Urinary nitric oxide synthase activity and cyclic GMP levels are decreased with interstitial cystitis and increased with urinary tract infections

Journal of Urology

Volumn 155, Issue 4, 1996, Pages 1432-1435

  Smith, Shannon D ^a   Wheeler, Marcia A ^a   Foster Jr , Harris E ^a   Weiss, Robert M ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cyclic GMP; cystitis; urinary tract infections

Indexed keywords

CREATININE; CYCLIC GMP; NITRIC OXIDE SYNTHASE;

ADULT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HUMAN; INTERSTITIAL CYSTITIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SEX DIFFERENCE; URINALYSIS; URINARY TRACT INFECTION;

EID: 0030007191     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(01)66301-8     Document Type: Article

References (29)

1. Batra, A. K., Wein, A. J. and Hanno, P. M.: Interstitial cystitis. A.U.A. Update Series, 12: 1, 1993.
2. Nathan, C.: Nitric oxide as a secretory product of mammalian cells. F.A.S.E.B. J., 6: 3051, 1992.
3. Nathan, C. and Xie, Q.: Nitric oxide synthases: roles, tolls, and controls. Cell, 78: 915, 1994.
4. Smith, S. D., Wheeler, M. A. and Weiss, R. M.: Nitric oxide synthase: an endogenous source of elevated nitrite in infected urine. Kidney Int., 45: 586, 1994.
5. Schmidt, H. H. H. W. and Walter, U.: NO at work. Cell, 78: 919, 1994.
6. Bradford, M.: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72: 248, 1976.
7. Slot, C.: Plasma creatinine determination. A new and specific Jaffé reaction method. Scand. J. Clin. Lab. Invest., 17: 381, 1965.
8. Cook, J. G. H.: Factors influencing the assay of creatinine. Ann. Clin. Biochem., 12: 219, 1975.
9. Wheeler, M. A., Smith, S. D., Weiss, E. D., Sessa, W. C. and Weiss, R. M.: Characterization of nitric oxide synthase (NOS) activity in leukocytes enriched from human infected urine. F.A.S.E.B. J., 9: A679, 1995.
10. Nussler, A. K. and Billiar, T. R.: Inflammation, immunoregulation and inducible nitric oxide synthase. J. Leukoc. Biol., 15: 171, 1993.
11. Umans, J. G. and Samsel, R. W.: L-canavanine selectively augments contraction in aortas from endotoxemic rats. Eur. J. Pharmacol., 210: 343, 1992.
12. Knowles, R. G., Palacios, M. and Palmer, R. M. J.: Kinetic characteristics of nitric oxide synthase from rat brain. Biochem. J., 269: 207, 1990.
13. Palmer, R. M. J. and Moncada, S.: A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells. Biochem. Biophys. Res. Commun., 158: 348, 1989.
14. Pang, X., Cotreau-Bibbo, M. M., Sant, G. R. and Theoharides, T. C.: Bladder mast cell expression of high affinity oestrogen receptors in patients with interstitial cystitis. Br. J. Urol., 75: 154, 1995.
15. Yallampalli, C., Byam-Smith, M., Nelson, S. O. and Garfield, R. E.: Steroid hormones modulate the production of nitric oxide and cGMP in the rat uterus. Endocrinology, 134: 1971, 1994.
16. Christmas, T. J. and Rode, J.: Characteristics of mast cells in normal bladder, bacterial cystitis and interstitial cystitis. Br. J. Urol., 68: 473, 1991.
17. Lundeberg, T., Liedberg, H., Nordling, L., Theodorsson, E., Owzarski, A. and Ekman, P.: Interstitial cystitis: correlation with nerve fibres, mast cells and histamine. Br. J. Urol., 71: 427, 1993.
18. Sant, G. R. and Theoharides, T. C.: The role of the mast cell in interstitial cystitis. Urol. Clin. North Am., 21: 41, 1994.
19. Theoharides, T. C., Sant, G. R., el-Mansoury, M., Letourneau, R., Ucci, A. A. Jr. and Meares, E. M., Jr.: Activation of bladder mast cells in interstitial cystitis: a light and electron microscopic study. J. Urol., 153: 629, 1995.
20. Dileepan, K. N., Lorsbach, R. B. and Stechschulte, D. J.: Mast cell granules inhibit macrophage-mediated lysis of mastocytoma cells (P815) and nitric oxide production. J. Leukoc. Biol., 53: 446, 1993.
21. Kanware, S., Wallace, J. L., Befus, D. and Kubes, P.: Nitric oxide synthesis inhibition increases epithelial permeability via mast cells. Am. J. Physiol., 266: G222, 1994.
22. Kubes, P., Samina, K., Xiao-fei, N. and Gaboury, J. P.: Nitric oxide synthesis inhibition induces leukocyte adhesion via superoxide and mast cells. F.A.S.E.B. J., 7: 1293, 1993.
23. el-Mansoury, M., Boucher, W., Sant, G. R. and Theoharides, T. C.: Increased urine histamine and methylhistamine in interstitial cystitis. J. Urol., 152: 350, 1994.
24. Palea, S., Artibani, W., Ostardo, E., Trist, D. G. and Pietra, C.: Evidence for purinergic neurotransmission in human urinary bladder affected by interstitial cystitis. J. Urol., 150: 2007, 1993.
25. Persson, K., Igawa, Y., Mattiasson, A. and Andersson, K.-E.: Effects of inhibition of the L-arginine/nitric oxide pathway in the rat lower urinary tract in vivo and in vitro. Br. J. Pharmacol., 107: 178, 1992.
26. Gianotti, L., Alexander, J. W., Pyles, T. and Fukushima, R.: Arginine-supplemented diets improve survival in gut-derived sepsis and peritonitis by modulating bacterial clearance. The role of nitric oxide. Ann. Surg., 217: 644, 1993.
27. Das, U. N., Mohan, I. K., Kumar, K. V., Kumar, G. S. and Sekhar, C. C.: Beneficial effect of L-arginine in non-insulin dependent diabetes mellitus: a potential role for nitric oxide. Med. Sci. Res., 21: 669, 1993.
28. Boger, R. H., Bode-Boger, S. M., Gerecke, U. and Frolich, J. C.: Long-term administration of L-arginine, L-NAME, and the exogenous NO donor molsidomine modulates urinary nitrate and cyclic GMP excretion in rats. Cardiovasc. Res., 28: 494, 1994.
29. Smith, S. D., Wheeler, M. A., Foster, H. E., Jr. and Weiss, R. M.: L-arginine decreases interstitial cystitis symptoms while increasing urinary nitric oxide synthase activity. F.A.S.E.B. J., 9: A921, 1995.