Salivary epidermal growth factor plays a role in protection of ileal mucosal integrity

Digestive Diseases and Sciences

Volumn 42, Issue 10, 1997, Pages 2175-2181

  Rao, R K ^a   Thomas, D W ^b   Pepperl, S ^b   Porreca, F ^b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b NONE

Author keywords

Mucosal protection; Paracellular permeability; Saliva; Tight junctions

Indexed keywords

EPIDERMAL GROWTH FACTOR; MYELOPEROXIDASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; INTESTINE MUCOSA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIOIMMUNOASSAY; SALIVA ANALYSIS; TIGHT JUNCTION;

EID: 0030731514     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018855525989     Document Type: Article

References (38)

1. Grisham MB, Granger DN: Neutrophil-mediated mucosal injury: role of reactive oxygen metabolites. Dig Dis Sci 33:6s-15s, 1988
2. Macdonald TT, Speneer J: Cell-mediated immune injury in the intestine. Gastroenterol Clin North Am 21:367-386, 1992
3. Mckay DM, Perdue MH: Intestinal Epithelial function: The case for immunophysiological regulation. Dig Dis Sci 38:1735-1745, 1993
4. Podolsky DK: Inflammatory bowel disease. N Engl J Med 325:928-937, 1991
5. Turnberg LA: Gastric mucosal defense mechanisms. Seand J Gastroenterol 20:37-40, 1985
6. Konturck JW, Bramnvski T, Konturek SJ: Epidermal growth factor in protection, repair, and healing of gastroduodenal mueosa. J Clin Gastroenterol 13:s88-s97, 1991
7. Cohen S: Isolation of mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the newborn animal. J Biol Chem 237:1555-1562, 1962
8. Rao RK: Biologically active peptides in the gastrointestinal lumen. Life Sci 48:1685-1704, 1991
9. Olsen PS, Kirkegaard P, Poulsen SS, Nexo E: Adrenergic effect on exocrine secretion of rat submandibular epidermal growth factor. Gut 25:1234-1240, 1984
10. Rao RK: Luminal processing of epidermal growth factor in mouse gastrointestinal tract in vivo. Peptides 16:505-513, 1995
11. Sarosiek J, Bilski J, Murthy VLN, Slomiany S, Slomiany BL: Role of salivary epidermal growth factor in the maintenance of physicochemical characteristics of oral and gastric mucus coat. Biochem Biophys Res Commun 152:1421-1427, 1988
12. Olsen PS, Poulsen SS, Kirkegaard P, Nexo E: Role of submandibular saliva and epidermal growth factor in gastric cytoprotection. Gastroenterology 87:103-108, 1984
13. 125Biol Chem 250:4297-4304, 1975
14. Sheldon RJ, Malarchick ME, Fox DA, Burks TF, Porreca F: Pharmacological characterization of neural mechanisms regulating mucosal ion transport in mouse jejunum. J Pharmacol Exp Ther 249:572-582, 1989
15. Wallace JL, Macnaughton WK, Morris GP, Beck PL: Inhibition of leukotriene synthesis markedly accelerate healing in a rat model of inflammatory bowel disease. Gastroenterology 96:795-803, 1989
16. 51Cr-labeled EDTA absorption test. Lancet 2:323-325, 1983
17. 99mTc-diethylenetriamminopentaacetic acid in inflammatory bowel disease. Am J Gastroenterol 81:767-770, 1986
18. Harris ML, Schiller HJ, Reilly PM, Donowitz M, Grisham MB, Buckley GB: Free radicals and other reactive oxygen metabolites in inflammatory bowel disease: cause, consequence or epiphenomenon? Pharmacol Ther 53:375-408, 1992
19. Hollander D, Vadheim CM, Bretholz E, Delahunty T, Rotter JI: Increased intestinal permeability in patients with Crohn's disease and their relatives. Ann Intern Med 105:883-885, 1986
20. Hui WM, Chen BW, Kung AWC, Cho CH, Luk CT, Lam SK. Effect of epidermal growth factor on gastric blood flow in rats. Gastroenterology 104:1605-1610, 1993
21. Jenkins RT, Rooney PJ, Jones DB, Bienenstock J, Goodacre RI: Increased intestinal permeability in patients with rheumatoid arthritis: A side-effect of oral nonsteroidal antiinflammatory drug therapy? Br J Rheumatol 26:103-107, 1987
22. Olaison G, Leandersson P, Sjodahl R, Tagesson C: Intestinal permeability to polyetheleneglycol 600 in Crohn's disease: Preoperative determination in a defined segment of the small intestine. Gut 29:196-199, 1988.
23. Williams JG, Hughes LE, Hallett MB: Toxic oxygen metabolite production by circulating phagocytic cells in inflammatory bowel disease. Gut 31:187-193, 1990
24. Job T, Itoh M, Miyamoto T, Imai S, Ikeda T, Matsusako K, Katsumi K, Noguchi Y, Yakeuchi T, Kato T and Tanaka R. Epidermal growth factor in mouse digestive organs: Use of a sinsitive enzyme immunoassay. Gastroenterologey 92:A1455, 1987
25. Kelly SM Crampton J, Hunter JO: Salivary epidermal growth factor deficiency in rheumatoid disease: Influence of sicca syndrome. Gut 30:A1485, 1989
26. Kingsnorth AN, Smith P, Richards RC: Parotid salivary epidermal growth factor levels in human reflux oesophagitis and peptic ulcer disease. Gastroenterology 96:A257. 1989
27. Ohmura E, Emoto N, Tsushima T, Watanabe S, Takeiuchi T, Kawamura M, Shigemoto M, Shizume K: Salivary immunoreactive human epidermal growth factor in patients with peptic ulcer-disease. Hepato-gastroenterology 34:160-163, 1987
28. Rao RK, Naon H, Mckilligan K, Sherman P, Thomas DW: Lower levels epidermal growth factor in saliva from patients with Crohn's disease and ulcerative colitis. Gastroenterology 106:A758, 1994
29. Li AKC, Schattenkerk ME, Huffman RG, Ross JS and Malt RA. Hypersecretion of submandibular saliva in male mice: Trophic response in small intestine. Gastroenterology 84:949-955, 1983
30. Freel RW, Hatch M, Earnest DI: Role of tight-junctional pathways in bile salt-induced increases in colonic permeability. Am J Physiol 245:G816-G823, 1983
31. Baker RD, Baker SS, Larosa K: Polarized Caco-2 cells: Effect of reactive oxygen metabolites on enterocyte barrier function. Dig Dis Sci 40:510-518, 1995
32. Velasquez OR, Henninger K, Fowler M, Tso P, Crissinger KD: Oleic acid-induced mucosal injury in developing piglet intestine. Am J Physiol 264:G576-G582, 1993
33. Rao RK, Porreca F: Epidermal growth factor inhibits Triton X-100-induced reduction in tissue resistance in mouse ileum in vitro. Eur J Pharmacol 104:209-212, 1996
34. Evangelista S, Maggi CA: Influence of sialoadenectomy on capsaicin-sensitive "gastric defense mechanism" in rats. Jpn J Pharmacol 56:377-380, 1991
35. Konturek SJ, Brzozowski T, Konturek PK, Majka J, Dembinski A: Role of salivary glands and epidermal growth factor (EGF) in gastric secretion and mucosal integrity in rats exposed to stress. Regul Pept 32:203-215, 1991
36. Tepperman BI, Soper BD: Interaction of nitric oxide and salivary gland epidermal growth factor in the modulation of rat gastric mucosal integrity. Br J Pharmacol 110:229-234, 1993
37. Scheving LA, Shiurba RA, Nguyen TD, Gray GM: Epidermal growth factor receptor of the intestinal enterocyte. Localization of lateral basal but not brush border membranes. J Biol Chem 264:1735-1741, 1989
38. Thompson JF, Vandenberg M, Stokkers PCF: Developmental regulation of epidermal growth factor receptor kinase in rat intestine. Gastroenterology 107:1278-1287, 1994