Basic strategy for avoiding drug interaction during stage of drug development; The proposals relative to planing of non-clinical and clinical studies how should it be the planing of clinical trials

Journal of Toxicological Sciences

Volumn 21, Issue 5, 1996, Pages 331-341

  Horie, Toru ^a   Nakata, Hiroshi ^a   Kusube, Kenichi ^a  

^a EISAI CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CONFERENCE PAPER; DRUG DESIGN; DRUG METABOLISM; DRUG SCREENING; ENZYME INDUCTION; ENZYME INHIBITION;

EID: 0030497595     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.21.5_331     Document Type: Article

References (7)

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2. Ciaccio, P. J. and Halpert, J. R. (1989): Characterization of a phenobarbital-inducible dog liver cytochrome P450 structurally related to rat and human enzymes of the P450IIIA (steroid-inducible) gene subfamily. Arch. Biochem. Biophys., 271,284-99.
3. Daling, Z., Tanaka, E., Nakamura, T. and Horie, T.(1994): Effect of - 5110, a novel non-steroidal anti-flammatory drug, on trimethadione metabolism as an indicator of hepatic drug-oxidizing capacity in beagle dog. Xenobiotica, 24,215-220.
4. Duignan, B. D., Sipes, I. G., Leonard, T. B. and Harpert, J. R.(1987): Purification and characterization of the dog hepatic cytochrome P-450 isozyme responsible for the metabolism of 2,2′,4,4′,5,5′- hexachlorobiphenyl. Arch. Biochem. Biophys., 255, 290-303.
5. Ged, C., Rouillon, J.M., Pichard, L., Combalbelt, L., Bressot, N., Borie, P., Michel, H., Beaune, P. and Maurel, P.(1989): The increase in urinary excretion of 6β-hydroxycortisol as a marker of human hepatic cytochrome P450IIIA induction. Br. J. Clin. Pharmac., 28, 373-387.
6. Kawamura, T., Adachi H. and Ogawa T.(1991): Cardiovascular effects of E4080, a novel bradycardiac agent with coronary vasodilating properties, in anesthetized dogs. Eur. J. Pharmacol., 203, 399-404.
7. Sagami, F., Sumigama, S., Kitada, M., Shimoyama, N., Horie, T., Yamatsu, K. and Kanakubo, Y.(1992): The relationship between the structure of methylenedioxyphenyl derivatives and induction of cytochrome P-450 isozymes in rat liver microsomes. VII International Congress of Toxicology, Rome, Italy June 28-July 3.