Sepsis and nitric oxide

Advances in Experimental Medicine and Biology

Volumn 388, Issue , 1996, Pages 551-567

  Avontuur, J A M ^a   Bruining, H A ^a   Ince, C ^b  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGUANIDINE; ARGININE; HEMOGLOBIN; METHYLENE BLUE; N ACETYL S NITROSOPENICILLAMINE; N ACETYLSEROTONIN; N(G) METHYLARGININE; N(G) NITROARGININE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; SUPEROXIDE; SUPEROXIDE DISMUTASE; TETRAHYDROBIOPTERIN;

CLINICAL TRIAL; CONFERENCE PAPER; DOSE RESPONSE; HUMAN; HYPOTENSION; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SEPSIS; VASODILATATION;

EID: 0029841670     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4613-0333-6_71     Document Type: Conference Paper

References (128)

1. Abel FL: Myocardial function in sepsis and endotoxin shock. Am J Physiol 1989;257:R1265-R1281.
2. Adams HR, Parker JL, Laughlin MH: Intrinsic Myocardial dysfunction during endotoxemia: Dependent or independent of myocardial ischemia. Circ Shock 1990;30:63-76.
3. Amezcua JL, Dusting GJ, Palmer RM, Moncada S: Acetylcholine induces vasodilatation in the rabbit isolated heart through the release of nitric oxide, the endogenous nitrovasodilator. Br J Pharmacol 1988 95:830-834.
4. Amezcua JL, Palmer RMJ, de Souza BM, Moncada S: Nitric oxide synthesized from L-arginine regulates vascular tone in the coronary circulation of the rabbit. Br J Pharmacol 1989;97:1119-1124.
5. Amrani M, O'shea J, Allen NJ, Harding SE, Jayakumar J, Pepper JR, Moncada S, Yacoub MH: Role of basal release of nitric oxide on coronary flow and mechanical performance of the isolated rat heart. J Physiol 1992;456:681-678.
6. Astiz ME, Rackow EC, Falk JL, Kaufman BS, Weil MH: Oxygen delivery and consumption in patients with hyperdynamic septic shock. Crit Care Med 1987;15(1):26-28.
7. Avontuur JA, Bruining HA, Ince C: Inhibition of nitric oxide synthesis causes myocardial ischemia in endotoxemic rats. Circ Res 1995;76:418-425.
8. Baydoun AR, Peers SH, Cirino G, Woodward B: Vasodilator action of endothelin-1 in the perfused rat heart. J Cardiovasc Pharmacol 1990;15:759-763.
9. Baydoun AR, Foale RD, Mann GE: Bacterial endotoxin rapidly stimulates prolonged endothelium-dependent vasodilatation in the rat isolated perfused heart. Br J Pharmacol 1993;109:987-991.
10. Belder De AJ, Radomski MR, Why HJ, Richardson PJ, Bucknall CA, Salas E, Martin JF, Moncada S: Nitric oxide synthase activities in human myocardium. Lancet 1993;341:84-85.
11. Billiar TC, Curran RD, Harbrecht BG, et al: Modulation of nitrogen oxide synthesis in vivo:: NG-monomethyl-L-arginine inhibits endotoxin-induced nitrite/nitrate biosynthesis while promoting hepatic damage. J Leukoc Biol 1990;48:565-569.
12. Blough NV, Zafiriou OC: Reaction of superoxide with nitric oxide to form peroxonitrite in alkaline aqueous solution. Inorg Chem 1985;24:3502-3504.
13. Bone RC: The pathogenesis of sepsis. Ann Int Med 1991;115:457-469.
14. Boughton-Smith NK, Hutcheson IR, Deakin AM, Whittle BJR, Moncada S: Protective effect of S-nitroso-N-acetyl-penicillamine in endotoxin-induced acute intestinal damage in the rat. Eur J Pharmacol 1990;191:485-488.
15. Brady JB, Poole-Wilson, Harding SE, Warren JB: Nitric Oxide production within cardiac myocytes reduces their contractility in endotoxemia. Am J Physiol 1992;263 (Heart Circ Physiol 32): H1963-H1966.
16. Busse R, Mülsch A: Calcium-dependent nitric oxide synthesis in endothelial cytosol is mediated by calmodulin. FEBS Lett 1990;265:133-136.
17. Cain MS, Curtis SE: Experimental models of pathologic oxygen supply dependency. Crit Care Med 1991;19: 603-612.
18. Calver A, Collier J, Vallance P: L-arginine-induced hypotension. Lancet 1990;ii:1016-1017.
19. Chu A, Chambers DE, Lin CC, Kuehl WD, Palmer RM: Effects of inhibition of Nitric Oxide formation on basal vasomotion and endothelium-dependent responses of the coronary arteries in awake dogs. J Clin Invest 1991;87: 1964-1968
20. Clutton-Brock J: Two cases of poisoning by contamination of nitrous oxide with higher oxides of nitrogen during anaesthesia. J Anaesth 1967;39:388-392.
21. ω-Amino-L-arginine, an inhibitor of Nitric Oxide Synthase, raises vascular resisistance but increases mortality rates in awake canines challenged with endotoxin. J Exp Med 1992;176:1175-1182
22. Corbett JA, Tilton RG, Chang K, Hasan KS, Ido Y, Wang JL, Sweetland MA, Lancaster JR, Williamson JR, McDanie ML: Aminoguanidine, a novel inhibitor of nitric oxide formation, prevents diabetic vascular dysfunction. Diabetes 1992;41,552-556.
23. Cunnion RE, Schaer GL, Parker MM, Natanson C, Parillo JE: The coronary circulation in human septic shock. Circulation 1986;73(4):637-644.
24. Dhainaut JF, Huygebaert MF, Monsalier JF, Lefevre G, Ava-Santucci J, Brunet F, Villemant D, Carli A, Raichvarg D: Coronary hemodynamics and myocardial metabolism of lactate, free fatty acids, glucose, and ketones in patients with septic shock. Circulation 1987;75(3):533-541.
25. Duncker DJ, Bache RJ: Inhibition of nitric oxide production aggrevates myocardial hypoperfusion during exercise in the presence of a coronary artery stenosis. Circ Res 1994;74:629-640.
26. Fink MP, Heard SO: Laboratory models of sepsis and septic shock. J Surg Res 1990;49:186-196.
27. Flemming I, Gray GA, Julou-schaeffer G, Parret JR, Stoclet JC: Incubation with endotoxin activates the L-arginine pathway in vascular tissue. Biochem Biophys Res Commun 1990;171:562-568.
28. Flemming I, Julou-Schaeffer, Gray GA, Parret JR, Stoclet JC: Evidence that an L-arginine nitric oxide dependent elevation of tissue cyclic GMP content is involved in depression of vascular reactivity by endotoxin. Br J Pharmacol 1991a;103:1047-1052
29. Flemming I, Gray GA, Schott C, Stoclet JC: Inducible but not constitutive production of nitric oxide by vascular smooth muscle cells. Eur J Pharmacol 1991b;200:375-376.
30. Freund H, Atamian S, Holroyde J, Fischer JE: Plasma amino acids as predictors of the severity and outcome of sepsis. Ann Surg 1979;190:571-576
31. Freund H, Ryan JA, Fischer4 JE: Aminoacids derangements in patients with sepsis: Treatment with branched chain aminoacids rich infusions. Ann Surg 1978;188:423-429
32. Geller DA, Nussler AK, Di Silvio M, Lowenstein CJ, Shapiro RA, Wang SC, Simmons RL, Billiar TR: Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes. Proc Natl Acad Sci USA 1993;90;522-526
33. Gianotti L, Alexander W, Pyles T, Fukushima R: Arginine-supplemented diets improve survival in gut-derived sepsis and peritonitis by modulating bacterial clearance. Ann Surg 1993;217:644-654.
34. Goldfarb RD, Nightingale LM, Kish P, Weber PB, Loegering DJ: Left ventricular function during lethal and sublethal endotoxemia in the swine. Am J Physiol 1986;251(20): H364-H373.
35. Goodman LS and Gilman A: The pharmacological basis of therapeutics. Macmillan, New York 1975: pp. 1003-1004.
36. Gonzales C, Fernandez A, Martin C, Moncada S, Estrada C: Nitric oxide from endothelium and smooth muscle modulates resposes to sympathetic nerve stimulation: Implications for endotoxin shock. Biochem Biophys Res Commun 1992;86:151-156.
37. Gosh S, Latimer RD, Gray BM, Harwood RJ, Oduro A: Endotoxin induced organ injury. Crit Care Med 1993;21:S19-S24.
38. Gray GA, Julou-schaeffer G, Oury K, Flemming I, Parret JR, Stoclet JC: A L-arginine-derived factor mediates endotoxine-induced vascular hyposensivety to calcium. Eur J Pharmacol 1990;191:89-92
39. Gray GA, Schott C, Juluo Schaeffer G, Fleming I, Parratt JR, Stoclet JC: The effect of inhibitors of the L-arginine nitric oxide pathway on endotoxin induced loss of vascular responsiveness in anaesthelized rats. Br J Pharmacol 1991;103:1218-1224
40. Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR: Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal Biochem 1982;126:131-138
41. Griffiths MJ, Messent M, MacAllister RJ, Evans TW: Aminoguanidine selectively inhibits inducible nitric oxide synthase. Br J Pharmacol 1993;110:963-968.
42. Groeneveld AB, Bronsveld W, Thijs LG: Hemodynamic determinants of mortality in human septic shock. Surgery 1985:140-152.
43. Groeneveld AB, Lambalgen van AA, Bos van den GC, Bronsveld W, Nauta JP, Lambertus GT: Maldistribution of heterogeneous coronary blood flow during canine endotoxin shock. Cardiovasc Res 1991;25:80-88.
44. Gross SS and Levi R: Tetrahydrobiopterin Synthesis. J Biol Chem 1992;267:25:722-25729.
45. Gryglewski RJ, Palmer RM, Moncada S: Superoxide anion is involved in the breakdown of endothelium-derived relaxing factor. Nature 1986;320:454-456.
46. G-nitro-L-arginine methyl ester and vasopressin in endotoxin-treated pitched rats. Eur J Pharmacol 1992;224:63-69.
47. Hecker M, Mitchell JA, Harris HJ, Katsura M, Thiemermann C, Vane JR: NG-monomethyl-L-arginine is metabolized by endothelial cells to L-citrulline. Biochem Biophys Res Commun 1990;167:1037-1043.
48. Hibbs JB, Vavrin Z, Taintor RR: L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells. J Immunol 1987;138:550-565.
49. Hibbs JB, Westenfelder C, Taintor R, Vavrin Z, Kablitz C, Baranowski RL, Ward JH, Menlove RL, MCCurry MP, Kusher JP: Evidence for cytokine-inducible nitric-oxide synthesis from L-arginine in patients receiving IL-2 therapy. J Clin Invest 1992;89:867-877
50. Hotchkiss RS, Karl IE, Parker JL, Adams HR: Letter to the editor. Lancet 1992;339(15):434-435.
51. Hutcheson IR, Whittle BJ, Boughton-Smith NK: Role of nitric oxide in maintainining vascular integrety in endotoxin-induced acute intestinal damage in the rat. Br J Pharmacol 1990;101:815-820.
52. Ignarro LJ, Byrns RE, Buga GM, Wood KS: Endothelium derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical. Circ Res 1987;61:866-879.
53. Ignarro LJ, Lippton H, Edwards JC, Baricos WH, Hyman AL, Kadowitz PJ, Gruetter CA: Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates. J Pharmacol Exp Ther 1981;218:739-749
54. Ignarro LJ, Lippton, Kadowitz PJ: The pharmacological and physiological role of cyclic GMP in vascular smooth muscle. Ann Rev Pharmacol Toxicol 1985;25:171-191.
55. Julou-Schaeffer G, Gray GA, Fleming I, Scott C, Parrat JR, Stoclet JC: Loss of vascular respon-siveness induced by endotoxin involves L-arginine pathway. Am J Physiol 1990:259 (Heart Circ Physiol 28): H1038-H1043.
56. Kelm M, Schrader J: Control of coronary vascular tone by Nitric Oxide. Circ Res 1990;66:1561-1575
57. G-methyl-L-arginine, an inhibitor of nitric oxide synthesis. Biochem Biophys Res Comm 1990a;172(3):1132-1138
58. G-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: Implications for the involvement of nitric oxide. Proc Natl Acad Sci USA 1990b;87:3629-3632.
59. Kilbourn RG, Belloni P: Endothelial cell production of nitrogen oxides in response to interferon gamma in combination with tumor necrosis factor, interleukine-1, or endotoxin. J Natl Cancer Inst 1990c;82:772-776
60. Kilbourn RG, Gross SS, Lodato RF, Levi R, Miller LL, Lachman LB, Griffith OW: Inhibition of interleukin-1-alpha-induced nitric oxide synthase in vascular smooth muscle and full reversal of interleukin-1-alpha-induced hypotension by N-omega-amino-L-arginine. J Natl Cancer Inst 1992;84:1008-1016
61. G-monomethyl-L-arginine (NMA) restores arterial blood pressure but reduces cardiac output in a canine model of endotoxic shock. Biochem Biophys Res Comm 1991;178 (3):1135-1140
62. Klemm P, Ostrowski J, Morath T, Gruber C, Martorana PA, Henning R: N-Acetylserotonine prevents the hypotension induced by bacterial lipopolysaccharides in the rat. Eur J Pharmacol 1993;250:R9-R10.
63. Knowles RG, Palacios M, Palmer RM, Moncada S: Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanyl-cyclase. Proc Natl Acad Sci USA 1989;86:5159-5162.
64. Knowles RG, Salter M, Brooks SL, Moncada S: Anti-inflammatory glucocorticoids inhibit the induction by endotoxin of nitric oxide synthase in the lung, liver and aorta of the rat. Biochem Biophys Res Comm 1990;172(3):1042-1048.
65. G-nitro-L-Arginine methylester in canine blood in vitro. Arch Pharmacol 1993;347:342-345.
66. Lang CH, Bagby GJ, Ferguson JL, Spitzer JJ: Cardiac output and redistribution of blood flow in hypermetabolic sepsis. Am J Physiol 1983;246:R331-R337
67. Lefroy DC, Crake T, Uren NG, Davies GJ, Maseri A: Effect of inhibition of Nitric Oxide synthesis on epicardial caliber and coronary blood flow in humans. Circulation 1993;88:43-54
68. Leone AM, Palmer RMJ, Knowles RG, Francis PL, Ashton DS, Moncada S: Constitutive and inducible nitric oxide synthases incorporate molecular oxygen into both nitric oxide and citrulline. J Biol Chem 1991;266:23790-23795.
69. Lorente JA, Landin L, Pablo de R, Renes F, Liste D: L-Arginine pathway in the sepsis syndrome. Crit Care Med 1993;21:1287-1295.
70. Martin W, Smith JA, White DG: The mechanisms by which haemoglobin inhibits the relaxation of rabbit aorta induced by nitrovasodilators, nitric oxide, or bovine retractor penis inhibitory factor. Br J Pharmacol 1986;89:563-571.
71. Martin W, Villani GM, Jothianandan D, Furchgott RF: Selective blockade of endothelium dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta. J Pharmacol Exp Ther 1985;232:708-716.
72. Marietta MA, Yoon PS, Iyengar R, Leaf CD, Wishnok JS: Macrophage oxidation of L-arginine to nitrite and nitrate: Nitric oxide is an intermediate. Biochemistry 1988;27:8706-8711.
73. Mayer B, Brunner F, Schmidt K: Inhibition of nitric oxide synthesis by methylene blue. Biochem Pharmacol 1993;45:367-374.
74. Mayer B, John M, Heinzel B: Brain nitric oxide synthase is a biopterin and flavin containing multi-functional oxido-reductase. FEBS Lett 1991;288:187.
75. McCall TB, Feelisch M, Palmer RM, Moncada S: Identification of N-iminoethyl-L-ornithine as an irreversible inhibitor of nitric oxide synthase in phagocytic cells. Br J Pharmacol 1991;102:234-238.
76. McDonough KH, Lang CH, Spitzer JJ: Depressed function of isolated hearts from hyperdynamic septic rats. Circ Shock 1984;12:241-251.
77. McKenna TC, Martin FM, Chernow B, Brigua FA: Vascular endothelium contributes to decreased aorctic contractility in experimental sepsis. Circ Shock 1986;19:267-273.
78. Meyer J, Stothert JC, Pollard V, Hinder F, Herndon DN, Traber DL: Increased organ bloodflow in sepsis and its reversal with the nitric oxide synthesis inhibitor L-NAME. Crit Care Med 1993;21:S280(Abst)
79. Meyer J, Traber LD, Nelson S, Nelson S, Lentz CW, Nakazawa H, Herndon DN, Noda H, Traber DL: Reversal of hyperdynamic responses to continuous endotoxin administration by inhibition of NO synthesis. J Appl Physiol 1992;73:324-328
80. Moncada S, Higgs EA: The L-argininc - Nitric Oxide pathway. N Engl J Med 1993;30:2002-2012
81. Moncada S, Palmer RM, Higgs RA: Nitric Oxide: Physiology, Pathophysiology, and Pharmacolo-gy. Pharmacol Rev 1991;43:109-142.
82. G-nitro-arginine (L-NOARG), a novel. L-arginine-reversible inhibitor of endothelium-dependent vasodilation in vitro. Br J Pharmacol 1990;99:408-412.
83. Murray HW and Teitelbaum RF: L-arginine-dependent reactive nitrogen intermediates and the antimicrobial effect of activated human mononuclcar phagocytes. J Infect Dis 1992;165:513-517.
84. Nava E, Palmer RM, Moncada S: Inhibition of nitric oxide synthesis in septic shock: how much is beneficial? Lancet 1991;338:1555-1557
85. G-monomethyl-L-arginine. J Cardiovasc Pharmacol 1992;20:S132-134.
86. Ochoa JB, Udekwu AO, Billiar TR, Curran RD, Cerra FB, Simmons RL, Peitzman AB: Nitrogen oxide levels in patients after trauma and during sepsis. Ann Surg 1991;214:621-626.
87. Osaka K: Prolonged vasospasm produced by the breakdown products of erythrocytes. J Neurosurg 1977;47:403-410.
88. Palmer RM, Ferrige AG, Moncada S: Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987;327:524-526.
89. Palmer RM, Ashton DS, Moncada S: Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 1988;333:664-666.
90. Parillo JE: Septic shock in humans. Ann Intern Med 1990;113:227-242.
91. Parker MM, Shelhamer JH, Natanson C, Alling DW, Parillo JE: Serial cardiovascular variables in survivors and nonsurvivors of human septic shock: Heart rate as an early predictor of prognosis. Crit Care Med 1987;15:923-929.
92. Petros A, Bennet D, Vallance P: Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock. Lancet 1991;338:1557-1558.
93. Petros A, Lamb G, Leone A, Moncada S, Rennet D, Vallance P: Effects of a nitric oxide synthase inhibitor in humans with septic shock. Cardiovasc Res 1994;28:34-39.
94. Quezado ZM, Natanson C: Systemic hemodynamic abnormalities and vasopressor therapy in sepsis ans septic shock. Am J Kidney Dis 1992;20:214-222.
95. Rackow EC, Astiz ME, Weil MH: Cellular oxygen metabolism during sepsis and shock. JAMA 1988:259 (13):1989-1993.
96. Radomski MW, Palmer RM, Moncada S: An L-arginine:nitric oxide pathway present in human platelets regulates aggregation. Proc Natl Acad Sci USA 1990;87:5193-5197.
97. Rees DD, Palmer RM, Moncada S: Role of endothelium derived nitric oxide in the regulation of blood pressure. Proc Natl Acad Sci USA 1989a;86:3375-3378.
98. Rees DD, Palmer RMJ, Hodson HF, Moncada S: A specific inhibitor of nitric oxide formation from L-arginine attenuates endothelium dependent relaxation. Br J Pharmacol 1989b;96:418-424.
99. Rees DD, Cellek S, Palmer RM, Moncada S: Dexamethasone prevents the induction by endotoxin of a nitric oxide synthase and the associated effects on vascular tone: an insight into endotoxin shock. Biochem Biophys Res Comm 1990a;173 (2):541-547
100. Rees DD, Palmer RM, Schulz R, Hodson HF, Moncada S: Characterisation of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br J Pharmacol 1990b;101:746-752.
101. Rubanyi GM, Romero JC, Vanhoutte PM: Flow-induced release of endothelium-derived relaxing factor. Am J Physiol 1986;250(Heart Circ Physiol 19):H1145-H1149.
102. Rumsey WL, Kilpatrick L, Wilson DF, Erecinska M: Myocardial metabolism and coronary flow: effects of endotoxemia. Am J Physiol 1988;255(Heart Circ Physiol 24): H1295-H1304.
103. Ruokonen E, Takala J, Kari A, Alhava E: Septic shock and multiple organ failure. Crit Care Med 1991;19: 1146-1151
104. G-monomethyl-L-arginine, an inhibitor of the nitric oxide synthethase. Intensive Care Med 1993;19:227-231
105. Schneider F, Lutun P, Hasselmann M, Stoclet JC, Tempe JD: Methylene blue increases vascular systemic resistance in human septic shock. Intensive Care Med 1992;18:309-311.
106. Schneider F, Lutun P, Couchot A, Bilbault P, Tempe JD: Plasma cyclic guanosine 3′-5′monophosphate concentrations and low vascular resistance in human septic shock. Intensive Care Med 1993;19:99-104
107. Schneemann M, Schoedon G, Hofer S, Blau N, Guerrero L, Schaffner A: Nitric oxide synthase is not a constituent of the antimicrobial armature of human mononuclear phagocytes. J Infect Dis 1993;167:1358-1363.
108. Schulz R, Smith JA, Lewis MJ, Moncada S: Nitric oxide synthase in cultured endocardial cells of the pig. Br J Pharmacol 1991;104:21-14.
109. 2+-independent nitric oxide synthase in the myocardium. Br J Pharmacol 1992a;105:575-580
110. Schultz PJ, Raij L: Endogenously synthesized nitric oxide prevents endotoxin-induced glomerular trombosis. J Clin Investig 1992b;90:1718-1725.
111. G-Nitro-Arginine Methyl Ester in the anaesthetized rabbit: venous vasomotion and plasma levels. J Vasc Res 1992;29:290-292.
112. Shah AM, Lewis MJ, Henderson AH: Effects of 8-bromo-cyclic GMP on contraction and on inotropic response of ferret cardiac muscle. J Mol Cell Cardiol 1991;23:55-64.
113. Smith RE, Palmer RM, Moncada S: Coronary vasodilatation induced by endotoxin in the rabbit isolated perfused heart is nitric oxide-dependent and inhibited by dexamethasone. Br J Pharmacol 1991;104:5-6.
114. Smith JA, Shah AM, Lewis MJ: Factors released from endocardium of the ferret and pig modulate myocardial contraction. J Physiol 1991;439:1-14.
115. Stuehr DJ, Gross SS, Sakuma I, Levi R, Nathan C: Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide. J Exp Med 1989;169:1011-1020.
116. Suffredini AF, Fromm RE, Parker MM, Brenner M, Kovacs JA, Wesley RA, Parillo JE: The cardiovascular response of normal humans to the administration of endotoxin. N Engl J Med 1989;321: 280-287.
117. Szabo C, Mitchell JA, Thiemermann C, Vane JR: Nitric-oxide-mediated hyporeactivity to noradrenaline preceeds the induction of nitric oxide synthase in endotoxin shock. Br J Pharmacol 1993;108:786-792
118. Tayeh and Marietta: Macrophage oxidation of L-arginine to nitric oxide, nitrite, and nitrate. J Biol Chem 1989;264:19654-19658.
119. Teale DM, Akinson AM: Inhibition of nitric oxide synthesis improves survival in a murine peritonitis model of sepsis and that is not cured by antibiotics alone. J Antimicrob Chemother 1992;30:839-842
120. Thiemermann C, Vane JR: Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysacharidcs in the rat in vivo. Eur J Pharmacol 1990;182:591-595
121. Tilton RG, Chang K, Hasan KS, Smith SR, Petrash JM, Misko TP, Moore WM, Currie MG, Corbett JA, McDaniel ML, Williamson JR: Prevention of diabetic vascular function by guanides. Inhibition of nitric oxide synthase versus advanced glycation end-product formation. Diabetes 1993;42:221-232.
122. Umans GJ, Samsel RW: L-Canavanine selectively augments contraction in aortas from endotoxemic rats. Eur J Pharmacol 1992;210:343-346.
123. Vallance P, Collier J, Moncada S: Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet 1991;997-998
124. Vallance P, Leone A, Calver A, Collier J, Moncada S: Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 1992;339:572-575.
125. Wang J, Stuerhr DJ, Ikeda-Saito M, Rousseau DL: Heme coordination and structure of the catalytic site in nitric oxide synthase. J Biol Chem 1993;268:22255-22258.
126. Whittle BJ, Lopez-Belmonte J, Rees DD: Modulation of the vasopressor actions of acetylcholine, bradykinine, substance P and endothelin in the rat by a specific inhibitor of nitric oxide formation. Br J Pharmacol 1989;98:646-652.
127. Wolin MS, Cherry PD, Rodenburg JM, Messina EJ, Kaley G: Methylene blue inhibits vasodilation of skeletal muscle arterioles to acetylcholine and nitric oxide via the extracellular generation of superoxide anion. J Pharmacol Exp Ther 1990;254:872-876.
128. Wright CE, Rees DD, Moncada: Protective and pathological roles of nitric oxide in endotoxin shock. Cardiovasc Res 1992;26:48-57.