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Volumn 5, Issue 2, 2000, Pages 99-107

Oral chemotherapeutic agents for colorectal cancer

Author keywords

Colon cancer; Economic analysis; Oral chemotherapy; Patient compliance; Rectal cancer

Indexed keywords

5 ETHYNYLURACIL; 9 AMINOCAMPTOTHECIN; CAPECITABINE; DIHYDROPYRIMIDINE DEHYDROGENASE; DNA TOPOISOMERASE INHIBITOR; ENZYME INHIBITOR; FLUOROPYRIMIDINE DERIVATIVE; FOLINATE CALCIUM; IRINOTECAN; LONAFARNIB; ORZEL; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RUBITECAN; TIPIFARNIB; UFT;

EID: 0034049660     PISSN: 10837159     EISSN: None     Source Type: Journal    
DOI: 10.1634/theoncologist.5-2-99     Document Type: Article
Times cited : (42)

References (69)
  • 2
    • 0000513017 scopus 로고
    • Colorectal cancer
    • De Vita V, Hellman S, Rosenberg S, eds. Philadelphia: J.B. Lippincott
    • Cohen A, Minsky B, Schilsky P. Colorectal cancer. In: De Vita V, Hellman S, Rosenberg S, eds. Cancer: Principles and Practice of Oncology. Philadelphia: J.B. Lippincott, 1993:929-977.
    • (1993) Cancer: Principles and Practice of Oncology , pp. 929-977
    • Cohen, A.1    Minsky, B.2    Schilsky, P.3
  • 3
    • 0031859489 scopus 로고    scopus 로고
    • Oral chemotherapy: Rationale and future directions
    • DeMario MD, Ratain MJ. Oral chemotherapy: rationale and future directions. J Clin Oncol 1998;16:2557-2567.
    • (1998) J Clin Oncol , vol.16 , pp. 2557-2567
    • DeMario, M.D.1    Ratain, M.J.2
  • 4
    • 0026633085 scopus 로고
    • Patient compliance with oral chemotherapy as assessed by a novel oral technique
    • Lee CR, Nicholson PW, Souhami RL et al. Patient compliance with oral chemotherapy as assessed by a novel oral technique. J Clin Oncol 1992;10:1007-1013.
    • (1992) J Clin Oncol , vol.10 , pp. 1007-1013
    • Lee, C.R.1    Nicholson, P.W.2    Souhami, R.L.3
  • 5
    • 0001560702 scopus 로고
    • Capecitabine: An orally available fluoropyrimidine with tumor selectivity
    • Ishitsuka H, Miwa M, Ishikawa T et al. Capecitabine: an orally available fluoropyrimidine with tumor selectivity. Proc Am Assoc Cancer Res 1995;36:2426a.
    • (1995) Proc Am Assoc Cancer Res , vol.36
    • Ishitsuka, H.1    Miwa, M.2    Ishikawa, T.3
  • 6
    • 0000092359 scopus 로고    scopus 로고
    • Xeloda (capecitabine) a new oral fluoropyrimidine carbamate with an improved efficacy profile over other fluoropyrimidines
    • Ishikawa T, Sawada N, Sekiguchi F et al. Xeloda (capecitabine) a new oral fluoropyrimidine carbamate with an improved efficacy profile over other fluoropyrimidines. Proc Am Soc Clin Oncol 1997:16:796a.
    • (1997) Proc Am Soc Clin Oncol , vol.16
    • Ishikawa, T.1    Sawada, N.2    Sekiguchi, F.3
  • 7
    • 0000092361 scopus 로고    scopus 로고
    • Antitumor efficacy of capecitabine against fluorouracil-sensitive and resistant tumors
    • Cao S, Lu K, Ishitsuka H et al. Antitumor efficacy of capecitabine against fluorouracil-sensitive and resistant tumors. Proc Am Soc Clin Oncol 1997:16:795a.
    • (1997) Proc Am Soc Clin Oncol , vol.16
    • Cao, S.1    Lu, K.2    Ishitsuka, H.3
  • 9
    • 0029021896 scopus 로고
    • The expression of thymidine phosphorylase and thrombomodulin in human colorectal carcinomas
    • Takebayashi, Y, Yamada K, Maruyama I et al. The expression of thymidine phosphorylase and thrombomodulin in human colorectal carcinomas. Cancer Lett 1995;25:1-7
    • (1995) Cancer Lett , vol.25 , pp. 1-7
    • Takebayashi, Y.1    Yamada, K.2    Maruyama, I.3
  • 10
    • 0002407449 scopus 로고    scopus 로고
    • A phase I study of continuous twice daily treatment with capecitabine in patients with advanced and/or metastatic tumors
    • Meropol N, Budman D, Creaven P et al. A phase I study of continuous twice daily treatment with capecitabine in patients with advanced and/or metastatic tumors. Ann Oncol 1996;7(suppl 1):298a.
    • (1996) Ann Oncol , vol.7 , Issue.1 SUPPL.
    • Meropol, N.1    Budman, D.2    Creaven, P.3
  • 11
    • 0002407449 scopus 로고    scopus 로고
    • A phase I study of intermittent twice daily oral therapy with capecitabine in patients with advanced and/or metastatic solid cancer
    • Hughes M, Planting A, Twelves C et al. A phase I study of intermittent twice daily oral therapy with capecitabine in patients with advanced and/or metastatic solid cancer. Ann Oncol 1996;7(suppl 1):297a.
    • (1996) Ann Oncol , vol.7 , Issue.1 SUPPL.
    • Hughes, M.1    Planting, A.2    Twelves, C.3
  • 12
    • 85038045911 scopus 로고    scopus 로고
    • Pharmacokinetics (PK) and pharmacodynamics (PD) of capecitabine in two phase I studies
    • Osterwalder B, Reigner B. Pharmacokinetics (PK) and pharmacodynamics (PD) of capecitabine in two phase I studies. Proc Am Soc Clin Oncol 1996;15:727a.
    • (1996) Proc Am Soc Clin Oncol , vol.15
    • Osterwalder, B.1    Reigner, B.2
  • 13
    • 0000344523 scopus 로고    scopus 로고
    • A randomized phase II study of Xeloda (capecitabine) in patients with advanced colorectal cancer
    • Findlay M, Van Custem E, Kocha W et al. A randomized phase II study of Xeloda (capecitabine) in patients with advanced colorectal cancer. Proc Am Soc Clin Oncol 1997;16:798a.
    • (1997) Proc Am Soc Clin Oncol , vol.16
    • Findlay, M.1    Van Custem, E.2    Kocha, W.3
  • 14
    • 0000114292 scopus 로고    scopus 로고
    • A phase III trial (S014796) of Xeloda in previously untreated advanced/ metastatic colorectal cancer
    • Twelves C, Harper P, Van Custem E et al. A phase III trial (S014796) of Xeloda in previously untreated advanced/ metastatic colorectal cancer. Proc Am Soc Clin Oncol 1999;18:1010a.
    • (1999) Proc Am Soc Clin Oncol , vol.18
    • Twelves, C.1    Harper, P.2    Van Custem, E.3
  • 15
    • 0000286971 scopus 로고    scopus 로고
    • A phase III trial of Xeloda in previously untreated advanced/metastatic colorectal cancer
    • Cox JV, Pazdur R, Thibault A et al. A phase III trial of Xeloda in previously untreated advanced/metastatic colorectal cancer. Proc Am Soc Clin Oncol 1999;18:1016a.
    • (1999) Proc Am Soc Clin Oncol , vol.18
    • Cox, J.V.1    Pazdur, R.2    Thibault, A.3
  • 16
    • 0019980347 scopus 로고
    • Metabolic activation of ftorafur [R,S-1(tetrahydro-2-furanyl)-5-fluorouracil]: The microsomal oxidative pathway
    • El Sayed YM, Sadee W. Metabolic activation of ftorafur [R,S-1(tetrahydro-2-furanyl)-5-fluorouracil]: the microsomal oxidative pathway. Biochem Pharmacol 1982;31:3006-3008.
    • (1982) Biochem Pharmacol , vol.31 , pp. 3006-3008
    • El Sayed, Y.M.1    Sadee, W.2
  • 17
    • 0020394630 scopus 로고
    • Antineoplastic effect of UFT therapy (uracil-FT-207 combination therapy) on experimental pancreatic cancer transplanted in the pancreas and subcutaneous region
    • Ohyama K, Koike D, Odake Y et al. Antineoplastic effect of UFT therapy (uracil-FT-207 combination therapy) on experimental pancreatic cancer transplanted in the pancreas and subcutaneous region. Jpn J Cancer Chemother 1982;9:2168-2174.
    • (1982) Jpn J Cancer Chemother , vol.9 , pp. 2168-2174
    • Ohyama, K.1    Koike, D.2    Odake, Y.3
  • 18
    • 0019252664 scopus 로고
    • Clinical study on the enhancement of drug delivery into tumor tissue by using UFT
    • Fukui T, Imbayashi N, Nishi M et al. Clinical study on the enhancement of drug delivery into tumor tissue by using UFT. Jpn J Cancer Chemother 1980;7:2124-2129.
    • (1980) Jpn J Cancer Chemother , vol.7 , pp. 2124-2129
    • Fukui, T.1    Imbayashi, N.2    Nishi, M.3
  • 19
    • 0023213918 scopus 로고
    • Clinical results of treatment with the UFT fine granule preparation under cooperative study. Tokyo Cancer Chemotherapy Cooperative Study Group
    • Futatsuki K, Komita T, Kamano T. Clinical results of treatment with the UFT fine granule preparation under cooperative study. Tokyo Cancer Chemotherapy Cooperative Study Group. Jpn J Cancer Chemother 1987;14:1274-1280.
    • (1987) Jpn J Cancer Chemother , vol.14 , pp. 1274-1280
    • Futatsuki, K.1    Komita, T.2    Kamano, T.3
  • 20
    • 0030223052 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of oral UFT, a combination of the 5-fluorouracil prodrug tegafur and uracil
    • Muggia F, Wu X, Spicer D et al. Phase I and pharmacokinetic study of oral UFT, a combination of the 5-fluorouracil prodrug tegafur and uracil. Clin Cancer Res 1996;2:1461-1467.
    • (1996) Clin Cancer Res , vol.2 , pp. 1461-1467
    • Muggia, F.1    Wu, X.2    Spicer, D.3
  • 21
    • 0000642139 scopus 로고    scopus 로고
    • Comparative steady state pharmacokinetics of oral UFT versus protracted intravenous 5-fluorouracil (FU)
    • Pazdur R, Covington WP, Brown NS et al. Comparative steady state pharmacokinetics of oral UFT versus protracted intravenous 5-fluorouracil (FU). Proc Am Soc Clin Oncol 1996;474:1948a.
    • (1996) Proc Am Soc Clin Oncol , vol.474
    • Pazdur, R.1    Covington, W.P.2    Brown, N.S.3
  • 22
    • 0029966745 scopus 로고    scopus 로고
    • Phase I trials of uracil-tegafur (UFT) using 5 and 28 day administration schedules: Demonstration of schedule dependent toxicities
    • Pazdur R, Lassere Y, Diaz-Canton E et al. Phase I trials of uracil-tegafur (UFT) using 5 and 28 day administration schedules: demonstration of schedule dependent toxicities. Anticancer Res 1996;7:728-733.
    • (1996) Anticancer Res , vol.7 , pp. 728-733
    • Pazdur, R.1    Lassere, Y.2    Diaz-Canton, E.3
  • 23
    • 0031043439 scopus 로고    scopus 로고
    • Augmentation of the chemotherapeutic effectiveness of UFT, a combination of tegafur [1-(2-tetrahydrofuryl)-5-fluorouracil] with uracil, by oral 1-leucovorin
    • Okabe H, Toko T, Saito H et al. Augmentation of the chemotherapeutic effectiveness of UFT, a combination of tegafur [1-(2-tetrahydrofuryl)-5-fluorouracil] with uracil, by oral 1-leucovorin. Anticancer Res 1997;17:157-164.
    • (1997) Anticancer Res , vol.17 , pp. 157-164
    • Okabe, H.1    Toko, T.2    Saito, H.3
  • 24
    • 0028099423 scopus 로고
    • Phase II trial of uracil and tegafur plus oral leucovorin: An effective oral regimen in the treatment of metastatic colorectal carcinoma
    • Pazdur R, Lassere Y, Rhodes V et al. Phase II trial of uracil and tegafur plus oral leucovorin: an effective oral regimen in the treatment of metastatic colorectal carcinoma. J Clin Oncol 1994;12:2296-2300.
    • (1994) J Clin Oncol , vol.12 , pp. 2296-2300
    • Pazdur, R.1    Lassere, Y.2    Rhodes, V.3
  • 25
    • 0000082787 scopus 로고    scopus 로고
    • Multicenter phase III study of 5-fluorouracil (5-FU) or UFT in combination with leucovorin (LV) in patients with metastatic colorectal cancer
    • Pazdur R, Douillard J-Y, Skillings JR et al. Multicenter phase III study of 5-fluorouracil (5-FU) or UFT in combination with leucovorin (LV) in patients with metastatic colorectal cancer. Proc Am Soc Clin Oncol 1999;18:1009a.
    • (1999) Proc Am Soc Clin Oncol , vol.18
    • Pazdur, R.1    Douillard, J.-Y.2    Skillings, J.R.3
  • 26
    • 0013605801 scopus 로고    scopus 로고
    • A phase III randomized study of oral UFT (tegafur + uracil) as maintenance therapy in adjuvant treatment of surgically resected colorectal cancer patients
    • Mok TSK, Leung TWT, Chan ATC et al. A phase III randomized study of oral UFT (tegafur + uracil) as maintenance therapy in adjuvant treatment of surgically resected colorectal cancer patients. Proc Am Soc Clin Oncol 1998;17:1042a.
    • (1998) Proc Am Soc Clin Oncol , vol.17
    • Mok, T.S.K.1    Leung, T.W.T.2    Chan, A.T.C.3
  • 27
    • 4243392711 scopus 로고    scopus 로고
    • Preoperative UFT, oral leucovorin (LV) and radiotherapy (RT) for patients with resectable rectal carcinoma: An oral regimen with complete pathologic responses
    • Hoff PM, Brito R, Slaughter M et al. Preoperative UFT, oral leucovorin (LV) and radiotherapy (RT) for patients with resectable rectal carcinoma: an oral regimen with complete pathologic responses. Proc Am Soc Clin Oncol 1998;17:860a.
    • (1998) Proc Am Soc Clin Oncol , vol.17
    • Hoff, P.M.1    Brito, R.2    Slaughter, M.3
  • 28
  • 29
    • 24044475880 scopus 로고    scopus 로고
    • Pilot study on the new dose intensive oral UFT schedule as adjuvant chemotherapy for colorectal cancer
    • Sadahiro S, Ohki S, Takahashi T et al. Pilot study on the new dose intensive oral UFT schedule as adjuvant chemotherapy for colorectal cancer. Proc Am Soc Clin Oncol 1998;17:1054a.
    • (1998) Proc Am Soc Clin Oncol , vol.17
    • Sadahiro, S.1    Ohki, S.2    Takahashi, T.3
  • 30
    • 0342680785 scopus 로고    scopus 로고
    • Safety, toxicity and antitumor efficacy of the modulated oral fluoropyrimidine derivative S-1 in patients with metastatic colorectal cancer: Preliminary results of an early phase II study
    • Schoffski P, Vermoken J, Schellens J et al. Safety, toxicity and antitumor efficacy of the modulated oral fluoropyrimidine derivative S-1 in patients with metastatic colorectal cancer: preliminary results of an early phase II study. Clin Cancer Res 1999;5(suppl):S3772.
    • (1999) Clin Cancer Res , vol.5 , Issue.SUPPL.
    • Schoffski, P.1    Vermoken, J.2    Schellens, J.3
  • 31
    • 0028281781 scopus 로고
    • 5-Ethinyluracil (776C85): Modulation of 5-fluorouracil efficacy and therapeutic index in rats bearing advanced colorectal carcinoma
    • Cao S, Rustum YM, Spector T. 5-Ethinyluracil (776C85): modulation of 5-fluorouracil efficacy and therapeutic index in rats bearing advanced colorectal carcinoma. Cancer Res 1994;54:1507-1510.
    • (1994) Cancer Res , vol.54 , pp. 1507-1510
    • Cao, S.1    Rustum, Y.M.2    Spector, T.3
  • 32
    • 0032784111 scopus 로고    scopus 로고
    • Eniluracil treatment completely inactivates dihydropyrimidine dehydrogenase in colorectal cancers
    • Ahmed FY, Johnston SJ, Cassidy J et al. Eniluracil treatment completely inactivates dihydropyrimidine dehydrogenase in colorectal cancers. J Clin Oncol 1999;17:2439-2445.
    • (1999) J Clin Oncol , vol.17 , pp. 2439-2445
    • Ahmed, F.Y.1    Johnston, S.J.2    Cassidy, J.3
  • 33
    • 0027135995 scopus 로고
    • 5-Ethynyluracil (776C85): Inactivation of dihydropyrimidine dehydrogenase in vivo
    • Spector T, Harrington JA, Porter DJ. 5-Ethynyluracil (776C85): inactivation of dihydropyrimidine dehydrogenase in vivo. Biochem Pharmacol 1993;46:2243-2248.
    • (1993) Biochem Pharmacol , vol.46 , pp. 2243-2248
    • Spector, T.1    Harrington, J.A.2    Porter, D.J.3
  • 34
    • 0031900670 scopus 로고    scopus 로고
    • Phase I and pharmacologic study of eniluracil plus fluorouracil in patients with advanced cancer
    • Schilsky RL, Hohneker J, Ratain MJ et al. Phase I and pharmacologic study of eniluracil plus fluorouracil in patients with advanced cancer. J Clin Oncol 1998;16:1450-1457.
    • (1998) J Clin Oncol , vol.16 , pp. 1450-1457
    • Schilsky, R.L.1    Hohneker, J.2    Ratain, M.J.3
  • 35
    • 10544243363 scopus 로고    scopus 로고
    • Pharmacokinetic, oral bioavailability, and safety study of fluorouracil in patients treated with 776C85, an inactivator of dihydropyrimidine dehydrogenase
    • Baker SD, Khor SP, Adjei AA. Pharmacokinetic, oral bioavailability, and safety study of fluorouracil in patients treated with 776C85, an inactivator of dihydropyrimidine dehydrogenase. J Clin Oncol 1996;14:3085-3096.
    • (1996) J Clin Oncol , vol.14 , pp. 3085-3096
    • Baker, S.D.1    Khor, S.P.2    Adjei, A.A.3
  • 36
    • 0000419698 scopus 로고    scopus 로고
    • A phase II open label study to evaluate a 28-day regimen of oral 5-fluorouracil (5-FU) plus 776C85 for the treatment of patients with previously untreated metastatic colorectal cancer (CRC)
    • Mani S, Beck T, Chevlen E et al. A phase II open label study to evaluate a 28-day regimen of oral 5-fluorouracil (5-FU) plus 776C85 for the treatment of patients with previously untreated metastatic colorectal cancer (CRC). Proc Am Soc Clin Oncol 1998;18:1083a.
    • (1998) Proc Am Soc Clin Oncol , vol.18
    • Mani, S.1    Beck, T.2    Chevlen, E.3
  • 37
    • 0000513126 scopus 로고    scopus 로고
    • A phase II study of 5-fluorouracil (5-FU) plus GW776 (776C85) with or without leucovorin in patients with metastatic colorectal cancer
    • Schilsky R, Bukowski R, Burris H et al. A phase II study of 5-fluorouracil (5-FU) plus GW776 (776C85) with or without leucovorin in patients with metastatic colorectal cancer. Proc Am Soc Clin Oncol 1997;16:271a.
    • (1997) Proc Am Soc Clin Oncol , vol.16
    • Schilsky, R.1    Bukowski, R.2    Burris, H.3
  • 38
    • 0008619246 scopus 로고    scopus 로고
    • Phase I trial of oral BOF-A2 plus leucovorin (LV) in advanced colorectal cancer: Anti-tumor activity in fluorouracil-resistant patients
    • Matei S, Hoff PM, Brito R et al. Phase I trial of oral BOF-A2 plus leucovorin (LV) in advanced colorectal cancer: anti-tumor activity in fluorouracil-resistant patients. Proc Am Soc Clin Oncol 1998;18:882a
    • (1998) Proc Am Soc Clin Oncol , vol.18
    • Matei, S.1    Hoff, P.M.2    Brito, R.3
  • 39
    • 0025133118 scopus 로고
    • Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons
    • D'Arpa P, Beardmore C, Liu LF. Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons. Cancer Res 1990;50:6919-6924.
    • (1990) Cancer Res , vol.50 , pp. 6919-6924
    • D'Arpa, P.1    Beardmore, C.2    Liu, L.F.3
  • 40
    • 0030452955 scopus 로고    scopus 로고
    • Schedule dependent efficacy of camptothecins in models of human cancer
    • Houghton PJ, Clinton FS, Zamboni WC et al. Schedule dependent efficacy of camptothecins in models of human cancer. Ann N Y Acad Sci 1996;803:188-201.
    • (1996) Ann N Y Acad Sci , vol.803 , pp. 188-201
    • Houghton, P.J.1    Clinton, F.S.2    Zamboni, W.C.3
  • 41
    • 0033053185 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic trial of oral irinotecan administered daily for 5 days every 3 weeks in patients with solid tumors
    • Drengler RA, Kuhn JG, Schaaf LJ et al. Phase I and pharmacokinetic trial of oral irinotecan administered daily for 5 days every 3 weeks in patients with solid tumors. J Clin Oncol 1999;17:685-696.
    • (1999) J Clin Oncol , vol.17 , pp. 685-696
    • Drengler, R.A.1    Kuhn, J.G.2    Schaaf, L.J.3
  • 42
    • 0031977028 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of oral 9-aminocamptothecin (NSC-603071)
    • Mani S, Iyer L, Janisch L et al. Phase I clinical and pharmacokinetic study of oral 9-aminocamptothecin (NSC-603071). Cancer Chemother Pharmacol 1998;42:84-87.
    • (1998) Cancer Chemother Pharmacol , vol.42 , pp. 84-87
    • Mani, S.1    Iyer, L.2    Janisch, L.3
  • 43
    • 0010296059 scopus 로고    scopus 로고
    • Oral bioavailability of 9-aminocamptothecin in adult patients with solid tumors
    • Sparreboom A, Stoter G, Loos WJ et al. Oral bioavailability of 9-aminocamptothecin in adult patients with solid tumors. Proc Am Assoc Cancer Res 1997;38:504a.
    • (1997) Proc Am Assoc Cancer Res , vol.38
    • Sparreboom, A.1    Stoter, G.2    Loos, W.J.3
  • 44
    • 0032457859 scopus 로고    scopus 로고
    • Phase II trial of 9-aminocamptothecin administered as a 120-hr continuous infusion weekly for three weeks in metastatic colorectal cancer
    • Pazdur R, Medgysey DC, Winn RJ et al. Phase II trial of 9-aminocamptothecin administered as a 120-hr continuous infusion weekly for three weeks in metastatic colorectal cancer. Invest New Drugs 1998;16:341-346.
    • (1998) Invest New Drugs , vol.16 , pp. 341-346
    • Pazdur, R.1    Medgysey, D.C.2    Winn, R.J.3
  • 45
    • 0030856927 scopus 로고    scopus 로고
    • Phase II trial of 9-Aminocamptothecin administered as a 72-hour continuous infusion in metastatic colorectal carcinoma
    • Pazdur R, Diaz-Canton E, Ballard WP et al. Phase II trial of 9-Aminocamptothecin administered as a 72-hour continuous infusion in metastatic colorectal carcinoma. J Clin Oncol 1997;15:2905-2909.
    • (1997) J Clin Oncol , vol.15 , pp. 2905-2909
    • Pazdur, R.1    Diaz-Canton, E.2    Ballard, W.P.3
  • 46
    • 0030667871 scopus 로고    scopus 로고
    • 9-Aminocamptothecin by 72-hour continuous intravenous infusion is inactive in the treatment of patients with 5-fluorouracil-refractory colorectal cancer
    • Saltz LB, Kemeny NE, Tong W et al. 9-Aminocamptothecin by 72-hour continuous intravenous infusion is inactive in the treatment of patients with 5-fluorouracil-refractory colorectal cancer. Cancer 1997;80:1727-1732.
    • (1997) Cancer , vol.80 , pp. 1727-1732
    • Saltz, L.B.1    Kemeny, N.E.2    Tong, W.3
  • 47
    • 0031909978 scopus 로고    scopus 로고
    • A phase I clinical and pharmacological study of oral 9-nitrocamtothecin, a novel water-insoluble topoisomerase I inhibitor
    • Verschraegen CF, Natelson EA, Giovanella BC et al. A phase I clinical and pharmacological study of oral 9-nitrocamtothecin, a novel water-insoluble topoisomerase I inhibitor. Anticancer Drugs 1998;9:36-44.
    • (1998) Anticancer Drugs , vol.9 , pp. 36-44
    • Verschraegen, C.F.1    Natelson, E.A.2    Giovanella, B.C.3
  • 48
    • 0025838675 scopus 로고
    • Regulators and effectors of ras proteins
    • Bollag G, McCormick F. Regulators and effectors of ras proteins. Annu Rev Cell Dev Biol 1991;7:601-632.
    • (1991) Annu Rev Cell Dev Biol , vol.7 , pp. 601-632
    • Bollag, G.1    McCormick, F.2
  • 49
    • 14344254868 scopus 로고    scopus 로고
    • Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice
    • Liu M, Bryant MS, Chen J et al. Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice. Cancer Res 1998;58:4947-4956.
    • (1998) Cancer Res , vol.58 , pp. 4947-4956
    • Liu, M.1    Bryant, M.S.2    Chen, J.3
  • 50
    • 0000494252 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of SCH 66336, a novel FPTI, using a 2-week on, 2-week off schedule
    • Hurwitz HI, Colvin OM, Petros WP et al. Phase I and pharmacokinetic study of SCH 66336, a novel FPTI, using a 2-week on, 2-week off schedule. Proc Am Soc Clin Oncol 1999;18:599a.
    • (1999) Proc Am Soc Clin Oncol , vol.18
    • Hurwitz, H.I.1    Colvin, O.M.2    Petros, W.P.3
  • 51
    • 0000375697 scopus 로고    scopus 로고
    • Phase I and pharmacologic study of continuous daily oral SCH 66336, a novel farnesyl transferase inhibitor in patients with solid tumors
    • Eskens E, Awada A, Verweij J et al. Phase I and pharmacologic study of continuous daily oral SCH 66336, a novel farnesyl transferase inhibitor in patients with solid tumors. Proc Am Soc Clin Oncol 1999;18:600a.
    • (1999) Proc Am Soc Clin Oncol , vol.18
    • Eskens, E.1    Awada, A.2    Verweij, J.3
  • 52
    • 4243577676 scopus 로고    scopus 로고
    • A clinical and pharmacokinetic study of SCH 66336(SCH) an oral inhibitor of the enzyme farnesyl transferase given once daily in patients with solid tumors
    • Awada A, Eskens F, Piccart MJ et al. A clinical and pharmacokinetic study of SCH 66336(SCH) an oral inhibitor of the enzyme farnesyl transferase given once daily in patients with solid tumors. Clin Cancer Res 1999;5(suppl):S3733.
    • (1999) Clin Cancer Res , vol.5 , Issue.SUPPL.
    • Awada, A.1    Eskens, F.2    Piccart, M.J.3
  • 53
    • 0000179877 scopus 로고    scopus 로고
    • R115777, a novel imidazole farnesyl transferase inhibitor (FTI) with potent oral antitumor activity
    • Skrzat S, Angibaud P, Venet M et al. R115777, a novel imidazole farnesyl transferase inhibitor (FTI) with potent oral antitumor activity. Proc Am Assoc Cancer Res 1998;39:2170a.
    • (1998) Proc Am Assoc Cancer Res , vol.39
    • Skrzat, S.1    Angibaud, P.2    Venet, M.3
  • 54
    • 0000535592 scopus 로고    scopus 로고
    • Phase I clinical and pharmacologic trial of the farnesylation inhibitor R115777 on a 21-day dosing schedule
    • Hudes GR, Schol J, Baab J et al. Phase I clinical and pharmacologic trial of the farnesylation inhibitor R115777 on a 21-day dosing schedule. Proc Am Soc Clin Oncol 1999;18:601a.
    • (1999) Proc Am Soc Clin Oncol , vol.18
    • Hudes, G.R.1    Schol, J.2    Baab, J.3
  • 55
    • 18544412314 scopus 로고    scopus 로고
    • A phase I and pharmacokinetic study of farnesyl protein transferase inhibitor R115777, in advanced cancer
    • Zujewski J, Horak ID, Bol CJ et al. A phase I and pharmacokinetic study of farnesyl protein transferase inhibitor R115777, in advanced cancer. J Clin Oncol 2000;18:927.
    • (2000) J Clin Oncol , vol.18 , pp. 927
    • Zujewski, J.1    Horak, I.D.2    Bol, C.J.3
  • 56
    • 0003221837 scopus 로고    scopus 로고
    • Phase-I combination trial of the farnesyltransferase inhibitor (FTI) R115777 with a 5FU/LV regimen in advanced colorectal (CRC) or pancreatic cancer (PC)
    • Peeters M, Van Cutsem E, Marse H et al. Phase-I combination trial of the farnesyltransferase inhibitor (FTI) R115777 with a 5FU/LV regimen in advanced colorectal (CRC) or pancreatic cancer (PC). Proc Am Soc Clin Oncol 1999;18:858a.
    • (1999) Proc Am Soc Clin Oncol , vol.18
    • Peeters, M.1    Van Cutsem, E.2    Marse, H.3
  • 57
    • 0032470250 scopus 로고    scopus 로고
    • A possible mechanism of eighteen patient deaths caused by interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs
    • Okuda H, Ogura K, Kato A et al. A possible mechanism of eighteen patient deaths caused by interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs. J Pharmacol Exp Ther 1998;287:791-799.
    • (1998) J Pharmacol Exp Ther , vol.287 , pp. 791-799
    • Okuda, H.1    Ogura, K.2    Kato, A.3
  • 58
    • 0025339525 scopus 로고
    • Acute phenytoin intoxication associated with the antineoplastic agent UFT
    • Wakisaka S, Shimauchi M, Kaji Y et al. Acute phenytoin intoxication associated with the antineoplastic agent UFT. Fukuoka Igaku Zasshi 1990;81:192-196.
    • (1990) Fukuoka Igaku Zasshi , vol.81 , pp. 192-196
    • Wakisaka, S.1    Shimauchi, M.2    Kaji, Y.3
  • 59
    • 0000025843 scopus 로고    scopus 로고
    • A randomized phase III trial comparing irinotecan+5FU/folinic acid (FA) to the same schedule of 5FU/FA in patients with metastatic colorectal cancer (MCRC) as front-line chemotherapy
    • Douillard JY, Cunningham D, Roth AD et al. A randomized phase III trial comparing irinotecan+5FU/folinic acid (FA) to the same schedule of 5FU/FA in patients with metastatic colorectal cancer (MCRC) as front-line chemotherapy. Proc Am Soc Clin Oncol 1999;18:899a.
    • (1999) Proc Am Soc Clin Oncol , vol.18
    • Douillard, J.Y.1    Cunningham, D.2    Roth, A.D.3
  • 60
    • 0000389059 scopus 로고    scopus 로고
    • Weekly irinotecan (CPT-11), leucovorin (LV) and fluorouracil (FU) is superior to daily X 5 LV/FU in patients with previously untreated colorectal cancer (CRC)
    • Saltz LB, Locker PK, Elfring GL et al. Weekly irinotecan (CPT-11), leucovorin (LV) and fluorouracil (FU) is superior to daily X 5 LV/FU in patients with previously untreated colorectal cancer (CRC). Proc Am Soc Clin Oncol 1999;18:898a.
    • (1999) Proc Am Soc Clin Oncol , vol.18
    • Saltz, L.B.1    Locker, P.K.2    Elfring, G.L.3
  • 61
    • 0000280299 scopus 로고    scopus 로고
    • Evaluation of the addition of oxaliplatin to the same mayo or german 5-FU regimen in advanced refractory colorectal cancer
    • Van Cutsem E, Szanto J, Roth A et al. Evaluation of the addition of oxaliplatin to the same mayo or german 5-FU regimen in advanced refractory colorectal cancer. Proc Am Soc Clin Oncol 1999;18:900a.
    • (1999) Proc Am Soc Clin Oncol , vol.18
    • Van Cutsem, E.1    Szanto, J.2    Roth, A.3
  • 62
    • 0003322817 scopus 로고    scopus 로고
    • Neoadjuvant therapy of rectal carcinoma with UFT-folinic acid (LV) plus radiotherapy
    • Feliu J, Calvillo J, Escribano A et al. Neoadjuvant therapy of rectal carcinoma with UFT-folinic acid (LV) plus radiotherapy. Proc Am Soc Clin Oncol 1999;18:917a.
    • (1999) Proc Am Soc Clin Oncol , vol.18
    • Feliu, J.1    Calvillo, J.2    Escribano, A.3
  • 63
    • 0030056443 scopus 로고    scopus 로고
    • Comparison of costs for infusion versus bolus chemotherapy administration: Analysis of five standard chemotherapy regimens in three common tumors - Part one
    • Lokich JJ, Moore CL, Anderson NR. Comparison of costs for infusion versus bolus chemotherapy administration: analysis of five standard chemotherapy regimens in three common tumors - Part one. Cancer 1996;78:294-299.
    • (1996) Cancer , vol.78 , pp. 294-299
    • Lokich, J.J.1    Moore, C.L.2    Anderson, N.R.3
  • 64
    • 0030037491 scopus 로고    scopus 로고
    • Comparisons of costs of infusion versus bolus chemotherapy administration - Part two
    • Lokich JJ, Moore CL, Anderson NR. Comparisons of costs of infusion versus bolus chemotherapy administration - Part two. Cancer 1996;78:300-303.
    • (1996) Cancer , vol.78 , pp. 300-303
    • Lokich, J.J.1    Moore, C.L.2    Anderson, N.R.3
  • 65
    • 0031017851 scopus 로고    scopus 로고
    • Patient preferences for oral versus intravenous palliative chemotherapy
    • Liu G, Franssen E, Fitch MI et al. Patient preferences for oral versus intravenous palliative chemotherapy. J Clin Oncol 1997;15:110-115.
    • (1997) J Clin Oncol , vol.15 , pp. 110-115
    • Liu, G.1    Franssen, E.2    Fitch, M.I.3
  • 66
    • 0028820944 scopus 로고
    • A fixed-ratio combination of uracil and Ftorafur (UFT) with low dose leucovorin. An active oral regimen for advanced colorectal cancer
    • Saltz LB, Leichman CG, Young CW et al. A fixed-ratio combination of uracil and Ftorafur (UFT) with low dose leucovorin. An active oral regimen for advanced colorectal cancer. Cancer 1995;75:782-785.
    • (1995) Cancer , vol.75 , pp. 782-785
    • Saltz, L.B.1    Leichman, C.G.2    Young, C.W.3
  • 67
    • 0028692706 scopus 로고
    • Tegafur-uracil (UFT) plus folinic acid in advanced rectal cancer
    • Sanchiz F, Milla A. Tegafur-uracil (UFT) plus folinic acid in advanced rectal cancer. Jpn J Clin Oncol 1994;24:322-326.
    • (1994) Jpn J Clin Oncol , vol.24 , pp. 322-326
    • Sanchiz, F.1    Milla, A.2
  • 68
    • 0030639034 scopus 로고    scopus 로고
    • UFT modulated with leucovorin in advanced colorectal cancer: Oncopaz experience
    • Gonzalez-Baron M, Feliu J, Garcia Giron C et al. UFT modulated with leucovorin in advanced colorectal cancer: Oncopaz experience. Oncology 1997;54(suppl 1):24-29.
    • (1997) Oncology , vol.54 , Issue.1 SUPPL. , pp. 24-29
    • Gonzalez-Baron, M.1    Feliu, J.2    Garcia Giron, C.3
  • 69
    • 0003612806 scopus 로고    scopus 로고
    • Montvale, NJ: Medical Economics Company
    • 1999 Drug Topics - Red Book. Montvale, NJ: Medical Economics Company, 1999.
    • (1999) 1999 Drug Topics - Red Book


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.