Replacement of Histidine 340 with alanine inactivates the group A Streptococcus extracellular cysteine protease virulence factor

Infection and Immunity

Volumn 68, Issue 6, 2000, Pages 3716-3719

  Gubba, Siddeswar ^a   Cipriano, Vincent ^a   Musser, James M ^a,b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; CASEIN; CYSTEINE PROTEINASE; FIBRONECTIN; HISTIDINE; VIRULENCE FACTOR;

AMINO ACID SUBSTITUTION; ARTICLE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME INACTIVATION; ENZYME PURIFICATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STREPTOCOCCUS GROUP A; STRUCTURE ACTIVITY RELATION;

ALANINE; AMINO ACID SEQUENCE; BACTERIAL PROTEINS; CASEINS; CATALYTIC DOMAIN; CONSERVED SEQUENCE; CYSTEINE ENDOPEPTIDASES; ENZYME PRECURSORS; EXOTOXINS; FIBRONECTINS; HISTIDINE; MEMBRANE PROTEINS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECOMBINANT PROTEINS; STREPTOCOCCUS PYOGENES;

EID: 0034034908     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.68.6.3716-3719.2000     Document Type: Article

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