Human immunodeficiency virus (HIV)-positive sera obtained shortly after seroconversion neutralize autologous HIV type 1 isolates on primary macrophages but not on lymphocytes

Journal of Virology

Volumn 74, Issue 12, 2000, Pages 5403-5411

  Ruppach, Horst ^a,d   Nara, Peter ^b   Raudonat, Ina ^a   Elanjikal, Ziju ^a   Rübsamen Waigmann, Helga ^c   Dietrich, Ursula ^a  

^a INSTITUTE FOR TUMOR BIOLOGY AND EXPERIMENTAL THERAPY   (Germany)

^b Biological Mimetics Inc   (United States)

^c BAYER AG   (Germany)

^d Analysis GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

NEUTRALIZING ANTIBODY;

ANTIBODY TITER; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE; MACROPHAGE; PRIORITY JOURNAL; SEROCONVERSION; VIRUS NEUTRALIZATION; VIRUS REPLICATION;

CELLS, CULTURED; COCULTURE TECHNIQUES; FEMALE; GIANT CELLS; HIV ANTIBODIES; HIV ENVELOPE PROTEIN GP120; HIV INFECTIONS; HIV-1; HUMANS; IMMUNOGLOBULIN G; LYMPHOCYTES; MACROPHAGE INFLAMMATORY PROTEIN-1; MACROPHAGES; MALE; MONOCYTES; NEUTRALIZATION TESTS; RANTES; TIME FACTORS; VIRAL LOAD; VIREMIA; VIRUS REPLICATION;

EID: 0034039811     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.12.5403-5411.2000     Document Type: Article

References (59)

1. Baldinotti, F., D. Matteucci, P. Mazzetti, C. Giannelli, P. Bandecchi, F. Tozzini, and M. Bendinelli. 1994. Serum neutralization of feline immunodeficiency virus is markedly dependent on passage history of the virus and host system. J. Virol. 68:4572-4579.
2. Binley, J. M., P. J. Klasse, Y. Z. Cao, I. Jones, M. Markowitz, D. D. Ho, and J. P. Moore. 1947. Differential regulation of the antibody responses to Gag and Env proteins of human immunodeficiency virus type 1. J. Virol. 71: 2799-2809.
3. Bleul, C. C., L. Wu, J. A. Hoxie, T. A. Springer, and C. R. Mackay. 1997. The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. Proc. Natl. Acad. Sci. USA 94:1925-1930.
4. + cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. J. Virol. 68:6103-6110.
5. Chang, J., H. M. Naif, S. Li, J. S. Sullivan, C. M. Randle, and A. L. Cunningham. 1996. Twin studies demonstrate a host cell genetic effect on productive human immunodeficiency virus infection of human monocytes and macrophages in vitro. J. Virol. 70:7792-7803.
6. Choe, H., M. Farzan, Y. Sun, N. Sullivan, B. Rollins, P. D. Ponath, L. Wu, C. R. Mackay, G. LaRosa, W. Newman, N. Gerard, C. Gerard, and J. Sodroski. 1996. The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 85:1135-1148.
7. + T cells. Science 270:1811-1815.
8. Daar, E. S., T. Moudgil, A. D. Meyer, and D. D. Ho. 1991. Transient high levels of viremia in patients with primary human immunodeficiency virus type 1 infection. N. Engl. J. Med. 324:961-964.
9. Delwart, E. L., H. W. Sheppard, B. D. Walker, J. Goudsmit, and J. I. Mullins. 1994. Human immunodeficiency virus type 1 evolution in vivo tracked by DNA heteroduplex mobility assays. J. Virol. 68:6672-6683.
10. Dietrich, U., H. Ruppach, S. Gehring, H. Knechten, M. Knickmann, H. Jäger, E. Wolf, R. Husak, C. E. Orfanos, H. D. Brede, H. Rübsamen-Waigmann, and H. von Briesen. 1997. Large proportion of non-B HIV-1 subtypes and presence of zidovudine resistance mutations among German seroconverters. AIDS 11:1532-1533.
11. Doranz, B. J., J. Rucker, Y. Yi, R. J. Smyth, M. Samson, S. C. Peoper, M. Parmentier, R. G. Collman, and R. W. Doms. 1996. A dual-tropic primary HIV-1 isolate that uses fusin and the β-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell 85:1149-1158.
12. Esser, R., W. Glienke, H. von Briesen, H. Rübsamen-Waigmann, and R. Andreesen. 1996. Differential regulation of proinflammatory and hematopoietic cytokines in human macrophages after infection with HIV. Blood 88: 3474-3481.
13. Farzan, M., T. Mirzabekov, P. Kolchinsky, R. Wyatt, M. Cayabyab, N. P. Gerard, C. Gerard, J. Sodroski, and H. Choe. 1999. Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry. Cell 96:667-676.
14. Fenyö, E. M., L. Morfeldt-Manson, F. Chiodi, B. Lind, A. von Gegerfelt, J. Albert, E. Olausson, and B. Asjo. 1988. Distinct replicative and cytopathic characteristics of human immunodeficiency virus isolates. J. Virol. 62:4414-4419.
15. Gartner, S., P. Markovitz, and D. M. Markovitz. 1986. The role of mononuclear phagocytes in HTLV-III/LAV infection. Science 233:215-219.
16. Gehring, S., S. Maayan, H. Ruppach, P. Balfe, J. Juraszczyk, I. Yust, N. Vardinon, A. Rimlawi, S. Polak, Z. Bentwich, H. Rübsamen-Waigmann, and U. Dietrich. 1997. Molecular epidemiology of HIV in Israel. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 15:296-303.
17. Gendelman, H. E., J. M. Orenstein, L. M. Baca, B. Weiser, H. Burger, D. C. Kalter, and M. S. Meltzer. 1989. The macrophage in the persistence and pathogenesis of HIV-1 infection. AIDS 3:475-495.
18. Hill, C. M., D. Kwon, M. Jones, C. B. Davis, S. Marmon, B. L. Daugherty, J. A. DeMartino, M. S. Springer, D. Unutmaz, and D. R. Littman. 1998. The amino terminus of human CCR5 is required for its function as receptor for diverse human and simian immunodeficiency virus envelope glycoproteins. Virology 248:357-371.
19. Housset, C., O. Boucher, P. M. Girard, J. Leibowitch, A. G. Saimot, C. Brechot, and C. Marche. 1990. Immunohistochemical evidence for human immunodeficiency virus-1 infection of liver Kupffer cells. Hum. Pathol. 21: 404-408.
20. Kärber, G. 1931. Beitrag zur kollektiven Behandlung pharmakologischer Reihenversuche. Naunyn-Schmiedebergs Arch. Exp. Pathol. Pharmakol. 152:380.
21. Karlsson, A., K. Parsmyr, E. Sandström, E. M. Fenjö, and J. Albert. 1994. MT-2 cell tropism as a prognostic marker for disease progression in HIV-1 infection. J. Clin. Microbiol. 32:364-370.
22. Koenig, S., H. E. Gendelman, J. M. Orenstein, M. C. dal Canto, G. H. Pezeshkpour, M. Yungbluth, R. Janota, A. Aksamed, M. A. Martin, and A. S. Fauci. 1986. Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science 233:1089.
23. Koup, R. A., J. T. Safrit, Y. Z. Cao, C. A. Andrews, G. McLeod, W. Borkowsky, C. Farthing, and D. D. Ho. 1994. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J. Virol. 68:4650-4655.
24. Kühnel, H., H. von Briesen, U. Dietrich, M. Adamski, D. Mix, L. Biesert, R. Kreutz, A. Immelmann, K. Henco, C. Meichsner, R. Andreesen, H. Gelderblom, and H. Rübsamen-Waigmann. 1989. Molecular cloning of two West African human immunodeficiency virus type 2 isolates that replicate well on macrophages: a Gambian isolate, from a patient with neurologic acquired immunodeficiency syndrome and a highly divergent Ghanian isolate. Proc. Natl. Acad. Sci. USA 86:2383-2387.
25. Mackewitz, C. E., L. C. Yang, J. D. Lifson, and J. A. Levy. 1994. Non cytolylic CD8 T-cell anti-HIV responses in primary HIV-1 infection. Lancet 344: 1671-1673.
26. Marzio, P. D., J. Tse, and N. R. Landau. 1998. Chemokine receptor regulation and HIV type 1 tropism in monocyte-macrophages. AIDS Res. Hum. Retrovir. 14:129-138.
27. Mellors, J. W., C. R. Rinaldo, Jr., P. Gupta, R. M. White, J. A. Todd, and L. A. Kingsley. 1996. Prognosis in HIV-1 infection predicted by the quantity of virus in plasma. Science 272:1167-1170.
28. Meyerhans, A., R. Cheynier, J. Albert, M. Seth, S. Kwok, J. Sninsky, L. Morfeldt-Manson, B. Asjo, and S. Wain-Hobson. 1989. Temporal fluctuations in HIV quasispecies in vivo are not reflected by sequential HIV isolates. Cell 58:901-910.
29. Milman, G., and O. Sharma. 1994. Mechanisms of HIV/SIV mucosal transmission. AIDS Res. Hum. Retovir. 10:1305-1312.
30. Moog, C., H. J. A. Fleury, I. Pellegrin, A. Kirn, and A. M. Aubertin. 1997. Autologous and heterologous neutralizing antibody responses following initial seroconversion in human immunodeficiency virus type 1-infected individuals. J. Virol. 71:3734-3741.
31. Moore, J. P., Y. Z. Cao, D. D. Ho, and R. A. Koup. 1994. Development of the anti-gp120 antibody response during seroconversion to human immunodeficiency virus type 1. J. Virol. 68:5142-5155.
32. Moriuchi, H., M. Moriuchi, C. Combadiere, P. Murphy, and A. S. Fauci. 1996. CD8+ T-cell derived soluble factors, but not β-chemokines RANTES, MIP-1α and MIP-1β, suppress HIV-1 replication in monocyte/macrophages. Proc. Natl. Acad. Sci. USA 93:15341-15345.
33. Olson, W. C., G. E. E. Rabut, K. A. Nagashima, D. N. H. Tran, D. J. Anselma, S. P. Monard, J. P. Segal, D. A. D. Thompson, F. Kajumo, Y. Guo, J. P. Moore, P. J. Maddon, and T. Dragic. 1999. Differential inhibition of human immunodeficiency virus type 1 fusion, gp120 binding, and CC-chemokine activity by monoclonal antibodies to CCR5. J. Virol. 73:4145-4155.
34. Rübsamen-Waigmann, H., H. von Briesen, H. Holmes, A. Bjorndal, B. Korber, R. Esser, S. Ranjbar, P. Tomlinson, B. Galvao-Castro, E. Karita, et al. 1994. Standard conditions of virus isolation reveal biological variability of HIV type 1 in different regions of the world. AIDS Res. Hum. Retrovir. 10: 1401-1408.
35. Rübsamen-Waigmann, H., W. R. Willems, U. Bertram, and H. von Briesen. 1989. Reversal of HIV-phenotype to fulminant replication on macrophages in perinatal transmission. Lancet ii:1155-1156.
36. Rübsamen-Waigmann, H., W. B. Becker, E. B. Helm, R. Brodt, H. Fischer, K. Henco, and H. D. Brede. 1986. Isolation of variants of lymphocytopathic retroviruses from the peripheral blood and cerebrospinal fluid of patients with ARC or AIDS. J. Med. Virol. 19:335-344.
37. Sattentau, Q. J. 1996. Neutralization of HIV-1 by antibody. Curr. Opin. Immunol. 8:540-545.
38. Scarlatti, G., E. Tresoldi, A. Bjorndal, R. Fredriksson, C. Colognesi, H. K. Dend, M. S. Malnati, A. Plebani, A. G. Siccardi, D. R. Littman, E. M. Fenyö, and P. Lusso. 1997. In vivo evolution of HIV-1 coreceptor usage and sensitivity to chemokine-mediated suppression. Nat. Med. 3:1259-1265.
39. Shioda, T., J. A. Levy, and C. Cheng-Mayer. 1992. Small amino acid changes in the V3 hypervariable region of gp120 can affect the T-cell line and macrophage tropism of human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. USA 15:9434-9438.
40. Shpaer, E. G., E. L. Delwart, C. L. Kuiken, J. Goudsmit, M. H. Bachmann, and J. Mullins. 1994. Conserved V3 loop sequences and transmission of human immunodeficiency virus type 1. AIDS Res. Hum. Retrovir. 10:1679-1684.
41. Simmons, G., P. R. Clapham, L. Picard, R. E. Offord, M. M. Rosenkilde, T. W. Schwartz, R. Buser, T. N. C. Wells, and A. E. I. Proudfoot. 1997. Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist. Science 276:276-279.
42. Simmons, G., D. Wilkinson, J. D. Reeves, M. T. Dittmar, S. Beddows, J. Weber, G. Carnegie, U. Desselberger, P. W. Gray, R. A. Weiss, and P. R. Clapham. 1996. Primary, syncytium-inducing human immunodeficiency virus type 1 isolates are dual-tropic and must can use either Lestr or CCR5 as coreceptors for virus entry. J. Virol. 70:8355-8360.
43. Smith, P. D., G. Meng, G. M. Shaw, and L. Li. 1997. Infection of gastrointestinal tract macrophages by HIV-1. J. Leukoc. Biol. 62:72-77.
44. Spearman, C. 1908. The method of "right or wrong cases" (constant stimuli) without Gauss's formulae. Br. J. Psychol. 2:227.
45. Spira, A. I., and D. D. Ho. 1995. Effect of different donor cells on human immunodeficiency virus type 1 replication and selection in vitro. J. Virol. 69: 422-429.
46. Stamatatos, L., S. Zolla-Pazner, M. K. Gorny, and C. Cheng-Mayer. 1997. Binding of antibodies to virion-associaled gp120 molecules of primary-like human immunodeficiency virus type 1 (HIV-1) isolates: effect on HIV-1 infection of macrophages and peripheral blood mononuclear cells. Virology 229:360-369.
47. Toossi, Z., K. Nicolacakis, L. Xia, N. A. Ferrari, and E. A. Rich. 1997. Activation of latent HIV-1 by Mycobacterium tuberculosis and its purified protein derivative in alveolar macrophages from HIV-1 infected individuals in vitro. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 15:325-331.
48. Trkola, A., W. A. Paxton, S. P. Monard, J. A. Hoxie, M. A. Siani, D. A. Thompson, L. Wu, C. R. Mackay, R. Horuk, and J. Moore. 1998. Genetic subtype-independent inhibition of human immunodeficiency virus type 1 replication by CC and CXC chemokines. J. Virol. 72:396-404.
49. Tsai, W. P., S. R. Conley, H. F. Kung, R. R. Garrity, and P. L. Nara. 1996. Preliminary in vitro growth cycle and transmission studies of HIV-1 in an autologous primary cell assay of blood-derived macrophages and peripheral blood mononuclear cells. Virology 226:205-216.
50. Valentin, A., J. Albert, E. M. Fenyoe, and B. Asjo. 1994. Dual tropism for macrophages and lymphocytes is a common feature of primary human immunodeficiency virus type 1 and 2 isolates. J. Virol. 68:6684-6689.
51. van't Wout, A. B., N. A. Kootstra, G. A. Mulder-Kampinga, N. Albrecht-van Lent, H. J. Scherpbier, J. Veenstra, K. Boer, R. A. Coutinho, F. Miedema, and H. Schuitemaker. 1994. Macrophage-tropic variants initiate human immunodeficiency virus type 1 infection after sexual, parenteral and vertical transmission J. Clin. Investig. 94:2060-2067.
52. von Briesen, H., M. Grez, H. Ruppach, I. Raudonat, R. E. Unger, K. Becker, B. Panhans, U. Dietrich, and H. Rübsamen-Waigmann. 1999. Selection of HIV-1 genotypes by cultivation in different primary cells. AIDS 13:307-315.
53. von Briesen, H., R. Andreesen, R. Esser, W. Bruger, C. Meichsner, K. Becker, and H. Rübsamen-Waigmann. 1990. Infection of monocytes/macrophages by HIV in vitro. Res. Virol. 141:225-231.
54. von Briesen, H., R. Andressen, and H. Rübsamen-Waigmann. 1990. Systematic classification of HIV biological subtypes on lymphocytes and monocytes/ macrophages. Virology 178:597-602.
55. Westervelt, P., D. B. Trowbridge, L. G. Epstein, B. M. Blumberg, Y. Li, B. H. Hahn, G. M. Shaw, R. W. Price, and L. Ratner. 1992. Macrophage tropism determinants of human immunodeficiency virus type 1 in vivo. J. Virol. 66: 2577-2582.
56. Wolinsky, S. M., B. T. Korber, A. U. Neumann, M. Daniels, K. J. Kunstman, A. J. Whetsell, M. R. Furtado, Y. Cao, D. D. Ho, and J. T. Safrit. 1996. Adaptive evolution of human immunodeficiency virus-type 1 during the natural course of infection. Science 272:537-542.
57. Yoo, J., H. Chen, T. Krais, D. Hirsch, S. Plyak, I. George, and K. Sperber. 1996. Altered cytokine production and accessory cell function after HIV-1 infection. J. Immunol. 157:1313-1320.
58. Zhu, T., H. Mo, N. Wang, D. S. Nam, Y. Cao, R. A. Koup, and D. D. Ho. 1993. Genotypic and phenotypic characterization of HIV-1 in patients with primary infection. Science 261:1179-1181.
59. mac-infected macaques have antibodies with a broader spectrum of virus neutralization activity in macrophage versus lymphocyte cultures. Virology 227:24-33.