Bacteriologic efficacy of a three-day intramuscular ceftriaxone regimen in nonresponsive acute otitis media

Pediatric Infectious Disease Journal

Volumn 17, Issue 12, 1998, Pages 1126-1131

  Leibovitz, Eugene ^a   Piglansky, Lolita ^a   Raiz, Simon ^a   Greenberg, David ^a   Yagupsky, Pablo ^a   Press, Joseph ^a   Fliss, Dan M ^a   Leiberman, Alberto ^a   Dagan, Ron ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

Acute otitis media; Antibiotic resistance; Ceftriaxone; Haemophilus influenzae; Streptococcus pneumoniae

Indexed keywords

AMOXICILLIN; AMOXICILLIN PLUS CLAVULANIC ACID; CEFACLOR; CEFTRIAXONE; CEFUROXIME; PENICILLIN G;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; ARTICLE; BACTERIUM CULTURE; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; HAEMOPHILUS INFLUENZAE; HUMAN; INFANT; INTRAMUSCULAR DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; MINIMUM INHIBITORY CONCENTRATION; MORAXELLA CATARRHALIS; OTITIS MEDIA; PRESCHOOL CHILD; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES;

ACUTE DISEASE; ANTI-BACTERIAL AGENTS; CEFTRIAXONE; CEPHALOSPORINS; CHILD, PRESCHOOL; DRUG ADMINISTRATION SCHEDULE; DRUG RESISTANCE, MULTIPLE; FEMALE; FOLLOW-UP STUDIES; HUMANS; INFANT; INJECTIONS, INTRAMUSCULAR; MALE; MICROBIAL SENSITIVITY TESTS; OTITIS MEDIA; PROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 0032425280     PISSN: 08913668     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006454-199812000-00005     Document Type: Article

References (26)

1. Baquero F, Loza E. Antibiotic resistance of microorganisms involved in ear, nose and throat infections. Pediatr Infect Dis J 1994;13:S9-14.
2. Neu HC. Otitis media: antibiotic resistance of causative pathogens and treatment alternatives. Pediatr Infect Dis J 1995;14:S51-6.
3. Gehanno P, Lenoir G, Berche P. In vivo correlates for Streptococcus pneumoniae penicillin resistance in acute otitis media. Antimicrob Agents Chemother 1995;39:271-2.
4. Block SL, Harrison CJ, Hedrick JA, et al. Penicillin-resistant Streptococcus pneumoniae in acute otitis media: risk factors, susceptibility and antimicrobial management. Pediatr Infect Dis J 1995;14:751-9.
5. Dagan R, Abramson O, Leibovitz E et al. Impaired bacteriologic response to oral cephalosporins in acute otitis media caused by pneumococci with intermediate resistance to penicillin. Pediatr Infect Dis J 1996;15:980-5.
6. Dagan R, Abramson O, Leibovitz E, et al. Bacteriologic response to oral cephalosporins: are established susceptibility breakpoints appropriate in the case of acute otitis media? J Inf Dis 1997;176:1253-9.
7. Dagan R, Leibovitz E, Jacobs M, Fliss DM, Leiberman A, Jagupsky P. Bacteriologic response in acute otitis media caused by Haemophilus influenzae treated with azithromycin [Abstract K102]. In: Program and abstracts of the 37th International Conference on Antimicrobial Agents and Chemotherapy, Toronto, September 28 to October 1, 1997. Washington, DC: American Society for Microbiology, 1997.
8. Dagan R, Piglansky L, Yagupsky P, et al. Bacteriologic response to acute otitis media: comparison between azithromycin, cefaclor and amoxicillin. In: Program and abstracts of the 37th International Conference on Antimicrobial Agents and Chemotherapy, Toronto, September 28 to October 1, 1997. Washington, DC: American Society of Microbiology, 1997.
9. Green SM, Rothrock SG. Single-dose intramuscular ceftriaxone for acute otitis media in children. Pediatrics 1993;91:23-30.
10. Chamberlain JM, Boenning DA, Waisman Y, Ochsenschlager DW, Klein BL. Single-dose ceftriaxone versus 10 days of cefaclor for otitis media. Clin Pediatr 1994;33:642-6.
11. Barnett ED, Teele DW, Klein JO, Cabral HJ, Kharasch SJ. Comparison of ceftriaxone and trimethoprim-sulfamethoxazole for acute otitis media. Pediatrics 1997;99:23-8.
12. Howie VM. Eradication of bacterial pathogens from middle ear infections. Clin Infect Dis 1992;14(Suppl. 2):209-10.
13. Austrian R. The Quellung reaction, a neglected microbiologic technique. Mt Sinai J Med NY 1976;43:669-705.
14. National Committee for Clinical Laboratory Standards. Performance standards for antimicrobial susceptibility testing: Sixth Informed Supplement. NCCLS Document M100-S6. vol 15, no. 14. Villanova, PA: National Committee for Clinical Laboratory Standards, 1995.
15. Dagan R, Leibovitz E, Fliss DM, Yagupsky P, Leiberman A. Early eradication of pathogens from middle ear fluid during treatment of acute otitis media is associated with improved clinical outcome [Abstract K24]. In: Program and abstracts of the 36th International Conference on Antimicrobial Agents and Chemotherapy, New Orleans, September 15 to 18, 1996. Washington, DC: American Society for Microbiology, 1996.
16. Teele DW, Pelton SI, Klein JO. Bacteriology of acute otitis media unresponsive to initial antimicrobial therapy. J Pediatr 1981;98:537-9.
17. Harrison CJ, Marks MI, Welch DF. Microbiology of recently treated acute otitis media compared with previously untreated acute otitis media. Pediatr Infect Dis J 1985;4:641-6.
18. Pichichero ME, Pichichero CL. Persistent acute otitis media: I. Causative pathogens. Pediatr Infect Dis J 1995;14:178-83.
19. Leibovitz E, Raiz S, Piglansky L, et al. Resistance pattern of middle ear fluid isolates in acute otitis media recently treated with antibiotics. Pediatr Infect Dis J 1998;17:463-9.
20. Pichichero ME. Persistent acute otitis media: II. Antimicrobial treatment. Pediatr Infect Dis J 1995;14:183-8.
21. Block SL. Causative pathogens, antibiotic resistance and therapeutic considerations in acute otitis media. Pediatr Infect Dis J 1997;16:449-56.
22. Hoberman A, Paradise J, Burch D, et al. Equivalent efficacy and reduced occurrence of diarrhea from a new formulation of amoxicillin/clavulanate potassium (Augmentin®) for the treatment of acute otitis media. Pediatr Infect Dis J 1997;16: 463-70.
23. Schaad U, Stoeckel K. Single-dose pharmacokinetics of ceftriaxone in infants and young children. Antimicrob Agents Chemother 1982;21:248-53.
24. Fraschini F, Braga PC, Scarpazza G, et al. Human pharmacokinetics and distribution in various tissues of ceftriaxone. Chemotherapy 1986;32:192-9.
25. Gudnason T, Gudbrandsson F, Barsanti F, Kristinsson KG. Penetration of ceftriaxone into the middle ear fluid of children. Pediatr Infect Dis J 1998;17:258-60.
26. Gehanno P, Berche P, N'Guyen L, Derriennic M, Pichon F, Goehrs JM. Resolution of clinical failure in acute otitis media confirmed by in vivo bacterial eradication: efficacy and safety of ceftriaxone injected once daily, for 3 days [Abstract LM45]. In: Programs and abstracts of the 37th International Conference on Antimicrobial Agents and Chemotherapy, Toronto, September 28 to October 1, 1997. Washington, DC: American Society of Microbiology, 1997.