Diverse effects of P-glycoprotein inhibitory agents on human leukemia cells expressing the multidrug resistance protein (MRP)

International Journal of Clinical Pharmacology and Therapeutics

Volumn 38, Issue 4, 2000, Pages 187-195

  Lehne, G ^b   Morkrid L ^c   Den Boer, M ^a   Rugstad, H E ^c  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c NONE

Author keywords

Anthracycline; Cyclopeptolide; Cyclopropyldibenzosuberane; Cyclosporin; Leukemia; Multidrug resistance protein; P glycoprotein

Indexed keywords

DAUNORUBICIN; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN; VALSPODAR;

ARTICLE; CANCER CHEMOTHERAPY; CANCER INHIBITION; CELL COUNT; CONCENTRATION RESPONSE; DRUG SENSITIZATION; HUMAN; HUMAN CELL; LEUKEMIA CELL; MULTIDRUG RESISTANCE;

EID: 0034029922     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: 10.5414/CPP38187     Document Type: Article

References (33)

1. Bedi A, Barber JP, Bedi GC et al 1995 BCR-ABL-mediated inhibition of apoptosis with delay of G2/M transition after DNA damage: a mechanism of resistance to multiple anticancer agents. Blood 86: 1148-1158
2. Boote DJ, Dennis IF, Twentyman PR et al 1996 Phase I study of etoposide with SDZ PSC 833 as a modulator of multidrug resistance in patients with cancer. J Clin Oncol 14: 610-618
3. Bordow SB, Haber M, Madafiglio J et al 1994 Expression of the multidrug resistance-associated protein (MRP) gene correlates with amplification and overexpression of the N-myc oncogene in childhood neuroblastoma. Cancer Res 54: 5036-5040
4. Candell J, Valle V, Soler M et al 1979 Acute intoxication with verapamil. Chest 75: 200-201
5. Cole SP, Bhardwaj G, Gerlach JH et al 1992 Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258: 1650-1654
6. Dantzig AH, Shepard RL, Cao J et al 1996 Reversal of P-glycoprotein-mediated multidrug resistance by a potent cyclopropyldihenzosuberane modulator, LY335979. Cancer Res 56: 4171-4179
7. Davey MW, Hargrave RM and Davey RA 1996 Comparison of drug accumulation in P-glycoprotein-expressing and MRP-expressing human leukaemia cells. Leuk Res 20: 657-664
8. den Boer ML, Pieters R, Kazemier KM et al 1998 Relationship between major vault protein/lung resistance protein, multidrug resistance-associated protein, P-glycoprotein expression, and drug resistance in childhood leukemia. Blood 91: 2092-2098
9. den Boer ML, Zwaan CM, Pieters R et al 1997 Optimal immunocytochemical and flow-cytometric detection of P-gp, MRP and LRP in childhood acute lymphoblastic leukemia. Leukemia 11: 1078-1085
10. D'Hondt V, Caruso M, Bank A 1997 Retrovirus-mediated gene transfer of the multidrug resistance-associated protein (MRP) cDNA protects cells from chemotherapeutic agents. Hum Gene Ther 8: 1745-1751
11. Fillpits M, Suchomel RW, Dekan G et al 1997 Expression of the multidrug resistance-associated protein (MRP) gene in colorectal carcinomas. Br J Cancer 75: 208-212
12. Ford JM 1995 Modulators of multidrug resistance. Preclinical studies. Hematol Oncol Clin North Am 9: 337-361
13. German UA, Pastan I, Gottesman MM 1993 P-glycoproteins: mediators of multidrug resistance. Semin Cell Biol 4: 63-76
14. Grant CE, Valdimarsson G, Hipfner DR et al 1994 Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs. Cancer Res 54: 357-361
15. Gruber A, Briese B, Arestrom I et al 1993 Effect of verapamil on daunorubicin accumulation in human leukemic cells with different levels of MDR1 gene expression. Leuk Res 17: 353-358
16. Kornblau SM, Estey E, Madden T et al 1997 Phase 1 study of mitoxantrone plus etoposide with multidrug blokkade by SDZ PSC-833 in relapsed or refractory acute myelogenous leukemia. J Clin Oncol 15: 1796-1802
17. Lehne G, De Angelis P, Clausen OP et al 1995 Binding diversity of antibodies against external and internal epitopes of the multidrug resistance gene product P-glycoprotein. Cytometry 20: 228-237
18. Lehne G, De Angelis P, Clausen OPF et al 1996 Human hepatoma cells rich in P-glycoprotein are sensitive to aclarubicin and resistant to three other anthracyclines. Br J Cancer 74: 1719-1729
19. Lehne G, De Angelis P, den Boer M et al 1999 Growth inhibition, cytokinesis failure and apoptosis of multidrug-resistant leukemia cells after treatment with P-glycoprotein inhibitory agents. Leukemia 13: 768-778
20. Ling V 1997 Multidrug resistance: molecular mechanisms and clinical relevance. Cancer Chemother Pharmacol 40: S3-8
21. Linn SC, Pinedo HM, van Ark-Otte J et al 1997 Expression of drug resistance proteins in breast cancer, in relation to chemotherapy. Int J Cancer 71: 787-95
22. Loe DW, Almquist KC, Cole SP et al 1996 ATP-dependent 17 beta-estradiol 17-(beta-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroids. J Biol Chem 271: 9683-9689
23. Loor F, Boesch D, Gaveriaux C et al 1992 SDZ 280-446, a novel semi-synthetic cyclopeptolide: in vitro and in vivo circumvention of the P-glycoprotein-mediated tumour cell multidrug resistance. Br J Cancer 65: 11-18
24. Naito M, Watanahe T, Tsuge H et al 1996 Potentiation of the reversal activity of SDZ PSC833 on multi-drug resistance by an anti-P-glycoprotein monoclonal antibody MRK-16. Int J Cancer 67: 435-440
25. Nakamura T, Oka M, Aizawa K et al 1999 Direct interaction between a quinoline derivative, MS-209, and multidrug resistance protein (MRP) in human gastric cancer cells. Biochem Biophys Res Commun 255: 618-624
26. Ota E, Abe Y, Oshika Y et al 1995 Expression of the multidrug resistance-associated protein (MRP) gene in non-small-cell lung cancer. Br J Cancer 72: 550-554
27. Pastan I, Gottesman MM, Ueda K et al 1988 A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells. Proc Natl Acad Sci USA 85: 4486-4490
28. Scambia G, Panici PB, Contu G et al 1994 Mechanisms and modulation of resistance to anthracyclines (Review). Int J Oncol 4: 951-959
29. Stride BD, Grant CE, Loe DW et al 1997 Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells. Mol Pharmacol 52: 344-353
30. Tiberghien F and Loor F 1996 Ranking of P-glycoprotein substrates and inhibitors by a calcein-AM fluorometry screening assay. Anticancer Drugs 7: 568-578
31. Tsuruo T, Iida H, Tsukagoshi S et al 1981 Overcoming of vincristine resistance in P38H leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil. Cancer Res 41: 1967-1972
32. Twentyman PR, Bleehen NM 1991 Resistance modification by PSC-833, a novel non-immunosuppressive cyclosporin. Eur J Cancer 27: 1639-1642
33. Versantvoort CH, Broxterman HJ, Bagrij T et al 1995 Regulation by glutathione of drug transport in multidrug-resistant human lung tumour cell lines overexpressing multidrug resistance-associated protein. Br J Cancer 72: 82-89