In vivo toxicity of prion protein in murine scrapie: Ultrastructural and immunogold studies

Neuropathology and Applied Neurobiology

Volumn 23, Issue 2, 1997, Pages 93-101

  Jeffrey, M ^a   Goodsir, C M ^a   Bruce, M E ^b   McBride, P A ^b   Fraser, J R ^b  

^a Lasswade Veterinary Laboratory   (United Kingdom)

^b INSTITUTE FOR ANIMAL HEALTH   (United Kingdom)

Author keywords

Amyloid; Electron microscopy; Immunogold; Prion protein; Prp; Scrapie; Spongiform encephalopathies

Indexed keywords

PRION PROTEIN; SIALOGLYCOPROTEIN;

ANIMAL TISSUE; ARTICLE; CELL VACUOLE; CONTROLLED STUDY; DENDRITE; IMMUNOGOLD STAINING; MOUSE; NERVE FIBER; NEUTROPHIL; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; SCRAPIE; SCRAPIE AGENT; TISSUE INJURY; TOXICITY; ULTRASTRUCTURE;

EID: 0030896017     PISSN: 03051846     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2990.1997.tb01191.x     Document Type: Article

References (22)

1. Brandner S, Isenmann S, Raeber A et al. Normal host prion protein necessary for scrapie induced toxicity. Nature 1995; 379: 339-43
2. Brown DR, Schmidt S, Kretzschmar HA. The neurotoxicity of a prion protein fragment requires microglia and neuronal expression of PrP. In: Proceedings of a Conference: Prion Diseases: Epidemiology, Biochemistry and Molecular Biology. Gottingen, October 26-27, Universitat Gottingen, 1995: 108-9
3. Bruce ME, Fraser H. Scrapie strain variation and its implications. Current topics in Microbiol and Immunol 1992; 172: 125-38
4. Bruce ME, McBride PA, Farquhar CF. Precise targeting of the pathology of the sialoglycoprotein PrP, and vacuolar degeneration in mouse scrapie. Neurosci Letters 1989; 102: 1-6
5. Caughey B. Scrapie-associated PrP accumulation and agent replication: effects of sulphated glycosaminoglycan analogues. Phil Transact Royal Soc London 1994; 343: 399-404
6. Caughey B, Race RE. Potent inhibition of scrapie-associated PrP accumulation by Congo-red. J Neurochem 1992; 59: 768-71
7. Caughey B, Raymond GJ. Sulphated polyanion inhibition of scrapie-assodated PrP accumulation in cultured cells. J of Virol 1993; 67: 643-50
8. Forloni G, Bo RD, Angeretti N et al. A neurotoxic prion protein fragment induces rat astroglial proliferation and hypertrophy. Eur J Neurosci 1994; 6: 1415-22
9. Forloni G, Angeretti N, Chiesa R et al. Neurotoxicity of a prion protein fragment. Nature 1993; 362: 543-6
10. Fraser H. The pathogenesis and pathology of scrapie. In: Aspects of Slow and Persistent Virus Infections: Proceedings of the European Workshop sponsored by the Commission of the European Communities on the advice of the Committee on Medical and Public Health Research, London, April 5-6, Ed. Tyrell DAJ. The Hague: Martinus Nijhoff, 1979: 30-58
11. Hope J, Morton LJD, Farquhar CF et al. The major protein of scrapie-associated fibrils (SAF) has the same size, charge distribution and N-terminal protein sequence as predicted for the normal brain protein (PrP). EMBO J 1986; 5: 2591-7
12. Jeffrey M, Goodsir CM, Fowler N et al. Ultrastructural immuno-localisation of synthetic prion protein peptide antibodies in 87 V murine scrapie. Neurodegeneration 1996; 5: 101-9
13. Jeffrey M, Goodsir CM, Bruce ME et al. Correlative light and electron microscopy studies of PrP localisation in 87 V scrapie. Brain Res 1994a; 656: 329-43
14. Jeffrey M, Goodsir CM, Bruce ME et al. Morphogenesis of amyloid plaques in 87 V murine scrapie. Neuropathol and Appl Neurobiol 1994b; 20: 535-42
15. Jeffrey M, Goodsir CM, Bruce ME et al. Murine scrapie-infected neurons in vivo release excess PrP into the extracellular space. Neurosci Lett 1994c; 174: 39-42
16. Kimberlin RH, Walker CA. Suppression of scrapie infection in mice by heteropolyanion 23, dextransulphate, and some other polyanions. Antimicr Agents Chemother 1986; 30: 409-13
17. Marsh RF, Sipe JC, Morse SS, Hanson RP. Transmissible mink encephalopathy. Reduced vacuolation in aged mink of the Chediak-Higashi genotype. Lab Invest 1976; 34: 3432-6
18. Meda L, Cassatella MA, Szendrei GI et al. Activation of microglial cells by β-amyloid protein and interferon-γ. Nature 1995; 374: 647-50
19. Muller WEG, Ushijima H, Schroder HC et al. Cytoprotective effect of NMDA receptor antagonists on prion protein (Prion sc)-induced toxicity in rat cortical cell cultures. Eur J Pharmacol 1993; 246: 261-7
20. Parchi P, Castellani R, Cottelli P et al. Regional distribution of protease-resistant prion protein in fatal familial insomnia. Ann Neurol 1995; 38: 21-9
21. Prusiner SB. Molecular biology and genetics of prion diseases. Phil Transact Royal Soc London 1994; 343: 447-63
22. Snow AD, Kisilevsky R, Willmer et al. Sulphated glycosaminoglycans in amyloid plaques of prion diseases. Acta Neuropathol 1989; 77: 337-42