The range and biological activity of FMRFamide-related peptides and classical neurotransmitters in nematodes

Advances in Parasitology

Volumn 45, Issue , 2000, Pages 109-180

  Brownlee, David ^a   Holden Dye, Lindy ^a   Walker, Robert ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; ACETYLCHOLINE; DOPAMINE; GLUTAMIC ACID; NEUROTRANSMITTER; NITRIC OXIDE; NORADRENALIN; PHENYLALANYLMETHIONYLARGINYLPHENYLALANINAMIDE; SEROTONIN;

CAENORHABDITIS ELEGANS; NEMATODE; NERVOUS SYSTEM; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; REVIEW;

CAENORHABDITIS ELEGANS; INSECTA; NEMATODA;

EID: 0034021272     PISSN: 0065308X     EISSN: None     Source Type: Book Series    
DOI: 10.1016/s0065-308x(00)45004-9     Document Type: Review

References (248)

1. Agarwal, A., Mishra, S.K., Mishra, A., Katiyar, J.C. and Ghatak, S. (1983). The effect of levamisole on the level of biogenic amines in Nippostrongylus brasiliensis. Indian Journal of Medical Research 78, 651-655.
2. Agarwal, A., Shukla, O.P., Ghatak, S. and Tekwani, B.L. (1990). Biogenic amines, metabolites and monoamine oxidase in filarial worm, Setaria cervi. International Journal of Parasitology 20, 873-881.
3. Albertson, D.G. and Thomson, J.N. (1976). The pharynx of Caenorhabditis elegans. Philosophical Transactions of the Royal Society of London. Biological Sciences Series B 275, 299-325.
4. Alfonso, A., Grundahl, K., Duerr, J.S., Han, H.P. and Rand, J.B. (1993). The Caenorhabditis elegans une-17 gene: A putative vesicular acetylcholine transporter. Science 261, 617-619.
5. Alfonso, A., Grundahl, K., McManus, J.R. and Rand, J.B. (1994). Cloning and characterization of the choline acetyltransferase structural gene (cha-1) from C. elegans. Journal of Neuroscience 14, 2290-2300.
6. Anderson, R.C. (1984). The origins of zooparasitic nematodes. Canadian Journal of Zoology 62, 317-328.
7. Avery, L. and Horvitz, H.R. (1990). Effects of starvation and neuroactive drugs on feeding in Caenorhabditis elegans. Journal of Experimental Zoology 253, 263-270.
8. Avery, L. and Thomas, J.H. (1997). Feeding and defaecation. In: C. elegans II (D.L. Riddle, T. Blumenthal, B.J. Meyer and J.R. Priess, eds), pp. 679-716. Cold Spring Harbor Laboratory Press.
9. Avery, L., Raizen, D. and Lockery, S. (1995). Electrophysiological methods. Methods in Cell Biology, 48, 251-269.
10. Baldwin, E. and Moyle, V. (1949). A contribution to the physiology and pharmacology of Ascaris lumbricoides from the pig. British Journal of Pharmacology 4, 145-152.
11. Ballivet, M., Alliod, C., Bertrand, S. and Bertrand, D. (1996). Nicotinic acetylcholine receptors in the nematode Caenorhabditis elegans. Journal of Molecular Biology 258, 261-269.
12. Barnes, RSK, Calow, P. and Olive, P.J.W. (1993). The Invertebrates: A New Synthesis p. 90, edition 2. Oxford: Blackwell Scientific Publications.
13. Barreteau, H., Trouvin, J.H., Goudey-Perriere, F., Jacquot, C. and Gayral, P. (1991). Biogenic amines and GABA in the larval and adult forms of the nematode Nippostrongylus brasiliensis. Comparative Biochemistry and Physiology 100C, 445-449.
14. Bascal, Z.A., Montgomery, A., Holden-Dye, L., Williams, R.G. and Walker, R.J. (1995a). Histochemical mapping of NADPH diaphorase in the nervous system of the parasitic nematode, Ascaris suum. Parasitology 110, 625-637.
15. Bascal, Z.A., O'Shea, M., Cunningham, J., Holden-Dye, L. and Walker, R.J. (1995b). A possible role for nitric oxide in the motornervous system of the parasitic nematode Ascaris suum. Abstract of the Society for Neuroscience 21, 256.2.
16. Bascal, Z., Holden-Dye, L., Willis, R.J., Smith, S.W.G. and Walker, R.J. (1996a). Novel azole derivatives are antagonists at the inhibitory GABA receptor on the somatic muscle cells of the parasitic nematode Ascaris suum. Parasitology 112, 253-259.
17. Bascal, Z.A., Montgomery, A., Holden-Dye, L., Williams, R.G., Thorndyke, M.C. and Walker, R.J. (1996b). Co-localization of NADPH diaphorase, SALMFamide-like immunoreactivity and calcitonin gene related peptide-like immunoreactivity in the nervous system of the parasite nematode, Ascaris suum. Parasitology 112, 125-134.
18. Benjamin, P.R. and Burke, J.F. (1994). Alternative mRNA splicing of the FMRFamide gene and its role in neuropeptidergic signalling in a defined neural network. Bio Essays 16, 335-342.
19. Bowman, J.W., Winterowd, C.A., Friedman, A.R., Thompson, D.P., Klein, R.D., Davis, J.P., Maule, A.G., Blair, K.V. and Geary, T.G. (1995). Nitric oxide mediates the inhibitory effects of SDPNFLRFamide, a nematode FMRFamide-related neuropeptide, in Ascaris suum. Journal of Neurophysiology 74, 1880-1887.
20. Bowman, J.W., Friedman, A.R., Thompson, D.P., Ichhpurani, A.K., Kellman, M.F., Marks, N., Maule, A.G. and Geary, T.G. (1996). Structure-activity relationships of KNEFIRFamide (AF1), a nematode FMRFamide-related peptide, on Ascaris suum muscle. Peptides 17, 381-387.
21. Brezina, V. and Weiss, K.R. (1997). Analyzing the functional consequences of transmitter complexity. Trends in Neurosicence 20, 538-543.
22. Brezina, V., Bank, B., Cropper, E.C., Rosen, S., Vilim, F.S., Kupfermann, I. and Weiss, K.R. (1995). 9 members of the myomodulin family of peptide cotransmitters at the B16-arc neuromuscular-junction of Aplysia. Journal of Neurophysiology 74, 54-72.
23. Brezina, V., Orekhova, I.V. and Weiss, K.R. (1996). Functional uncoupling of linked neurotransmitter effects by combinatorial convergence. Science 273, 806-810.
24. Brooman, J. (1998). Characterization of putative 5-hydroxytryptamine receptors in the parasitic nematode, Ascaris suum. PhD Thesis, University of Southampton, UK.
25. Brownlee, D.J.A., Fairweather, I. and Johnston, C.F. (1993a). Immunocytochemical demonstration of neuropeptides in the peripheral nervous system of the roundworm Ascaris suum (Nematoda: Ascaroidea). Parasitology Research 79, 302-308.
26. Brownlee, D.J.A., Fairweather, I., Johnston, C.F. and Shaw, C. (1993b). Immunocytochemical demonstration of peptidergic and serotoninergic components in the enteric nervous system of the roundworm, Ascaris suum. Parasitology 108, 89-103.
27. Brownlee, D.J.A., Brennan, G.P., Halton, D.W., Fairweather, I. and Shaw, C. (1994a). Ultrastructural localization of pancreatic polypeptide and FMRFamide-like immunoreactivities within the central nervous system of the nematode Ascaris suum. Parasitology 108, 587-593.
28. Brownlee, D.J.A., Fairweather, I., Johnston, C.F. and Shaw, C. (1994b). Immunocytochemical demonstration of peptidergic and serotoninergic components in the enteric nervous system of the roundworm, Ascaris suum (Nematoda, Ascaroidea). Parasitology 108, 89-103.
29. Brownlee, D.J.A., Holden-Dye, L., Fairweather, I. and Walker, R.J. (1995a). The action of serotonin and the nematode neuropeptide KSAYMRFamide on the pharyngeal muscle of the parasitic nematode, Ascaris suum. Parasitology 111, 379-384.
30. Brownlee, D.J.A., Holden-Dye, L., Walker, R.J. and Fairweather, I. (1995b). The pharynx of the nematode Ascaris suum: Structure and function. Acta Biologica Hungarica 46, 195-204.
31. Brownlee, D.J.A., Fairweather, I., Holden-Dye, L. and Walker, R.J. (1996a). Nematode neuropeptides: Localization, isolation and function. Parasitology Today 12(9), 343-351.
32. Brownlee, D.J.A., Fairweather, I., Thorndyke, M.C. and Johnston, C.F. (1996b). Cellular and subcellular localization of SALMFamide (S1)-like immunoreactivity within the central nervous system of the nematode Ascaris suum (Nematoda, Ascaroidea). Parasitology Research 82(2), 149-156.
33. Brownlee, D.J.A., Holden-Dye, L. and Walker, R.J. (1997). Actions of the anthelmintic ivermectin on the pharyngeal muscle of the parasitic nematode, Ascaris suum. Parasitology 115, 553-561.
34. Bullock, T.H. (1965). Pseudocoelomate Phyla: Acanthocephala, Rotifer, Gastrotricha, Kinorhyncha, Nematoda, Nematomorpha, and Entoprocta. In: Structure and Function in the Nervous System of Invertebrates (Bullock, T.H. and Horridge, G.A., eds), pp. 597-629. San Francisco and London: W.H. Freeman and Company.
35. Bürglin, T.R., Lobos, E. and Blaxter, M.L. (1998). Caenorhabditis elegans as a model for parasitic nematodes. International Journal of Parasitology 28, 395-411.
36. Chaudhuri, J. and Donahue, M.J. (1989). Serotonin receptors in the tissues of adult Ascaris suum. Molecular Biochemical Parasitology 35, 191-198.
37. Chaudhuri, J., Martin, R.E. and Donahue, M.J. (1988). Evidence for the absorption and synthesis of 5-hydroxytryptamine in perfused muscle and intestinal tissue and whole worms of adult Ascaris suum. Parasitology 96, 157-170.
38. Chen, X-H., Holden-Dye, L. and Walker, R.J. (1997). Inhibitory actions of dopamine in the motor nervous system of the parasitic nematode, Ascaris suum. Journal of Physiology 504P, p25.
39. Chitwood, B.G. and Chitwood, M.B. (1974). The nervous system. In: Introduction to Nematodology (Chitwood, B.G. and Chitwood, M.B.), pp. 160-174. Baltimore: University Park Press.
40. Colquhoun, L.M., Holden-Dye, L. and Walker, R.J. (1991). The pharmacology of cholinoceptors on the somatic muscle cells of the parasitic nematode Ascaris suum. Journal of Experimental Biology 158, 509-530.
41. Colquhoun, L.M., Holden-Dye, L. and Walker, R.J. (1993). The action of nicotinic receptor specific toxins on the somatic muscle cells of the parasitic nematode Ascaris suum. Molecular Neuropharmacology 3, 11-16.
42. Coombs, I. and Crompton, D.W.T. (eds) (1991). A Guide to Human Helminths. London: Taylor and Francis.
43. Coons, A.H., Leduc, E.H. and Connolly, J.M. (1955). Studies on antibody production. 1. A method for the histochemical demonstration of specific antibody and its application to a study of the hyperimmune rabbit. Journal of Experimental Medicine 102, 49-60.
44. Cottrell, G.A. (1997). The first peptide-gated ion channel. Journal of Experimental Biology 200, 2377-2386.
45. Cowden, C. and Stretton, A.O.W. (1993). AF2, an Ascaris neuropeptide: isolation, sequence and bioactivity. Peptides 14, 423-430.
46. Cowden, C. and Stretton, A.O.W. (1995). Eight novel FMRFamide-like neuropeptides isolated from the nematode Ascaris suum. Peptides 16, 491-500.
47. Cowden, C., Stretton, A.O.W. and Davis, R.E. (1989). AF1, a sequenced bioactive neuropeptide isolated from the nematode Ascaris suum. Neuron 2, 1465-1473.
48. Cowden, C., Sithigorngul, P., Brackley, P., Guastella, J. and Stretton, A.O.W. (1993). Localization and differential expression of FMRFamide-like immuno-reactivity in the nematode Ascaris suum. Journal of Comparative Neurology 333, 455-468.
49. Crofton, H.D. (1966). Nematodes. London: Hutchinson and Company Ltd.
50. Croll, N.A. (1975). Indolealkylamines in the co-ordination of nematode behavioural activities. Canadian Journal of Zoology 53, 894-903.
51. Crompton, D.W.T. (1985). Chronic Ascariasis and malnutrition. Parasitology Today 1, 2.
52. Cropper, E.C., Kupfermann, I. and Weiss, K.R. (1990a). Differential firing patterns of the peptide-containing cholinergic motor neurons B15 and B16 during feeding behaviour in Aplysia. Brain Research 522, 176-179.
53. Cropper, E.C., Price, D.A., Tenenbaum, R., Kupfermann, I. and Weiss, K.R. (1990b). Release of peptide co-transmitters from a cholinergic motor neuron under physiological conditions. Proceedings of the National Academy of Sciences of the USA 87, 933-937.
54. Cully, D.F., Vassilatis, D.K., Liu, K.K., Paress, P.S., Van derPloeg, L.H.T., Schaeffer, J.M. and Arena, J.P. (1994). Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans. Nature 371, 707-711.
55. Cully, D.F., Wilkinson, H., Vassilatis, D.K., Etter, A. and Arena, J.P. (1996a). Molecular biology and electrophysiology of glutamate-gated chloride channels of invertebrates. Parasitology 113, S191-S200.
56. Cully, D.F., Paress, P.S., Liu, K.K., Schaeffer, J.M. and Arena, J.P. (1996b). Identification of a Drosophila melanogaster glutamate-gated chloride channel sensitive to the antiparasitic agent avermectin. Journal of Biological Chemistry 271, 20187-20191.
57. Culotti, J.G. and Klein, W.L. (1983). Occurrence of muscarinic acetylcholine receptors in the wild type and cholinergic mutants of Caenorhabditis elegans. Journal of Neuroscience 3, 359-368.
58. Culotti, J.G., Von Ehrenstein, G., Culotti, M.R. and Russell, R.L. (1981). A second class of acetylcholinesterase-deficient mutants of the nematode Caenorhabditis elegans. Genetics 97, 281-305.
59. Davey, K.G. (1966). Neurosecretion and molting in some parasitic nematodes. American Zoologist 6, 243-249.
60. Davey, K.G. (1988). Endocrinology of nematodes. In: Invertebrate Endocrinology, Vol. 2, Endocrinology of Selected Invertebrate Types (Downer, R.G.H. and Laufer, H., eds), pp. 63-86. New York: Alan R. Liss.
61. Davey, K.G. and Goh, S.L. (1984). Ecdysis in a parasitic nematode: direct evidence for an ecdysial factor from the head. Canadian Journal of Zoology 62, 2293-2296.
62. Davis, R.E. (1998a). Neurophysiology of glutamatergic signalling and anthelmintic action in Ascaris suum: pharmacological evidence for a kainate receptor. Parasitology 116, 471-486.
63. Davis, R.E. (1998b). Action of excitatory amino acids on hypodermis and the motornervous system of Ascaris suum: pharmacological evidence for a glutamate transporter. Parasitology 116, 487-500.
64. Davis, R.E. and Stretton, A.O.W (1995). Neurotransmitters of helminths. In: Biochemistry and Molecular Biology of Parasites (Marr, J.J. and Muller, M., eds), pp. 267-287. London: Academic Press.
65. Davis, R.E. and Stretton, A.O.W. (1996). The motornervous system of Ascaris: Electrophysiology and anatomy of the neurons and their control by neuromodulators. Parasitology 113, S97-S117.
66. Del Castillo, J. and Morales, T. (1967). The electrical and mechanical activity of the esophageal cell of Ascaris lumbricoides. The Journal of General Physiology 50, 603-629.
67. Del Castillo, J., De Mello, W.C. and Morales, T. (1963). The physiological role of acetylcholine in the neuromusculature system of Ascaris lumbricoides. Archives International Physiology and Biochimie 71, 741-757.
68. Dent, J.A., Davis, M.W. and Avery, L. (1997). avr-15 encodes a chloride channel subunit that mediates inhibitory glutamatergic neurotransmission and ivermectin sensitivity in Caenorhabditis elegans. The European Molecular Biology Organization Journal 18, 5867-5879.
69. Desai, C. and Horvitz, H.R. (1989). Caenorhabditis elegans mutants defective in the functioning of the motor neurons responsible for egg laying. Genetics 121, 703-721.
70. Desai, C., Garriga, G., McIntyre, S.L. and Horvitz, H.R. (1988). A genetic pathway for the development of the Caenorhabditis elegans HSN motor neurons. Nature 336, 638-646.
71. Donahue, M.J., Yacoub, N.J., Kaeini, M.R., Masaracchia, R.A. and Harris, B.G. (1981). Glycogen metabolizing enzymes during starvation and feeding of Ascaris suum maintained in a perfusion chamber. Journal of Parasitology 67, 505-510.
72. Donahue, M.J., Yacoub, N. and Harris, B. (1982). Correlation of muscle activity with glycogen metabolism in muscle of Ascaris suum. American Journal of Physiology 242, R514-R521.
73. Duittoz, A.H. and Martin, R.J. (1991a). Effects of SR95103 on GABA-activated single-channel currents from Ascaris suum muscle. Comparative Biochemistry and Physiology C- Pharmacology, Toxicology and Endocrinology 98, 423-432.
74. Duittoz, A.H. and Martin, R.J. (1991b). Antagonist properties of arylaminopyridazine GABA derivatives at the Ascaris muscle GABA receptor. Journal of Experimental Biology 159, 149-164.
75. Edison, A.S., Messinger, L.A. and Stretton, A.W. (1997). AFP-1: A gene encoding multiple transcripts of a new class of FMRFamide-like neuropeptides in the nematode Ascaris suum. Peptides 18, 929-935.
76. Elphick, M.R., Price, D.W., Lee, T.D. and Thorndyke, M.C. (1991a). The SALMFamides - A new family of neuropeptides isolated from an echinoderm. Proceedings of the Royal Society of London Series B -Biological Sciences 43, 121-127.
77. Elphick, M.R., Reeve, J.R., Burke, R.D. and Thorndyke, M.C. (1991b). Isolation of the neuropeptide SALMFamide-1 from starfish using a new antiserum. Peptides 12, 455-459.
78. Etter, A., Cully, D.F., Schaeffer, J.M., Liu, K.K. and Arena, J.P. (1996). An amino acid substitution in the pore region of a glutamate-gated chloride channel enables the coupling of ligand binding to channel gating. Journal of Biological Chemistry 271, 16035-16039.
79. Evans, A.M. and Martin, R.J. (1996). Activation and co-operative multi-ion block of single nicotinic-acetylcholine channel currents of Ascaris muscle by the tetra-hydropyrimidine anthelmintic, morantel. British Journal of Pharmacology 118, 1127-1140.
80. Evans, P.D., Robb, S. and Cuthbert, B.A. (1989). Insect neuropeptides: identification, establishment of functional roles and novel target sites for pesticides. Pesticide Science 25, 71-83.
81. Fairweather, I. and Halton, D.W. (1991). Neuropeptides in platyhelminths. Parasitology 102, S77-S92.
82. Fairweather, I. and Threadgold, L.T. (1983). Hymenolepis nana: the fine structure of the adult nervous system. Parasitology 86, 89-103.
83. Faulk, W.P. and Taylor, C.M. (1970). An immunocolloid method for the electron microscope. Immunocytochemistry 8, 1081-1083.
84. Fellowes, R.A., Maule, A.G., Marks, N.J., Geary, T.G., Thompson, D.P., Shaw, C. and Halton, D.W. (1998). Modulation of the motility of the vagina vera of Ascaris suum in vitro by FMRF-amide related peptides. Parasitology 116, 277-287.
85. Fleming, J.T., Baylis, H.A., Sattelle, D.B. and Lewis, J.A. (1996). Molecular cloning and in vitro expression of C. elegans and parasitic nematode ionotropic receptors. Parasitology 113, S175-S190.
86. Fleming, J.T., Squire, M.D., Barnes, T.M., Tornoe, C., Matsuda, K., Ahnn, J., Fire, A., Sulston, J.E., Barnard, E.A., Sattelle, D.B. and Lewis, J.A. (1997). Caenorhabditis elegans levamisole resistance genes lev-1, unc-29 and unc-38 encode functional nicotinic acetylcholine receptor subunits. Journal of Neuroscience 17, 5843-5857.
87. Forsum, E., Nesheim, M.C. and Crompton, D.W.T. (1981). Nutritional aspects of Ascaris infection in young protein-deficient pigs. Parasitology 83, 497-512.
88. Frandsen, J.C. and Bone, L.W. (1987). Biogenic amines and their metabolites in Trichostrongylus colubriformis, a nematode parasite of ruminants. Comparative Biochemistry and Physiology 87C, 75-77.
89. Frandsen, J.C. and Bone, L.W. (1988). Derivatives of epinephrine, norepinephrine, octopamine and histamine by homogenates of Trichostrongylus colubriformis, a nematode parasite of ruminants. Comparative Biochemistry and Physiology 91C, 385-387.
90. Franks, C.J., Holden-Dye, L., Williams, R.G., Pang, F.Y. and Walker, R.J. (1994). A nematode FMRFamide-like peptide, SDPNFLRFamide (PF1), relaxes the dorsal muscle strip preparation of Ascaris suum. Parasitology 108, 229-236.
91. Franks, C.J., Walker, R.J. and Holden-Dye, L. (1997). Pharyngeal muscle cell action potentials recorded from Caenorhabditis elegans. Journal of Physiology 504P, 15.
92. Fujita, T., Kanno, T. and Kobayashi, S. (1988). The Paraneuron. New York: Springer.
93. Geary, T.G. (1995). The pharmacology of FMRFamide-related peptides: new opportunities for rational anthelmintic discovery? International Journal of Parasitology 25, 1273-1280.
94. Geary, T.G., Price, D.A., Bowman, J.W., Winterowd, C.A., Mackenzie, C.D., Garrison, R.D., Williams, J.F. and Friedman, A.R. (1992). Two FMRFamide-like peptides from the free-living nematode Panagrellus redivivus. Peptides 13, 209-214.
95. Geary, T.G., Sims, S.M., Thomas, E.M., Vanover, L., Davis, J.P., Winterowd, C.A., Klein, R.D., Ho, N.F.H. and Thompson, D.P. (1993). Haemonchus contortus: Ivermectin-induced paralysis of the pharynx. Experimental Parasitology 77, 88-96.
96. Goh, S.L. and Davey, K.G. (1985). Occurrence of noradrenaline in the central nervous system of Phocanema decipiens and its possible role in the control of ecdysis. Canadian Journal of Zoology 63, 475-479.
97. Golding, D.W. (1974). A survey of neuroendocrine phenomena in non-arthropod invertebrates. Biological Reviews 49, 161-224.
98. Goodman, M.B., Hall, D.H., Avery, L. and Lockery, S.R. (1998). Active currents regulate sensitivity and dynamic range in C. elegans neurons. Neuron 20, 763-772.
99. Greenberg, M.J. and Price, D.A. (1983). Invertebrate neuropeptides: native and naturalized. Annual Reviews in Physiology 45, 271-288.
100. Grimmelikhuijzen, C.J.P. (1986). FMRFamide-like peptides in the primitive nervous systems of coelenterates and complex nervous systems of higher animals. In: Handbook of Comparative Opioid and Related Neuropeptide Mechanisms (Stephano, G. ed.), pp. 103-115. Boca Raton: CRC Press.
101. Grimmelikhuijzen, C.J.P. and Graff, D. (1986). Isolation of 〈Glu-Gly-Arg-Phe-NH2〉 (Antho-RFamide), a neuropeptide from sea anemones. Proceedings of the National Academy of Sciences of the USA 83, 9817-9821.
102. Grimmelikhuijzen, C.J.P. and Spencer, A.N. (1984). FMRFamide immunoreactivity in the nervous system of the medusa Polyorchis penicillatus. Journal of Comparative Neurology 230, 361-371.
103. Grimmelikhuijzen, C.J.P., Carstensen, K., Darmer, D., Moosler, A., Nothacker, H.-P., Reinscheid, R.K., Schmutzler, C., Voolert, H., McFarlane, I. and Reinehart, K.L. (1992a). Coelenterate neuropeptides: Structure, action and biosynthesis. American Zoologist 32, 1-12.
104. Grimmelikhuijzen, C.J.P., Darmer, D., Schmutzler, C., Carstensen, K., Moosler, A. Nothacker, H.-P., Reinscheid, R.K., Voolert, H., Reinehart, K.L. and McFarlane, I. (1992b). The peptidergic nervous system of coelenterates. In: Progress in Brain Research (Joose, Buijs and Tilders, eds), eh. 11, pp. 137-148. Elsevier Science Publishers.
105. 3H-GABA uptake sites in the nematode Ascaris. Journal of Comparative Neurology 307, 598-608.
106. Guastella, J., Johnson, C.D. and Stretton, A.O.W. (1991). GABA-immunoreactive neurones in the nematode Ascaris. Journal of Comparative Neurology 307, 584-597.
107. Halton, D.W., Shaw, C., Maule, A.G., Johnston, C.F. and Fairweather, I. (1992). Peptidergic messengers: a new perspective of the nervous system of parasitic platyhelminths. Journal of Parasitology 78, 179-193.
108. Halton, D.W., Shaw, C., Maule, A.G. and Smart, D. (1994). Regulatory peptides in helminth-parasites. Advances in Parasitology 34, 163-227.
109. Harnett, W. and Harnett, M.M. (1998). Heterotrimeric guanine nucleotide-binding proteins in eukaryotic parasites. Parasitology Today 14, 27-31.
110. Hermans-Borgmeyer, I., Zopf, D., Ryseck, R.P., Hovemann, B., Betz, H. and Gundelfinger, E.D. (1986). Primary structure of a developmentally regulated nicotinic acetylcholine receptor protein from Drosophila. European Molecular Biology Organization Journal 5, 1503-1508.
111. Hershey, A.D. and Krause, J.E. (1990). Molecular characterization of a functional cDNA encoding the rat substance P receptor. Science 247, 958-962.
112. Hökfelt, T. (1991). Neuropeptides in perspective: The last ten years. Neuron 7, 867-879.
113. Hökfelt, T., Elfvin, L.G., Eide, R., Schultzberg, M., Goldstein, M. and Luff, R. (1977). Occurrence of somatostatin-like immunoreactivity in some peripheral sympathetic noradrenergic neurons. Proceedings of the National Academy of Siences of the USA 74, 3587-3591.
114. Hökfelt, T., Holets, V.R., Staines, W., Meister, B., Melander, T., Schalling, M., Schultzberg, M., Freedman, J., Bjorklund, H., Olston, L., Lindh, B., Elevin, L.-G., Lundberg, J.M., Lindgren, J.A., Samuelsson, B., Pernow, B., Terenius, L., Post, C., Everitt, B. and Goldstein, M. (1986). Coexistence of neuronal messengers - an overview. Progress in Brain Research 68, 33-70.
115. Holden-Dye, L. and Walker, R.J. (1990). Avermectin and avermectin derivatives are antagonists at the 4-aminobutyric acid (GABA) receptor on the somatic muscle cells of Ascaris: is this the site of anthelmintic action? Parasitology 101, 265-271.
116. Holden-Dye, L., Hewitt, G.M., Wann, K.T., Krogsgaard-Larsen, P. and Walker, R.J. (1988). Studies involving avermectin and the 4-aminobutyric acid (GABA) receptor of Ascaris suum. Pesticide Science 24, 231-245.
117. Holden-Dye, L., Krogsgaard-Larsen, P., Nielsen, L. and Walker, R.J. (1989). GABA receptors on the somatic muscle cells of the parasitic nematode, Ascaris suum: Stereoselectivity indicates similarity to a GABA-A type agonist recognition site. British Journal of Pharmacology 98, 841-851.
118. Holden-Dye, L., Franks, C.J., Williams, R.G. and Walker, R.J. (1995). The effect of the nematode peptides SDPNFLRFamide (PF1) and SADPNFLRFamide (PF2) on synaptic transmission in the parasitic nematode Ascaris suum. Parasitology 110, 449-455.
119. Holden-Dye, L., Brownlee, D.J.A. and Walker, R.J. (1997). The effects of the peptide KPNFIRFamide (PF4) on the somatic muscle cells of the parasitic nematode Ascaris suum. British Journal of Pharmacology 120, 379-386.
120. Horn, D.H., Wilkie, J.S. and Thomson, J.A. (1974). The isolation of beta-ecdysone (20-hydroxyecdysone) from the parasitic nematode Ascaris lumbricoides. Experiential, 1109-1110.
121. Horvitz, H.R., Chalfie, M., Trent, C., Sulston, J.E. and Evans, P. (1982). Serotonin and octopamine in the nematode Caenorhabditis elegans. Science 216, 1012-1014.
122. Huang, X., Diaz, F., Duran, E., Hinman, C. and Komuniecki, R.W. (1997). Characterization of serotonin receptors in the pharynx of parasitic nematode Ascaris suum. American Society for Neuroscience Abstracts 23, 1217.
123. Isaac, R.E., Muimo, R. and MacGregor, D. (1990). N-acetylation of serotonin, octopamine and dopamine by adult Brugia pahangi. Molecular and Biochemical Parasitology 43, 193-198.
124. Isaac, R.E., Eaves, L., Muimo, R. and Lamango, N. (1991). N-acetylation of biogenic amines in Ascaridia galli. Parasitology 102, 445-450.
125. Isaac, R.E., MacGregor, D. and Coates, D. (1996). Metabolism and inactivation of neurotransmitters in nematodes. Parasitology 113, S157-S173.
126. Iversen, L.L. (1984). Amino acids and peptides: fast and slow chemical signals in the nervous system. Proceedings of the Royal Society, London, Series B 221, 245-260.
127. Jarman, M. (1976). Neuromuscular physiology of nematodes. In: The Organisation of Nematodes (Croll, N.A., ed.), pp. 293-312. New York and London: Academic Press.
128. Johnson, C.D. and Stretton, A.O.W. (1985). Localization of choline acetyltransferase within identified motoneurones of the nematode, Ascaris. Journal of Neuroscience 5, 1984-1992.
129. Johnson, C.D. and Stretton, A.O.W. (1987). GABA immunoreactivity in inhibitory motoneurones of the nematode, Ascaris. Journal of Neuroscience 7, 223-235.
130. Johnson, C.D., Duckett, J.G., Culotti, J.G., Herman, R.K., Meneely, P.M. and Russell, R.L. (1981). An acetylcholinesterase-deficient mutant of the nematode Caenorhabditis elegans. Genetics 97, 261-279.
131. Johnson, C.D., Rand, J.B., Herman, R.K., Stern, B.D. and Russell, R.L. (1988). The acetylcholinesterase genes of C. elegans: Identification of a third gene (ace-3) and mosaic mapping of a synthetic lethal phenotype. Neuron 1, 165-173.
132. Joose, J. (1988). What is special about peptides as neuronal messengers? In: Neurohormones in Invertebrates (Thorndyke, M.C. and Goldsworthy, G.J. eds) Cambridge: Cambridge University Press, pp. 1-3. New York: Alan R. Liss.
133. Jorgensen, E.M. and Rankin, C. (1997). Neural plasticity. In: C. elegans II. (Riddle, D.L., Blumenthal, T., Meyer, B.J. and Priess, J.R., eds), pp. 769-790. Cold Spring Harbor Laboratory Press.
134. Kao, P.N. and Karlin, A. (1986) Acetylcholine receptor binding site contains a disulfide cross-link between adjacent half-cystinyl residues. Journal of Biological Chemistry 261, 8085-8088.
135. Keating, C.D., Holden-Dye, L., Thorndyke, M.C., Williams, R.G., Mallett, A. and Walker, R.J. (1995). The FMRFamide-like neuropeptide AF2 is present in the parasitic nematode Haemonchus contortus. Parasitology 111, 515-521.
136. Kelly, R.B. (1985). Pathways of protein secretion in eukaryotes. Science 230, 25-32.
137. Knowles, C.O. and Casida, J.E. (1966). The mode of action of organophosphate anthelmintics. Cholinesterase inhibition in Ascaris lumbricoides. Journal of Agriculture and Food Chemistry 14, 566-572.
138. Kolson, D.L. and Russell, R.L. (1985a). A novel class of acetylcholinesterase, revealed by mutations, in the nematode Caenorhabditis elegans. Journal of Neurogenetics 2, 93-110.
139. Kolson, D.L. and Russell, R.L. (1985b). New acetylcholinesterase-deficient mutants of the nematode Caenorhabditis elegans. Journal of Neurogenetics 2, 69-91.
140. Kupfermann, I. (1991). Functional studies of cotransmission. Physiological Reviews 71, 683-732.
141. Kuroki, Y., Kanda, T., Kubota, L., Ikeda, T., Fujisawa, Y., Minakata, H. and Muneoka, Y. (1993). FMRFamide-related peptides isolated from the prosobranch mollusc, Fusinus ferrugineus. Acta Biologica Hungarica 44, 41-44.
142. Laughton, D.L., Lunt, G.G. and Wolstenholme, A.J. (1997). Reporter gene constructs suggest that the Caenorhabditis elegans avermectin receptor β-subunit is expressed solely in the pharynx. Journal of Experimental Biology 200, 1509-1514.
143. Le Novere, N. and Changeux, J.P. (1995). Molecular evolution of the nicotinic acetylcholine receptor: an example of multigene family in excitable cells. Journal of Molecular Evolution 40, 155-172.
144. Lee, D.L. (1962). The distribution of esterase enzymes in Ascaris lumbricoides. Parasitology 52, 241-260.
145. Lee, D.L. and Ko, R.C. (1991). Catecholaminergic neurons in Trichinella spiralis (Nematoda). Parasitology Research 77, 269-270.
146. Lewis, J.A., Wu, C.H., Levine, J.H. and Berg, H. (1980). Levamisole-resistant mutants of the nematode Caenorhabditis elegans appear to lack pharmacological acetylcholine receptors. Neuroscience 5, 967-989.
147. Lewis, J.A., Fleming, J.T., McLafferty, S., Murphy, H. and Wu, C. (1987a). The levamisole receptor, a cholinergic receptor of the nematode Caenorhabditis elegans. Molecular Pharmacology 31, 185-193.
148. Lewis, J.A., Elmer, J.S., Skimming, J., McLafferty, S., Fleming, J. and McGee, T. (1987b). Cholinergic receptor mutants of the nematode Caenorhabditis elegans. Journal of Neuroscience 7, 3059-3071.
149. Li, H., Avery, L., Denk, W. and Hess, G.P. (1997). Identification of chemical synapses in the pharynx of Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the USA 94, 5912-5916.
150. Lingueglia, E., Champigny, G., Lazdunski, M. and Barbry, P. (1995). Cloning of the amiloride-sensitive FMRFamide peptide-gated sodium channel. Nature 378, 730-733.
151. Loer, C.M. and Kenyon, C.J. (1993). Serotonin-deficient mutants and male mating behaviour in the nematode Caenorhabditis elegans. Journal of Neuroscience 13, 5407-5417.
152. Mackie, G.O. (1990). The elementary nervous system revisited. American Zoologist 30, 907-920.
153. Mapes, C.J. (1966). Structure and function in the nematode pharynx. 3. The pharyngeal pump of Ascaris lumbricoides. Parasitology 56, 137-149.
154. Marder, E., Christie, A.E. and Kilman, V.L. (1995). Functional organization of cotransmission systems: lessons from small nervous systems. Invertebrate Neuroscience 1, 105-112.
155. Marks, N.J., Shaw, C., Maule, A.G., Davis, J.P., Halton, D.W., Verhaert, P., Geary, T.G. and Thompson, D.P. (1995). Isolation of AF2 (KHEYLRFamide) from Caenorhabditis elegans: evidence for the presence of more than one FMRFamide-related peptide-encoding gene. Biochemical and Biophysical Research Communications 217, 845-851.
156. Marks, N.J., Maule, A.G., Geary, T.G., Thompson, D.P., Davis, J.P., Halton, D.W., Verhaert, P. and Shaw, C. (1997). APEASPFIRFamide, a novel FMRFamide-related decapeptide from Caenorhabditis elegans: structure and myoactivity. Biochemical and Biophysical Research Communications 231, 591-595.
157. Marks, N.J., Maule, A.G., Geary, T.G., Thompson, D.P., Li, C., Halton, D.W. and Shaw, C. (1998). KSAYMRFamide (PF3/AF8) is present in the free-living nematode, Caenorhabditis elegans. Biochemical Biophysical Research Communications 248, 422-425.
158. Martin, R.J. (1980). The effect of gamma-aminobutyric acid on the input conductance and membrane potential of Ascaris muscle. British Journal of Pharmacology 71, 99-106.
159. Martin, R.J. (1985). γ-Aminobutyric acid- and piperazine-activated single channel currents from Ascaris suum body muscle. British Journal of Pharmacology 84, 445-461.
160. Martin, R.J. and Valkanov, M.A. (1996). Effects of acetylcholine on a slow voltage-activated non-selective cation current mediated by non-nicotinic receptors on isolated Ascaris muscle bags. Experimental Physiology 81, 909-925.
161. Martin, R.J., Sitamze, J.M., Duittoz, A.H. and Wermuth, C.G. (1995). Novel arylaminopyridazine-GABA receptor antagonists examined electrophysiologically in Ascaris suum. European Journal of Pharmacology 276, 9-19.
162. Martin, R.J., Valkanov, M.A., Dale, V.M.E., Robertson, A.P. and Murray, I. (1996). Electrophysiology of Ascaris muscle and anti-nematodal drug action. Parasitology 113, S137-S156.
163. Martin, R.J., Robertson, A.P. and Bjorn, H. (1997). Target sites of anthelmintics. Parasitology 114, S111-S124.
164. Masu, Y., Nakayama, K., Tamaki, H., Harada, Y., Kuno, M. and Nakanishi, S. (1987). CDNA cloning of bovine substance-K receptor through oocyte expression system. Nature 329, 836-838.
165. Matthews, B.E. (1998). An Introduction to Parasitology. Cambridge: Cambridge University Press.
166. Maule, A., Shaw, C., Halton, D. and Thim, L. (1993). GNFFRFAMIDE - A novel FMRFamide-immunoreactive peptide isolated from the sheep tapeworm Monieza expansa. Biochemical and Biophysical Research Communications 193, 1054-1060.
167. Maule, A.G., Shaw, C., Bowman, J.W., Halton, D.W., Thompson, D.P., Geary, T.G. and Thim, L. (1994a). The FMRFamide-like neuropeptide AF2 (Ascaris suum) is present in the free-living nematode, Panagrellus redivivus (Nematoda, Rhabditida). Parasitology 109, 351-356.
168. Maule, A.G., Shaw, C., Bowman, J.W., Halton, D.W., Thompson, D.P., Geary, T.G. and Thim, L. (1994b). KSAYMFRamide - a novel FMRFamide-related heptapeptide from the free-living nematode, Panagrellus redivivus, which is myoactive in the parasitic nematode, Ascaris suum. Biochemical and Biophysical Research Communications 200, 973-980.
169. Maule, A.G., Geary, T.G., Bowman, J.W., Marks, N.J., Blair, K.L., Halton, D.W., Shaw, C. and Thompson, D.P. (1995a). Inhibitory effects of nematode FMRFamide-related peptides (FaRPs) on muscle strips from Ascaris suum. Invertebrate Neuroscience 1, 255-265.
170. Maule, A.G., Shaw, C., Bowman, J.W., Halton, D.W., Thompson, D.P., Thim, L., Kubiak, T.M., Martin, R.A. and Geary, T.G. (1995b). Isolation and preliminary biological characterization of KPNFIRFamide, a novel FMRFamide-related peptide from the free-living nematode, Panagrellus redivivus. Peptides 16, 87-93.
171. Maule, A.G., Bowman, J.W., Thompson, D.P., Marks, N.J., Friedman, A.R. and Geary, T.G. (1996). FMRFamide-related peptides (FaRPs) in nematodes: Occurrence and neuromuscular physiology. Parasitology 113, S119-135.
172. Mclntire, S.L., Garriga, G., White, J., Jacobson, D. and Horvitz, H.R. (1992). Genes necessary for directed axonal elongation or fasciculation in C. elegans. Neuron 8, 307-322.
173. McIntyre, S.L., Jorgensen, J. and Horvitz, H.R. (1993a). Genes required for GABA function in Caenorhabditis elegans. Nature 364, 334-337.
174. McIntyre, S.L., Jorgensen, E., Kaplan, J. and Horvitz, H.R. (1993b). The GABAergic nervous system of Caenorhabditis elegans. Nature 364, 337-341.
175. Mellanby, H. (1955). Identification and estimation of acetylcholine in three parasitic nematodes (Ascaris lumbricoides, Litomosoides carinii and the microfilatiae of Dirofilaria repens). Parasitology 45, 287-294.
176. o in multiple aspects of behaviour in C. elegans. Science 267, 1652-1655.
177. Mishra, S.K., Sen, R. and Ghatak, S. (1984). Ascaris lumbricoides and Ascaridia galli: biogenic amines in adults and developmental stages. Experimental Parasitology 57, 34-39.
178. Nakazawa, M., Yamada, M., Uchikawa, R. and Arizono, N. (1995). Immunocytochemical localization of secretory acetylcholinesterase of the parasitic nematode Nippostrongylus brasiliensis. Cell and Tissue Research 280, 59-64.
179. Natoff, I.L. (1969). The pharmacology of the cholinoceptor in muscle preparations of Ascaris lumbricoides. British Journal of Pharmacology 37, 251-257.
180. Nelson, L.S., Kim, K.Y., Memmott, R.E. and Li, C. (1998a). FMRFamide-related gene family in the nematode, Caenorhabditis elegans. Molecular Brain Research 58, 103-111.
181. Nelson, L.S., Rosoff, M.L. and Li, C. (1998b). Disruption of a neuropeptide gene, flp-1, causes multiple behavioral defects in Caenorhabditis elegans. Science 281, 1686-1690.
182. Nonet, M.L., Staunton, J.E., Kilgard, M.P., Fergestad, T., Hartwieg, E., Horvitz, H.R., Jorgensen, E.M. and Meyer, B.J. (1997). Caenorhabditis elegans rab-3 mutant synapses exhibit impaired function and are partially depleted of vesicles. Journal of Neuroscience 17, 8061-8073.
183. Olde, B. and McCombie, W.R. (1997). Molecular cloning and functional expression of a serotonin receptor from Caenorhabditis elegans. Journal of Molecular Neuroscience 8, 53-62.
184. Pang, F.Y., Mason, J., Holden-Dye, L., Franks, C.J., Williams, R.G. and Walker, R.J. (1995). The effects of the nematode peptide, KHEYLRFamide (AF2), on the somatic musculature of the parasitic nematode Ascaris suum. Parasitology 110, 353-362.
185. Parri, H.R., Holden-Dye, L. and Walker, R.J. (1991). Studies on the ionic selectivity of the GABA-operated chloride channel on the somatic muscle bag cells of the parasitic nematode Ascaris suum. Experimental Physiology 76, 597-606.
186. Peters, W. and Gilles, H.M. (1989). A Colour Atlas of Tropical Medicine and Parasitology, edition 3. London: Wolfe Medical Publications Ltd.
187. 2+ pools in smooth muscle of 'Mytilus edulis'. Comparative Biochemistry and Physiology 84C, 23-28.
188. Rand, J.B. and Nonet, M.L. (1997). Synaptic transmission. In: C. elegans II (Riddle, D.L., Blumenthal, T., Meyer B.J. and Priess, J.R., eds), pp. 611-643. Cold Spring Harbor Laboratory Press.
189. Reiner, D.J. and Thomas, J.H. (1995). Reversal of a muscle response to GABA during C. elegans male development. Journal of Neuroscience 15, 6094-6102.
190. Reinitz, C.A. and Stretton, A.O.W. (1996). Behavioural and cellular effects of serotonin on locomotion and male mating posture in Ascaris suum (Nematoda). Journal of Comparative Physiology 178, 655-667.
191. Reuter, M. and Gustafsson, M. (1989). 'Neuroendocrine cells' in flatworms - progenitors to Metazoan neurons? Archives of Histology and Cytolology 52, Suppl. 253-263.
192. Reuter, M. and Kuusisto, A. (1992). Growth factors in asexually reproducing Catenulida and Macrostomida (Platyhelminthes)? Zoomorphology 112, 155-166.
193. Reuter, M., Gustafsson, M.K.S., Lang, J. and Grimmelikhuijzen, C.J.P. (1990). The release sites and targets of nerve cells immunoreactive to RFamide - an ultrastructural study of Microstomwn lineare and Diphyllobothriwn dendritium (Platyhelminthes). Zoomorphology 109, 303-308.
194. Rew, R.S. and Fetterer, R.H. (1986). Mode of action of antinematodal drugs. In: Chemotherapy of Parasitic Diseases (Campbell, W.C. and Rew, R.S., eds), pp. 321-337. New York and London: Plenum Press.
195. Robertson, S.J. and Martin, R.J. (1993). Levamisole-activated single-channel currents from muscle of the nematode parasite Ascaris suum. British Journal of Pharmacology 108, 170-178.
196. Rosoff, M.L., Burglin, R. and Li, C. (1992). Alternatively spliced transcripts of the flp-1 gene encode distinct FMRFamide-like peptides in Caenorhabditis elegans. Journal of Neuroscience 12, 2356-2361.
197. Rosoff, M.L., Doble, K.E., Price, D.A. and Li, C. (1993) The flp-1 propeptide is processed into multiple, highly similar FMRFamide-like peptides in Caenorhabditis elegans. Peptides 14, 331-338.
198. Roth, J. (1982). The protein A-gold (pAg) technique Qualitative and quantitative approach for antigen localization on thin sections. In: Roth, J., Techniques in Immunocytochemistry, Vol. 1, pp. 104-137. London: Academic Press.
199. Rozhkova, E.K., Malyutina, T.A. and Shishov, B.A. (1980). Pharmacological characteristics of cholinoreception in the somatic muscles of the nematode Ascaris suum. General Pharmacology 11, 141-146.
200. Sajid, M. and Isaac, R.E. (1995). Identification and properties of a neuropeptide-degrading endopeptidase (neprilysin) of Ascaris suum muscle. Parasitology 111, 599-608.
201. 2) in the nematode, Ascaris suum, by aminopeptidase, endopeptidase and deamidase enzymes. Molecular and Biochemical Parasitology 75, 159-168.
202. Santama, N., Benjamin, P.R. and Burke, J.F. (1995). Alternative RNA splicing generates diversity of neuropeptide expression in the brain of the snail Lymnaea - in-situ analysis of mutually exclusive transcripts of the FMRFamide gene. European Journal of Neuroscience 7, 65-76.
203. Santama, N., Li, K.W., Geraerts, W.P.M., Benjamin, P.R. and Burke, J.F. (1996). Post-translational processing of the alternative neuropeptide precursor encoded by the FMRFamide gene in the pulmonate snail Lymnaea stagnalis. European Journal of Neuroscience 8, 968-977.
204. Schaefer, M., Picciotto, M.R., Kreiner, T., Kaldany, R.-R., Taussig, R. and Scheller, R.H. (1985). Aplysia neurons express a gene encoding multiple FMRFamide neuropeptides. Cell 41, 457-467.
205. Schaeffer, J.M., Bergstrom, A.R. and Turner, M.J. (1989a). MK-801 is a potent nematocidal agent. Characterization of MK-801 binding sites in Caenorhabditis elegans. Biochemical Journal 260, 923-926.
206. Schaeffer, J.M., Ruiz-Sanchez, J., Shih, T.L. and Mrozik, H. (1989b). Argiopine differentiates between vertebrate and invertebrate glutamate binding sites. Pesticide Biochemistry and Physiology 36, 220-228.
207. Schafer, W.R. and Kenyon, C.J. (1995). A calcium-channel homologue required for adaptation to dopamine and serotonin in Caenorhabditis elegans. Nature 375, 73-78.
208. Scheller, R.H. (1986). Neuropeptides. Multiple regulatory mechanisms and their roles in mediating simple behaviours. In: Invertebrate Peptides and Hormones (Thorndyke, M.C. and Goldsworthy, G., eds). Cambridge: Cambridge University Press.
209. Schinkmann, K. and Li, C. (1992). Localization of FMRFamide-like peptides in Caenorhabditis elegans. Journal of Comparative Neurology 316, 251-260.
210. Schinkmann, K. and Li, C. (1994). Comparison of two Caenorhabditis genes encoding FMRFamide (Phe-Met-Arg-Phe-NH2)-like peptides. Molecular Brain Research 1-4, 238-246.
211. o in Caenorhabditis elegans. Science 267, 1648-1651.
212. Sharpe, M.J. and Atkinson, H.J. (1980). Improved visualization of dopaminergic neurons in nematodes using the Glyoxylic acid fluorescence method. Journal of Zoology 190, 273-284.
213. Shisov, B.A. (1980). Biogenic amines in helminthes. In: Neurotransmitters: Comparative Aspects (Salanki, J. and Turpaev, T.M., eds), pp. 31-56. Budapest, Akademiai Kiado.
214. Singer, S.J. (1959). Preparation of an electron-dense antibody conjugate. Nature 183, 1523-1524.
215. Sithigorngul, P. and Stretton, A.O.W. (1991). Differential distribution of AF1, a FMRFamide-like peptide in the Ascaris nervous system, revealed by a specific monoclonal antibody. Society for Neuroscience Abstracts 17, 279.
216. Sithigorngul, P., Stretton, A.O.W. and Cowden, C. (1990). Neuropeptide diversity in Ascaris: an immunocytochemical study. Journal of Comparative Neurology 294, 362-376.
217. Smart, D. (1988). Catecholamine synthesis in Ascaridia galli (Nematoda). International Journal of Parasitology 18, 458-492.
218. Sossin, W.S., Sweet-Cordero, A. and Scheller, R.H. (1998). Dale's hypothesis revisited: different neuropeptides derived from a common prohormone are targeted to different processes. Proceedings of the National Academy of Sciences of the USA 87, 4845-4848.
219. Squire, M.D., Tornoe, C., Bayliss, H.A., Fleming, J.T., Barnard, E.A. and Sattelle, D.B. (1995). Molecular cloning and functional co-expression of a Caenorhabditis elegans nicotinic acetylcholine receptor subunit (acr-2). Receptors and Channels 3, 107-115.
220. Stretton, A.O.W. (1992). Chemical intercellular signalling mechanisms in the nervous system of the nematode Ascaris suum: potential sites of actions of new generations of anthelmintic drugs. In: Neurotox 91. Molecular Basis of Drug and Pesticide Action (Duce, I.A., ed.), pp. 123-138. Amsterdam: Elsevier Applied Science.
221. Stretton, A.O.W., Fishpool, E., Southgate, E., Donmoyer, J.E., Walrond, J.P., Moses, J.E.R. and Kass, I.S. (1978). Structure and physiological activity of the motor neurons of the nematode Ascaris. Proceedings of the National Academy of Sciences of the USA 75, 3493-3497.
222. Stretton, A.O.W., Davies, R.E., Angstadt, J.D., Donmoyer, J.E. and Johnson, C.D. (1985). Neural control of behaviour in Ascaris. Trends in Neuroscience 8, 294-300.
223. Sulston, J.E. and Horvitz, H.R. (1977). Post-embryonic cell lineages of the nematode Caenorhabditis elegans. Developmental Biology 56, 110-156.
224. Sulston, J., Dew, M. and Brenner, S. (1975). Dopaminergic neurons in the nematode Caenorhabditis elegans. Journal of Comparative Neurology 163, 215-226.
225. Takemoto, T. (1978). Isolation and structural identification of naturally occurring excitatory amino acids. In: Kainic Acid as a Tool in Neurobiology (McGeer, E.G., Olney, J.W. and McGeer, P.L., eds), pp. 1-15. New York, Raven Press.
226. Tanaka, K., Masu, M. and Natanishi, S. (1990). Structure and functional expression of the cloned rat neurotensin receptor. Neuron 4, 847-854.
227. Thorndyke, M.C., Crawford, B.D. and Burke, R.D. (1992). Localisation of a SALMFamide neuropeptide in the larval nervous system of the sand dollar Dendraster excentricus. Acta Zoologica 73, 207-212.
228. Tornoe, C., Bai, D., Holden-Dye, L., Abramson, S.N. and Sattelle, D.B. (1995). Actions of neurotoxins (bungarotoxins, neosurugatoxin and lophotoxins) on insect and nematode nicotinic acetylcholine receptors. Toxicon 33, 411-424.
229. Treinin, M. and Chalfie, M. (1995). A mutated acetylcholine receptor subunit causes neuronal degeneration in C. elegans. Neuron 14, 871-877.
230. Trent, C., Tsung, N. and Horvitz, H.R. (1983). Egg-laying defective mutants of the nematode Caenorhabditis elegans. Genetics 104, 619-647.
231. Trim, N., Brooman, J.E., Holden-Dye, L. and Walker, R.J. (1997). Mechanism of action of a stimulatory peptide AF3 (AVPGVLRFamide) in the motor nervous system of the parasitic nematode Ascaris suum. Journal of Physiology-London 504P, 11-12.
232. Trim, N., Brooman, J.E., Holden-Dye, L. and Walker, R.J. (1998). The role of cyclicAMP in the action of the peptide AF3 (AVPGVLRFamide) in the parasitic nematodes Ascaris suum and Ascaridia galli. Molecular and Biochemical Parasitology 93, 263-271.
233. Turner, M.J. and Schaeffer, J.M. (1989). Mode of action of ivermectin. In: Ivermectin and Abamectin (Campbell, W.C., ed.), pp. 73-88. New York: Springer-Verlag.
234. Van Noorden, S. and Varndell, I.A. (1987). Regulatory peptide immunocytochemistry at light- and electron microscopical levels. Experientia 43, 724-734.
235. Vehovszky, A., Bokisch, A.J., Krogsgaard-Larsen, P. and Walker, R.J. (1988). Pharmacological profile of gamma-aminobutyric acid (GABA) receptors of identified central neurones from Helix aspersa. Comparative Biochemistry and Physiology 92C, 391-399.
236. Vilim, F.S., Cropper, E.C., Rosen, S.C., Tenenbaum, R., Kupfermann, I. and Weiss, K.R. (1994). Structure, localization, and action of buccalin-b - a bioactive peptide from Aplysia. Peptides 15, 959-969.
237. Vilim, F.S., Cropper, E.C., Price, D.A., Kupfermann, I. and Weiss, K.R. (1996a). Release of peptide cotransmitters in Aplysia: Regulation and functional implications. Journal of Neuroscience 16, 8105-8114.
238. Vilim, F.S., Price, D.A., Lesser, W., Kupfermann, I. and Weiss, K.R. (1996b). Costorage and corelease of modulatory peptide cotransmitters with partially antagonistic actions on the accessory radula closer muscle of Aplysia californica. Journal of Neuroscience 16, 8092-8104.
239. Walker, R.J. (1992). Neuroactive peptides with an RFamide or Famide carboxyl terminal. Comparative Biochemistry and Physiology 102C, 213-222.
240. Walker, R.J., Bascal, Z.A., White, A.R., Pedder, S., Franks, C.J., Muneoka, Y. and Holden-Dye, L. (1995). Actions of neuroactive peptides and nitric oxide on Ascaris, Achatina and Helix tissues. Acta Biologica Hungarica 46, 183-193.
241. Ward, S., Thomson, N., White, J.G. and Brenner, S. (1975). Electron microscopical reconstruction of the nematode Caenorhabditis elegans. Journal of Comparative Neurology 160, 313-338.
242. Wenshenker, D., Garriga, G. and Thomas, J.H. (1995). Genetic and pharmacological analysis of neurotransmitters controlling egg laying in Caenorhabditis elegans. Journal of Neuroscience 15, 6975-6985.
243. Willett, J.D. (1980). Control mechanisms in nematodes. In: Nematodes as Biological Models (Zuckerman, B.M., ed.), Vol. 1, pp. 197-225. New York and London: Academic Press.
244. Williams, J.A., Shahkolahi, A.M., Abbassi, M. and Donahue, M.J. (1992). Identification of a novel 5-HTN (Nematoda) receptor from Ascaris suum muscle. Comparative Biochemistry and Physiology 101C, 469-474.
245. Wright, D.J. and Awan, F.A. (1978). Catecholaminergic structures in the nervous system of three nematode species, with observations on related enzymes. Journal of Zoology 185, 477-489.
246. Xiao, P.G. and Fu, S.H. (1986). Traditional antiparasitic drugs in China. Parasitology Today 2, 353-355.
247. Yokota, Y., Sasai, Y., Tanaka, K., Fujiwara, T., Tsuchida, K., Shigemoto, R., Kakizuka, A., Ohkubo, H. and Nakanishi, S. (1989). Molecular characterisation of a functional cDNA for rat substance P receptor. Journal of Biological Chemistry 264, 17649-17652.
248. You, S.J., Dochoi, J. and Cho, N.J. (1996). Ligand-binding properties of muscarinic acetylcholine receptors in Caenorhabditis elegans. Journal of Biochemistry and Molecular Biology 29, 525-529.