Dexamethasone blocks sepsis-induced protection of the heart from ischemia reperfusion injury

Proceedings of the Society for Experimental Biology and Medicine

Volumn 223, Issue 1, 2000, Pages 82-87

  Spanier, Adam J ^a   Mcdonough, Kathleen H ^a,b  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; NITRATE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CYTOKINE PRODUCTION; DRUG MECHANISM; ENTEROBACTER INFECTION; HEART HEMODYNAMICS; HEART MUSCLE ISCHEMIA; HEART PROTECTION; MALE; NONHUMAN; RAT; REPERFUSION INJURY; SEPSIS;

ANIMALIA; ENTEROBACTER; ESCHERICHIA COLI;

EID: 0034027250     PISSN: 00379727     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1525-1373.2000.22311.x     Document Type: Article

References (28)

1. Avontuur JA, Bruining HA, Ince C. Sepsis and nitric oxide. Adv Exp Med Biol 388:551-567, 1996.
2. Parker MM, Shelhamer JH, Bacharach SL, Green MV, Natanson C, Frederick TM, Damske BA, Parrillo JE. Profound but reversible myocardial depression in patients with septic shock. Ann Intern Med 100:483-190, 1984.
3. Kilbourn RG, Szabó C, Traber DL. Beneficial versus detrimental effects of nitric oxide synthase inhibitors in circulatory shock: Lessons learned from experimental and clinical studies. Shock 7:235-246, 1997.
4. Natanson C, Fink MP, Ballantyne HK, MacVittie TJ, Conklin JJ, Parrillo PE. Gram-negative bacteremia produces both severe systolic and diastolic cardiac dysfunction in a canine model that simulates human septic shock. J Clin Invest 78:259-270, 1986.
5. Natanson C, Danner RL, Fink MP, Macvittie TJ, Walker RI, Conklin JJ, Parrillo. Cardiovascular performance with E. coli challenges in a canine model of human sepsis. Am J Physiol 254:H558-H569, 1988.
6. McDonough KH, Causey KM. Effects of sepsis on recovery of the heart from 50 min ischemia. Shock 1:432-437, 1994.
7. McDonough KH, Lang CH, Spitzer JJ. Depressed function of isolated hearts from hyperdynamic septic rats. Circ Shock 12:241-251, 1984.
8. McDonough KH, Causey KM. Sepsis protects the heart of alcoholic rats from ischemia-reperfusion injury. Alcohol Clin Exp Res 18:1423-1429, 1994.
9. Bolli R, Bhatti ZA, Tang XL, Qui Y, Zhang Q, Guo Y, Jadoon AK. Evidence that late preconditioning against myocardial stunning in conscious rabbits is triggered by the generation of nitric oxide. Circ Res 81:42-52, 1997.
10. Bolli R, Manchikalapudi S, Tang XL, Takano H, Qui Y, Zhang Q, Jadoon AK. The protective effect of late preconditioning against myocardial stunning in conscious rabbits is mediated by nitric oxide synthase: Evidence that nitric oxide acts both as a trigger and as a mediator of the late phase of ischemic preconditioning. Circ Res 81:1094-1107, 1997.
11. Kelly RA, Smith TW. Cytokines and cardiac contractile function. Circulation 95:778-781, 1997.
12. Kelly RA, Balligand JL, Smith TW. Nitric oxide and cardiac function. Circ Res 79:363-380, 1996.
13. Murrell GAC, Dolan MM, Jang D, Szabó C, Warren RF, Hannahn JA. Nitric oxide: An important articular free radical. J Bone Joint Surg 78:265-274, 1996.
14. Lorente JA, Landín L, Cañas P, Delgado MA, Albaya E, Renes E, Jorge P, Liste D. Effects of nitric oxide synthase inhibition on the cardiovascular response to low output shock. Crit Care Med 24:482-487, 1996.
15. Kimura A, Roseto J, Suh K, Bing RJ. Dexamethasone on inducible nitric oxide synthase and nitrite/nitrate production in myocardial infarction. Proc Soc Exp Biol Med 219:138-143, 1998.
16. Mashage H, Kok B, Huizeny J, Jansen PLM. Nitrite and nitrate determinations in plasma: A critical evaluation. Clin Chem 41:892-896, 1995.
17. Finkel MS, Oddis CV, Jacob TD, Watkins SC, Hattler BG, Simmons RL. Negative inotropic effects of cytokines on the heart mediated by nitric oxide. Science 257:387-389, 1992.
18. Gross WL, Bak MI, Ingwall JS, Arstall MA, Smith TW, Balligand JL, Kelly RA. Nitric oxide inhibits creatinine kinase and regulates rat heart contractile reserve. Proc Natl Acad Sci U S A 93:5604-5609, 1996.
19. Grocott-Mason R, Ford S, Lewis MJ, Shah AM. Myocardial relaxant effect of exogenous nitric oxide in isolated ejecting hearts. Am J Physiol 26:H1699-H1705, 1994.
20. Meng X, Ao L, Brown JM, Fullerton DA, Banjerjee A, Harken AH. Nitric oxide synthase is not involved in cardiac contractile dysfunction in a rat model of endotoxemia without shock. Shock 7:111-118, 1997.
21. Klabunde RE, Coston AF. Nitric oxide synthase inhibition does not prevent cardiac depression in endotoxin shock. Shock 3:73-78, 1995.
22. McDonough KH, Smith T, Patel K, Quinn M. Myocardial dysfunction in the septic rat heart: Role of nitric oxide. Shock 10:371-376, 1998.
23. Zweier JL. Measurement of superoxide derived free radicals in the reperfused heart. J Biol Chem 263:1353-1357, 1988.
24. Rajashree S, Puvanakrishnan R. Alterations in certain lysosomal glycohydrolases and cathepsins in rats on dexamethasone administration. Mol Cell Biochem 154:165-170, 1996.
25. Singh K, Balligand JL, Fischer TA, Smith TW, Kelly RA. Glucocorticoids increase osteopontin expression in cardiac myocytes and microvascular endothelial cells. J Biol Chem 270:28471-28478, 1995.
26. Wu C, Croxtall JD, Perretti M, Bryant CE, Thiermermann C, Flowers RJ, Vane JR. Lipocortin 1 mediates the inhibition by dexamethasone of the induction by endotoxin of nitric oxide synthase in the rat. Proc Natl Acad Sci U S A 92:3473-3477, 1995.
27. 2. Exp Eye Res 65:73-81, 1997.
28. Ostrov CS, Sirkin SR, Deutsch WE. Ketorolac, Prednisolone, and Dexamethasone for postoperative inflammation. Clin Ther 19:259-272, 1997.