Fas- and tumor necrosis factor receptor 1-dependent but not perforin- dependent pathways cause injury in livers infected with an adenovirus construct in mice

Hepatology

Volumn 31, Issue 3, 2000, Pages 665-673

  Liu, Zhang Xu ^a   Govindarajan, Sugantha ^a   Okamoto, Shigefumi ^a   Dennert, Gunther ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; BETA ACTIN; FAS ANTIGEN; MESSENGER RNA; PERFORIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR BINDING PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR;

ADENOVIRUS 5; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; GENE EXPRESSION; HISTOPATHOLOGY; LIVER INJURY; LYMPHOCYTIC INFILTRATION; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS INFECTION;

EID: 0033999781     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510310317     Document Type: Article

References (29)

1. Chisari FV. Cytotoxic T cells and viral hepatitis. J Clin Invest 1997;99:1472-1477.
2. Dennert G, Podack ER. Cytolysis by H-2-specific T killer cells. Assembly of tubular complexes on target membranes. J Exp Med 1983;157:1483-1495.
3. Kagi D, Ledermann B, Burki K, Seiler P, Odermatt B, Olson KJ, Podack ER, et al. Cytotoxity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature 1994;369:31-37.
4. Rouvier E, Luciani MF; Golstein P. Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity. J Exp Med 1993;177:195-200.
5. Lowin B, Hahne M, Mattmann C, Tschopp J. Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways. Nature 1994;370:650-652.
6. Nagata S, Golstein E The Fas dealth factor. Science 1995;267:1449-1456.
7. Ratner A, Clark WR. Role of TNF-alpha in CD8+ cytotoxic T lymphocyte-mediated lysis. J Immunol 1993;150:4303-4314.
8. Sarin A, Conan-Cibotti M, Henkart PA. Cytotoxic effect of TNF and lymphotoxin on T lymphoblasts. J Immunol 1995;155:3716-3718.
9. Zheng L, Fisher G, Miller RE, Peschon J, Lynch DH, Lenardo MJ. Induction of apoptosis in mature T cells by tumour necrosis factor. Nature 1995;377:348-351.
10. Lacronique V, Mignon A, Fabre M, Viollet B, Rouquet N, Molina T, Porteu A, et al. Bcl-2 protects from lethal hepatic apoptosis induced by an anti-Fas antibody in mice. Nat Med 1996;2:80-86.
11. Ogasawara J, Watanabe-Fukunaga R, Adachi M, Matsuzawa A, Kasugai T, Kitamura Y, Itoh N, et al. Lethal effect of the anti-Fas antibody in mice. Nature 1993;364:806-809.
12. Yang Y, Ertl HC, Wilson JM. MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses. Immunity 1994;1:433-442.
13. Jooss K, Ertl HC, Wilson JM. Cytotoxic T-lymphocyte target proteins and their major histocompatibility complex class I restriction in response to adenovirus vectors delivered to mouse liver. J Virol 1998;72:2945-2954.
14. Juillard V, Villefroy P, Godfrin D, Pavirani A, Venet A, Guillet J-G. Long-term humoral and cellular immunity induced by a single immunization with replication-defective adenovirus recombinant vector. Eur J Immunol 1995;25:3467-3473.
15. Yang Y, Li Q, Ertl HC, Wilson JM. Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses. J Virol 1995;69:2004-2015.
16. Yang Y, Wilson JM. Clearance of adenovirus-infected hepatocytes by MHC class I-restricted CD4+ CTLs in vivo. J Immunol 1995;155:2564-2570.
17. Yang Y, Su Q, Wilson JM. Role of viral antigens in destructive cellular immune responses to adenovirus vector-transduced cells in mouse lungs. J Virol 1996;70:7209-7212.
18. Zhang HG, Zhou T, Yang P, Edwards CK III, Curiel DT, Mountz JD. Inhibition of tumor necrosis factor alpha decreases inflammation and prolongs adenovirus gene expression in lung and liver. Hum Gene Ther 1998;9:1875-1884.
19. Ksontini R, Colagiovanni DB, Josephs MD, Edwards CK III, Tannahill CL, Solorzano CC, Norman J, et al. Disparate roles for TNF-alpha and Fas ligand in concanavalin A-induced hepatitis. J Immunol 1998;160:4082-4089.
20. Watanabe H, Ohtsuka K, Kimura M, Ikarashi Y, Ohmori K, Kusumi A, Ohteki T, et al. Details of an isolation method for hepatic lymphocytes in mice. J Immunol Methods 1992;146:145-154.
21. Goossens PL, Jouin H, Marchal G, Milon G. Isolation and flow cytometric analysis of the free lymphomyeloid cells present in murine liver. J Immunol Methods 1990;132:137-144.
22. Ebnet K, Hausmann M, Lehmann-Grube F, Mullbacher A, Kopf M, Lamers M, Simon MM. Granzyme A-deficient mice retain potent cell-mediated cytotoxicity. EMBO J 1995;14:4230-4239.
23. Tsutsui H, Nakanishi K, Matsui K, Higashino K, Okamura H, Miyazawa Y, Kaneda K. IFN-gamma-inducing factor up-regulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones. J Immunol 1996;157:3967-3973.
24. Yang Y, Raper SE, Cohn JA, Engelhardt JF, Wilson JM. An approach for treating the hepatobiliary disease of cystic fibrosis by somatic gene transfer. Proc Natl Acad Sci U S A 1993;90:4601-4605.
25. Song W, Kong HL, Traktman Crystal RG. Cytotoxic T lymphocyte responses to proteins encoded by heterologous transgenes transferred in vivo by adenoviral vectors. Hum Gene Ther 1997;8:1207-1217.
26. Kaplan JM, Armentano D, Sparer TE, Wynn SG, Peterson PA, Wadsworth SC, Couture KK, et al. Characterization of factors involved in modulating persistence of transgene expression from recombinant adenovirus in the mouse lung. Hum Gene Ther 1997;8:45-56.
27. Duerksen-Hughes P, Wold WS, Gooding LR. Adenovirus E1A renders infected cells sensitive to cytolysis by tumor necrosis factor. J Immunol 1989;143:4193-4200.
28. Gooding LR, Sofola IO, Tollefson AE, Duerksen-Hughes P, Wold WS. The adenovirus E3-14.7K protein is a general inhibitor of tumor necrosis factor-mediated cytolysis. J Immunol 1990;145:3080-3086.
29. Worgall S, Wolff G, Falck-Pedersen E, Crystal RG. Innate immune mechanisms dominate elimination of adenoviral vectors following in vivo administration. Hum Gene Ther 1997;8:37-44.