Retrovirus-mediated gene transfer of the multidrug resistance-associated protein (MRP) cDNA protects cells from chemotherapeutic agents

Human Gene Therapy

Volumn 8, Issue 15, 1997, Pages 1745-1751

  D'Hondt, Veronique ^b   Caruso, Manuel ^b   Bank, Arthur ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; ETOPOSIDE; GLUTATHIONE; GLYCOPROTEIN P; VINCRISTINE; VIRUS VECTOR;

ANIMAL CELL; ARTICLE; BONE MARROW; CELL CLONE; CELL PROTECTION; CELL STRAIN 3T3; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG RESISTANCE; FIBROBLAST; FLUORESCENCE ACTIVATED CELL SORTER; GENE EXPRESSION; GENE TARGETING; GENE TRANSFER; GENETIC TRANSDUCTION; LONG TERMINAL REPEAT; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; RETROVIRUS; SOUTHERN BLOTTING; TARGET CELL; TUMOR RESISTANCE;

ANIMALIA; UNIDENTIFIED RETROVIRUS;

EID: 0030662096     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1997.8.15-1745     Document Type: Article

References (3)

1. BARRAND, M., HEPELL-PARTON, A., WRIGHT, K., RABBITS, P., and TWENTYMAN, P. (1994). A 190-kilodalton protein over-expressed in non-P-glycoprotein-containing multidrug resistant cells and its relationship to the MRP gene. J. Natl. Cancer Inst. 86, 110-117.
2. BROXTERMAN, H.J., GIACCONE, G., and LANKELMA, J. (1995). Multidrug resistance proteins and other drug transport-related resistance to natural products agents. Curr. Opin. Oncol. 7, 532-540.
3. COLE, S.P.C., BHARDWAJ, G., GERLACH, J.H., MACKIE, J.E., GRANT, C.E., ALMQUIST, K.C., STEWART, A.J., KURZ, E.U., DUNCAN, A.M.V., and DEELEY, R.G. (1992). Overexpression of a novel transporter gene in a multidrug resistant human lung cancer cell line. Science 258, 1650-1654.