Dietary glycine prevents increases in hepatocyte proliferation caused by the peroxisome proliferator WY-14,643

Chemical Research in Toxicology

Volumn 10, Issue 10, 1997, Pages 1198-1204

  Rose, Michelle L ^a   Germolec, Dori ^c   Arteel, Gavin E ^a   Schoonhoven, Robert ^b   Thurman, Ronald G ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A OXIDASE; ANTILIPEMIC AGENT; BROXURIDINE; CARCINOGEN; DRUG VEHICLE; GLYCINE; HYDROGEN PEROXIDE; MESSENGER RNA; PEROXISOME PROLIFERATOR; PIRINIXIC ACID; PLASTICIZER; SOLVENT; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER PREVENTION; CELL PROLIFERATION; CONTROLLED STUDY; DIETARY INTAKE; DRUG MECHANISM; ENZYME ACTIVITY; INTRAPERITONEAL DRUG ADMINISTRATION; KUPFFER CELL; LIVER CANCER; LIVER CARCINOGENESIS; LIVER CELL; MALE; MITOGENESIS; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT;

ANIMALS; BODY WEIGHT; CARCINOGENS; CELL DIVISION; GLYCINE; LIVER; MALE; MICROBODIES; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0030881268     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx970079u     Document Type: Article

References (36)

1. Reddy, J. K., and Lalwani, N. D. (1983) Carcinogenesis by hepatic peroxisome proliferators: Evaluation of the risk of hypolipidemic drugs and industrial plasticizers to humans. CRC Crit. Rev. Toxicol. 12, 1-58.
2. Marsman, D. S., Cattley, R. C., Conway, J. G., and Popp, J. A. (1988) Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators di(2-ethylhexyl)phthalate and [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (Wy-14,643) in rats. Cancer Res. 48, 6739-6744.
3. WHO. (1980) Cooperative trial on primary prevention of ischaemic heart disease using clofibrate to lower serum cholesterol: mortality follow-up. Report of the Committee of Prinicpal Investigators. Lancet 2, 379-385.
4. Newman, T. B., and Hulley, S. B. (1996) Carcinogenicity of lipid-lowering drugs. JAMA 275, 55-60.
5. Dalen, J. E., and Dalton, W. S. (1996) Does lowering cholesterol cause cancer? JAMA 275, 67-69.
6. Cohen, S. M., and Ellwein, L. B. (1990) Cell proliferation in carcinogenesis. Science 249, 1007-1011.
7. Gerbracht, U., Bursch, W., Kraus, P., Putz, B., Reinacher, M., Timmermann-Trosiener, I., and Schulte-Hermann, R. (1990) Effects of hypolipidemic drugs nafenopin and clofibrate on phenotypic expression and cell death (apoptosis) in altered foci of rat liver. Carcinogenesis 11, 617-624.
8. Cattley, R. C., Marsman, D. S., and Popp, J. A. (1991) Age-related susceptibility to the carcinogenic effect of the peroxisome proliferator WY-14,643 in rat liver. Carcinogenesis 12, 469-473.
9. Kraupp-Grasl, B., Huber, W., Taper, H., and Schulte-Hermann, R. (1991) Increased susceptibility of aged rats to hepatocarcinogenesis by the peroxisome proliferator nafenopin and the possible involvement of altered liver foci occurring spontaneously. Cancer Res. 51, 666-671.
10. Decker, K. (1990) Biologically active products of stimulated liver macrophages (Kupffer cells). Eur. J. Biochem. 192, 245-261.
11. 2 by rat Kupffer cells. Biol. Chem. Hoppe-Seyler 372, 829-834.
12. Bojes, H. K., and Thurman, R. G. (1996) Peroxisome proliferators activate Kupffer cells in vivo. Cancer Res. 56, 1-4.
13. Rose, M. L., Germolec, D. R., Schoonhoven, R., and Thurman, R. G. (1997) Kupffer cells are causally responsible for the mitogenic effect of peroxisome proliferators. Carcinogenesis, in press.
14. Bojes, H. K., Germolec, D. R., Simeonova, P., Bruccoleri, A., Luster, M. I., and Thurman, R. G. (1997) Antibodies to tumor necrosis factor α prevent increases in cell replication in liver due to the potent peroxisome proliferator, WY-14,643. Carcinogenesis 18, 669-674.
15. Ikejima, K., Iimuro, Y., Forman, D. T., and Thurman, R. G. (1996) A diet containing glycine improves survival in endotoxin shock in the rat. Am. J. Physiol. 271, G97-G103.
16. Rose, M. L., Bojes, H. K., Ikejima, K., Germolec, D. R., Simeonova, P., Bruccoleri, A., Schoonhoven, R., Luster, M. I., and Thurman, R. G. (1997) A diet containing glycine inhibits the mitogenic effect of the non-genotoxic carcinogen WY-14,643: Role of Kupffer cells. In Cells of the Hepatic Sinusoid (Wisse, E., Knook, D. L., and Balahaud, C., Eds.) The Kupffer Cell Foundation, Leiden, The Netherlands.
17. Inestrosa, N. C., Bronfman, M., and Leighton, F. (1979) Detection of peroxisomal fatty acyl-coenzyme A oxidase activity. Biochem. J. 182, 779-788.
18. Nash, T. (1953) The colorimetric estimation of formaldehyde by means of the Hantzch reaction. Biochem. J. 55, 416-422.
19. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol.Chem. 193, 265-275.
20. Schulte-Hermann, R., Bursch, W., Grasl-Kraupp, B., Mullauer, L., and Ruttkay-Nedecky, B. (1995) Apoptosis and multistage carcinogenesis in rat liver. Mutation Res. 333, 81-87.
21. Grasl-Kraupp, B., Ruttkay-Nedecky, B., Koudelka, H., Bukowska, K., Bursch, W., and Schulte-Hermann, R. (1995) In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note. Hepatology 21, 1465-1468.
22. Marsman, D. S., Goldsworthy, T. L., and Popp, J. A. (1992) Contrasting hepatocytic peroxisome proliferation, lipofuscin accumulation and cell replication for the hepatocarcinogens WY-14,643 and clofibric acid. Carcinogenesis 15, 1011-1017.
23. Hart, R. W., Leakey, J., Duffy, D. H., Feuers, R. J., and Turturro, A. (1996) The effects of dietary restriction on drug testing and toxicity. Exp. Toxicol. Pathol. 48, 121-127.
24. Thurman, R. G., Zhong, Z., Frankenberg, M. V., Stachlewitz, R. F., and Bunzendahl, H. (1997) Prevention of cyclosporin-induced nephrotoxicity with dietary glycine. Transplantation 63, 1661-1667.
25. Hertz, R., and Bar-Tana, J. (1987) Increased response to peroxisomal proliferators in starved rats. Biochim. Biophys. Acta 917, 57-61.
26. Tartaglia, L. A., Weber, R. F., Figari, I. S., Reynolds, C., Palladino, Jr., and Goeddel, D. V. (1991) The two different receptors for tumor necrosis factor mediate distinct cellular responses. Proc. Natl. Acad. Sci. U.S.A. 88, 9292-9296.
27. Feingold, K. R., Soued, M., and Grunfeld, C. (1988) Tumor necrosis factor stimulates DNA synthesis in the liver of intact rats. Biochem. Biophys. Res. Commun. 153, 576-582.
28. Beyer, H. S., and Theologides, A. (1993) Tumor necrosis factor-α is a direct hepatocyte mitogen in the rat. Biochem. Mol. Biol. Int. 29, 1-4.
29. Ankerman, P., Cote, P., Yang, S. Q., McClain, C., Nelson, S., Bagby, G. J., and Diehl, A. M. (1992) Antibodies to tumor necrosis factor-α inhibit liver regeneration after partial hepatectomy. Am. J. Physiol. 263, G579-G585.
30. 2+ in Kupffer cells by endotoxin (LPS) via actions on a chloride channel. Am. J. Physiol. 272, G1581-G1586.
31. 2+ requirement of prostanoid but not of superoxide production by rat Kupffer cells. Eur. J. Biochem. 177, 61-67.
32. Kawada, N., Mizoguchi, Y., Kobayashi, K., Monna, T., and Morisawa, S. (1992) Calcium-dependent prostaglandin biosynthesis by lipopolysaccharide-stimulated rat Kupffer cells. Prostaglandins Leukot. Essent. Fatty Acids 47, 209-214.
33. Currin, R. T., Lichtman, S. N., Thurman, R. G., and Lemasters, J. J. (1991) Pentoxyfylline, adenosine, prostaglandin E1 and nisoldipine inhibit tumor necrosis factor release from LPS-stimulated Kupffer cells. Hepatology 14, 470.
34. Watanabe, N., Suzuki, J., and Kobayashi, Y. (1996) Role of calcium in tumor necrosis factor-α production by activated macrophages. J. Biochem. 120, 1190-1195.
35. Lee, S. S., Pineau, T., Drago, J., Lee, E. J., Owens, J. W., Kroetz, D. L., Fernandez-Salguero, P. M., Westphal, H., and Gonzalez, F. J. (1995) Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol. Cell Biol. 15, 3012-3022.
36. Nanji, A. A., Dannenberg, A. J., Thomas, P., and Bass, N. M. (1996) Alcohol selectively induces expression of peroxisome proliferator-activated receptor α (PPARα) in hepatocytes: Evidence for a role of oxidized products of arachidonic acid. Hepatology 24, 440A.