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Volumn 29, Issue 1, 1997, Pages 53-64

Inducible nitric oxide synthase in pancreatic islets of the non-obese diabetic mouse: A light and confocal microscopical study of its ontogeny, co-localization and up-regulation following cytokine administration

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1BETA; NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR ALPHA;

EID: 0030905393     PISSN: 00182214     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026416918339     Document Type: Article
Times cited : (18)

References (49)
  • 1
    • 0027934873 scopus 로고
    • TNF-α and IFN-γ potentiate the deleterious effects of IL-1β on mouse pancreatic islets mainly via generation of nitric oxide
    • CETKOVIC-CVRLJE, M. & EIZIRIK, D.L. (1994) TNF-α and IFN-γ potentiate the deleterious effects of IL-1β on mouse pancreatic islets mainly via generation of nitric oxide. Cytokine 6, 399-406.
    • (1994) Cytokine , vol.6 , pp. 399-406
    • Cetkovic-Cvrlje, M.1    Eizirik, D.L.2
  • 2
    • 0028236275 scopus 로고
    • Regulation of inducible nitric oxide synthase mRNA levels by LPS, INF-γ, TGF-β and IL-10 in murine macrophage cell lines and rat peritoneal macrophages
    • CHESROWN, S.E., MONNIER, J., VISNER, G. & NICK, H.S. (1994) Regulation of inducible nitric oxide synthase mRNA levels by LPS, INF-γ, TGF-β and IL-10 in murine macrophage cell lines and rat peritoneal macrophages. Biochem. Biophys. Res. Commun. 200, 126-34.
    • (1994) Biochem. Biophys. Res. Commun. , vol.200 , pp. 126-134
    • Chesrown, S.E.1    Monnier, J.2    Visner, G.3    Nick, H.S.4
  • 3
    • 0027489210 scopus 로고
    • Nitric oxide production in islets from nonobese diabetic mice: Aminoguanidine-sensitive and -resistant stages in the immunological diabetic process
    • CORBETT, J.A., MIKHAEL, A., SHIMIZU, J., FREDERICK, K., MISKO, T.P., MCDANIEL, M.L., KANAGAWA, O. & UNANUE, E.R. (1993a) Nitric oxide production in islets from nonobese diabetic mice: aminoguanidine-sensitive and -resistant stages in the immunological diabetic process. Proc. Natl. Acad. Sci. USA 90, 8992-5.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 8992-8995
    • Corbett, J.A.1    Mikhael, A.2    Shimizu, J.3    Frederick, K.4    Misko, T.P.5    Mcdaniel, M.L.6    Kanagawa, O.7    Unanue, E.R.8
  • 4
    • 0027534895 scopus 로고
    • Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans
    • CORBETT, J.A., SWEETLAND, M.A., WANG, J.L., LANCASTER, J.R. & MCDANIEL, M.L. (1993b) Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans. Proc. Natl. Acad. Sci. USA 90, 1731-5.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 1731-1735
    • Corbett, J.A.1    Sweetland, M.A.2    Wang, J.L.3    Lancaster, J.R.4    Mcdaniel, M.L.5
  • 5
    • 0028900805 scopus 로고
    • Intraislet release of interleukin 1 inhibits β cell function by inducing β cell expression of inducible nitric oxide synthase
    • CORBETT, J.A. & MCDANIEL, M.L. (1995) Intraislet release of interleukin 1 inhibits β cell function by inducing β cell expression of inducible nitric oxide synthase. J. Exp. Med. 181, 559-68.
    • (1995) J. Exp. Med. , vol.181 , pp. 559-568
    • Corbett, J.A.1    Mcdaniel, M.L.2
  • 6
    • 0027054055 scopus 로고
    • Interleukin 1β induces the formation of nitric oxide by β-cells purified from rodent islets of Langerhans. Evidence for the β-cell as a source and site of action of nitric oxide
    • CORBETT, J.A., WANG, J.L., SWEETLAND, M.A., LANCASTER, J.R. & MCDANIEL, M.L. (1992) Interleukin 1β induces the formation of nitric oxide by β-cells purified from rodent islets of Langerhans. Evidence for the β-cell as a source and site of action of nitric oxide. J. Clin. Invest. 90, 2384-91.
    • (1992) J. Clin. Invest. , vol.90 , pp. 2384-2391
    • Corbett, J.A.1    Wang, J.L.2    Sweetland, M.A.3    Lancaster, J.R.4    Mcdaniel, M.L.5
  • 7
    • 0030068610 scopus 로고    scopus 로고
    • Tumour necrosis factor-α and interferon-γ inhibit insulin secretion and cause DNA damage in unweaned-rat islets: Extent of nitric oxide involvement
    • DUNGER, A., CUNNINGHAM, J.M., DELANEY, C.A., LOWE, J.E., GREEN, M.H.L., BONE, A.J. & GREEN, I.C. (1996) Tumour necrosis factor-α and interferon-γ inhibit insulin secretion and cause DNA damage in unweaned-rat islets: extent of nitric oxide involvement. Diabetes 45, 183-9.
    • (1996) Diabetes , vol.45 , pp. 183-189
    • Dunger, A.1    Cunningham, J.M.2    Delaney, C.A.3    Lowe, J.E.4    Green, M.H.L.5    Bone, A.J.6    Green, I.C.7
  • 8
    • 0027406798 scopus 로고
    • Interleukin-1-induced expression of nitric oxide synthase in insulin-producing cells is preceded by c-fos induction and depends on gene transcription and protein synthesis
    • EIZIRIK, D.L., BJORKLUND, A. & WELSH, N. (1993) Interleukin-1-induced expression of nitric oxide synthase in insulin-producing cells is preceded by c-fos induction and depends on gene transcription and protein synthesis. FEBS Lett. 317, 62-6.
    • (1993) FEBS Lett. , vol.317 , pp. 62-66
    • Eizirik, D.L.1    Bjorklund, A.2    Welsh, N.3
  • 9
    • 0025230418 scopus 로고
    • Genes encoding tumour necrosis factor α and granzyme A are expressed during development of autoimmune diabetes
    • HELD, W., MACDONALD, H.R., WEISSMAN, I.L., HESS, M.W. & MUELLER, C. (1990) Genes encoding tumour necrosis factor α and granzyme A are expressed during development of autoimmune diabetes. Proc. Natl. Acad. Sci. USA 87, 2239-43.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 2239-2243
    • Held, W.1    Macdonald, H.R.2    Weissman, I.L.3    Hess, M.W.4    Mueller, C.5
  • 11
    • 0027771348 scopus 로고
    • Aminoguanidine, an inhibitor of nitric oxide formation, fails to protect against insulitis and hyperglycaemia induced by multiple low dose streptozotocin injections in mice
    • HOLSTAD, M. & SANDLER, S. (1993) Aminoguanidine, an inhibitor of nitric oxide formation, fails to protect against insulitis and hyperglycaemia induced by multiple low dose streptozotocin injections in mice. Autoimmunity 15, 311-14.
    • (1993) Autoimmunity , vol.15 , pp. 311-314
    • Holstad, M.1    Sandler, S.2
  • 12
    • 0028793469 scopus 로고
    • Cytokine-stimulated expression of inducible nitric oxide synthase by mouse, rat, and human osteoblast-like cells and its functional role in osteoblast metabolic activity
    • HUKKANEN, M., HUGHES, F.J., BUTTERY, L.D.K., GROSS, S.S., EVANS, T.J., SEDDON, S., RIVEROS-MORENO, V., MACINTYRE, I. & POLAK, J.M. (1995) Cytokine-stimulated expression of inducible nitric oxide synthase by mouse, rat, and human osteoblast-like cells and its functional role in osteoblast metabolic activity. Endocrinology 136, 5445-53.
    • (1995) Endocrinology , vol.136 , pp. 5445-5453
    • Hukkanen, M.1    Hughes, F.J.2    Buttery, L.D.K.3    Gross, S.S.4    Evans, T.J.5    Seddon, S.6    Riveros-Moreno, V.7    Macintyre, I.8    Polak, J.M.9
  • 13
    • 0028942160 scopus 로고
    • Localization and characterization of interleukin-1 receptors in the islets of Langerhans from control and nonobese diabetic mice
    • JAFARIAN-TEHRANI, M., AMRANI, A., HOMO-DELARCHE, F., MARQUETTE, C., DARDENNE, M. & HAOUR, F. (1995) Localization and characterization of interleukin-1 receptors in the islets of Langerhans from control and nonobese diabetic mice. Endocrinology 136, 609-13.
    • (1995) Endocrinology , vol.136 , pp. 609-613
    • Jafarian-Tehrani, M.1    Amrani, A.2    Homo-Delarche, F.3    Marquette, C.4    Dardenne, M.5    Haour, F.6
  • 15
    • 0025817159 scopus 로고
    • Cytokine gene expression in the islets of the diabetic biobreeding/Worcester rat
    • JIANG, Z. & WODA, B.A. (1991) Cytokine gene expression in the islets of the diabetic biobreeding/Worcester rat. J. Immunol. 146, 2990-4.
    • (1991) J. Immunol. , vol.146 , pp. 2990-2994
    • Jiang, Z.1    Woda, B.A.2
  • 16
    • 0026753125 scopus 로고
    • Toxicity of chemically generated nitric oxide towards pancreatic islet cells can be prevented by nicotinamide
    • KALLMANN, B., BURKART, V., KKONCKE, K-D., KOLBBACHOVEN, v. & KOLB, H. (1992) Toxicity of chemically generated nitric oxide towards pancreatic islet cells can be prevented by nicotinamide. Life Sci. 51, 671-8.
    • (1992) Life Sci. , vol.51 , pp. 671-678
    • Kallmann, B.1    Burkart, V.2    Kkoncke, K.-D.3    Kolbbachoven, V.4    Kolb, H.5
  • 19
  • 20
    • 0027164671 scopus 로고
    • Transcription and translation of inducible nitric oxide synthase in the pancreas of prediabetic BB rats
    • KLEEMANN, R., ROTHE, H., KOLB-BACHOFEN, V., XIE, Q-W., NATHAN, C., MARTIN, S. & KOLB, H. (1993) Transcription and translation of inducible nitric oxide synthase in the pancreas of prediabetic BB rats. FEBS Lett. 328, 9-12.
    • (1993) FEBS Lett. , vol.328 , pp. 9-12
    • Kleemann, R.1    Rothe, H.2    Kolb-Bachofen, V.3    Xie, Q.-W.4    Nathan, C.5    Martin, S.6    Kolb, H.7
  • 21
    • 0000435224 scopus 로고
    • Suppression of low dose streptozotocin induced diabetes in mice by administration of a nitric oxide synthase inhibitor
    • KOLB, H., KIESEL, V., KRONCKE, K-D. & KOLB-BACHOVEN, V. (1991) Suppression of low dose streptozotocin induced diabetes in mice by administration of a nitric oxide synthase inhibitor. Life Sci. 49, 213-17.
    • (1991) Life Sci. , vol.49 , pp. 213-217
    • Kolb, H.1    Kiesel, V.2    Kroncke, K.-D.3    Kolb-Bachoven, V.4
  • 22
    • 0009643387 scopus 로고
    • Cytokine-activated capillary-forming islet endothelial cells lyse beta-cells via nitric oxide generation
    • KRONCKE, K., STEINER, L., FEHSEL, K. & KOLB-BACHOFEN, v. (1995) Cytokine-activated capillary-forming islet endothelial cells lyse beta-cells via nitric oxide generation. Autoimmunity 21, 42.
    • (1995) Autoimmunity , vol.21 , pp. 42
    • Kroncke, K.1    Steiner, L.2    Fehsel, K.3    Kolb-Bachofen, V.4
  • 24
  • 26
    • 0024385035 scopus 로고
    • Cytokines as immune effector molecules in autoimmune endocrine diseases with special reference to insulin-dependent diabetes mellitus
    • MANDRUP-POULSEN, T., HELQVIST, S., MOLVIG, J., WOGENSEN, L.D & NERUP, J. (1989) Cytokines as immune effector molecules in autoimmune endocrine diseases with special reference to insulin-dependent diabetes mellitus. Autoimmunity 4, 191-218.
    • (1989) Autoimmunity , vol.4 , pp. 191-218
    • Mandrup-Poulsen, T.1    Helqvist, S.2    Molvig, J.3    Wogensen, L.D.4    Nerup, J.5
  • 28
    • 0025883342 scopus 로고
    • Nitric oxide: Physiology, pathophysiology, and pharmacology
    • MONCADA, S., PALMER, R.M.J. & HIGGS, E.A. (1991) Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43, 109-42.
    • (1991) Pharmacol. Rev. , vol.43 , pp. 109-142
    • Moncada, S.1    Palmer, R.M.J.2    Higgs, E.A.3
  • 29
    • 0026651708 scopus 로고
    • Heterogeneity in pancreatic β-cell population
    • PIPELEERS, D.G. (1992) Heterogeneity in pancreatic β-cell population. Diabetes 41, 777-81.
    • (1992) Diabetes , vol.41 , pp. 777-781
    • Pipeleers, D.G.1
  • 30
    • 0029989197 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase (iNOS) in pancreatic islets of nonobese diabetic mice: Identification of iNOS expressing cells and relationships to cytokines expressed in the islets
    • RABINOVITCH, A., SUAREZ-PINZON, W.L., SORENSEN, O. & BLEACKLEY, R.C. (1996) Inducible nitric oxide synthase (iNOS) in pancreatic islets of nonobese diabetic mice: identification of iNOS expressing cells and relationships to cytokines expressed in the islets. Endocrinology 137, 2093-9.
    • (1996) Endocrinology , vol.137 , pp. 2093-2099
    • Rabinovitch, A.1    Suarez-Pinzon, W.L.2    Sorensen, O.3    Bleackley, R.C.4
  • 31
    • 0023684290 scopus 로고
    • Ontogeny of islet cell antibodies, insulin autoantibodies and insulitis in the non-obese diabetic mouse
    • REDDY, S., BIBBY, N.J. & ELLIOTT, R.B. (1988) Ontogeny of islet cell antibodies, insulin autoantibodies and insulitis in the non-obese diabetic mouse. Diabetologia 31, 322-8.
    • (1988) Diabetologia , vol.31 , pp. 322-328
    • Reddy, S.1    Bibby, N.J.2    Elliott, R.B.3
  • 32
    • 0027209814 scopus 로고
    • Distribution of pancreatic macrophages preceding and during insulitis in young NOD mice
    • REDDY S., LIU, W. & ELLIOTT, R.B. (1993) Distribution of pancreatic macrophages preceding and during insulitis in young NOD mice. Pancreas 8, 602-8.
    • (1993) Pancreas , vol.8 , pp. 602-608
    • Reddy, S.1    Liu, W.2    Elliott, R.B.3
  • 33
    • 0028906729 scopus 로고
    • Long-term effects of nicotinamide-induced inhibition of poly(adenosine diphosphate-ribose) polymerase activity in rat pancreatic islets exposed to interleukin-1β
    • REDDY, S., SALARI-LAK, N. & SANDLER, S. (1995a) Long-term effects of nicotinamide-induced inhibition of poly(adenosine diphosphate-ribose) polymerase activity in rat pancreatic islets exposed to interleukin-1β. Endocrinology 136, 1907-12.
    • (1995) Endocrinology , vol.136 , pp. 1907-1912
    • Reddy, S.1    Salari-Lak, N.2    Sandler, S.3
  • 34
    • 0029063844 scopus 로고
    • Immunohistochemical analyses of pancreatic macrophages and CD4 and CD8 T cell subsets prior to and following diabetes in the NOD mouse
    • REDDY, S., WU, D., SWINNEY, C. & ELLIOTT, R.B. (1995b) Immunohistochemical analyses of pancreatic macrophages and CD4 and CD8 T cell subsets prior to and following diabetes in the NOD mouse. Pancreas 11, 16-25.
    • (1995) Pancreas , vol.11 , pp. 16-25
    • Reddy, S.1    Wu, D.2    Swinney, C.3    Elliott, R.B.4
  • 35
    • 0029940012 scopus 로고    scopus 로고
    • Glutamic acid decarboxylase 65 and 67 isoforms in fetal, neonatal and adult porcine islets: Predominant beta cell co-localization by light and confocal microscopy
    • REDDY, S., WU, D. & POOLE, C.A. (1996) Glutamic acid decarboxylase 65 and 67 isoforms in fetal, neonatal and adult porcine islets: predominant beta cell co-localization by light and confocal microscopy. J. Autoimmun. 9, 21-7.
    • (1996) J. Autoimmun. , vol.9 , pp. 21-27
    • Reddy, S.1    Wu, D.2    Poole, C.A.3
  • 36
    • 0027970206 scopus 로고
    • Cyclophosphamide treatment of female non-obese diabetic mice causes enhanced expression of inducible nitric oxide synthase and interferon-gamma, but not of interleukin-4
    • ROTHE, H., FAUST, A., SCHADE, U., KLEEMANN, R., BOSSE, G., HIBINO, T., MARTIN, S. & KOLB, H. (1994) Cyclophosphamide treatment of female non-obese diabetic mice causes enhanced expression of inducible nitric oxide synthase and interferon-gamma, but not of interleukin-4. Diabetologia 37, 1154-8.
    • (1994) Diabetologia , vol.37 , pp. 1154-1158
    • Rothe, H.1    Faust, A.2    Schade, U.3    Kleemann, R.4    Bosse, G.5    Hibino, T.6    Martin, S.7    Kolb, H.8
  • 37
    • 0023203183 scopus 로고
    • Inhibitory effects of interleukin-1 on insulin secretion, insulin biosynthesis, and oxidative metabolism of isolated rat pancreatic islets
    • SANDLER, S., ANDERSSON, A. & HELLERSTROM, C. (1987) Inhibitory effects of interleukin-1 on insulin secretion, insulin biosynthesis, and oxidative metabolism of isolated rat pancreatic islets. Endocrinology 121, 1424-31.
    • (1987) Endocrinology , vol.121 , pp. 1424-1431
    • Sandler, S.1    Andersson, A.2    Hellerstrom, C.3
  • 39
    • 0024312829 scopus 로고
    • The natural history of lymphocyte subsets infiltrating the pancreas of NOD mice
    • SIGNORE, A., POZZILLI, P., GALE, E.A.M., ANDREANI, D. & BEVERLEY, P.C.L. (1989) The natural history of lymphocyte subsets infiltrating the pancreas of NOD mice. Diabetologia 32, 282-9.
    • (1989) Diabetologia , vol.32 , pp. 282-289
    • Signore, A.1    Pozzilli, P.2    Gale, E.A.M.3    Andreani, D.4    Beverley, P.C.L.5
  • 40
    • 0025685395 scopus 로고
    • Inhibition of insulin secretion by interleukin-1β and tumour necrosis factor-α by an L-arginine-dependent nitric oxide generating mechanism
    • SOUTHERN, C., SCHULSTER, D. & GREEN, I.C. (1990) Inhibition of insulin secretion by interleukin-1β and tumour necrosis factor-α by an L-arginine-dependent nitric oxide generating mechanism. FEBS Lett. 276, 42-4.
    • (1990) FEBS Lett. , vol.276 , pp. 42-44
    • Southern, C.1    Schulster, D.2    Green, I.C.3
  • 41
    • 0029093835 scopus 로고
    • Effects of prolonged exposure in vitro to interferon-γ and tumour necrosis factor-α on nitric oxide and insulin production of rat pancreatic islets
    • STERNESJO, J., BENDTZEN, K. & SANDLER, S. (1995) Effects of prolonged exposure in vitro to interferon-γ and tumour necrosis factor-α on nitric oxide and insulin production of rat pancreatic islets. Autoimmunity 20, 185-90.
    • (1995) Autoimmunity , vol.20 , pp. 185-190
    • Sternesjo, J.1    Bendtzen, K.2    Sandler, S.3
  • 42
    • 0028258386 scopus 로고
    • Mechanisms of cytokine-induced destruction of rat insulinoma cells: The role of nitric oxide
    • SUAREZ-PINZON, W.L., STRYNADKA, K., SCHULZ, R. & RABINOVITCH, A. (1994) Mechanisms of cytokine-induced destruction of rat insulinoma cells: the role of nitric oxide. Endocrinology 134, 1006-10.
    • (1994) Endocrinology , vol.134 , pp. 1006-1010
    • Suarez-Pinzon, W.L.1    Strynadka, K.2    Schulz, R.3    Rabinovitch, A.4
  • 43
    • 0025373999 scopus 로고
    • Islets of Langerhans: The puzzle of intraislet interactions and their relevance to diabetes
    • WEIR, G.C. & BONNER-WEIR, S. (1990) Islets of Langerhans: the puzzle of intraislet interactions and their relevance to diabetes. J. Clin. Invest. 85, 983-7.
    • (1990) J. Clin. Invest. , vol.85 , pp. 983-987
    • Weir, G.C.1    Bonner-Weir, S.2
  • 44
    • 0025833992 scopus 로고
    • Interleukin-1β induced nitric oxide production in isolated rat pancreatic islets requires gene transcription and may lead to inhibition of the Krebs cycle enzyme, aconitase
    • WELSH, N., EIZIRIK, D.L., BENDTZEN, K. & SANDLER, S. (1991) Interleukin-1β induced nitric oxide production in isolated rat pancreatic islets requires gene transcription and may lead to inhibition of the Krebs cycle enzyme, aconitase. Endocrinology 129, 3167-73.
    • (1991) Endocrinology , vol.129 , pp. 3167-3173
    • Welsh, N.1    Eizirik, D.L.2    Bendtzen, K.3    Sandler, S.4
  • 45
    • 0028054338 scopus 로고
    • Nitric oxide and pancreatic β-cell destruction in insulin dependent diabetes mellitus: Don't take NO for an answer
    • WELSH, N., EIZIRIK, D.L. & SANDLER, S. (1994) Nitric oxide and pancreatic β-cell destruction in insulin dependent diabetes mellitus: don't take NO for an answer. Autoimmunity 18, 285-90.
    • (1994) Autoimmunity , vol.18 , pp. 285-290
    • Welsh, N.1    Eizirik, D.L.2    Sandler, S.3
  • 46
    • 0028819008 scopus 로고
    • Comparison of mRNA contents of interleukin-1β and nitric oxide synthase in pancreatic islets isolated from female and male nonobese diabetic mice
    • WELSH, M., WELSH, N., BENDTZEN, K., MARES, J., STRANDELL, E., OBERG, C. & SANDLER, S. (1995) Comparison of mRNA contents of interleukin-1β and nitric oxide synthase in pancreatic islets isolated from female and male nonobese diabetic mice. Diabetologia 38, 153-60.
    • (1995) Diabetologia , vol.38 , pp. 153-160
    • Welsh, M.1    Welsh, N.2    Bendtzen, K.3    Mares, J.4    Strandell, E.5    Oberg, C.6    Sandler, S.7
  • 47
    • 0028876449 scopus 로고
    • Nitric oxide in physiology and pathology
    • WHITTLE, B.J.R. (1995) Nitric oxide in physiology and pathology. Histochem. J. 27, 727-37.
    • (1995) Histochem. J. , vol.27 , pp. 727-737
    • Whittle, B.J.R.1
  • 48
    • 0028956376 scopus 로고
    • G-monomethyl-L-arginine on the onset of diabetes in the spontaneously diabetic BB rat
    • G-monomethyl-L-arginine on the onset of diabetes in the spontaneously diabetic BB rat. Diabetes 44, 360-4.
    • (1995) Diabetes , vol.44 , pp. 360-364
    • Wu, G.1


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