Thrombin upregulates interleukin-8 in lung fibroblasts via cleavage of proteolytically activated receptor-I and protein kinase C-γ activation

American Journal of Respiratory Cell and Molecular Biology

Volumn 22, Issue 2, 2000, Pages 235-243

  Ludwicka Bradley, Anna ^a,b   Tourkina, Elena ^a,b   Suzuki, Shuzo ^a,b   Tyson, Elizabeth ^a,b   Bonner, Michael ^a,b   Fenton II, John W ^a,b   Hoffman, Stanley ^a,b   Silver, Richard M ^a,b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b WADSWORTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CELL MOTILITY; CELL RECEPTOR; CELL STIMULATION; ENZYME ACTIVATION; FIBROBLAST; INTERLEUKIN 8; LUNG; MESSENGER RNA; PROTEIN INDUCTION; PROTEIN KINASE C GAMMA; PROTEIN SYNTHESIS REGULATION; THROMBIN; THROMBIN RECEPTOR AGONIST PEPTIDE 14;

EID: 0034034708     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.22.2.3642     Document Type: Article

References (54)

1. 1. Berk, B. C., M. B. Taubman, K. K. Griendling, E. J. Cragoe, Jr., J. W. Fenlon, and T. A. Brock. 1991. Thrombin-stimulated events in cultured vascular smooth-muscle cells. Biochem. J. 274:799-805.
2. 2. McNamara, C. A., I. J. Sarembock, L. W. Gimple, J. W. Fenton II, S. R. Coughlin, and G. K. Owens. 1993. Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor. J. Clin. Invest. 91:94-98.
3. 3. Malik, A. B., and M. J. Horgan. 1987. Mechanisms of thrombin induced lung vascular injury and edema. Am. Rev. Respir. Dis. 136:467-470.
4. 4. Garcia, J. G. N., A. Siflinger-Birnboim, R. Bizios, P. J. Del Vecchio, J. W. Fenton II, and A. B. Malik. 1986. Thrombin-induced increases in albumin permeability across the endothelium. J. Cell. Physiol. 128:96-104.
5. 5. Daves, K. E., A. J. Gray, and G. J. Laurent. 1993. Thrombin stimulates fibroblasts chemotaxis and replication. Eur. J. Cell Biol. 61:126-130.
6. 6. Steen, V. D., C. Conte, G. R. Owens, and T. A. Medsger, Jr. 1994. Severe restrictive lung disease systemic sclerosis. Arthritis Rheum. 37:1283-1289.
7. 7. Ward, P. A., and G. W. Hunninghake. 1998. Lung inflammation and fibrosis. Am. J. Respir. Crit. Care Med. 157:S123-S129.
8. 8. Schmidt, B., P. Davis, H. L. Pointe, S. Monokman, G. Coates, and D. DeSa. 1996. Thrombin inhibitors reduce intrapulmonary accumulation of fibrinogen and procoagulant activity of bronchoalveolar lavage fluid during acute lung injury induced by pulmonary overdistention in newborn piglets. Pediatr. Res. 39:798-804.
9. 9. Uhiba, M., K. Okajima, K. Murakami, H. Okabe, and K. Takatsaki. 1996. Attenuation of endotoxin-induced pulmonary vascular injury by anti-thrombin III. Am. J. Physiol. 270:L921-L930
10. 10. Dabbagh, K., G. J., Laurent, R. J. McAnulty, and R. C. Chambers. 1998. Thrombin stimulates smooth muscle cell procollagen synthesis and mRNA via a PAR-1 mediated mechanism. Thromb. Haemost. 79:405-409.
11. 11. Bizios, R., L. Lai, J. W. Fenton II, and A. B. Malik. 1986. Thrombin-induced chemotaxis and aggregation of neutrophils. J. Cell. Physiol. 128: 485-490.
12. 12. Bar-Shavit, R., M. Benezra, V. Sabbah, W. Bode, and I. Vlodasky. 1992. Thrombin as a multifunctional protein: induction of cell adhesion and proliferation Am. J. Respir. Cell Mol. Biol. 6:123-130.
13. 13. Henton, J. W. 1988. Regulation of thrombin generation and functions. Semin. Thromb. Hemost. 14:234-240.
14. 14. Ohba, T., J. K. McDonald, R. M. Silver, C. Strange, E. C. LeRoy, and A. Ludwicka. 1994. Seleroderma BAL fluid contains thrombin, a mediator of human lung fibroblast proliferation via induction of the PDGF α-receptor. Am. J. Respir. Cell Mol. Biol. 10:405-412.
15. 15. Van Obberghen-Schilling, E., J. C. Chanbard, S. Paris, G. L. Allemain, and J. Pouyssegur. 1985. α-Thrombin-induced early mitogenic signalling events and G0 to S-phase transition of fibroblasts require continual external stimulation. EMBO J. 4:2927-2932.
16. 16. Bachhuber, B. G., I. J. Sarembock, L. W. Gimple, and G. K. Owens. 1997. α-Thrombin induces transforming growth faclor-βI mRNA and protein in cultured vascular smooth muscle cells via proteolytically activated receptor. J. Vasc. Res. 34:41-48.
17. B fibroblast. J. Histochem. Cytochem. 39:413-423.
18. 18. Papadimitriou, E., V. G. Manolopoulos, G. T. Hayman, M. E. Maragoudakis, B. R. Unsworth, J. W. Fenton II, and P. I. Lelkes. 1997. Thrombin modulates vectorial secretion of extracellular matrix proteins in cultured endothelial cells. Am. J. Physiol. 272:C1112-C1122.
19. 19. Tani, K., S. Yasuoka, F. Ogushi, K. Asada, K. Fujisawa, T. Ozaki, N. Sano, and T. Ogura. 1991. Thrombin enhances lung fibroblast proliferation in bleomycin-induced pulmonary fibrosis. Am. J. Respir. Cell Mol. Biol. 5:34-40.
20. 20. Ludwicka, A., E. Tourkina, S. Suzuki, E. Streett, E. Bulesbach, M. Bong, and R. Silver. 1996. Thrombin upregulates interleukin-8 in human lung fibroblasts. Mol. Biol. Cell 7(Suppl.):417a.
21. 21. White, B., F. M. Wigley, R. Wise, and F. Blecker. 1994. Expression of chemokines interleukin 8 (IL-8), RANTES, and macrophage inhibitory faclor-1 (MIP-1) in hronchoalveolar lavage fluid of patients with systemic sclerosis (SSc). Arthritis Rheum. 37:S263. (Abstr.)
22. 22. Ludwicka, A., T. Ohba, M. Trojanowska, A. Yamakage, C. Strange, E. A. Smith, E. C. LeRoy, S. Sutherland, and R. M. Silver. 1995. Elevated levels of platelet derived growth factor and transforming growth factor-β1 in bronchoalveolar lavage fluid from patients with scleroderma. J. Rheumatol. 22:1876-1883.
23. 23. Bolster, M. B., A. Ludwicka, S. E. Sutherland, C. Strange, and R. M. Silver. 1997. Cytokine concentrations in bronchoalveolar lavage fluid of patients with systemic sclerosis. Arthritis Rheum. 40:743-751.
24. 24. Crestani, B., N. Seta, E. Palazzo, C. Rolland, P. Venembre, M. Dehoux, A. Boutten, P. Soler, M.-C. Dombert, M.-F. Kahn, and M. Aubier. 1994. Interleukin-8 and neutrophils in systemic sclerosis with lung involvement. Am. J. Respir. Crit. Care Med. 150:1363-1367.
25. 25. Southcott, A. M., K. P. Jones, D. Li, S. Majumdar, A. D. Cambrey, P. Panlelidis, C. M. Black, G. J. Laurent, B. H. Davies, P. K. Jeffry, and R. M. duBois. 1995. Interleukin-8 differential expression in lone fibrosing alveolitis and systemic sclerosis. Am. J. Respir. Crit. Care Med. 151:1604-1612.
26. 26. Vu, T.-K. H., D. T. Hung, V. I. Wheaton, and S. R. Coughlin. 1991. Molecular cloning of a functional thrombin receptor reveals a novel protcolytic mechanism of receptor activation. Cell 64:1057-1068.
27. 27. Sower, L. E., C. J. Froelich, D. H. Carney, J. W. Fenton II, and G. R. Klimpel. 1995. Thrombin induces IL-6 production in fibroblasts and epithelial cells: evidence for the involvement of the seven-transmembrane domain (STD) receptor for α-thrombin. J. Immunol. 155:895-901.
28. 28. Vu, T.-K. H., D. T. Hung, and V. I. Wheaton. 1992. Characterization of a functional thrombin receptor: issues and opportunities. J. Clin. Invest. 89: 351-353.
29. 29. Stasek, J. E., C. E. Patterson, and J. G. N. Garcia. 1992. Protein kinase C phosphorylates caldesmon and vimentin and enhances albumin permeability across cultured bovine pulmonary artery endothelial cell monolayers. J. Cell Physiol. 153:62-75.
30. 30. Merrifield, R. B. 1963. Solid phase peptide synthesis: the synthesis of a tetrapeptide. J. Am. Chem. Soc. 85:2149-2154.
31. 31. Chomczynski, P., and N. Sacchi. 1987. Single step method RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Ann. Biochem. 162:156-158.
32. 32. Ueno, A., K. Murakami, K. Yamanouchi, M. Wanatabe, and T. Kondo, 1996. Thrombin stimulates production of interleukin-8 in human umbilical vein endothelial cells. Immunology 88:76-81.
33. 33. Harkar, L. A., S. R. Hanson, and M. S. Runge. 1995. Thrombin hypothesis of thrombus generation and vascular lesion formation. Am. J. Cardiol. 75:12B-17B.
34. 34. Miller, E. J., A. B. Cohen, S. J. P. Christophers, and M. A. Matthay. 1992. Elevated levels of NAP-1/interleukin-8 are present in the airspaces of patients with the adult respiratory distress syndrome and are associated with increased mortality. Am. Rev. Respir. Dis. 146:427-432.
35. 35. Chollet-Martin, S., P. Montravers, C. Gibert, C. Elbim, J. M. Desnouts, J. Y. Fagon, and M. A. Gougerot-Pocidalo. 1993. High levels of interleukin-8 in the blood and alveolar spaces of patients with pneumonia and adult respiratory distress syndrome. Infect. Immun. 61:4553-4559.
36. 36. Mulligan, M. S., M. L. Jones, M. A. Bolanowski, M. P. Baganoff, C. L. Deppeler, D. M. Meyers, U. S. Ryan, and P. A. Ward. 1993. Inhibition of lung inflammatory reactions in rats by an anti-human IL-8 antibody. J. Immunol. 150:5585-5595.
37. 37. Sekido, N., N. Mukaida, N. Harada, I. Nakanishi, Y. Watanabe, and K. Matsushima. 1993. Prevention of lung reperfusion injury in rabbits by monoclonal antibody against interleukin-8. Nature 356:654-657.
38. 38. Folkesson, H. G., M. A. Matthay, C. A. Herbert, and V. C. Broaddus. 1995. Acid aspiration-induced lung injury in rabbits is mediated by interleukin-8-dependent mechanisms. J. Clin. Invest. 96:107-116.
39. 39. Barrett, J. R. 1997. Chemokines. Blood 90:909-929.
40. 40. Grand, R. J. A., A. S. Turnell, and P. W. Graham. 1996. Cellular consequences of thrombin-receptor activation. Biochem. J. 313:353-368.
41. 41. Morris, R., P. G. Winyard, L. W. Brass, D. R. Blake, and C. J. Morris. 1996. Thrombin receptor expression in rheumatoid and osteoarthritic synovial tissue. Ann. Rheum. Dis. 55:841-843.
42. 42. Yichun, X., Z. Ute, M.-N. Peraldi, C.-J. He, C. Lu, J.-D. Sraer, L. F. Brass, and E. Rondeau. 1995. Constitutive expression and modulation of the functional thrombin receptor in the human kidney. Am. J. Pathol. 146:101-110.
43. 43. Molino, M., D. F. Bainton, J. A. Hoxie, S. R. Coughlin, and L. F. Brass. 1997. Thrombin receptors on human platelets: initial localization and subsequent redistribution during platelet activation. J. Biol. Chem. 272:6011-6017.
44. 44. Trejo, A., A. J. Connolly, and S. R. Coughlin. 1996. The cloned thrombin receptor is necessary and sufficient for activation of mitogen-activated protein kinase and mitogenesis in mouse lung fibroblasts. J. Biol. Chem. 271:21536-21541.
45. 45. Connolly, A. J., H. Ishihara, M. L. Kahn, R. V. Farese, Jr., and S. R. Coughlin. 1996. Role of the thrombin receptor in development and evidence for a second receptor. Nature 381:516-519.
46. 46. Derian, C. K., R. J. Santulli, K. A. Tomoko, B. J. Haertlein, and P. Andrade-Gordon. 1995. Species differences in platelet responses to thrombin and SFLLRN receptor-mediated calcium mobilization and aggregation, and regulation by protein kinases. Thromb. Res. 78:505-519.
47. 47. Baffy, G., L. Yang, S. Raj, D. R. Manning, and J. R. Wiliamson. 1994. G protein coupling to the thrombin receptor in chinese hamster lung fibroblasts. J. Biol. Chem. 269:8483-8487.
48. 48. Antonaccio, M. J., D. Normandin, R. Serafino, and S. Moreland. 1993. Effects of thrombin and thrombin receptor activating peptides on rat aortic vascular smooth muscle. J. Pharmacol. Exp. Ther. 266:125-132.
49. 49. Herbert, J.-M., E. Dupuy, M.-C. Laplace, J.-M. Zini, R. Bar-Shavit, and G. Tobelem. 1994. Thrombin induces endothelial cell growth via both a proteolytic and non-proteolytic pathway. Biochem. J. 303:227-231.
50. 50. Coughlin, S. R., T.-K. H. Vu, D. T. Hung, and V. I. Wheaton. 1992. Expression cloning and characterization of a functional thrombin receptor reveal a novel proteolytic mechanism of receptor activation. Semin. Thromb. Hemost. 18:161-166.
51. 51. Hung, D. T., T.-K. H. Vu, N. A. Nelken, and S. R. Coughlin. 1992. Thrombin-induced events in non-platelet cells are mediated by unique proteolytic mechanism established for the cloned platelet thrombin receptor. J. Cell Biol. 116:827-832.
52. 52. Godin, O., F. Rioux, F. Marceau, and G. Drapeau. 1995. Mode of action of thrombin in rabbit aorta. Br. J. Pharmacol. 115:903-908.
53. 53. Berk, B. C., M. B. Taubman, E. J. Cragoe, Jr., J. W. Fenton II, and K. K. Griendling. 1990. Thrombin signal transduction mechanisms in rat vascular smooth muscle cells: calcium and protein kinase C-dependent and -independent pathways. J. Biol. Chem. 265:17334-17340.
54. 54. Paintz, E., and E. Galusa. 1995. Involvement of inositol,4,5,-triphosphate and protein kinase C in thrombin-induced contraction of porcine pulmonary artery. Biochem. Pharmacol. 49:33-38.