Exploring the feasibility of an anti-idiotypic cocaine vaccine: Analysis of the specificity of anticocaine antibodies (Ab1) capable of inducing Ab2β anti-idiotypic antibodies

Immunology

Volumn 100, Issue 1, 2000, Pages 48-56

  Schabacker, D S ^a   Kirschbaum, K S ^b   Segre, Mariangela ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY CONJUGATE; COCAINE; DRUG CARRIER; IDIOTYPIC ANTIBODY; MONOCLONAL ANTIBODY; VACCINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY RESPONSE; ANTIGEN PRESENTATION; ARTICLE; BRAIN TISSUE; COCAINE DEPENDENCE; CONTROLLED STUDY; DRUG TARGETING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN STABILITY; VACCINE PRODUCTION;

ANIMALS; ANTIBODIES, ANTI-IDIOTYPIC; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; BRAIN; COCAINE; COCAINE-RELATED DISORDERS; FEASIBILITY STUDIES; IMMUNOTHERAPY, ACTIVE; MICE; MICE, INBRED BALB C; SPLEEN;

EID: 0034050543     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.2000.00004.x     Document Type: Article

References (28)

1. 1. GAVIN F.H. (1991) Cocaine addiction: psychology and neurophysiology. Science 251, 1580.
2. 2. CARRERA M.R.A., ASHLEY J.A., PARSONS L.H., WIRSCHING P., KOOB G.F. & JANDA K.D. (1995) Suppression of psychoactive effect of cocaine by active immunization. Nature 378, 727.
3. 3. FOX B.S., KANTAK K., EDWARDS M. et al. (1996) Efficacy of a therapeutic cocaine vaccine in rodent models. Nature Med 2, 1129.
4. 4. ETTINGER R.H., ETTINGER W. & HARLESS W. (1997) Active immunization with cocaine-protein conjugate attenuates cocaine effects. Pharm Biochem Behav 58, 215.
5. 5. BONESE K.F., WAINER B.H., FITCH F.W., ROTHBERG R.M. & SCHUSTER C.R. (1974) Changes in heroin self-administration by a rhesus monkey after morphine immunization. Nature 252, 708.
6. 6. BORMAN S. (1995) Cocaine vaccine developed: antibodies block drug's psychoactivity. Chem Engineering News, Dec 18, 6.
7. 7. TRAMONTANO A., JANOLA K.D. & LERNER R.A. (1986) Catalytic antibodies. Science 234, 1566.
8. 8. CHANDRAKUMAR N.S., CARRON C.P., MEYER D.M. et al. (1993) Phenylphosphonate monoester analogs of cocaine. Potential haptens for the generation of catalytic antibodies. Biorg Med Chem Lett 3, 309.
9. 9. LANDRY D.W., ZHAO K., YANG G.X.-Q., GLICKMAN M. & GEORGIADIS T.M. (1993) Antibody-catalyzed degradation of cocaine. Science 259, 1899.
10. 10. JERNE N.K. (1974) Toward a network theory of the immune system. Ann Immunol (Inst Pasteur) 125C, 373.
11. 11. THANAVALA Y. (1996) Novel approaches to vaccine development against HBV. J Biotechnol 44, 67.
12. 12. DECKERT P.M., BALLMAIER M., LANG S., DEICHER H. & SCHEDEL I. (1996) CD4-imitating human antibodies in HIV infection and anti-idiotypic vaccination. J Immunol 157, 826.
13. 13. HUTCHINS W.A., KIEBER-EMMONS T., CARLONE G.M. & WESTERINK M.A. (1999) Human immune response to a peptide mimic of Neisseria meningitidis serogroup C in hu-PBMC-SCD mice. Hybridoma 18, 121.
14. 14. WHITTUM-HUDSON J.A., AN L., SALTZMAN W.M., PRENDERGAST R.A. & MACDONALD A.B. (1996) Oral immunization with anti-idiotypic antibody to the exoglycolipid antigen protects against experimental Chlamydia trachomatis infections. Nature Med 2, 1116.
15. 15. TRIPATHI P.K., QIN H., BHATTACHARYA-CHATTERJEE M., CERIANI R.L., FOON K.A. & CHATTERJEE S.K. (1999) Construction and characterization of a chimeric fusion protein consisting of an anti-idiotype antibody mimicking a breast cancer-associated antigen and the cytokine GM-CSF. Hybridoma 18, 193.
16. 16. FIELD S.K. & MORRISON D.C. (1994) An anti-idiotype antibody which mimics the inner-core region of lipopolysaccharide protects mice against a lethal challenge with endotoxin. Infect Immun 62, 3994.
17. 17. GRANT S.C., KRIS M.G., HOUGHTON A.N. & CHAPMAN P.B. (1999) Long survival of patients with small cell lung cancer after adjuvant treatment with anti-idiotypic antibody BEC2 plus bacillus Calmette-Guerin. Clin Cancer Res 5, 1319.
18. 18. REINARTZ S., BOERNER H., KOEHLER S., VON REUCKER A., SCHLEBUSCH H. & WAGNER U. (1999) Evaluation of immunological responses in patients with ovarian cancer treated with the anti-idiotype vaccine ACA125 by determination of intracellular cytokines; a preliminary report. Hybridoma 18, 41.
19. 19. LEWIN A.H., GAO Y., ABRAHAM P., BOJA J.W., KUHAR M.J. & CARROLL F.I. (1992) 2 Beta-substituted analogues of cocaine. Synthesis and inhibition of binding to the cocaine receptor. J Med Chem 35, 135.
20. 20. MELTZER P.C., LIANG A.Y., BROWNELL A.-L., ELMALEH D.R. & MADRA B.K. (1993) Substituted 3-phenyltropane analogs of cocaine: synthesis, inhibition of binding at cocaine recognition sites, and positron tomography imaging. J Med Chem 36, 855.
21. 21. OI V.T. & HERZENBERG L.A. (1980) Immunoglobulin-producing hybrid cell lines. In: Selected Methods in Cellular Immunology (eds B. Bhishell & S. H. Shiigi), pp. 303 and pp. 354. W. H. Freeman & Co., San Francisco, CA.
22. 22. MUHUMUZA L., SEGRE D. & SEGRE M. (1998) Antibodies with idiotypic and anti-idiotypic reactivity (epibodies) in conventional immune responses to dinitrophenylated carriers. Immunology 93, 572.
23. 23. MUELLER U.W., HAWES C.S. & JONES W.R. (1986) Monoclonal antibody production by hybridoma growth in Freund's adjuvant primed mice. J Immunol Methods 87, 193.
24. 24. REIK L.M., MAINES S.L., RYAN D.E., LEVIN W., BANDIERA S. & THOMAS P.E. (1987) A simple, non-chromatographic purification procedure for monoclonal antibodies. J Immunol Methods 100, 123.
25. 25. FRIGUET B., CHAFFOTTE A.F., DJARADI-OHANIANCE L. & GOLBERG M.E. (1985) Measurements of the true affinity constant in solution of antigen-antibody complexes by ELISA. J Immunol Methods 77, 305.
26. 26. NIH (1999) Current Protocols in Immunology. Wiley Interscience, New York, NY.
27. 27. WHITLOW M., HOWARD A.J., WOOD J.F., VOSS E.W. & HARDMAN K.D. (1995) L85A structure of anti-fluorescein 4-4-20 Fab. Protein Eng 8, 749.
28. 28. VOLKOW N., WANG G., FISCHMAN M. et al. (1997) Relationship between subjective effects of cocaine and dopamine transporter occupancy. Nature 386, 827.