Thrombin receptor expression in rheumatoid and osteoarthritic synovial tissue

Annals of the Rheumatic Diseases

Volumn 55, Issue 11, 1996, Pages 841-843

  Morris, Ruth ^a   Winyard, Paul G ^a   Brass, Lawrence F ^b   Blake, David R ^a   Morris, Christopher J ^a  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

THROMBIN RECEPTOR;

ARTICLE; CONTROLLED STUDY; HUMAN; IMMUNOHISTOCHEMISTRY; NORMAL HUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYNOVIUM;

EID: 0029831183     PISSN: 00034967     EISSN: None     Source Type: Journal    
DOI: 10.1136/ard.55.11.841     Document Type: Article

References (17)

1. Bar-Shavit R, Kahn A, Wilner GD, Fenton JW. Monocyte chemotaxis: stimulation by specific exosite region in thrombin. Science 1983;220:728-31.
2. Chen LB, Buchanan JM. Mitogenic activity of blood components I: thrombin and prothrombin. Proc Natl Acad Sci USA 1975;72:131-5.
3. Laposta M, Dovnarsky DK, Shin HS. Thrombin-induced gap formation in confluent endothelial cell monolayers in vitro. Blood 1983;62:549-56.
4. Vu T-KH, Hung DT, Wheaton VI, Couglin SR. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 1991; 64:1057-68.
5. Hung DT, Vu T-KH, Nelken NA, Coughlin SR. Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanism established for the cloned platelet thrombin receptor. J Cell Biol 1992;116:827-32.
6. Weinberg JB, Pippen AMM, Greenberg CS. Extravascular fibrin formation and dissolution in synovial tissue of patients with osteoarthritis and rheumatoid arthritis. Arthritis Rheum 1991;34:996-1005.
7. Lindahl U, Pejler G, Bogwald J, Seljelid R. A prothrombinase complex of mouse peritoneal macrophages. Arch Biochem Biophys 1989;273:180-8.
8. Brass LF, Vassallo RR, Belmonte E, Ahuja M, Cichowski K, Hoxie JA. Structure and function of the human platelet thrombin receptor. J Biol Chem 1992;267:13795-8.
9. Shu S, Ju G, Fan L. The glucose oxidase DAB nickel method in peroxidase histochemistry of the nervous system. Neurosci Lett 1988;85:169-71.
10. Gomori G. Histochemistry of human esterases. J Histochem Cytochem 1955;3:479-94.
11. Nelken NA, Soifer SJ, O'Keefe J, Vu T-KH, Charo IF, Coughlin SR. Thrombin receptor expression in normal and atherosclerotic human arteries. J Clin Invest 1992; 90:1614-21.
12. Sugama Y, Tiruppathi C, Janakidevi K, Andersen TT, Fenton JW, Malik AB. Thrombin-induced expression of endothelial P-selectin and intercellular adhesion molecule-1: a mechanism for stabilising neutrophil adhesion. J Cell Biol 1992;119:935-44.
13. Grober JS, Bowen BL, Ebling H, Athey B, Thompson CB, Fox DA, et al. Monocyte-endothelial adhesion in chronic rheumatoid arthritis. J Clin Invest 1993;91:2609-19.
14. Morris R, Winyard PG, Blake DR, Morris CJ. Thrombin in inflammation and healing: relevence to rheumatoid arthritis. Ann Rheum Dis 1994;53:72-9.
15. Morris CJ, Blake DR, Wainwright AC, Steven MM. The relationship between iron deposits and tissue damage in the synovium - an ultrastructural study. Ann Rheum Dis 1986;45:21-6.
16. Qu Z, Garcia CH, O'Rourke LM, Planck SR, Kohli M, Rosenbaum JT. Local proliferation of fibroblast-like synoviocytes contributes to synovial hyperplasia. Arthritis Rheum 1994;37:212-20.
17. Howells GL, Macey M, Curtis MA, Stone SR. Peripheral blood lymphocytes express the platelet-type thrombin receptor. Br J Haematol 1993;84:156-60.