Construction and characterization of a chimeric fusion protein consisting of an anti-idiotype antibody mimicking a breast cancer-associated antigen and the cytokine GM-CSF

Hybridoma

Volumn 18, Issue 2, 1999, Pages 193-202

  Tripathi, Pulak K ^a   Qin, Hongxing ^a   Bhattacharya Chatterjee, Malaya ^a   Ceriani, Roberto L ^b   Foon, Kenneth A ^a   Chatterjee, Sunil K ^a,c  

^a UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

^b Cancer Research Fund of Contra Costa   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIIDIOTYPIC ANTIBODY; CANCER VACCINE; CYTOKINE; DNA FRAGMENT; EPITOPE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HYBRID PROTEIN; POLYACRYLAMIDE GEL; TUMOR ANTIGEN;

ARTICLE; BREAST CANCER; CHIMERA; DNA SEQUENCE; ELECTROPHORESIS; ELECTROPORATION; GENETIC TRANSFECTION; HUMAN; IMMUNOGENICITY; IMMUNOTHERAPY; MOLECULAR WEIGHT; PLASMA CELL; PLASMID; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PURIFICATION; SEQUENCE ANALYSIS;

EID: 0032993163     PISSN: 0272457X     EISSN: None     Source Type: Journal    
DOI: 10.1089/hyb.1999.18.193     Document Type: Article

References (41)

1. Bhattacharya-Chatterjee M, Pride MW, Seon BK, and Kohler H: Idiotype vaccines against human T cell acute lymphoblastic leukemia. I. Generation and characterization of biologically active monoclonal anti-idiotopes. J Immunol 1987;139:1354-1360.
2. Bhattacharya-Chatterjee M, Mrozek E, Mukerjee S, Ceriani RL, Kohler H, and Foon KA: Anti-idiotype antibodies as potential therapeutic agents for human breast cancer. In: Antigen and Antibody Molecular Engineering in Breast Cancer Diagnosis and Treatment. Ceriani RL (Ed.). New York, Plenum Publishing Corp., 1994, pp. 139-148.
3. Bhattacharya-Chatterjee M, Mukerjee S, Biddle W, Foon KA, and Kohler H: Murine monoclonal anti-idiotype antibody as a potential network antigen for human carcinoembryonic antigen. J Immunol 1990;145:2758-2765.
4. Sen G, Chakrahorty M, Foon KA, Reisfeld RA, and Bhattacharya-Chatterjee M: Induction of IgG antibodies by an anti-idiotype antibody mimicking disialoganglioside GD2. J Immunother 1998; 21:75-83.
5. Foon KA, Oseroff AR, Vaickus L, Greenberg SJ, Russell D, Bernstein Z, Pincus S, Kohler H, Seon B, Tahaoglu E, Beers T, Chakraborty M, and Bhattacharya-Chatterjee: Immune responses in patients with T-cell lymphoma treated with an anti-idiotype antibody mimicking a highly restricted T-cell antigen. Clin Cancer Res 1995;1:1285-1294.
6. Foon KA, John WJ, Chakraborty M, Sherratt A, Garrison J, Flett M, and Bhattacharya-Chatterjee M: Clinical and immune responses in advanced colorectal cancer patients treated with anti-idiotype monoclonal antibody vaccine that mimics the carcinoembryonic antigen. Clin Cancer Res 1997;3:1267-1276.
7. Foon KA, Chakraborty M, John WJ, Sherratt A, Kohler H, and Bhattacharya-Chatterjee M: Immune responses to the carcinoembryonic antigen in patients treated with an anti-idiotype antibody vaccine. J Clin Invest 1995;96:334-342.
8. Jerne NK: Towards a network theory of the immune system. Ann Immunol (Paris) 1974;125C:373-389.
9. Pervin S, Chakraborty M, Bhattacharya-Chatterjee M, Zeytin H, Foon KA, and Chatterjee SK: Induction of antitumor immunity by an anti-idiotype antibody mimicking carcinoembryonic antigen. Cancer Res 1997;57:728-734.
10. Sacks DL, Kirchhoff LV, Hieny S, and Sher A: Molecular mimicry of a carbohydrate epitope on a major surface glycoprotein of Trypanosoma cruzi by using anti-idiotypic antibodies. J Immunol 1985;135:4155-4159.
11. Ceriani RL, Peterson JA, Lee JY, Moncada R, and Blank EW: Characterization of cell surface antigens of human mammary epithelial cells with monoclonal antibodies prepared against human milk fat globule. Somatic Cell Genet 1983;9:415-427.
12. Taylor-Papadimitriou J, Peterson JA, Arklie J, Burchell J, Ceriani RL, and Bodmer WF: Monoclonal antibodies to epithelium-specific components of the human milk fat globule membrane: Production and reaction with cells in culture. Int J Cancer 1981;28:17-21.
13. Chakraborty M, Mukerjee S, Foon KA, Kohler H, Ceriani RL, Bhattacharya-Chatterjee M: Induction of human breast cancer-specific antibody responses in cynomolgus monkeys by a murine monoclonal anti-idiotype antibody. Cancer Res 1995;55: 1525-1530.
14. Tao MH and Levy R: Idiotype/granulocyte-macrophage colony-stimulating factor fusion protein as a vaccine for B-cell lymphoma. Nature 1993;362:755-758.
15. Chomczynski P and Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Ann Biochem 1987;162:156-159.
16. Sambrook J, Fritsch EF, and Maniatis T: Molecular cloning: A laboratory manual, second ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor NY, 1989.
17. Chatterjee SK, Tripathi PK, Chakraborty M, Yannelli J, Wang H, Foon KA, Maier CC, Blalock JE, and Bhattacharya-Chatterjee M: Molecular mimicry of carcinoembryonic antigen by peptides derived from the structure of an anti-idiotype antibody. Cancer Res 1998;58:1217-1224.
18. Towbin H, Staehelin T, and Gordon J: Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 1979; 76:4350-4354.
19. Shin SU and Morrison SL: Production and properties of chimeric antibody molecules. Methods Enzymol 1989;178:459-476.
20. Kabat EA, Wu TT, Perry HM, Gottesman KS, and Foeller C: Sequences of proteins of immunological interest, 5th ed. Bethesda, MD, U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, 1991.
21. Altschul SF, Gish W, Miller W, Myers EW, and Lipman DJ: Basic local alignment search tool. J Mol Biol 1990;215:403-410.
22. Chen TT, Tao MH, and Levy R: Idiotype-cytokine fusion proteins as cancer vaccines. Relative efficacy of IL-2, IL-4, and granulocyte-macrophage colony-stimulating factor. J Immunol 1994;153: 4775-4787.
23. Chen TT and Levy R: Induction of autoantibody responses to GM-CSF by hyperimmunization with an Id-GM-CSF fusion protein. J Immunol 1995;154:3105-3117.
24. Kozak M: Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes. Nucleic Acids Res 1981;9:5233-5262.
25. Chaudhary VK, Batra JK, Gallo MG, Willingham MC, FitzGerald DJ, and Pastan I: A rapid method of cloning functional variable-region antibody genes in Escherichia coli as single-chain immunotoxins. Proc Natl Acad Sci USA 1990;87:1066-1070.
26. Xiang JH, Roder J, and Hozumi N: Production of murine V-human Cr1 chimeric anti-TAG72 antibody using V region cDNA amplified by PCR. Mol Immunol 1990;27:809-817.
27. Gillies SD, Morrison SL, Oi VT, and Tonegawa S: A tissues-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene. Cell 1983;33:717-728.
28. Foon KA and Bhattacharya-Chatterjee M: Idiotype vaccines in the clinic. Nature Med 1998;4:70.
29. Heufler C, Koch F, and Schuler G: Granulocyte/macrophage colony-stimulating factor and interleukin 1 mediate the maturation of murine epidermal Langerhans cells into potent immunostimulatory dendritic cells. J Exp Med 1988;167:700-705.
30. Morrissey PJ, Bressler L, Park LS, Alpert A, and Gillis S: Granulocyte-macrophage colony-stimulating factor augments the primary antibody response by enhancing the function of antigen-presenting cells. J Immunol 1987;139:1113-1119.
31. Fischer HG, Frosch S, Reske K, and Reske-Kunz AB: Granulocyte-macrophage colony-stimulating factor activates macrophages derived from bone marrow cultures to synthesis of MHC class II molecules and to augmented antigen presentation function. J Immunol 1988;141:3882-3888.
32. Smith PD, Lamerson CL, Wong HL, Wahl LM, and Wahl SM: Granulocyte-macrophage colony-stimulating factor stimulates human monocyte accessory cell function. J Immunol 1990;144: 3829-3834.
33. Steis RG, VanderMolen LA, Longo DL, Clark JW, Smith JW, Kopp WC, Ruscetti FW, Creekmore SP, Elwood LJ, Hursey J, et al.: Recombinant human granulocyte-macrophage colony-stimulating factor in patients with advanced malignancy: A phase Ib trial. J Natl Cancer Inst 1990;82:697-703.
34. Blanchard DK and Djeu JY: Differential modulation of surface antigens on human macrophages by IFN-gamma and GM-CSF: effect on susceptibility to LAK lysis. J Leukoc Biol 1991;50:28-34.
35. Young DA, Lowe LD, and Clark SC: Comparison of the effects of IL-3, granulocyte-macrophage colony-stimulating factor, and macrophage colony-stimulating factor in supporting monocyte differentiation in culture. Analysis of macrophage antibody-dependent cellular cytotoxicity. J Immunol 1990;145:607-615.
36. Grabstein KH, Urdal DL, Tushinski RJ, Mochizuki DY, Price VL, Cantrell MA, Gillis S, and Conlon PJ: Induction of macrophage tumoricidal activity by granulocyte-macrophage colony-stimulating factor. Science 1986;232:506-508.
37. Arnaout MA, Wang EA, Clark SC, and Sieff CA: Human recombinant granulocyte-macrophage colony-stimulating factor increases cell-to-cell adhesion and surface expression of adhesion-promoting surface glycoproteins on mature granulocytes. J Clin Invest 1986;78:597-601.
38. Santoli D, Clark SC, Kreider BL, Maslin PA, and Rovera G: Amplification of IL-2-driven T cell proliferation by recombinant human IL-3 and granulocyte-macrophage colony-stimulating factor. J Immunol 1988;141:519-526.
39. Metcalf D: The granulocyte-macrophage colony-stimulating factors. Science 1985;229:16-22.
40. Metcalf D: Hematopoietic regulators: redundancy or subtlety? Blood 1993;82:3515-3523.
41. Dranoff G, Jaffee E, Lazenby A, Golumbek P, Levitsky H, Brose K, Jackson V, Hamada H, Pardoll D, and Mulligan RC: Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc Natl Acad Sci USA 1993;90:3539-3543.