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Volumn 32, Issue 4, 2000, Pages 195-206

Temporal relationship between immune cell influx and the expression of inducible nitric oxide synthase, interleukin-4 and interferon-γ in pancreatic islets of NOD mice following adoptive transfer of diabetic spleen cells

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 4; NITRIC OXIDE SYNTHASE;

EID: 0034041181     PISSN: 00182214     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1004084232446     Document Type: Article
Times cited : (8)

References (55)
  • 1
    • 0028026652 scopus 로고
    • Insulin-dependent diabetes mellitus as an autoimmune disease
    • Bach JF (1994) Insulin-dependent diabetes mellitus as an autoimmune disease. Endocr Rev 15: 516-542.
    • (1994) Endocr Rev , vol.15 , pp. 516-542
    • Bach, J.F.1
  • 3
    • 0027934873 scopus 로고
    • TNF-α and IFN-γ potentiate the deleterious effects of IL-1β on mouse pancreatic islets mainly via generation of nitric oxide
    • Cetkovic-Cvrlje M, Eizirik DL (1994) TNF-α and IFN-γ potentiate the deleterious effects of IL-1β on mouse pancreatic islets mainly via generation of nitric oxide. Cytokine 6: 399-406.
    • (1994) Cytokine , vol.6 , pp. 399-406
    • Cetkovic-Cvrlje, M.1    Eizirik, D.L.2
  • 4
    • 0024272635 scopus 로고
    • Administration of silica particles or anti-Lyt 2 antibody prevents β-cell destruction in NOD mice given cyclophosphamide
    • Charlton B, Bacelj A, Mandel TE (1988) Administration of silica particles or anti-Lyt 2 antibody prevents β-cell destruction in NOD mice given cyclophosphamide. Diabetes 37: 930-935.
    • (1988) Diabetes , vol.37 , pp. 930-935
    • Charlton, B.1    Bacelj, A.2    Mandel, T.E.3
  • 5
    • 0027489210 scopus 로고
    • Nitric oxide production in islets from nonobese diabetic mice: Aminoguanidine-sensitive and -resistant stages in the immunological diabetic process
    • Corbett JA, Mikhael A, Shimizu J, Frederick K, Misko TP, McDaniel ML, Kanagawa O, Unanue ER (1993) Nitric oxide production in islets from nonobese diabetic mice: aminoguanidine-sensitive and -resistant stages in the immunological diabetic process. Proc Natl Acad Sci USA 90: 8992-8995.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 8992-8995
    • Corbett, J.A.1    Mikhael, A.2    Shimizu, J.3    Frederick, K.4    Misko, T.P.5    McDaniel, M.L.6    Kanagawa, O.7    Unanue, E.R.8
  • 8
    • 0023520177 scopus 로고
    • Immunoreactive α-interferon in insulin-secreting β cells in type 1 diabetes mellitus
    • Foulis AK, Farquharson MA, Meager A (1987) Immunoreactive α-interferon in insulin-secreting β cells in type 1 diabetes mellitus. Lancet 2: 1423-1427.
    • (1987) Lancet , vol.2 , pp. 1423-1427
    • Foulis, A.K.1    Farquharson, M.A.2    Meager, A.3
  • 9
    • 0025951776 scopus 로고
    • Insulitis in type 1 (insulin-dependent) diabetes mellitus in man - Macrophages, lymphocytes, and interferon-γ containing cells
    • Foulis AK, Mcgill M, Farquharson MA (1991) Insulitis in type 1 (insulin-dependent) diabetes mellitus in man - macrophages, lymphocytes, and interferon-γ containing cells. J Histopathol 165: 97-103.
    • (1991) J Histopathol , vol.165 , pp. 97-103
    • Foulis, A.K.1    Mcgill, M.2    Farquharson, M.A.3
  • 11
    • 0026015364 scopus 로고
    • Expression of perforin and granzymes in vivo: Potential diagnostic markers for activated cytotoxic cells
    • Griffiths GM, Mueller C (1991) Expression of perforin and granzymes in vivo: Potential diagnostic markers for activated cytotoxic cells. Immunology Today 12: 415-419.
    • (1991) Immunology Today , vol.12 , pp. 415-419
    • Griffiths, G.M.1    Mueller, C.2
  • 12
    • 0021716386 scopus 로고
    • Promotion of spontaneous diabetes in non-obese diabetic-prone mice by cyclophosphamide
    • Harada M, Makino S (1984) Promotion of spontaneous diabetes in non-obese diabetic-prone mice by cyclophosphamide. Diabetolgia 27: 604-606.
    • (1984) Diabetolgia , vol.27 , pp. 604-606
    • Harada, M.1    Makino, S.2
  • 13
    • 0030456670 scopus 로고    scopus 로고
    • Aerosol insulin induces regulatory CD8 γδ T cells that prevent murine insulin-dependent diabetes
    • Harrison LC, Dempsey-Collier M, Kramer DR, Takahashi K (1996) Aerosol insulin induces regulatory CD8 γδ T cells that prevent murine insulin-dependent diabetes. J Exp Med 184: 2167-2174.
    • (1996) J Exp Med , vol.184 , pp. 2167-2174
    • Harrison, L.C.1    Dempsey-Collier, M.2    Kramer, D.R.3    Takahashi, K.4
  • 14
    • 0025230418 scopus 로고
    • Genes encoding tumour necrosis factor alpha and granzyme A are expressed during development of autoimmune diabetes
    • Held W, MacDonald HR, Weissman IL, Hess MW, Mueller C (1990) Genes encoding tumour necrosis factor alpha and granzyme A are expressed during development of autoimmune diabetes. Proc Natl Acad Sci USA 87: 2239-2243.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 2239-2243
    • Held, W.1    MacDonald, H.R.2    Weissman, I.L.3    Hess, M.W.4    Mueller, C.5
  • 15
    • 0028501432 scopus 로고
    • Islet expression of interferon-α precedes diabetes in both the BB rat and streptozotocin-treated mice
    • Huang X, Hultgren B, Dybdal N, Stewart TA (1994) Islet expression of interferon-α precedes diabetes in both the BB rat and streptozotocin-treated mice. Immunity 1: 469-478.
    • (1994) Immunity , vol.1 , pp. 469-478
    • Huang, X.1    Hultgren, B.2    Dybdal, N.3    Stewart, T.A.4
  • 17
    • 0029948898 scopus 로고    scopus 로고
    • Genetic absence of γ-inteferon delays but does not prevent diabetes in NOD mice
    • Hultgren B, Huang X, Dybdal N, Stewart TA (1996) Genetic absence of γ-inteferon delays but does not prevent diabetes in NOD mice. Diabetes 45: 812-817.
    • (1996) Diabetes , vol.45 , pp. 812-817
    • Hultgren, B.1    Huang, X.2    Dybdal, N.3    Stewart, T.A.4
  • 18
    • 0025647147 scopus 로고
    • Transfer of diabetes in mice prevented by blockade of adhesion-promoting receptor on macrophages
    • Hutchings P, Rosen H, O'Reilly L, Simpson E, Gordon S, Cooke A (1990) Transfer of diabetes in mice prevented by blockade of adhesion-promoting receptor on macrophages. Nature 348: 639-642.
    • (1990) Nature , vol.348 , pp. 639-642
    • Hutchings, P.1    Rosen, H.2    O'Reilly, L.3    Simpson, E.4    Gordon, S.5    Cooke, A.6
  • 19
    • 0028223127 scopus 로고
    • Immunohistochemical characterization of monocytes-macrophages and dendritic cells involved in the initiation of the insulitis and β-cell destruction in NOD mice
    • Jansen A, Homo-Delarche F, Hooijkaas H, Leenen PJ, Dardenne M, Drexhage HA (1994) Immunohistochemical characterization of monocytes-macrophages and dendritic cells involved in the initiation of the insulitis and β-cell destruction in NOD mice. Diabetes 43: 667-675.
    • (1994) Diabetes , vol.43 , pp. 667-675
    • Jansen, A.1    Homo-Delarche, F.2    Hooijkaas, H.3    Leenen, P.J.4    Dardenne, M.5    Drexhage, H.A.6
  • 20
    • 0025905091 scopus 로고
    • Characterization of pancreatic T lymphocytes associated with beta cell destruction in the non-obese diabetic (NOD) mouse
    • Kay TWH, Campbell IL, Harrison LC (1991) Characterization of pancreatic T lymphocytes associated with beta cell destruction in the non-obese diabetic (NOD) mouse. J Autoimmun 4: 263-276.
    • (1991) J Autoimmun , vol.4 , pp. 263-276
    • Kay, T.W.H.1    Campbell, I.L.2    Harrison, L.C.3
  • 21
    • 0026646694 scopus 로고
    • The murine autoimmune diabetes model: NOD and related strains
    • Kikutani H, Makino S (1992) The murine autoimmune diabetes model: NOD and related strains. Adv Immunol 51: 285-322.
    • (1992) Adv Immunol , vol.51 , pp. 285-322
    • Kikutani, H.1    Makino, S.2
  • 22
    • 17944384904 scopus 로고    scopus 로고
    • Sublytic concentrations of the membrane attack complex of complement induce endothelial interleukin-8 and monocyte chemoattractant protein-1 through nuclear factor-κ B activation
    • Kilgore KS, Schmid E, Shanley TP, Flory CM, Maheshwari V, Tramontini ML, Cohen H, Ward PA, Friedl HP, Warren JS (1997) Sublytic concentrations of the membrane attack complex of complement induce endothelial interleukin-8 and monocyte chemoattractant protein-1 through nuclear factor-κ B activation. Am J Pathol 150: 2019-2031.
    • (1997) Am J Pathol , vol.150 , pp. 2019-2031
    • Kilgore, K.S.1    Schmid, E.2    Shanley, T.P.3    Flory, C.M.4    Maheshwari, V.5    Tramontini, M.L.6    Cohen, H.7    Ward, P.A.8    Friedl, H.P.9    Warren, J.S.10
  • 23
    • 0027164671 scopus 로고
    • Transcription and translation of inducible nitric oxide synthase in the pancreas of prediabetic BB rats
    • Kleemann R, Rothe H, Kolb-Bachofen V, Xie Q-W, Nathan C, Martin S, Kolb H (1993) Transcription and translation of inducible nitric oxide synthase in the pancreas of prediabetic BB rats. FEBS Lett 328: 9-12.
    • (1993) FEBS Lett , vol.328 , pp. 9-12
    • Kleemann, R.1    Rothe, H.2    Kolb-Bachofen, V.3    Xie, Q.-W.4    Nathan, C.5    Martin, S.6    Kolb, H.7
  • 24
    • 0023864008 scopus 로고
    • Low dose streptozotocin-induced diabetes in mice. Electron microscopy reveals single-cell insulitis before diabetes onset
    • Kolb-Bachofen V, Epstein S, Kiesel U, Kolb H (1988) Low dose streptozotocin-induced diabetes in mice. Electron microscopy reveals single-cell insulitis before diabetes onset. Diabetes 37: 21-27.
    • (1988) Diabetes , vol.37 , pp. 21-27
    • Kolb-Bachofen, V.1    Epstein, S.2    Kiesel, U.3    Kolb, H.4
  • 25
    • 0024506159 scopus 로고
    • Regulation of lymphokine mRNA stability by a surface mediated T cell activation pathway
    • Lindsten T, June CH, Ledbetter JA, Stella G, Thompson CB (1989) Regulation of lymphokine mRNA stability by a surface mediated T cell activation pathway. Science 244: 339-343.
    • (1989) Science , vol.244 , pp. 339-343
    • Lindsten, T.1    June, C.H.2    Ledbetter, J.A.3    Stella, G.4    Thompson, C.B.5
  • 26
    • 0024385035 scopus 로고
    • Cytokines as immune effector molecules in autoimmune endocrine diseases with special reference to insulin-dependent diabetes mellitus
    • Mandrup-Poulsen T, Helqvist S, Molvig J, Wogensen LD, Nerup J (1989) Cytokines as immune effector molecules in autoimmune endocrine diseases with special reference to insulin-dependent diabetes mellitus. Autoimmunity 4: 191-218.
    • (1989) Autoimmunity , vol.4 , pp. 191-218
    • Mandrup-Poulsen, T.1    Helqvist, S.2    Molvig, J.3    Wogensen, L.D.4    Nerup, J.5
  • 28
    • 0024353079 scopus 로고
    • TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
    • Mossmann TR, Coffman RL (1989) TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties. Ann Rev Immunol 7: 145-173.
    • (1989) Ann Rev Immunol , vol.7 , pp. 145-173
    • Mossmann, T.R.1    Coffman, R.L.2
  • 29
    • 0028985199 scopus 로고
    • Accelerated β-cell destruction in adoptively transferred autoimmune diabetes correlates with an increased expression of the genes coding for TNF-α and granzyme A in the intra-islet infiltrates
    • Mueller C, Held W, Imboden MA, Carnaud C (1995) Accelerated β-cell destruction in adoptively transferred autoimmune diabetes correlates with an increased expression of the genes coding for TNF-α and granzyme A in the intra-islet infiltrates. Diabetes 44: 112-117.
    • (1995) Diabetes , vol.44 , pp. 112-117
    • Mueller, C.1    Held, W.2    Imboden, M.A.3    Carnaud, C.4
  • 30
    • 0032526840 scopus 로고    scopus 로고
    • Murine macrophages secrete interferon γ upon combined stimulation with interleukin (IL)-12 and IL-18: A novel pathway of autocrine macrophage activation
    • Munder M, Mallo M, Eichmann K, Modolell M (1998) Murine macrophages secrete interferon γ upon combined stimulation with interleukin (IL)-12 and IL-18: A novel pathway of autocrine macrophage activation. J Exp Med 187: 2103-2108.
    • (1998) J Exp Med , vol.187 , pp. 2103-2108
    • Munder, M.1    Mallo, M.2    Eichmann, K.3    Modolell, M.4
  • 31
    • 0030444632 scopus 로고    scopus 로고
    • The effects of a non-immunogenic form of murine soluble interferon-γ receptor on the development of autoimmune diabetes in the NOD mouse
    • Nicoletti F, Zaccone P, Di Marco R, Di Mauro M, Magro G, Grasso S, Mughini L, Meroni P, Garotta G (1996) The effects of a non-immunogenic form of murine soluble interferon-γ receptor on the development of autoimmune diabetes in the NOD mouse. Endocrinology 137: 5567-5575.
    • (1996) Endocrinology , vol.137 , pp. 5567-5575
    • Nicoletti, F.1    Zaccone, P.2    Di Marco, R.3    Di Mauro, M.4    Magro, G.5    Grasso, S.6    Mughini, L.7    Meroni, P.8    Garotta, G.9
  • 33
    • 0031127355 scopus 로고    scopus 로고
    • Monokine-producing cells predominate in the recruitment phase of NOD insulitis while cells producing Th1-type cytokines characterize the effector phase
    • Pilstrom B, Bjork L, Bohme J (1997) Monokine-producing cells predominate in the recruitment phase of NOD insulitis while cells producing Th1-type cytokines characterize the effector phase. J Autoimmun 10: 147-155.
    • (1997) J Autoimmun , vol.10 , pp. 147-155
    • Pilstrom, B.1    Bjork, L.2    Bohme, J.3
  • 34
    • 0000836601 scopus 로고
    • Roles of cytokines in IDDM pathogenesis and islet β-cell destruction
    • Rabinovitch A (1993) Roles of cytokines in IDDM pathogenesis and islet β-cell destruction. Diabetes Rev 1: 215-240.
    • (1993) Diabetes Rev , vol.1 , pp. 215-240
    • Rabinovitch, A.1
  • 35
    • 0031871335 scopus 로고    scopus 로고
    • An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus
    • Rabinovitch A (1998) An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus. Diabetes/Metab Rev 14: 129-151.
    • (1998) Diabetes/Metab Rev , vol.14 , pp. 129-151
    • Rabinovitch, A.1
  • 36
    • 0028989087 scopus 로고
    • IFN-γ gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in non-obese diabetic mice
    • Rabinovitch A, Suarez-Pinson WL, Sorensen O, Bleackley RC, Power RF (1995) IFN-γ gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in non-obese diabetic mice. J Immunol 154: 4874-4882.
    • (1995) J Immunol , vol.154 , pp. 4874-4882
    • Rabinovitch, A.1    Suarez-Pinson, W.L.2    Sorensen, O.3    Bleackley, R.C.4    Power, R.F.5
  • 37
    • 0030271678 scopus 로고    scopus 로고
    • Interleukin 12 mRNA expression in islets correlates with β-cell destruction in NOD mice
    • Rabinovitch A, Suarez-Pinson WL, Sorensen O (1996) Interleukin 12 mRNA expression in islets correlates with β-cell destruction in NOD mice. J Autoimmun 9: 645-651.
    • (1996) J Autoimmun , vol.9 , pp. 645-651
    • Rabinovitch, A.1    Suarez-Pinson, W.L.2    Sorensen, O.3
  • 38
    • 0023684290 scopus 로고
    • Ontogeny of islet cell antibodies, insulin autoantibodies and insulitis in the non-obese diabetic mouse
    • Reddy S, Bibby NJ, Elliott RB (1988a) Ontogeny of islet cell antibodies, insulin autoantibodies and insulitis in the non-obese diabetic mouse. Diabetologia 31: 322-328.
    • (1988) Diabetologia , vol.31 , pp. 322-328
    • Reddy, S.1    Bibby, N.J.2    Elliott, R.B.3
  • 39
    • 0023949740 scopus 로고
    • An immunofluorescent study of insulin-, glucagon-, pancreatic polypeptide-and somatostatin-containing cells in the early ovine fetal pancreas
    • Reddy S, Bibby NJ, Elliott RB (1988b) An immunofluorescent study of insulin-, glucagon-, pancreatic polypeptide-and somatostatin-containing cells in the early ovine fetal pancreas. Quart J Exp Physiol 73: 225-232.
    • (1988) Quart J Exp Physiol , vol.73 , pp. 225-232
    • Reddy, S.1    Bibby, N.J.2    Elliott, R.B.3
  • 40
    • 0026355309 scopus 로고
    • Time course of immune markers in the NOD mouse: Comparison between sexes and animals on an anti-diabetogenic diet
    • Reddy S, Bibby NJ, Elliott RB (1991) Time course of immune markers in the NOD mouse: Comparison between sexes and animals on an anti-diabetogenic diet. Diabetes Nutr & Metab Clin and Exp 4: 259-265.
    • (1991) Diabetes Nutr & Metab Clin and Exp , vol.4 , pp. 259-265
    • Reddy, S.1    Bibby, N.J.2    Elliott, R.B.3
  • 41
    • 0029063844 scopus 로고
    • Immunohistochemical analyses of pancreatic macrophages and CD4 and CD8 T cell subsets prior to and following diabetes in the NOD mouse
    • Reddy S, Wu D, Swinney C, Elliott RB (1995) Immunohistochemical analyses of pancreatic macrophages and CD4 and CD8 T cell subsets prior to and following diabetes in the NOD mouse. Pancreas 11: 16-25.
    • (1995) Pancreas , vol.11 , pp. 16-25
    • Reddy, S.1    Wu, D.2    Swinney, C.3    Elliott, R.B.4
  • 42
    • 0030905393 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase in pancreatic islets of the non-obese diabetic mouse: A light and confocal microscopical study of its ontogeny, co-localization and up-regulation following cytokine administration
    • Reddy S, Kaill S, Poole CA, Ross J (1997) Inducible nitric oxide synthase in pancreatic islets of the non-obese diabetic mouse: A light and confocal microscopical study of its ontogeny, co-localization and up-regulation following cytokine administration. Histochemical J 29: 53-64.
    • (1997) Histochemical J , vol.29 , pp. 53-64
    • Reddy, S.1    Kaill, S.2    Poole, C.A.3    Ross, J.4
  • 43
    • 0032781045 scopus 로고    scopus 로고
    • An immunohistochemical study of macrophage influx and the co-localization of inducible nitric oxide synthase in the pancreas of non-obese diabetic (NOD) mice during disease acceleration with cyclophosphamide
    • Reddy S, Yip S, Karanam M, Poole CA, Ross JM (1999) An immunohistochemical study of macrophage influx and the co-localization of inducible nitric oxide synthase in the pancreas of non-obese diabetic (NOD) mice during disease acceleration with cyclophosphamide. Histochemical J 31: 303-314.
    • (1999) Histochemical J , vol.31 , pp. 303-314
    • Reddy, S.1    Yip, S.2    Karanam, M.3    Poole, C.A.4    Ross, J.M.5
  • 44
    • 0027970206 scopus 로고
    • Cyclophosphamide treatment of female non-obese diabetic mice causes enhanced expression of inducible nitric oxide synthase and interferon-gamma, but not of interleukin-4
    • Rothe H, Faust A, Schade, U, Kleemann R, Bosse G, Hibino T, Martin S, Kolb H (1994) Cyclophosphamide treatment of female non-obese diabetic mice causes enhanced expression of inducible nitric oxide synthase and interferon-gamma, but not of interleukin-4. Diabetologia 37: 1154-1158.
    • (1994) Diabetologia , vol.37 , pp. 1154-1158
    • Rothe, H.1    Faust, A.2    Schade, U.3    Kleemann, R.4    Bosse, G.5    Hibino, T.6    Martin, S.7    Kolb, H.8
  • 45
    • 0029759337 scopus 로고    scopus 로고
    • β-cell destruction may be a late consequence of the autoimmune process in non-obese diabetic mice
    • Shimada, A, Charlton B, Taylor-Edwards C, Fathman CG (1996) β-cell destruction may be a late consequence of the autoimmune process in non-obese diabetic mice. Diabetes 45: 1063-1067.
    • (1996) Diabetes , vol.45 , pp. 1063-1067
    • Shimada, A.1    Charlton, B.2    Taylor-Edwards, C.3    Fathman, C.G.4
  • 47
    • 0031737908 scopus 로고    scopus 로고
    • α-Interferon inhibits the development of diabetes in NOD mice
    • Sobel DO, Ahvazi B (1998) α-Interferon inhibits the development of diabetes in NOD mice. Diabetes 47: 1867-1872.
    • (1998) Diabetes , vol.47 , pp. 1867-1872
    • Sobel, D.O.1    Ahvazi, B.2
  • 48
  • 49
    • 0027999706 scopus 로고
    • Administering glutamic acid decarboxylase to NOD mice prevents diabetes
    • Tisch R, Yang XD, Liblau RS, McDevitt HO (1994) Administering glutamic acid decarboxylase to NOD mice prevents diabetes. J Autoimmun 7: 845-850.
    • (1994) J Autoimmun , vol.7 , pp. 845-850
    • Tisch, R.1    Yang, X.D.2    Liblau, R.S.3    McDevitt, H.O.4
  • 51
    • 0032948046 scopus 로고    scopus 로고
    • Macrophages are a significant source of type 1 cytokines during mycobacterial infection
    • Wang J, Wakeham J, Harkness R, Xing Z (1999) Macrophages are a significant source of type 1 cytokines during mycobacterial infection. J Clin Invest 103: 1023-1029.
    • (1999) J Clin Invest , vol.103 , pp. 1023-1029
    • Wang, J.1    Wakeham, J.2    Harkness, R.3    Xing, Z.4
  • 52
    • 0028819008 scopus 로고
    • Comparison of mRNA contents of interleukin-1β and nitric oxide synthase in pancreatic islets isolated from female and male nonobese diabetic mice
    • Welsh M, Welsh N, Bendtzen K, Mares J, Strandell E, Oberg C, Sandler S (1995) Comparison of mRNA contents of interleukin-1β and nitric oxide synthase in pancreatic islets isolated from female and male nonobese diabetic mice. Diabetologia 38: 153-160.
    • (1995) Diabetologia , vol.38 , pp. 153-160
    • Welsh, M.1    Welsh, N.2    Bendtzen, K.3    Mares, J.4    Strandell, E.5    Oberg, C.6    Sandler, S.7
  • 53
    • 0022492875 scopus 로고
    • Transfer of autoimmune diabetes mellitus with splenocytes from nonobese diabetic (NOD) mice
    • Wicker LS, Miller BJ, Mullen Y (1986) Transfer of autoimmune diabetes mellitus with splenocytes from nonobese diabetic (NOD) mice. Diabetes 35: 855-860.
    • (1986) Diabetes , vol.35 , pp. 855-860
    • Wicker, L.S.1    Miller, B.J.2    Mullen, Y.3
  • 54
    • 0024817093 scopus 로고
    • In vivo expression of perforin by CD8 lymphocytes in autoimmune disease: Studies on spontaneous and adoptively transferred diabetes in nonobese diabetic mice
    • Young LHY, Peterson LB, Wicker LS, Persechini PM, Young JD (1989) In vivo expression of perforin by CD8 lymphocytes in autoimmune disease: Studies on spontaneous and adoptively transferred diabetes in nonobese diabetic mice. J Immunol 143: 3994-3999.
    • (1989) J Immunol , vol.143 , pp. 3994-3999
    • Young, L.H.Y.1    Peterson, L.B.2    Wicker, L.S.3    Persechini, P.M.4    Young, J.D.5


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