Structure-activity relationships of KNEFIRFamide (AF1), a nematode FMRFamide-related peptide, on Ascaris suum muscle

Peptides

Volumn 17, Issue 3, 1996, Pages 381-387

  Bowman, J W ^a   Friedman, A R ^a   Thompson, D P ^a   Ichhpurani, A K ^a   Kellman, M F ^a,b   Marks, N ^a,c   Maule, A G ^a,c   Geary, Timothy G ^a  

^a PFIZER INC   (United States)

^b VIRGINIA MARYLAND REGIONAL COLLEGE OF VETERINARY MEDICINE   (United States)

^c QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Ascaris suum; FMRFamide; KNEFIRFamide; Nematode; Neuropeptide

Indexed keywords

ALANINE; PHENYLALANYLMETHIONYLARGINYLPHENYLALANINAMIDE LIKE PEPTIDE;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; ARTICLE; ASCARIS SUUM; CARBOXY TERMINAL SEQUENCE; CONCENTRATION RESPONSE; DEAMINATION; FEMALE; MUSCLE; MUSCLE EXCITATION; MUSCLE TONE; NONHUMAN; PRIORITY JOURNAL; SPASTIC PARESIS; STRUCTURE ACTIVITY RELATION;

ANIMALIA; ASCARIS SUUM;

EID: 0029938836     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/0196-9781(96)00007-1     Document Type: Article

References (25)

1. Bowman, J. W.; Winterrowd, C. A.; Friedman, A. R.; et al. Nitric oxide mediates the inhibitory effects of SDPNFLRFamide, a nematode FMRFamide-related neuropeptide, on Ascaris suum. J. Neurophysiol. 74:1880-1888; 1995.
2. Cottrell, G. A.; Davies, N. W. Multiple receptor sites for a molluscan peptide (FMRFamide) and related peptides of Helix. J. Physiol. 382:51-68; 1987.
3. Cottrell, G. A. The wide range of actions of the FMRFamide-related peptides and the biological importance of peptidergic messengers. In: Pichon, Y., ed. Comparative molecular neurobiology. Basel: Birkhauser Verlag; 1993:279-285.
4. Cowden, C.; Stretton, A. O. W.; Davis, R. E. AF-1, a sequenced bioactive neuropeptide isolated from the nematode Ascaris. Neuron 2:1465-1473; 1989.
5. Cowden, C.; Stretton, A. O. W. AF2, an Ascaris neuropeptide: Isolation, sequence, and bioactivity. Peptides 14:423-430; 1993.
6. Cowden, C.; Stretton, A. O. W. Eight novel FMRFamide-like neuropeptides isolated from the nematode Ascaris suum. Peptides 16:491-500; 1995.
7. Cunningham, B. C.; Wells, J. A. High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis. Science 244:1081-1085; 1989.
8. Davis, R. E.; Stretton, A. O. W. Passive membrane properties of motorneurons and their role in long-distance signaling in the nematode Ascaris. J. Neurosci. 9:403-414; 1989.
9. Davis, R. E.; Stretton, A. O. W. Signaling properties of Ascaris motorneurons: Graded active responses, graded synaptic transmission and tonic transmitter release. J. Neurosci. 9:415-425; 1989.
10. Fields, C. G.; Lloyd, D. H.; McDonald, R. L.; Otteson, K. M.; Nobel, R. L. HBTU activation for automated FMOC solid-phase peptide synthesis. Pept. Res. 4:95-101; 1991.
11. Franks, C. J.; Holden-Dye, L.; Williams, R. G.; Pang, F. Y.; Walker, R. J. A nematode FMRFamide-like peptide, SDPNFLRFamide, relaxes the dorsal muscle strip preparation of Ascaris suum. Parasitology 108:229-236; 1994.
12. Geary, T. G.; Bowman, J. W.; Friedman, A. R.; et al. The pharmacology of FMRFamide-related neuropeptides in nematodes: New opportunities for rational anthelmintic discovery? Int. J. Parasitol. 25:1273-1280; 1995.
13. Halton, D. W.; Shaw, C.; Maule, A. G.; Smart, D. Regulatory peptides in helminth parasites. Adv. Parasitol. 34:163-227; 1994.
14. Kobayashi, M.; Muneoka, Y. Functions, receptors, and mechanisms of the FMRFamide-related peptides. Biol. Bull. 177:206-209; 1989.
15. Maule, A. G.; Shaw, C.; Bowman, J. W.; et al. KSAYMRFamide: A novel FMRFamide-related heptapeptide from the free-living nematode, Panagrellus redivivus, which is myoactive in the parasitic nematode, Ascaris suum. Biochem. Biophys. Res. Commun. 200: 973-980; 1994.
16. Maule, A. G.; Shaw, C.; Bowman, J. W.; et al. Isolation and preliminary biological characterization of KPNFIRFamide, a novel FMRFamide-related peptide from the free-living nematode, Panagrellus redivivus. Peptides 16:87-93; 1995.
17. Maule, A. G.; Geary, T. G.; Bowman, J. W.; Marks, N. J.; Blair, K. L.; Halton, D. W.; Shaw, C.; Thompson, D. P. Inhibitory effects of nematode FMRFamide-related peptides (FaRPs) on muscle strips from Ascaris suum. Invertebrate Neurosci. 1:255-265; 1995.
18. Pang, F.-Y.; Mason, J.; Holden-Dye, L.; Franks, C. J.; Williams, R. G.; Walker, R. J. The effects of the nematode peptide, KHEYLRFamide (AF2), on the somatic musculature of the parasitic nematode Ascaris suum. Parasitology 110:353-362; 1995.
19. Payza, K. FMRFamide receptors in Helix aspersa. Peptides 8:1065-1074; 1987.
20. Price, D. A.; Greenberg, M. J. The hunting of the FaRPs: The distribution of the FMRFamide-related peptides. Biol. Bull. 177:198-205; 1989.
21. Rosoff, M. L.; Burglin, T. R.; Li, C. Alternatively spliced transcripts of the flp-1 gene encode distinct FMRFamide-like peptides in Caenorhabditis elegans. J. Neurosci. 12:2356-2361; 1992.
22. Rosoff, M. L.; Doble, K. E.; Price, D. A.; Li, C. The flp-1 propeptide is processed into multiple highly similar FMRFamide-like peptides in Caenorhabditis elegans. Peptides 14:331-338; 1993.
23. Sims, S. M.; Magas, L. T.; Barsuhn, C. L.; Ho, N. F. H.; Geary, T. G.; Thompson, D. P. Mechanisms of microenvironmental pH regulation in the cuticle of Ascaris suum. Mol. Biochem. Parasitol. 53:135-148; 1992.
24. Stretton, A. O. W.; Cowden, C.; Sithigorngul, P.; Davis, R. E. Neuropeptides in the nematode Ascaris suum. Parasitology 102:S116-S207; 1991.
25. Walker, R. J. Neuroactive peptides with an RFamide or Famide carboxyl terminal. Comp. Biochem. Physiol. [C] 102:213-222; 1992.