Rare occurrence of inactivating p53 gene mutations in primary non-astrocytic tumors of the central nervous system: Reappraisal by yeast functional assay

Acta Neuropathologica

Volumn 95, Issue 3, 1998, Pages 291-296

  Nozaki, Michimasa ^a   Tada, Mitsuhiro ^a   Matsumoto, Ryoji ^a   Sawamura, Yutaka ^a   Abe, Hiroshi ^a   Iggo, Richard D ^b  

^a HOKKAIDO UNIVERSITY   (Japan)

^b SWISS INST FOR EXP CANCER RESEARCH   (Switzerland)

Author keywords

Human; Malignant lymphoma; Non astrocytic brain tumors; p53 mutation; Yeast functional assay

Indexed keywords

PROTEIN P53;

ADOLESCENT; ADULT; AGED; ARTICLE; BRAIN LYMPHOMA; CENTRAL NERVOUS SYSTEM TUMOR; CHILD; CRANIOPHARYNGIOMA; DNA SEQUENCE; EPENDYMOMA; FEMALE; GENE MUTATION; GENETIC TRANSCRIPTION; GERM CELL TUMOR; HUMAN; HUMAN TISSUE; INFANT; MAJOR CLINICAL STUDY; MALE; NEURILEMOMA; NEUROECTODERM TUMOR; NEUROEPITHELIOMA; PINEAL BODY TUMOR; PRIORITY JOURNAL; SKULL TUMOR;

ADOLESCENT; ADULT; AGED; BASE SEQUENCE; BRAIN NEOPLASMS; CHILD; CHILD, PRESCHOOL; DNA MUTATIONAL ANALYSIS; EPENDYMOMA; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC TECHNIQUES; HUMANS; LYMPHOMA; MALE; MEDULLOBLASTOMA; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION; NEURILEMMOMA; NEUROCYTOMA; TERATOMA; TUMOR SUPPRESSOR PROTEIN P53; YEASTS;

EID: 0031888205     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010050800     Document Type: Article

References (29)

1. Adesina AM. Nalbantoglu J, Cavenee WK (1994) p53 gene mutation and mdm2 gene amplification are uncommon in medulloblastoma. Cancer Res 54: 5649-5651
2. Bergmann M, Blasius S, Bankfalvi A, Mellin W (1996) Primary non-Hodgkin lymphomas of the CNS-proliferation, oncoproteins and Epstein-Barr-virus. Gen Diagn Pathol 141: 235-242
3. Bögler O, Su Huang H-J, Kleihues P, Cavenee WK (1995) The p53 gene and its role in human brain tumors. Glia 15: 308-327
4. Cotton RGH (1993) Current methods of mutation detection. Mutat Res 285: 125-144
5. D obashi Y, Sugimura H, Sato A, Hirabayashi T, Kanda H, Kitagiiwii T, Kawaguchi N, Imamura T, Machinami R (1993) Possible association of p53 overexpression and mutation with high-grade chondrosarcoma. Diagn Mol Pathol 2: 257-263
6. Feng X, Zhang S, Ichikawa T, Koga H, Washiyama K, Motoyama T, Kumanishi T (1995) Intracranial germ cell tumors: detection of p53 gene umatations by sigle-strand conformation polymorphism analysis. Jpn J Cancer Res 86: 555-561
7. Flaman J-M, Frebourg T, Moreau V, Charbonnier F, Martin C, Chappuis P, Sappino A-P, Limacher, J-M, Brons L, Benhattar J, Tada M, Van Meir EG, Estreicher A, Iggo RD (1995) A simple p53 functional assay for screening cell lines, blood, and tumors. Proc Natl Acad Sci USA 92: 3963-3967
8. Hayakawa T, Takakura K, Abe H, Yoshimoto T, Tanaka R, Sugita K, Kikuchi H, Uozumi T, Hori T, Fukui H, Ushio Y, Nomura K, Matsutani M, Mohri N, Kumanishi T, Aozasa K, Nagashima K (1994) Primary central nervous system lymphoma in Japan - a retrospective, co-operative study by CNS-Lymphoma Study Group in Japan. J Neurooncol 19: 197-215
9. Hollstein M, Rice K, Greenblatt MS, Soussi T, Fuchs R, Sørlie T, Hovig E, Smith-Sorensen B, Montesano R, Harris CC (1994) Database of p53 gene somatic mutations in human tumors and cell lines. Nucleic Acids Res 22: 3551-3555
10. Hsieh L-L, Hsia C-F, Wang L-Y, Chen C-J, Ho Y-S (1994) p53 gene mutations in brain tumors in Taiwan. Cancer Lett 78:25-32
11. Ichikawa A, Hotta T, Takagi N, Tsushita K. Kinoshita T, Nagai H, Murakami Y,Hayashi K,Saito H (1992) Mutations of p53 gene and their relation to disease progression in B-cell lymphoma. Blood 79: 2702-2707
12. Kleihues P, Burger PC. Scheithauer BW (1993) Histological typing of tumours of the central nervous system. In: World Health Organization, International Histological Classification of Tumours. Springer, Berlin Heidelberg New York, pp 1-112
13. Koga H, Zhang S, Ichikawa T, Washiyama K, Kuroiwa T, Tanaka R, Kumanishi T (1994) Primary malignant lymphoma of the brain: demonstration of the p53 gene mutations by PCR-SSCP analysis and immunohisiochemistry. Brain Tumor Pathol 11: 151-155
14. Kovach JS, Hartmann A, Blaszyk H, Cunningham J, Schaid D, Sommer SS (1996) Mutation detection by highly sensitive methods indicates that p53 gene mutations in breast cancer can have important prognostic value. Proc Natl Acad Sci USA 93: 1093-1096
15. Louis DN (1994) The p53 gene and protein in human brain tumors. J Neuropathol Exp Neurol 53: 11-21
16. Metzger AK. Sheffield VC, Duyk G, Daneshvar L, Edwards MS, Cogen PH (1991) Identification of a germ-line mutation in the p53 gene in a patient with an intracranial epcndymonu. Proc Natl Acad Sci USA 88: 7825-7829
17. Ohgaki H, Eibl RH, Wiestler OD, Yasargil MG, Newcomb EW, Kleihues P (1991) p53 mutations in nonastrocytic human brain tumors. Cancer Res 51: 6202-6205
18. Ohgaki H, Eibl RH, Schwab M, Reichel MB, Mariuni L, Gehring M, Petersen I, Höll T, Wiestler OD, Kleihues P (1993) Mutations of the p53 tumor suppressor gene in neoplasms of the human nervous system. Mol Carcinog 8: 74-80
19. Orita M, Suzuki Y, Sekiya T, Hayashi K (1989) Rapid and sensitive detection of point mutations and DNA polymorphism using the polymerase chain reaction. Genomics 5: 874-879
20. Saylors RL III, Sidransky D, Friedman HS, Bigner SH, Bigner DD, Vogelstein B, Brodeur GM (1991) Infrequent p53 gene mutations in medulloblastomas. Cancer Res 51: 4721-4723
21. Shvarts A, Steegenga WT, Riteco N, Laar T van, Dekker P, Bazuine M, Ham RC van, Houven van Oordl W van der, Hateboer G, Eb AJ van der, Jochemsen AG ( 1996) Mdmx - a novel p53-binding protein with some functional properties of mdm2. EMBO J 15: 5349-5357
22. Sidransky D, Mikkelsen T, Schwechheimer K, Rosenblum ML, Cavanee W, Vogclstein B (1992) Clonal expansion of p53 mutant cells is associated with brain tumour progression. Nature 355: 846-847
23. Sure U, Ruedi D, Tachibana O, Yonekawa Y, Ohgaki H, Kleihues P, Hegi ME (1997) Determination of p53 mutations, egfr overexpression. and loss of p1i6 expression in pediatric glioblastomas. J Neuropathol Exp Neurol 56: 782-789
24. Szekely L, Selivanova G. Magnusson KP, Klein G, Wiman KG (1993) EBNA-5, an Epstein-Barr virus-encoded nuclear antigen, binds to the retinoblastoma and p53 proteins. Proc Natl Acad Sci USA 90: 5455-5459
25. Tada M, Iggo RD, Ishii N, Shinohe Y, Sakuma S, Estreicher A, Sawamura Y, Abe H (1996) Clonality and stability of the p53 gene in human astrocytic tumor cells - quantitative analysis of p53 gene mutations by yeast functional assay. Int J Cancer 67: 447-450
26. Tada M, Iggo RD, Waridel F, Nozaki M, Matsumoto R, Sawamura Y, Shinohe Y, Ikeda J, Abe H (1997) Reappraisal of p53 mutations in human malignant astrocytic neoplasms by p53 functional assay - comparison with conventional structural analyses. Mol Carcinog 18: 171-176
27. Tsumanuma I, Sato M, Okazaki H, Tanaka R, Wahiyama K, Kawasaki T, Kumanishi T (1995) The analysis of p53 tumor suppressor eene in pineal parenchymal tumors. Brain Tumor Pathol 12:39-43
28. Waridel F, Estreicher A, Bron L, Flaman JM, Fontolliet C, Monnier P, Frebourg T, Iggo R (1997) Field cancerisation and polyclonal p53 mutation in the upper aerodigestive tract. Oncogene 14: 163-169
29. Wu JK, Ye Z, Darras BT (1993) Frequency of p53 tumor suppressor gene mutations in human primary brain tumors. Neurosurgery 33: 824-831