Nitric oxide in the lower urinary tract: Physiological and pathological implications

BJU International

Volumn 85, Issue 5, 2000, Pages 567-578

  Mumtaz, F H ^a   Khan, M A ^a   Thompson, C S ^b   Morgan, R J ^a   Mikhailidis, D P ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC GMP; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

DIABETES MELLITUS; HUMAN; INFLAMMATION; NONHUMAN; PATHOPHYSIOLOGY; PRENATAL DEVELOPMENT; PRIORITY JOURNAL; REVIEW; SMOOTH MUSCLE RELAXATION; SPINAL CORD INJURY; URETHRA; URETHRA DISEASE; URETHRA FUNCTION; URINARY TRACT CANCER;

ANIMALS; HUMANS; MUSCLE RELAXATION; MUSCLE, SMOOTH; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; URETHRA; URINARY BLADDER; URINARY BLADDER DISEASES;

EID: 0034048313     PISSN: 14644096     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1464-410x.2000.00459.x     Document Type: Review

References (122)

1. 1 Yoshimura N, de Groat WC. Neural control of the lower urinary tract. Int J Urol 1997; 4: 111-25
2. 2 Andersson KE. The pharmacology of the lower urinary tract smooth muscles and penile erectile tissues. Pharmacol Rev 1993; 45: 253-308
3. 3 Mitchell HH, Shnole HA, Grindley HS. The origin of nitrates in the urine. J Biol Chem 1916; 24: 461-90
4. 4 Iyengar R, Stuehr DJ, Martletta MA. Macrophage synthesis of nitrite, nitrate and N-nitrosamines: precursors and role of the respiratory burst. Proc Natl Acad Sci 1967; 84: 6369-73
5. 5 Furchgott RF, Zawadski JV. The obligatory role of the endothelial cells in the relaxation of arterial smooth muscle in the relaxation of the arterial smooth muscle by acetylcholine. Nature 1980; 288: 373-6
6. 6 Griffith TM, Edwards DH, Newby AC. Production of endothelium-derived relaxant factor is dependent on extracellular calcium. Cardiovas Res 1986; 20: 7-12
7. 7 Rapoport RM, Dranznin MB, Murad F. Endothelium-dependent relaxation in rat aorta may be mediated through cGMP-dependent phosphorylation. Nature 1983; 306: 174-6
8. 8 Palmer RMJ, Ferrige AG, Moncada S. Nitric oxide accounts for the biological activity of endothelium-derived relaxant factor. Nature 1987; 327: 524-6
9. 9 Ignarro LJ, Buga GM, Wood KS, Byrns RE, Chaudhuri G. Endothelium-derived relaxing factor produced and released by artery and vein is nitric oxide. Proc Natl Acad Sci USA 1987; 84: 9265-9
10. 10 Garthwaite J. Glutamate, nitric oxide and cell signaling in the nervous system. Trends Neurosci 1991; 14: 60-7
11. 11 Gillespie JS. Searching for the nonadrenergic, noncholinergic autonomic neurotransmitter. In Rand MJ, Raper C, eds. Pharmacology. Amsterdam: Excerpta Medica, 1987: 161-70
12. G-monomethyl-L-arginine on the response of the rat anococcygeus muscle to NANC nerve stimulation. Br J Pharmacol 1989; 98: 1080-2
13. 13 Andersson KE, Garcia-Pascual A, Forman A, Totrup A. Non-adrenergic non-cholinergic nerve mediated relaxation of the rabbit urethra is caused by nitric oxide. Acta Physiol Scand 1991; 141: 133-4
14. 14 Palmer RMJ, Moncada S. A novel citrulline forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells. Biochem Biophys Res Commun 1989; 158: 348-52
15. 15 Frostermann U, Closs EI, Pollack JS et al. Nitric oxide synthase isoenzymes: characterisation, purification, molecular cloning and functions. Hypertension 1994; 23: 112-31
16. 16 Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 1991; 43: 109-42
17. 17 Cooke JP, Dzau VJ. Nitric oxide synthase: Role in the genesis of vascular disease. Ann Rev Med 1997; 48: 489-509
18. 18 Andersson KE, Persson K. Nitric oxide synthase and nitric oxide-mediated effects in lower urinary tract smooth muscles. World J Urol 1994; 12: 274-80
19. 19 Ehern I, Adolfsson J, Wiklund NP. Nitric oxide synthase activity in the human urogenital tract. Urol Res 1994; 22: 287-90
20. G-nitro-L-arginine inhibits non-adrenergic, non-cholinergic relaxation in rabbit urethral smooth muscle. Life Sci 1991; 4: 2429-36
21. 21 Burnett AL, Calvin DC, Chamness SL et al. Urinary bladder-urethral sphincter dysfunction in mice with targeted disruption of neuronal nitric oxide synthase models idiopathic voiding disorders in humans. Nature Med 1997; 3: 571-4
22. 22 Lemack GE, Burkhard F, Zimmern PE, McConnell JD, Lin VK. Physiologic sequelae of partial infravesical obstruction in the mouse: role of inducible nitric oxide synthase. J Urol 1999; 161: 1015-22
23. 23 Dawson TM, Bredt DS, Fothui M, Hwang PM, Snyder SH. Nitric oxide synthase and neuronal NADPH-diaphorase are identical in brain and peripheral tissues. Proc Natl Acad Sci USA 1991; 88: 7797-801
24. 24 McNeill DL, Traugh NE Jr, Vaidya AM, Hua HT, Papka RE. Origin and distribution of NADPH-diaphorase-positive neurons and fibers innervating the urinary bladder of the rat. Neurosci Lett 1992; 147: 33-6
25. 25 Fraser MO, Flood HD, de Groat WC. Urethral smooth muscle relaxation is mediated by nitric oxide released from parasympathetic postganglionic neurons. J Urol 1995; 153: 461A
26. 26 Bennett BC, Kruse MN, Roppolo JR, Flood HD, Fraser M, de Groat WC. Neural control of urethral outlet activity in vivo: role of nitric oxide. J Urol 1995; 153: 2004-9
27. 27 Persson K, Igawa Y, Mattiasson A, Andersson KE. Effect of inhibition of the L-arginine/nitric oxide pathway in the rat lower urinary tract, in vivo and in vitro. Br J Pharmacol 1992; 107: 178-4
28. 28 Vizzard MA, Erdman SL, Forstermann U, de Groat WC. Differential distribution of nitric oxide synthase in neural pathways to the urogenital organs (urethra, penis, urinary bladder) of the rat. Brain Res 1994; 646: 279-91
29. 29 Persson K, Alm P, Johansson K, Larsson B, Andersson KE. Co-existence of nitrergic, peptidergic and acetylcholine esterase-positive nerves in the pig lower urinary tract. J Auton Nerv Syst 1995; 52: 115-236
30. 30 Alm P, Zygmunt PKE, Iselin C et al. Nitric oxide synthase-immunoreactive, adrenergic, cholinergic, and peptidergic nerves of the female rat urinary tract: a comparative study. J Auton Nerv Syst 1995; 56: 105-14
31. 31 Persson K, Alm P, Uvelius B, Andersson KE. Nitrergic and cholinergic innervation of the rat lower urinary tract after pelvic ganglionectomy. Am J Physiol 1998; 274: R389-97
32. 32 Keast JR, Kawatani M. Extensive distribution of NADPH diaphorase activity in the nerve supply of the cat lower urinary tract. J Autonom Nerv Syst 1994; 50: 161-9
33. 33 Persson K, Alm P, Johansson K, Larsson B, Andersson KE. Nitric oxide synthase in pig lower urinary tract: immunohistochemistry, NADPH diaphorase histochemistry and functional effects. Br J Pharmacol 1993; 110: 521-30
34. 34 Triguero D, Prieto D, Garcia-Pascual A. NADPH diaphorase and NANC relaxations are correlated in the sheep urinary tract. Neurosci Lett 1993; 163: 93-6
35. 35 Smet PJ, Jonavicius J, Marshall VR, de Vente J. Distribution of nitric oxide synthase-immunoreactive nerves and identification of cellular targets of nitric oxide in guinea pig and human urinary bladder by cGMP immunohistochemistry. Neuroscience 1996; 71: 337-48
36. 36 Smet PJ, Edyvane KA, Jonavicius J, Marshall VR. Distribution of NADPH-diaphorase-positive nerves supplying the human urinary bladder. J Autonom Nerv Syst 1994; 47: 109-13
37. 37 Ehren I, Adolfsson J, Wiklund NP. Nitric oxide synthase in the human urogenital tract. Urol Res 1994; 22: 287-90
38. 38 Garcia-Pascual A, Costa G, Labadia A, Persson K, Triguero D. Characterisation of nitric oxide synthase activity in sheep urinary tract: functional implications. Br J Pharmacol 1996; 118: 905-14
39. 39 Ehren I, Iversen H, Jansson O, Adolfsson J, Wiklund NP. Localisation of nitric oxide synthase activity in the human lower urinary tract and its correlation with neuroeffector responses. Urology 1994; 44: 683-7
40. 40 Garcia-Pascual A, Costa G, Labadia A, Persson K, Triguero D. Characterization of nitric oxide synthase activity in sheep urinary tract: functional implications. Br J Pharmacol 1996; 118: 905-14
41. 41 Saffrey MJ, Hassall CJS, Moules EW, Burnstock G. NADPH diaphorase and nitric oxide synthase are expressed by the majority of intramural neurons in the neonatal guinea pig urinary bladder. J Anat 1994; 185: 487-95
42. 42 Vizzard MA, Erdman SL, de Groat WC. Localization of NADPH diaphorase in bladder afferent and postganglionic efferent neurons of the rat. J Auton Nerv Syst 1993; 44: 85-90
43. 43 Vizzard MA, Erdman SL, Roppolo JR, Forstermann U, de Groat WC. Differential localisation of neuronal nitric oxide synthase immunoreactivity and NADPH-diaphorase activity in the cat spinal cord. Cell Tissue Res 1994; 278: 299-309
44. 44 Vizzard MA, Erdman SL, de Groat WC. Increased expression of neuronal nitric oxide synthase in bladder afferent pathways following chronic bladder irritation. J Comparat Neurol 1996; 370: 191-202
45. 45 Holzer P. Capsaicin: cellular targets, mechanism of action and selectivity for thin sensory neurons. Pharmacol Rev 1991; 43: 143-20
46. 46 Fowler CJ, Jewkes D, Mcdonald WI, Lynn B, de Groat W. Intravesical capsaicin for treatment of detrusor hyperreflexia. J Neurol 1994; 57: 169-73
47. 47 Brider LA, Apodaca G, de Groat WC, Kanai AJ. Adrenergic and capsaicin-evoked nitric oxide release from urothelium and afferent nerves in urinary bladder. Am J Physiol 1998; 275: F226-9
48. 48 Nishizawa S, Igawa Y, Okada N, Ohhashi T. Capsaicin-induced nitric-oxide-dependent relaxation in isolated dog urethra. Eur J Pharmacol 1997; 335: 211-9
49. 49 Pandita RK, Persson K, Andersson KE. Capsaicin-induced bladder overactivity and nociceptive behaviour in conscious rats: involvement of spinal nitric oxide. J Auton Nerv Syst 1997; 67: 184-91
50. 50 Zhou Y, Ling EA. Cololcalisation of nitric oxide synthase and some neurotransmitters in the intramural ganglia of the guinea pig urinary bladder. J Comparat Neurol 1998; 394: 496-505
51. 51 Dixon JS, Jen PY, Gosling JA. A double-label immunohistochemical study of intramural ganglia from the human male urinary bladder neck. J Anat 1997; 190: 125-34
52. 52 Ho KM, Ny L, Andersson KE, Brading AF, Noble JG. Colocalisation of tyrosine hydroxylase and nitric oxide synthase in the human female urethra. J Urol 1999; 161: 44
53. 53 Yoshida M, Akaike T, Inadome A et al. The possible effect of nitric oxide on relaxation and noradrenaline release in isolated rabbit urethra. Eur J Pharmacol 1998; 357: 213-9
54. 54 Liu SH, Lin-Shiau SY. Enhancement by nitric oxide of neurogenic contraction in mouse urinary bladder. Naunyn-Schmiedebergs Arch Pharmacol 1997; 356: 856-62
55. 55 Moon A, Pickard RS, Gillespie JI, Neal DE. Contractile responses to sodium nitroprusside and L-arginine in isolated human detrusor. J Urol 1997; 157: 258
56. 56 Mumtaz FH, Sullivan ME, Thompson CS et al. Alterations in the nitric oxide synthase binding sites and non-adrenergic, non-cholinergic mediated smooth muscle relaxation in the diabetic rabbit bladder outlet: Possible relevance to the pathogenesis of diabetic cystopathy. J Urol 1999; 162: 558-66
57. 57 James MJ, Birmingham AT, Hill SJ. Relaxation of human isolated detrusor strips in response to electrical field stimulation: a possible role for nitric oxide in human bladder. Br J Clin Pharmacol 1993; 35: 366-72
58. 58 Kobzik L, Reid MB, Bredt DS, Stamler JS. Nitric oxide in skeletal muscle. Nature 1994; 372: 546-8
59. 59 Grozdanovic S, Nakos G, Dahrmann G, Mayer B, Gossaru R. Species-independent expression of nitric oxide synthase in the sarcolemma region of visceral and somatic striated muscle fibers. Cell Tiss Res 1995; 281: 493-6
60. 60 Ho KM, McMurray G, Brading AF, Noble JG, Ny L, Andersson KE. Nitric oxide synthase in the heterogeneous population of intramural striated muscle fibres of the human membranous urethral sphincter. J Urol 1998; 159: 1091-6
61. 61 Ho KM, McMurray G, Brading AF, Noble JG, Andersson KE. The human female urethral striated sphincter and its association with neuronal nitric oxide synthase. J Urol 1999; 161: 40
62. 62 Dixon JS, Jen PYP. Development of nerves containing nitric oxide synthase in the human male urogenital organs. Br J Urol 1995; 76: 719-25
63. 63 Dixon JS, Jen PYP, Gosling JA. Immunohistochemical characteristics of human paraganglion cells and sensory corpuscles associated with the urinary bladder. A developmental study in the male fetus, neonate and infant. J Anat 1998; 192: 407-15
64. 64 Mevorach RA, Bogaert GA, Kogan BA. Role of nitric oxide in fetal lower urinary tract function. J Urol 1994; 152: 510-4
65. 65 Andersson KE, Mattiasson A, Sjogren C. Electrically induced relaxation of the noradrenaline contracted isolated urethra from rabbit and man. J Urol 1983; 129: 210-3
66. 66 Klarskov P, Gerstenberg T, Ramirez D, Hald T. Non-cholinergic, non-adrenergic nerve mediated relaxation of trigone, bladder neck and urethral smooth muscle in vitro. J Urol 1983; 129: 848-50
67. 67 Speakman MJ, Walmsley D, Brading AF. An in vitro pharmacological study of the human trigone - a site of nonadrenergic, noncholinergic neurotransmission. Br J Urol 1988; 61: 304-9
68. 68 Persson K, Andersson KE. Non-adrenergic, noncholinergic relaxation and levels of cyclic nucleotides in the rabbit lower urinary tract. Eur J Pharmacol 1994; 268: 159-67
69. 69 Dokita S, Smith SD, Nishimoto T, Wheeler MA, Weiss RM. Involvement of nitric oxide and cyclic GMP in rabbit urethral relaxation. Eur J Pharmacol 1994; 269: 269-75
70. 70 Kakizaki H, de Groat WC. Reorganization of somato-urethral reflexes following spinal cord injury in the rat. J Urol 1997; 158: 1562-7
71. 71 Morrison JF, Sato A, Sato Y, Suzuki A. The nitric oxide synthase inhibitor L-NAME reduces inhibitory components of somato-vesical parasympathetic reflexes in the rat. Neuroscience Res 1996; 24: 195-9
72. 72 Kakizaki H, Fraser MO, De Groat WC. Reflex pathways controlling urethral striated and smooth muscle function in the male rat. Am J Physiol 1647-56; 1997: 272:R
73. 73 Fraser MO, Jung SY, Ozawa H et al. Intraurethral nitric oxide donor relaxes the urethral smooth muscle. J Urol 1998; 159: 23
74. 74 Chung BH, Seung KC, Ki CC. Effects of nitric oxide on detrusor relaxation. J Urol 1996; 155: 2090-3
75. 75 Theobald RJ Jr The effect of NG-monomethyl-L-arginine on bladder function. Eur J Pharmacol 1996; 311: 73-8
76. 76 Desai KM, Sessa WC, Vane JR. Involvement of nitric oxide in the reflex relaxation of the stomach to accommodate food or fluid. Nature 1991; 351: 477-9
77. 77 Kozlowski MC, Krane RJ, Sirkoy MB, Azadzoi M. Neuroregulation of bladder blood flow during filling and contraction in the rabbit. J Urol 1999; 161: 38
78. 78 Burnett AL, Maguire MP, Chamness SL et al. Characterisation and localisation of nitric oxide synthase in human prostate. Urology 1995; 45: 435-46
79. 79 Burnett AL, Lowenstein CJ, Bredt DS, Chang TS, Snyder SH. Nitric oxide: a physiologic mediator of penile erection. Science 1991; 257: 401-3
80. 80 Bloch W, Klotz T, Loch C, Schmidt G, Engelmann U, Addicks K. Distribution of nitric oxide synthase implies a regulation of circulation, smooth muscle tone and secretory function in the human prostate by nitric oxide. Prostate 1997; 33: 1-8
81. 81 Machtens SA, Ueckert S, Christian G et al. Function of human seminal vesicle is controlled by nitric oxide. J Urol 1998; 159: 202
82. 82 Takeda M, Tang R, Shapiro E, Burnett AL, Lepor H. Effects of nitric oxide on human and canine prostate. Urology 1995; 45: 440-6
83. 83 Shabsigh A, Hayek O, Chen MW et al. Early effects of castration on the vascular system of the rat ventral prostate gland. J Urol 1999; 161: 227
84. 84 Robertson BE, Schubert R, Hescheler J, Nelson MT. cGMP-dependent protein kinase activates Ca-activated K-channels in cerebral artery smooth muscle cells. Am J Physiol 1993; 265: C299-C303
85. 85 Zygmunt PK, Hogestatt ED, Andersson KE. Effects of potassium channel inhibitors on nitrergic and adrenergic neurotransmission in lamina propria of the female rabbit urethra. Naunyn-Schmiedebergs Arch Pharmacol 1996; 354: 336-42
86. + channel opener, on the rabbit lower urinary tract. Gen Pharmacol 1995; 26: 1559-64
87. 87 Waldeck K, Ny L, Persson K, Andersson KE. Mediators and mechanisms of relaxation in rabbit urethral smooth muscle. Br J Pharmacol 1998; 123: 617-24
88. + channels in pulmonary vascular smooth muscle cells: role for nitric oxide. J Appl Physiol 1996; 81: 1264-72
89. 89 Mirvish SS. Role of N-nitroso compounds (NOC) and N-nitrosation in etiology of gastric, esophageal, nasopharyngeal and bladder cancer and contribution to cancer of known exposures to NOC. Cancer Lett 1995; 93: 17-48
90. 90 Billair TR. Nitric oxide: novel biology and clinical relevance. Ann Surg 1995; 221: 339-49
91. 91 Sutherland RS, Kogan BA, Piechota HJ, Bredt DS. Vesicourethral function in mice with genetic disruption of neuronal nitric oxide synthase. J Urol 1997; 157: 1109-16
92. 92 Lemack GE, Burkhard F, Zimmern PE, McConnell JD, Lin VK. Physiological sequelae of partial infravesical obstruction in the mouse: role of inducible nitric oxide synthase. J Urol 1999; 161: 1015-22
93. 93 Zhou Y, Ling EA. Effects of acute complete outlet obstruction on the NADPH-diaphorase reactivity in the intramural ganglia of the guinea pig urinary bladder: light and electron microscopic studies. J Urol 1997; 158: 916-23
94. 94 Saito M, Wada K, Kamisaki Y, Miyagawa I. Effect of ischaemia-reperfusion on contractile function of rat urinary bladder: Possible role of nitric oxide. Life Sci 1998; 62: PL149-56
95. 95 Felsen DE, Vaughan D, Lemer ML. Inhibition of inducible nitric oxide synthase (iNOS) differently affects bladder function in normal rats and in rats with partial bladder outlet obstruction (BOO): an in vivo cystometric evaluation. J Urol 1998; 159: 18
96. 96 Persson K, Pandita RK, Aszodi A, Fassler R, Andersson KE. The absence of cyclic GMP-dependent kinase I causes hyperactive voiding and impaired urethral relaxation. J Urol 1999; 161: 40
97. 97 Mathers M, Klotz T, Bloch W, Heidenreich A, Englemann U. Nitric oxide based influence of nitrates on micturition in patients with benign prostatic hyperplasia. J Urol 1999; 161: 370
98. 98 Yokoyama T, Fraser MO, Tirney S et al. Gene therapy as a potential treatment for BPH; injection of myoblast-adenovirus transfected with human inducible nitric oxide synthase (iNOS) into a proximal urethra. J Urol 1999; 161: 305
99. 99 Seemann C, Uckert S, Steif CG et al. Relaxation of human detrusor smooth muscle in vitro by modulation of cyclic nucleotide dependent pathways. J Urol 1999; 161: 44
100. 100 Kaplan SA, Te AE, Blavis JG. Urodynamic findings in patients with diabetic cystopathy. J Urol 1995; 153: 342-4
101. 101 Mumtaz FH, Thompson CS, Khan MA et al. Alterations in the formation of cyclic nucleotides and prostaglandins in the lower urinary tract of the diabetic rabbit. Urol Res 1999; in press
102. 102 Nussler AK, Billiar TR. Inflammation, immunoregulation and inducible nitric oxide synthase. J Leukoc Biol 1993; 54: 171-8
103. 103 Smith SD, Wheeler HE, Foster JR, Weiss RM. Urinary nitric oxide synthase activity and cyclic GMP levels are decreased with interstitial cystitis and increased with urinary tract infections. J Urol 1996; 155: 1432-35
104. 104 Lundberg JO, Ehren I, Jansson O et al. Elevated nitric oxide in the urinary bladder in infectious and non infectious cystitis. Urology 1996; 48: 700-2
105. 105 Ehern I, Hosseni A, Lundberg JON, Wilkund NP. Nitric oxide: a useful gas in the detection of lower urinary tract inflammation. J Urol 1999, 162: 327-9
106. 106 Olsson LE, Wheeler MA, Sessa WC, Weiss RM. Bladder instillation and intraperitoneal injection of Escherichia coli lipopolysaccharide up-regulate cytokines and iNOS in rat urinary bladder. J Pharmacol Expt Therap 1998; 284: 1203-8
107. 107 Souza-Fiho MV, Lima MV, Pompeu MM, Ballejo G, Cunha FQ, Ribeiro R. Involvement of nitric oxide in the pathogenesis of cyclophosphamide-induced haemorrhagic cystitis. Am J Path 1997; 150: 247-56
108. 108 Lotz M, Villiger P, Hughli T, Koziol J, Zuraw BL. Interleukin 6 and interstitial cystitis. J Urol 1994; 152: 869-73
109. 109 Baselli EC, Maerten SF, Puig RA, Pontari MA, Ruggieri MR. Nitric oxide synthase activity in the regulation of bladder blood flow in guinea pigs following antigen induced inflammation. J Urol 1999; 161: 308
110. 110 Birder LA, Kanai AJ, de Groat WC. DMSO effect on bladder afferent neurons and nitric oxide release. J Urol 1997; 158: 1989-95
111. 111 Ehren I, Lundberg JO, Adolfsson J, Wiklund NP. Effects of L-arginine treatment on symptoms and bladder nitric oxide levels in patients with interstitial cystitis. Urology 1998; 52: 1026-9
112. 112 Atta MA, Frank JJ, Elbadawi A. Intrinsic neuromuscular defects in the neurogenic bladder. II. Long term innervation of the unilaterally decentralised feline bladder, regenerated cholinergic, increased adrenergic and emergent probable 'peptidergic' nerves. Neurourol Urodynam 1984; 3: 185-92
113. 113 Vizzard MA. Increased expression of neuronal nitric oxide synthase in bladder afferent and spinal neurons following spinal cord injury. Dev Neurosci 1997; 19: 232-46
114. 114 Brider LA, Kanai AJ, Ruiz GW et al. Spinal cord injury alters nitric oxide release from the urinary bladder. J Urol 1998; 159: 20
115. 115 Maeda H, Akaike T. Nitric oxide and oxygen radicals in infection, inflammation and cancer. Biochem 1998; 63: 854-65
116. 116 Lala PK. Significance of nitric oxide in carcinogenesis, tumour progression and cancer therapy. Cancer Met Rev 1998; 17: 1-6
117. 117 Klotz T, Bloch W, Volberg C, Engleman U, Addicks K. Selective expression of inducible nitric oxide synthase in human prostate carcinoma. Cancer 1998; 82: 1897-903
118. 118 Moy PY, Sessa WC, Weiss RM. Inhibition of angiogenesis and tumour growth in human prostate cancer LNCaP cells with the inhibition of endothelial nitric oxide. J Urol 1999; 161: 130
119. 119 Swana HS, Smith SD, Perrotta PL, Saito N, Wheeler MA, Weiss RM. Inducible nitric oxide synthase with transitional cell carcinoma of the bladder. J Urol 1999; 162: 630-4
120. 120 Jansson OT, Morcos E, Brundin L et al. The role of nitric oxide in bacillus Calmette-Guerin mediated anti-tumour effects in human bladder cancer. Br J Can 1998; 78: 588-92
121. 121 Oh BR, Nakajima K, Dahiya R. Bacillus Calmette-Guerin (BCG) up-regulates iNOS gene and protein expression in rat bladder. J Urol 1999; 161: 118
122. 122 Jansson OT, Morcos E, Adolfsson J, Wilkund NP. Nitric oxide modulates the growth of bladder cancer cells. J Urol 1998; 159: 280