Complex. In: Escobar, H., Baquero, F., Suárez, L. (eds.) Clinical Ecology of Cystic Fibrosis. Elsevier, Amsterdam, pp 9-13
107. Thinnes, F.P., Flörke, H., Winkelhach, H., Stadtmüller, U., Heiden, M., Karabinos, A., Hesse, D., Kratzin, H.D., Fleer, E., Hilschmann, N. (1994a) Channel Active Mammalian Porin, Purified from Crude Membrane Fractions of Human B Lymphocytes or Bovine Skeletal Muscle, Reversibly Binds the Stilbene-Disulfonate Group of the Chloride Channel Blocker DIDS. Studies on Human Porin, part X. Biol. Chem. Hoppe-Seyler 375, 315-322
108. Thinnes, F.P., Babel, D., Heiden, M., Hein, A., Jürgens, L., König, U., Hilschmann, N. (1994b) "Porin 31HL" in the Plasmalemma of Human Cells: A VDAC Discussed as Part of a Chloride Channel Complex in Normal and Cystic Fibrosis B-Lymphocyte Cell Lines. In: Forte, M., Colombini, M. (eds.) Molecular Biology. Mitochondrial Transport Systems. NATO ASI Ser., Ser. H: Cell Biol, vol. 83. Springer, Berlin Heidelberg New York, pp. 389-408
109. Thomas, L., Blachly-Dyson, E., Colombini, M., Forte, M. (1993) Mapping of Residues Forming the Voltage Sensor of the Voltage-Dependent Anion-Selective Channel. Proc. Natl. Acad. Sci. USA 90, 5446-5449
110. Tilmann, M., Kunzelmann, K., Föbe, U., Cabantchik, I., Lang, H.J., Englert, H.C., Greger, R. (1991) Different Types of Blockers of the Intermediate-Conductance Outwardly Rectifying Chloride Channel (ICOR) in Epithelia. Pflügers Arch. 418, 556-563
111. Wang, Y., Roman, R., Lidofsky, S.D., Fitz, J.G. (1996) Autocrine Signaling Through ATP Release Represents a Novel Mechanisme for Cell Volume Regulation. Proc. Natl. Acad. Sci. USA 93, 12020-12025
112. Welsh, M.J. (1990) Abnormal Regulation of Ion Channels in Cystic Fibrosis Epithelia. FASEB J. 4, 2718-2725
113. Winkelbach, H., Walter, G., Morys-Wortmann, C., Paetzold, G., Hesse, D., Zimmermann, B., Flörke, H., Reymann, S., Stadtmüller, U., Thinnes, F.P., Hilschmann, N. (1994) Studies on Human Porin. XII. Eight Monoclonal Mouse Anti "Porin 31HL" Antibodies Discriminate Type 1 and Type 2 Mammalian Porin Channels/VDACs in Western Blotting and Enzyme-Linked Immunosorbent Assays. Biochem. Med. Metab. Biol. 52, 120-127
114. Xia, Y., Haws, C.M., Wine, J.J. (1997) Disruption of Monolayer Integrity Enables Activation of a Cystic Fibrosis 'Bypass' Channel in Human Airway Epithelia. Nature Med. 3, 802-805
115. Yang, Ch.-Y., Kratzin, H., Götz, H., Thinnes, F.P., Kruse, T., Egert, G., Pauly, E., Kölbel, S., Wernet P., Hilschmann, N. (1982) Primärstruktur Menschlicher Histokompatibilitätsantigene der Klasse II. 2. Mitteilung: Aminosäuresequenz der N-terminalen 179 Reste der α-Kette des HLA-Dw2/DR2-Alloantigens. Hoppe-Seyler's Z. Physiol. Chem. 363, 671-676
116. Yu, W.H., Forte, M. (1996) Is There VDAC in Cell Compartments Other Than the Mitochondria? J. Bioenerg. Biomembr. 28, 93-100
117. Yu, W.H., Wolfgang, W., Forte, M. (1995) Subcellular Localization of Human Voltage-Dependent Anion Channel Isoforms. J. Biol. Chem. 270, 12998-14006