Generation and evaluation of putative neuroregenerative drugs. Part 1: Virtual point mutations to the polyketide rapamycin

Bioorganic and Medicinal Chemistry

Volumn 8, Issue 3, 2000, Pages 617-624

  Adalsteinsson, Helgi ^a   Bruice, Thomas C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; FK 506 BINDING PROTEIN; IMMUNOPHILIN; IMMUNOSUPPRESSIVE AGENT; POLYKETIDE; PROTEIN; RAPAMYCIN; RAPAMYCIN DERIVATIVE; TACROLIMUS; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BIOSYNTHESIS; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; ENERGY; MOLECULAR DYNAMICS; NERVE REGENERATION; POINT MUTATION; PROTEIN BINDING; TECHNIQUE;

ANTI-BACTERIAL AGENTS; BINDING SITES; COMPUTER SIMULATION; GENETIC ENGINEERING; IMMUNOPHILINS; IMMUNOSUPPRESSIVE AGENTS; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MULTIENZYME COMPLEXES; NERVE REGENERATION; POINT MUTATION; SIROLIMUS; SOLVENTS; TACROLIMUS; TACROLIMUS BINDING PROTEINS; THERMODYNAMICS;

EID: 0034002725     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00323-5     Document Type: Article

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