Disruption of a neuropeptide gene, flp-1, causes multiple behavioral defects in Caernorhabditis elegans

Science

Volumn 281, Issue 5383, 1998, Pages 1686-1690

  Nelson, Laura S ^a   Rosoff, Marc L ^a   Li, Chris ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

NEUROPEPTIDE;

ARTICLE; BEHAVIOR DISORDER; CAENORHABDITIS ELEGANS; GENE DISRUPTION; GENE OVEREXPRESSION; GENETIC EPISTASIS; HYPERACTIVITY; HYPEROSMOLARITY; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; FMRFAMIDE; GENES, HELMINTH; GTP-BINDING PROTEINS; HELMINTH PROTEINS; MOTOR ACTIVITY; MOVEMENT; MUTATION; NEUROPEPTIDES; OSMOLAR CONCENTRATION; PHENOTYPE; POLYMERASE CHAIN REACTION; SEQUENCE DELETION; SEROTONIN; SIGNAL TRANSDUCTION; TRANSGENES;

EID: 0032508528     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.281.5383.1686     Document Type: Article

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55. We thank R. H. A. Plasterk for generously screening for and providing the flp-1::Tc1 insertional strain NL242 (pk41); L. Brundage, J. Mendel, P. Sternberg, J. Kaplan, L. Avery, and R. Korswagen for providing G protein-subunit mutants, advice on assays, and communication of unpublished results; H. R. Horvitz for providing mapping strains; A. Fire for providing microinjection vectors; J. Cherry and E. Widmaier for patiently providing help with the statistical analyses; S. Craven, H. Field, G. Jang, Y. Honzano, and C. Milliken for graciously providing technical assistance; T. Gilmore for comments on the manuscript; and members of the lab for helpful discussions. Supported in part by grants from NSF (IBN9320262) and NIH (AG00708) to C.L.