Capsaicin-induced nitric-oxide-dependent relaxation in isolated dog urethra

European Journal of Pharmacology

Volumn 335, Issue 2-3, 1997, Pages 211-219

  Nishizawa, Shuji ^a   Igawa, Yasuhiko ^a   Okada, Noboru ^a   Ohhashi, Toshio ^a  

^a SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Capsaicin; Nitric oxide (NO); Smooth muscle relaxation; Urethra, dog

Indexed keywords

ARGININE; ATROPINE; CALCITONIN GENE RELATED PEPTIDE; CAPSAICIN; INDOMETACIN; METHYLENE BLUE; N(G) NITROARGININE METHYL ESTER; NEUROKININ A; NITRIC OXIDE; NITROPRUSSIDE SODIUM; NORADRENALIN; PROPRANOLOL; SUBSTANCE P; TETRODOTOXIN; VASOACTIVE INTESTINAL POLYPEPTIDE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CRYOPRESERVATION; DOG; DOSE RESPONSE; ELECTROSTIMULATION; IN VITRO STUDY; NONADRENERGIC NONCHOLINERGIC NERVE; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE RELAXATION; TACHYPHYLAXIS; URETHRA;

ANIMALS; CAPSAICIN; COLD; DOGS; ELECTRIC STIMULATION; FEMALE; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH; NEUROPEPTIDES; NITRIC OXIDE; NITROPRUSSIDE; NOREPINEPHRINE; PEPTIDE FRAGMENTS; URETHRA; UROTHELIUM; VASOACTIVE INTESTINAL PEPTIDE; VASOCONSTRICTOR AGENTS; VASODILATOR AGENTS;

EID: 0030824716     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)01223-5     Document Type: Article

References (45)

1. Abelli L., Conte B., Somma V., Parlani M., Geppetti P., Maggi C.A. Mechanical irritation induces neurogenic inflammation in the rat urethra. J. Urol. 146:1991;1624-1626.
2. Akbarali H., Bieger D., Triggle C.R. Effects of cold storage on relaxation responses in the rat esophageal tunica muscularis mucosae. Can. J. Physiol. Pharmacol. 65:1987;23-29.
3. Alm P., Larsson B., Ekblad E., Sundler F., Andersson K.-E. Immunohistochemical localization of peripheral nitric oxide synthase-containing nerves using antibodies raised against synthesized C- and N-terminal fragments of a cloned enzyme from rat brain. Acta Physiol. Scand. 148:1993;421-429.
4. Andersson K.-E. Pharmacology of lower urinary tract smooth muscles and penile erectile tissues. Pharmacol. Rev. 45:1993;253-308.
5. Andersson K.-E., Persson K. Nitric oxide synthase and nitric oxide-mediated effects in lower urinary tract smooth muscles. World J. Urol. 12:1994;274-280.
6. Andersson K.-E., Mattiasson A., Sjogren C. Electrically induced relaxation of the noradrenaline contracted isolated urethra from rabbit and man. J. Urol. 129:1983;210-213.
7. Andersson K.-E., Pascual A.G., Persson K., Forman A., Tottrup A. Electrically-induced, nerve mediated relaxation of rabbit urethra involves nitric oxide. J. Urol. 147:1992;253-259.
8. Busse R., Mülsch A. Induction of nitric oxide synthase by cytokines in vascular smooth muscle cells. FEBS Lett. 275:1990;87-90.
9. Cullen W.C., Fletcher T.F., Bladley W.E. Histology of the canine urethra. I. Morphometry of the female urethra. Anat. Rec. 199:1981;177-186.
10. Docherty R.J., Robertson B., Bevan S. Capsaicin causes prolonged inhibition of voltage-activated calcium currents in adult rat dorsal root ganglion neurons in culture. Neuroscience. 40:1991;513-521.
11. Dun N.J., Dun S.L., Wu S.Y., Forstermann U., Schmidt H.H., Tseng L.F. Nitric oxide synthase immunoreactivity in the rat, mouse, cat and squirrel monkey spinal cord. Neuroscience. 54:1993;845-857.
12. Eckenfels A., Vane J.R. Prostaglandins, oxygen tension and smooth muscle tone. Br. J. Pharmacol. 45:1972;451-462.
13. Fazekas Á., Matheny J.L., Roth G.I., Richardson D.R. Effect of nitric oxide inhibition on capsaicin-elicited vasodilation in the rat oral circulation. Res. Exp. Med. 194:1994;357-365.
14. Fleming I., Gray G.A., Schott C., Stoclet J.-C. Inducible but not constitutive production of nitric oxide by vascular smooth muscle cells. Eur. J. Pharmacol. 200:1991;375-376.
15. Grider J.R., Rivier J.R. Vasoactive intestinal peptide (VIP) as transmitter of inhibitory motor neurons of the gut: Evidence from the use of selective VIP antagonists and VIP antiserum. J. Pharmacol. Exp. Ther. 253:1990;738-742.
16. Grider J.R., Murthy K.S., Jin J.-G., Makhlouf G.M. Stimulation of nitric oxide from muscle cells by VIP: Prejunctional enhancement of VIP release. Am. J. Physiol. 262:1992;G774-G778.
17. Griffiths M.J.D., Messent M., MacAllister R.J., Evans T.W. Aminoguanidine selectively inhibits inducible nitric oxide synthase. Br. J. Pharmacol. 110:1993;963-968.
18. Hashimoto S., Kigoshi S., Muramatsu I. Neurogenic responses of urethra isolated from the dog. Eur. J. Pharmacol. 213:1992;117-123.
19. Hashimoto S., Kigoshi S., Muramatsu I. Nitric oxide dependent and independent neurogenic relaxation of isolated dog urethra. Eur. J. Pharmacol. 231:1993;209-214.
20. Herbert M.K., Holzer P. Nitric oxide mediates the amplification by interleukin-1β of neurogenic vasodilation in the rat skin. Eur. J. Pharmacol. 260:1994;89-93.
21. Holzer P. Local effector functions of capsaicin-sensitive sensory nerve endings: Involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. Neuroscience. 24:1988;739-768.
22. Holzer P. Capsaicin: Cellular targets, mechanisms of action, and selectivity for thin sensory neurons. Pharmacol. Rev. 43:1991;143-201.
23. Jurkiewicz N.H., Garcia A.G., Jurkiewicz A. In vitro denervation of the rat vas deferens through hypothermic storage. Br. J. Pharmacol. 107:1992;610-615.
24. Kim Y.C., Kim J.H., Davies M.G., Hagen P.-O., Carson C.C. III Modulation of vasoactive intestinal polypeptide (VIP)-mediated relaxation by nitric oxide and prostanoids in the rabbit corpus cavernosum. J. Urol. 153:1995;807-810.
25. Maggi C.A. Capsaicin and primary afferent neurons: From basic science to human therapy? J. Auton. Nerv. Syst. 33:1991;1-14.
26. Maggi C.A., Meli A. The sensory-efferent function of capsaicin-sensitive sensory neurons. Gen. Pharmacol. 19:1988;1-43.
27. Merchant N.B., Dempsey D.T., Grabowski M.W., Marco Rizzo B.S., Ritchie W.P. Jr. Capsaicin-induced gastric mucosal hyperemia and protection: The role of calcitonin gene-related peptide. Surgery. 116:1994;419-425.
28. McNeill D.L., Traugh N.E. Jr., Vadya A.M., Hua H.T., Papka R.E. Origin and distribution of NADPH-diaphorase-positive neurons and fibers innervating the urinary bladder of the rat. Neurosci. Lett. 147:1992;33-36.
29. Misko T.P., Moore W.M., Kasten T.P., Nickols G.A., Corbett J.A., Tilton R.G., McDaniel M.L., Williamson J.R., Currie M.G. Selective inhibition of the nitric oxide synthase by aminoguanidine. Eur. J. Pharmacol. 233:1993;119125.
30. Nording L., Liedberg H., Ekman P., Lundberg T. Influence of the nervous system on experimentally induced urethral inflammation. Neurosci. Lett. 90:1990;183-188.
31. Parlani M., Conte B., Goso C., Szallasi A., Manzini S. Capsaicin-induced relaxation in the rat isolated external urethral sphincter: Characterization of the vanilloid receptor and mediation by CORP. Br. J. Pharmacol. 110:1993;989-994.
32. Parlani M., Conte B., Manzini S. Nonadrenergic, noncholinergic inhibitory control of the rat external urethral sphincter: Involvement of nitric oxide. J. Pharmacol. Exp. Ther. 265:1993;713-719.
33. Persson K., Andersson K.-E. Nitric oxide and relaxation of pig lower urinary tract. Br. J. Pharmacol. 106:1992;416-422.
34. Persson K., Alm P., Johansson K., Larsson B., Andersson K.-E. Nitric oxide synthase in pig lower urinary tract: Immunohistochemistry, NADPH diaphorase histochemistry and functional effects. Br. J. Pharmacol. 110:1993;521530.
35. Persson K., Alm P., Johansson K., Larsson B., Andersson K.-E. Coexistence of nitrergic, peptidergic and acetylcholine esterase-positive nerves in the pig lower urinary tract. J. Auton. Nerv. Syst. 52:1995;225-236.
36. Pinna C., Ventura S., Puglisi L., Burnstock G. A pharmacological and histochemical study of hamster urethra and the role of urothelium. Br. J. Pharmacol. 119:1996;655-662.
37. Su H.C., Wharton J., Polak J.M., Mulderry P.K., Ghatei M.A., Gibson S.J., Terenghi G., Morrison J.F.B., Ballesta J., Bloom S.R. Calcitonin gene-related peptide immunoreactivity in afferent neurons supplying the urinary tract: Combined retrograde tracing and immunohistochemistry. Neuroscience. 18:1986;727-747.
38. Szallasi A. The vanilloid (capsaicin) receptor: Receptor types and species differences. Gen. Pharmacol. 25:1994;223-243.
39. Takeda M., Lepor H. Nitric oxide synthase in dog urethra: A histochemical and pharmacological analysis. Br. J. Pharmacol. 116:1995;2517-2523.
40. Tamaki M., Iwanaga T., Takeda M., Adachi I., Sato S., Fujita T. Calcitonin gene-related peptide (CGRP)-immunoreactive nerve terminals in the whole mount preparations of the dog urethra. Arch. Histol. Cytol. 55:1992;1-11.
41. Vane J.R. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature New Biol. 231:1971;232-235.
42. Vizzard M.A., Erdman S.L., De Groat W.C. Localization of NADPH diaphorase in bladder afferent and postganglionic efferent neurons of the rat. J. Auton. Nerv. Syst. 44:1993;85-90.
43. Vizzard M.A., Erdman S.L., Forstermann U., De Groat W.C. Differential distribution of nitric oxide synthase in neural pathways to the urogenital organs (urethra, penis, urinary bladder) of the rat. Brain Res. 646:1994;279-291.
44. Werkström V., Persson K., Ny L., Bridgewater M., grading A.F., Andersson K.E. Factors involved in the relaxation of female pig urethra evoked by electrical field stimulation. Br. J. Pharmacol. 116:1995;1599-1604.
45. Whittle B.J.R., Lopez-Belmonte J., Moncada S. Nitric oxide mediates rat mucosal vasodilatation induced by intragastric capsaicin. Eur. J. Pharmacol. 218:1992;339-341.