Molecular mechanisms in myelodysplastic syndromes and implications for evolution to acute leukemias

Clinics in Laboratory Medicine

Volumn 20, Issue 1, 2000, Pages 49-69

  Crisan, D ^a  

^a WILLIAM BEAUMONT HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PLATELET DERIVED GROWTH FACTOR RECEPTOR; RETINOIC ACID RECEPTOR;

ACUTE LEUKEMIA; CHEMICAL CARCINOGENESIS; CHROMOSOME 11Q; CHROMOSOME 16; CHROMOSOME 3; CHROMOSOME 5; CHROMOSOME DELETION; CHROMOSOME INVERSION; CHROMOSOME LOSS; CHROMOSOME TRANSLOCATION; CLONOGENESIS; FUSION GENE; GENE ACTIVATION; GENE MUTATION; GENE REARRANGEMENT; HUMAN; ISOCHROMOSOME; LEUKEMOGENESIS; MYELODYSPLASTIC SYNDROME; ONCOGENE RAS; PRIORITY JOURNAL; PROGNOSIS; REVIEW; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE;

EID: 0034004114     PISSN: 02722712     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0272-2712(18)30076-3     Document Type: Review

References (107)

1. Aitken A. Jones D. Soneji Y. 14-3-3 proteins: Biological function and domain structure Biochem Soc Trans 23 1995 605
2. Anan K. Ito M. Misawa M. Clonal analysis of peripheral blood and haemopoietic colonies in patients with aplastic anaemia and refractory anaemia using the polymorphic short tandem repeat on the human androgen-receptor (HUMARA) gene Br J Haematol 89 1995 838
3. Antilla P. Ihalainen J. Salo A. Idiopathic macrocytic anaemia in the aged: Molecular and cytogenetic findings Br J Haematol 90 1995 797
4. Bartram C.R. Molecular genetic aspects of myelodysplastic syndromes Hematol Oncol Clin North Am 6 1992 557
5. Bartram C.R. Molecular genetic aspects of myelodysplastic syndromes Semin Hematol 33 1996 139
6. Bennett J.M. Catovsky D. Daniel M.T. The chronic myeloid leukaemias: Guidelines for distinguishing chronic granulocytic, atypical chronic myeloid, and chronic myelomonocytic leukaemia: Proposals by the French-American-British Cooperative Leukaemia Group Br J Haematol 87 1994 746
7. Bennett J.M. Catovsky D. Daniel M.T. Proposals for the classification of the myelodysplastic syndromes Br J Haematol 51 1982 189
8. Bincoletto C. Saad S.T.O. Soares da Silva E. Autonomous proliferation and bcl-2 expression involving haematopoietic cells in patients with myelodysplastic syndrome Br J Cancer 78 1998 621
9. Bischof D. Pulford K. Mason D.Y. Role of the nucleophosmin (NPM) portion of the non-Hodgkin’s lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis Mol Cell Biol 17 1997 2312
10. Borer R.A. Lehner C.F. Eppenberger H.M. Major nucleolar proteins shuttle between nucleus and cytoplasm Cell 56 1989 379
11. Boultwood J. Rack K. Kelly S. Loss of both CSF1R (FMS) alleles in patients with myelodysplasia and a chromosome 5 deletion Proc Natl Acad Sci U S A 88 1991 6167
12. Boultwood J. Wainscoat J.S. The 5q — syndrome Blood 84 1994 3253
13. Braselmann S. McCormick F. BCR and RAF form a complex in vivo via 14-3-3 proteins EMBO J 14 1995 4939
14. Carter G. Hughes D.C. Clark R.E. Ras mutations in patients following cytotoxic therapy for lymphoma Oncogene 5 1990 411
15. Chan W-Y. Lui Q.R. Borjigin J. Characterization of the cDNA encoding human nucleophosmin and studies of its role in normal and abnormal growth Biochemistry 28 1989 1033
16. Conklin D.S. Galaktionov K. Beach D. 14-3-3 proteins associate with cdc25 phosphatases Proc Natl Acad Sci U S A 92 1995 7892
17. Culligan D.J. Bowen D.T. May A. Refractory anaemia with preleukaemic polyclonal haemopoiesis and the emergence of monoclonal erythropoiesis on disease progression Br J Haematol 89 1995 675
18. Dunbar C.E. Nienhuis A.W. Myelodysplastic syndromes Handin R.I. Lux S.E. Stossel T.P. Blood Principles & Practice of Hematology 1995 JB Lippincott Philadelphia 377
19. Fanger G.R. Widmann C. Porter A.C. 14-3-3 proteins interact with specific MEK kinases J Biol Chem 273 1998 3476
20. Fenaux P. Morel P. Lai J.L. Cytogenetics of myelodysplastic syndromes Semin Hematol 33 1996 127
21. Fey M.F. Liechti-Gallati S. von Rohr A. Clonality and X-inactivation patterns in hematopoietic cell populations detected by the highly informative M27β DNA probe Blood 33 1994 931
22. Finiewicz K.J. Olopade O.I. Pathogenesis of early leukemia and lymphoma Srivastava S. Henson D.E. Gazdar A. Molecular Pathology of Early Cancer 1999 IOS Press Amsterdam 233
23. Fornerod M. Boer J. van Baal S. Relocation of the carboxyterminal part of CAN from the nuclear envelope to the nucleus as a result of leukemia-specific chromosome rearrangements Oncogene 10 1995 1739
24. Gale R.E. Wheadon H. Goldstone A.H. Frequency of clonal remission in acute myeloid leukaemia Lancet 341 1993 138
25. Ganser A. Janssen J.W.G. Ottmann O.G. In vivo effects of granulocytic-macro-phage colony-stimulating factor and interleukin-3 on clonal and non-clonal cell populations in patients with clonal hematopoietic disorders Leukemia 5 1991 487
26. Gilliland D.G. Blanchard K.L. Levy J. Clonality in myeloproliferative disorders: Analysis by means of the polymerase chain reaction Proc Natl Acad Sci U S A 88 1991 6848
27. Golub T.R. Barker G.F. Lovett M. Fusion of PDGF receptor β to a novel ets-like gene, tel , in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation Cell 77 1994 307
28. Hamblin T. Clinical features of MDS Leuk Res 16 1992 89
29. Head D.R. Revised classification of acute myeloid leukemia Leukemia 10 1996 1826
30. Hirsch-Ginsberg C. LeMaistre A.C. Kantarjian H. RAS mutations are rare events in Philadelphia chromosome-negative /ber gene rearrangement-negative chronic myelogenous leukemia, but are prevalent in chronic myelomonocytic leukemia Blood 76 1990 1214
31. Hitzler J.K. Witte D.P. Jenkins N.A. cDNA cloning, expression pattern and chromosomal localization of Mlfl, murine homologue of a gene involved in myelodysplasia and acute myeloid leukemia Am J Pathol 155 1999 53
32. Hodges E. Howell W.M. Boyd Y. Variable X-chromosome DNA methylation patterns detected with probe M27β in a series of lymphoid and myeloid malignancies Br J Haematol 77 1991 315
33. Hofmann W.K. Ottmann O.G. Ganser A. Myelodysplastic syndromes: Clinical features Semin Hematol 33 1996 177
34. Horiike S. Misawa S. Nakai H. N-ras mutation and karyotypic evolution are closely associated with leukemic transformation in myelodysplastic syndrome Leukemia 8 1994 1331
35. L/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and Pll Mol Endocrinol 11 1997 1858
36. Jacobs A. Genetic lesions in preleukaemia Leukaemia 5 1991 277
37. Janssen J.W.G. Buschle M. Layton M. Clonal analysis of myelodysplastic syndromes: Evidence of multipotent stem cell origin Blood 73 1989 248
38. Kiechle FL, Zhang X, Crisan D: Molecular diagnostic’s role in oncology testing. In Tumor Markers: Successful Laboratory Practice for Today & Tomorrow. AACC Monograph, ed 2. 1999, p 63
39. Koeffler H.P. Introduction: Myelodysplastic syndromes Semin Hematol 33 1996 87
40. Kouides P.A. Bennett J.M. Morphology and classification of myelodysplastic syndromes Hematol Oncol Clin North Am 6 1992 485
41. Kouides P.A. Bennett J.M. Morphology and classification of the myelodysplastic syndromes and their pathologic variants Semin Hematol 33 1996 95
42. Kouides P.A. Bennett J.M. Transformation of chronic myelomonocytic leukemia to acute lymphoblastic leukemia: Case report and review of the literature of lymphoblastic transformation of myelodysplastic syndrome Am J Hematol 49 1995 157
43. Kraemer D. Wozniak R.W. Blobel G. The human CAN protein, a putative oncogene product associated with myeloid leukemogenesis, is a nuclear pore complex protein that faces the cytoplasm Proc Natl Acad Sci U S A 91 1994 1519
44. Kroef MJPL. Fibbe W.E. Mout R. Myeloid but not lymphoid cells carry the 5q deletion: Polymerase chain reaction analysis of loss of heterozygosity using minirepeat sequences on highly purified cell fractions Blood 81 1993 1849
45. Kuefer M.U. Look A.T. Williams D.C. cDNA cloning, tissue distribution, and chromosomal localization of myelodysplasia/myeloid leukemia factor 2 (MLF2) Genomics 35 1996 392
46. Li Y. Bollag G. Clark R. Somatic mutations in neurofibromatosis 1 gene in human tumors Cell 69 1992 275
47. Licht J.D. Shaknovich R. English M.A. DNA-binding and transcriptional properties of the PLZF-retinoic acid receptor-alpha chimera generated in t(11;17)-associated acute promyelocytic leukemia Oncogene 12 1996 232
48. Look A.T. Genes altered by chromosomal translocations in leukemias and lymphomas Vogelstein B. Kanzler K.W. The Genetic Basis of Human Cancer 1998 McGraw-Hill New York 109
49. Lopingco M.C. Perkins A.S. Molecular analysis of EVI1, a zinc finger oncogene involved in myeloid leukemia Curr Top Microbiol Immunol 211 1996 211
50. Lyons J. Janssen J.W.G. Bartram C.R. Mutation of Ki-ras and N -ras oncogenes in myelodysplastic syndromes Blood 71 1988 1707
51. Malkin D. p53 and the Li-Fraumeni syndrome Cancer Genet Cytogenet 66 1993 83
52. Maschek H. Georgii A. Kaloutsi V. Myelofibrosis in primary myelodysplastic syndromes: A retrospective study of 352 patients Eur J Haematol 48 1992 208
53. Matsumoto N. Yoneda-Kato N. Yamamoto Y. Myelodysplasia/myeloid leukemia factor 1, MLF1, as a new marker of prognosis, and leukemia progression from myelodysplastic syndrome Blood 90 1997 201
54. Melani C. Haliassos A. Chomel J.C. Ras activation in myelodysplastic syndromes: Clinical and molecular study of the chronic phase of the disease Br J Haematol 74 1990 408
55. Meller N. Liu Y.C. Collins T.L. 14-3-3 overexpression results in inhibition of PKC translocation and function Mol Cell Biol 16 1996 5782
56. Michaux J.L. Martiat P. Chronic myelomonocytic leukaemia (CMML): A myelodysplastic or myeloproliferative syndrome? Leuk Lymphoma 9 1993 35
57. Morel P. Hebbar M. Lai J.L. Cytogenetic analysis has strong independent prognostic value in de novo myelodysplastic syndromes and can be incorporated in a new scoring system. A report on 408 cases Leukemia 7 1993 1315
58. Morris S.W. Kirstein M.N. Valentine M.B. Fusion of a kinase gene, ALK to a nucleolar protein gene, NPM, in non-Hodgkin’s lymphoma Science 263 1994 1281
59. Morrison D. 14-3-3: modulators of signaling proteins? Science 266 1994 56
60. Muslin A.J. Tanner J.W. Allen P.M. Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine Cell 84 1996 889
61. Negrin R.S. Haeuber D.H. Nagler A. Maintenance treatment of patients with myelodysplastic syndromes using recombinant human granulocyte colony stimulating factor Blood 76 1990 36
62. Neubauer A. Dodge R.K. George S.L. Prognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemia Blood 83 1994 1603
63. Neubauer A. Greenberg P. Negrin R. Mutations in the ras proto-oncogenes in patients with myelodysplastic syndromes Leukemia 8 1994 638
64. Newsham I.F. Hadjistilianou T. Cavenne W.K. Retinoblastoma Vogelstein B. Kinzler K.W. The Genetic Basis of Human Cancer 1998 McGraw-Hill New York 363
65. Nowell P.C. Chromosome abnormalities in myelodysplastic syndromes Semin Oncol 19 1992 25
66. Ohyashiki J.H. Ohyashiki K. Shimamoto T. Ecotropic vims integration site-1 gene preferentially expressed in post-myelodysplasia acute myeloid leukemia: Possible association with GATA-1, GATA-2 and stem cell leukemia gene expression Blood 85 1995 3713
67. Ohyashiki K. Sasao I. Ohyashiki J.H. Clinical and cytogenetic characteristics of myelodysplastic syndromes developing myelofibrosis Cancer 68 1991 178
68. Padua R.A. Carter G. Hughes D. RAS mutations in myelodysplasia detected by amplification, oligonucleotide hybridization, and transformation Leukemia 2 1988 503
69. Paquette R.L. Landaw E.M. Pierre R.V. N -ras mutations are associated with poor prognosis and increased risk of leukemia in myelodysplastic syndrome Blood 82 1993 590
70. Parker J.E. Mufti G.J. Ineffective haematopoiesis and apoptosis in myelodysplastic syndromes Br J Haematol 101 1998 202
71. Parker J. Mufti G.J. Ras and myelodysplasia: Lessons from the past decade Semin Hematol 33 1996 206
72. Passmore S.J. Hann I.M. Stiller C.A. Pediatric myelodysplasia: A study of 68 children and a new prognostic scoring system Blood 85 1995 1742
73. Peng C.Y. Graves P.R. Thoma R.S. Mitotic and G2 checkpoint control: Regulation of 14-3-3L protein binding by phosphorylation of Cdc25C on serine 216 Science 277 1997 1501
74. Prchal J.T. Trockmorton D.W. Carrol A.J. A common progenitor for myeloid and lymphoid cells Nature 274 1978 590
75. Pui C.H. Kane J.R. Crist W.M. Biology and treatment of infant leukemias Leukemia 9 1995 762
76. Raimondi S.C. Dube I.D. Valentine M.B. Clinicopathologic manifestations and breakpoints of the t(3;5) in patients with acute nonlymphocytic leukemia Leukemia 3 1989 42
77. Rajapaksa R. Ginzton N. Rott L.S. Altered oncoprotein expression and apoptosis in myelodysplastic syndrome marrow cells Blood 88 1996 4275
78. Raza A. Gezer S. Mundle S. Apoptosis in bone marrow biopsy samples involving stromal and hematopoietic cells in 50 patients with myelodysplastic syndromes Blood 86 1995 268
79. Raza A. Mundle S. Shetty V. A paradigm shift in myelodysplastic syndromes Leukemia 10 1996 1648
80. Redner R.L. Rush E.A. Faas S. The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion Blood 87 1996 882
81. Reuther G.W. Fu H. Cripe L.D. Association of the protein kinases c-Bcr and Bcr-Abl with proteins of the 14-3-3 family Science 266 1994 129
82. Reuther G.W. Pendergast A.M. The roles of 14-3-3 proteins in signal transduction Vitam Horm 52 1996 149
83. Robertson H. Langdon W.Y. Thien C.B.F. A c-Cbl yeast hybrid screen reveals interactions with 14-3-3 isoforms, and cytoskeletal components Biochem Biophys Res Comm 240 1997 46
84. Rosati S. Anastasi J. Vardiman J. Recurring diagnostic problems in the pathology of the myelodysplastic syndromes Semin Hematol 33 1996 111
85. Roy S. McPherson R.A. Apolloni A. 14-3-3 facillitates Ras-dependent Raf-1 activation in vitro and in vivo Mol Cell Biol 18 1998 3947
86. Russell M. List A. Greenberg P. Expression of EVI 1 in myelodysplastic syndromes and other hematologic malignancies without 3q26 translocations Blood 84 1994 1243
87. Schmidt-Zachmann M.S. Franke W.W. cDNA cloning and amino acid sequence determination of a major constituent protein of mammalian nucleoli: Correspondence of the nucleoplasmin-related protein N038 to mammalian protein B23 Chromosoma 96 1988 417
88. Suzuki Y. Demoliere C. Kitamura D. HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HSI, a substrate of Src family tyrosine kinases J Immunol 158 1997 2736
89. Taylor C. Hughes D.C. Zappone E. A screen for ras mutations in individuals at risk of secondary leukaemia due to occupational exposure to petrochemicals Leuk Res 19 1995 299
90. Taylor C. McGlynn H. Carter G. Ras and Fms mutations following cytotoxic therapy for childhood acute lymphoblastic leukaemia Leukemia 9 1995 466
91. Tefferi A. Thibodeau S.N. Solberg L.A. Clonal studies in the myelodysplastic syndrome using X-linked restriction fragment length polymorphism Blood 75 1990 1770
92. Thorson J.A. Yu L.W.K. Hsu A.L. 14-3-3 proteins are required for maintenance of Raf-1 phosphorylation, and kinase activity Mol Cell Biol 18 1998 5229
93. Toyama K. Ohyashiki K. Yoshida Y. Clinical implications of chromosomal abnormalities in 401 patients with myelodysplastic syndromes: A multicentric study in Japan Leukemia 7 1993 499
94. Tsukamoto N. Morita K. Maehara T. Clonality in myelodysplastic syndromes: Demonstration of pluripotent stem cell origin using X-linked restriction fragment length polymorphisms Br J Haematol 83 1993 589
95. Tzivion G. Luo Z. Avruch J. A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity Nature 394 1998 88
96. Vadham-Raj S. Broxmeyer H.E. Spitzer G. Stimulation of nonclonal hematopoiesis and suppression of the neoplastic clone after treatment with recombinant human granulocyte-macrophage colony stimulating factor in a patient with therapy-related myelodysplastic syndrome Blood 74 1989 1491
97. Waterman M.J.F. Stavridi E.S. Waterman J.L.F. ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins Nat Genet 19 1998 175
98. White N.H. Nacheva E. Asimakopoulos F.A. Deletion of chromosome 20q in myelodysplasia can occur in a multipotent precursor of both myeloid cells and B cells Blood 83 1994 2809
99. Williams J.H. Daly L.N. Ingley E. Characterization of novel genes associated with a hemopoietic lineage switch Blood 92 1998 475
100. Willman C.L. Acute leukemias: A paradigm for the integration of new technologies in diagnosis and classification Mod Pathol 12 1999 218
101. Willman C.L. Molecular assessment of clonality in hematopoietic lesions: Disease applications Am J Surg Pathol 19 1995 237
102. Wlodarska I. Mecucci C. Marynen P. TEL gene is involved in myelodysplastic syndromes with either the typical t(5;12) (q33;p13) translocation or its variant t(10;12) (q24;p13) Blood 85 1995 2848
103. Yaffe M.B. Rittinger K. Volinia S. The structural basis for 14-3-3; phosphopeptide binding specificity Cell 91 1997 961
104. Yan X.Q. Brady G. Iscove N.N. Overexpression of PDGFR-B in murine hematopoietic cells induces a lethal myeloproliferative syndrome in vivo Oncogene 9 1994 163
105. Yoneda-Kato N. Look A.T. Kirstein M.N. The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1 Oncogene 12 1996 265
106. Yunis J.J. Lobeil M. Arnesen M.A. Refined chromosome study helps define prognostic subgroups in most patients with primary myelodysplastic syndrome and acute myelogenous leukaemia Br J Haematol 68 1988 189
107. Zha J. Harada H. Yang E. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-XL Cell 87 1996 619