Treatment-resistant expansion of CD8+CD28-cells in pediatric HIV infection

Pediatric Research

Volumn 47, Issue 3, 2000, Pages 418-421

  Niehues, Tim ^a   Horneff, Gerd ^b   Knipp, Sabine ^a   Adams, Ortwin ^a   Wahn, Volker ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CD28 ANTIGEN; CD8 ANTIGEN; DIDANOSINE; LAMIVUDINE; NELFINAVIR; NUCLEOSIDE ANALOG; RITONAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; STAVUDINE; VIRUS RNA; ZIDOVUDINE;

ANTIGEN EXPRESSION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS REPLICATION;

EID: 0033996639     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/00006450-200003000-00022     Document Type: Article

References (23)

1. Horneff G, Adams O, Wahn V 1998 Pilot study of zidovudine-lamivudine combination therapy in vertically HIV-infected antiretroviral-naive children. AIDS 12:489-494
2. Vigano A, Saresella M, Rusconi S, Ferrante P, Clerici M 1998 Expression of CD38 on CD8 T cells predicts maintenance of high viraemia in HAART-treated HIV-1-infected children. Lancet 352:1905-1906
3. Giorgi JV, Hultin LE, McKeating JA, Johnson TD, Owens B, Jacobson LP, Shih R, Lewis J, Wiley DJ, Phair JP, Wolinsky SM, Detels R 1999 Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage. J Infect Dis 179:859-870
4. Viola A, Schroeder S, Sakakibara Y, Lanzavecchia A 1999 T lymphocyte costimulation mediated by reorganization of membrane microdomains. Science 283:680-682
5. Lewis DE, Tang DS, Adu-Oppong A, Schober W, Rodgers JR 1994 Anergy and apoptosis in CD8+ T cells from HIV-infected persons. J Immunol 153:412-420
6. Roos MT, Prins M, Koot M, de Wolf F, Bakker M, Coutinho RA, Miedema F, Schellekens PT 1998 Low T-cell responses to CD3 plus CD28 monoclonal antibodies are predictive of development of AIDS. AIDS 12:1745-1751
7. Niehues T, Ndagijimana J, Horneff G, Wahn V 1998 CD28 expression in pediatric human immunodeficiency virus infection. Pediatr Res 44:265-268
8. Melvin AJ, Mohan KM, Arcuino LA, Edelstein RE, Frenkel LM 1997 Clinical, virologie and immunologic responses of children with advanced human immunodeficiency virus type 1 disease treated with protease inhibitors. Pediatr Infect Dis J 16:968-974
9. Powderly WG, Landay A, Lederman MM 1998 Recovery of the immune system with antiretroviral therapy: the end of opportunism? JAMA 280:72-77
10. Cohen Stuart JW, Slieker WA, Rijkers GT, Noest A, Boucher CA, Suur MH, de Boer R, Geelen SP, Scherpbier HJ, Hartwig NG, Hooijkaas H, Roos MT, de Graeff-Meeder B, de Groot R 1998 Early recovery of CD4+ T lymphocytes in children on highly active antiretroviral therapy. Dutch study group for children with HIV infections. AIDS 12:2155-2159
11. Sleasman JW, Nelson RP, Goodenow MM, Wilfret D, Hutson A, Baseler M, Zuckerman J, Pizzo PA, Mueller BU 1999 Immunoreconstitution after ritonavir therapy in children with human immunodeficiency virus infection involves multiple lymphocyte lineages. J Pediatr 134:597-606
12. Böhler T, Walcher J, Holzl-Wenig G, Geiss M, Buchholz B, Linde R, Debatin KM 1999 Early effects of antiretroviral combination therapy on activation, apoptosis and regeneration of T cells in HIV-1-infected children and adolescents. AIDS 13:779-789
13. Pakker NG, Kroon ED, Roos MT, Otto SA, Hall D, Wit FW, Hamann D, van der Ende ME, Claessen FA, Kauffmann RH, Koopmans PP, Kroon FP, ten Napel CH, Sprenger HG, Weigel HM, Montaner JS, Lange JM, Reiss P, Schellekens PT, Miedema F 1999 Immune restoration does not invariably occur following long-term HIV-1 suppression during antiretroviral therapy. INCAS Study Group. AIDS 13:203-212
14. Douek DC, McFarland RD, Reiser PH, Gage EA, Massey JM, Haynes BF, Polis MA, Haase AT, Feinberg MB, Sullivan JL, Jamieson BD, Zack JA, Picker LJ, Koup RA 1998 Changes in thymic function with age and during the treatment of HIV infection. Nature 396:690-695
15. Pakker NG, Notermans DW, de Boer RJ, Roos MT, de Wolf F, Hill A, Leonard JM, Danner SA, Miedema F, Schellekens PT 1998 Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: a composite of redistribution and proliferation. Nat Med 4:208-214
16. Arno A, Ruiz L, Juan M, Zayat MK, Puig T, Balague M, Romeu J, Pujol R, O'Brien WA, Clotet B 1998 Impact on the immune system of undetectable plasma HIV-1 RNA for more than 2 years. AIDS 12:697-704
17. Angel JB, Kumar A, Parato K, Filion LG, Diaz-Mitoma F, Daftarian P, Pham B, Sun E, Leonard JM, Cameron DW 1998 Improvement in cell-mediated immune function during potent anti-human immunodeficiency virus therapy with ritonavir plus saquinavir. J Infect Dis 177:898-904
18. Bouscarat F, Levacher M, Landman R, Muffat-Joly M, Girard PM, Saimot AG, Brun-Vezinet F, Sinet M 1998 Changes in blood CD8+ lymphocyte activation status and plasma HIV RNA levels during antiretroviral therapy. AIDS 12:1267-1273
19. Giorgi JV, Majchrowicz MA, Johnson TD, Hultin P, Malud J, Detels R 1998 Immunologic effects of combined protease inhibitor and reverse transcriptase inhibitor therapy in previously treated chronic HIV-1 infection. AIDS 12:1833-1844
20. Mugnaini EN, Spurkland A, Egeland T, Sannes M, Brinchmann JE 1998 Demonstration of identical expanded clones within both CD8+CD28+ and CD8+CD28-T cell subsets in HIV type 1-infected individuals. Eur J Immunol 28:1738-1742
21. Effros RB, Allsopp R, Chiu CP, Hausner MA, Hirji K, Wang L, Harley CB, Villeponteau B, West MD, Giorgi JV 1996 Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis. AIDS 10:F17-F22
22. Mugnaini EN, Haaheim LL, Sannes M, Brinchmann JE 1999 In vivo expansion coincident with excessive in vitro cell death within the memory subset of CD8+ T cells in HIV type 1 infection. AIDS Res Hum Retroviruses 15:265-272
23. Fiorentino S, Dalod M, Olive D, Guillet JG, Gomard E 1996 Predominant involvement of CD8+CD28-lymphocytes in human immunodeficiency virus-specific cytotoxic activity. J Virol 70:2022-2026